EKS-TAG-00475
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00475
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR524.61.1E-157522855334
StatusUnreviewed
Ensembl ProteinENSTGUP00000011979
UniProt AccessionH0ZN05;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000011607ENSTGUP00000011979ENSTGUT00000012110
OrganismTaeniopygia guttata
Functional Description
Protein Length867
Protein Sequence
(FASTA)
IELRITMSIP NIISCFWFFK KSKACELSFD SENRYITSLA FSQIKEGQAG KYTLLVTSKS 60
GNYRVVVPVL IQSKSLLVIR TKPYFRKREK SDYIECISES YPQPSVEWIF CKTPEKRYVH 120
EETGEIDGKQ MVQHELFQTY IWCCAVNVLG RECTSLFTID LNERQAAPLP ELLLKVSEPL 180
LIRCRAVHQN YKFRIQLSFE NREVEQGCHF EGLEYQENFS AIRIQYVFIS AAEKNYSGHY 240
TCSSTAHPNQ TALITVLEKG FINITDSKED FEIGEEEFCF EVSFTAYPPV RCVWLYSNRT 300
FPCIQKALVK GCISSKFCNH QHQSGIYVFY AENDDAVATK KFTLYVRRKP EIRMQLLFKQ 360
ISCVAEGYPA SSWVWRNCLE LNSSNCAEEI TEGIQNFLPE RRSLGSWISS STLHVKETAT 420
TFSVECCANN SAGSACEKRF INLSGAVSSP LDNAAFYVSV GFFLLLITFV LVFFFLKYKK 480
QFKYESQWQM IQMIGPSDNE YIYIDFREFE YDIKWEFPRE NLEFGQVLGS GAFGKVVTAT 540
AYGINNAGDS VQVAVKMLKE KPDTAEEDAL MSELKMMTHI GSHENIVNLL GACTLSGPIY 600
LIFEYCCYGD LLNYLRSKRE KFHWTLTDIF KQQNFSFYHN IHQDQNSRED ECETMQRSQN 660
INVTLGSNGI VLFSEEVLEY KNTHLYFVSD EEDFNVLTFE DLLCFSFQVA KGMEFLESKS 720
CIHRDLAARN ILVTHGKVVK ICDFGLARDV MNDSNYIVRG NARLPVKWMA PESLFERTYT 780
MKSDVWSYGI LLWEIFSLGV NPYPGIQVDT NFYKLIQSGF KMDQPYYATK DVYCLMRSCW 840
ALDSRKRPSF SYLVSSLACQ LAEAEGA 867
Nucleotide Sequence
(FASTA)
ATTGAATTAA GAATAACAAT GAGTATTCCA AATATCATTT CATGCTTCTG GTTCTTTAAA 60
AAGAGCAAAG CCTGTGAACT TTCTTTCGAC TCAGAGAATA GATATATAAC ATCTTTGGCT 120
TTTTCCCAAA TAAAAGAAGG ACAAGCTGGA AAATACACCC TCTTGGTCAC AAGTAAATCT 180
GGCAATTACA GAGTAGTTGT GCCCGTTCTC ATCCAAAGTA AAAGTTTGCT GGTTATCAGA 240
ACCAAACCCT ATTTCAGGAA AAGGGAAAAA TCGGATTATA TCGAGTGCAT ATCTGAGAGC 300
TACCCCCAGC CCTCTGTGGA ATGGATATTC TGCAAAACAC CAGAAAAGAG GTATGTGCAT 360
GAAGAAACTG GAGAAATAGA TGGCAAACAG ATGGTGCAAC ATGAATTATT TCAAACTTAC 420
ATATGGTGCT GTGCAGTTAA TGTCCTGGGC AGAGAATGCA CCAGCCTCTT TACAATAGAT 480
TTAAATGAAA GACAAGCAGC ACCTTTACCT GAGCTACTAC TTAAGGTCAG TGAACCATTG 540
CTGATCAGAT GCAGAGCTGT TCACCAAAAT TATAAATTCA GAATACAACT GTCTTTTGAA 600
AACAGAGAAG TTGAGCAGGG CTGTCACTTT GAAGGATTAG AATATCAAGA AAACTTCTCA 660
GCAATTCGTA TCCAGTATGT GTTTATTTCA GCAGCAGAAA AAAATTACAG TGGACATTAC 720
ACCTGTTCTT CTACTGCTCA TCCGAATCAA ACTGCTTTGA TCACAGTTCT AGAAAAGGGA 780
TTTATAAATA TAACTGACTC TAAAGAAGAT TTTGAAATTG GTGAAGAAGA GTTTTGCTTT 840
GAAGTCAGCT TTACAGCATA TCCTCCAGTT AGATGCGTGT GGCTATATTC CAATAGAACA 900
TTTCCATGTA TACAAAAGGC ATTAGTAAAA GGCTGCATTT CATCGAAGTT CTGCAACCAT 960
CAGCACCAGT CTGGGATATA TGTATTTTAT GCTGAAAATG ATGATGCAGT TGCAACAAAA 1020
AAATTCACTC TATATGTGAG AAGAAAGCCT GAAATAAGGA TGCAGTTGTT GTTCAAGCAG 1080
ATCTCCTGTG TTGCTGAAGG CTACCCTGCC TCATCCTGGG TTTGGAGGAA CTGTCTTGAA 1140
CTGAATTCAT CCAACTGCGC AGAGGAAATC ACAGAGGGGA TTCAGAACTT CTTGCCAGAG 1200
AGGAGATCCC TGGGGTCATG GATTTCAAGC AGTACTTTAC ATGTAAAGGA GACAGCAACA 1260
ACCTTCTCTG TGGAGTGCTG TGCAAATAAT TCAGCTGGTT CAGCCTGTGA AAAGCGTTTC 1320
ATTAACCTGT CAGGAGCTGT TTCTTCCCCC CTGGACAATG CTGCGTTCTA TGTCTCCGTT 1380
GGATTTTTTC TCCTCTTGAT CACTTTTGTG CTTGTCTTCT TTTTTCTAAA ATACAAAAAG 1440
CAATTTAAAT ATGAAAGCCA GTGGCAAATG ATACAGATGA TAGGGCCATC AGATAATGAA 1500
TACATCTACA TCGACTTCAG AGAATTTGAA TATGATATAA AATGGGAATT TCCCAGGGAA 1560
AATCTGGAAT TTGGACAGGT TCTTGGTTCT GGGGCCTTTG GGAAAGTAGT GACTGCAACA 1620
GCTTATGGAA TTAACAATGC AGGAGATTCA GTCCAGGTCG CAGTCAAAAT GCTAAAAGAA 1680
AAACCTGATA CTGCAGAAGA AGATGCTCTA ATGTCTGAGC TGAAAATGAT GACTCATATT 1740
GGAAGCCATG AAAATATTGT GAACCTACTA GGAGCTTGTA CTCTGTCAGG ACCAATCTAC 1800
TTGATATTTG AATACTGTTG CTATGGTGAC CTTCTGAACT ACTTAAGGAG CAAGAGAGAA 1860
AAGTTTCACT GGACACTGAC AGATATTTTT AAACAGCAAA ACTTCAGCTT TTACCACAAT 1920
ATCCATCAGG ACCAAAACTC TAGAGAGGAT GAATGTGAAA CCATGCAAAG AAGCCAAAAC 1980
ATAAATGTGA CACTGGGATC AAATGGGATT GTGCTGTTTT CTGAGGAAGT ACTTGAATAC 2040
AAAAATACTC ACCTTTATTT TGTATCTGAT GAGGAAGACT TTAATGTGCT CACTTTTGAA 2100
GACCTTCTTT GCTTTTCTTT TCAAGTTGCC AAAGGAATGG AATTTCTTGA GTCCAAATCG 2160
TGCATTCACA GAGACCTCGC TGCCCGGAAC ATACTGGTGA CCCATGGGAA AGTGGTGAAA 2220
ATATGTGACT TTGGCCTTGC CAGAGATGTA ATGAACGACT CCAACTACAT CGTCAGGGGC 2280
AATGCTCGAC TGCCAGTCAA ATGGATGGCT CCCGAAAGCT TGTTCGAGAG GACATACACC 2340
ATGAAGAGCG ATGTCTGGTC GTATGGAATA CTGCTGTGGG AAATATTCTC CTTGGGTGTA 2400
AATCCTTACC CTGGTATTCA GGTTGACACA AATTTCTACA AATTAATACA GAGTGGATTT 2460
AAAATGGACC AACCATATTA TGCTACAAAA GATGTCTATT GCCTGATGAG GTCCTGTTGG 2520
GCTCTTGACT CCAGGAAAAG ACCCTCTTTC TCTTACCTGG TTTCCTCTCT GGCCTGTCAG 2580
CTGGCTGAGG CAGAAGGAGC A 2601
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkvv atayG+ +++ +++vavkmlk++ +++e +almselk+++h+G
Q: 522   LEFGQVLGSGAFGKVVTATAYGINNAGDSVQVAVKMLKEKPDTAEEDALMSELKMMTHIG  581
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+ + ++++k+++++++++ 
Q: 582   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHWTLTDIFKQQNFSFYHN-  640
         ******************************************************99887.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         +      ++++++  e++ e ++ +++++    s+   l se++ ++++ +   + +eed
Q: 641   I------HQDQNSR-EDECETMQRSQNINVTLGSNGIVLFSEEVLEYKNTHLYFVSDEED  693
         5......4444433.34444467777777777888999999999****************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+fs+qvakGmefl+sk+c+hrdlaarn+l+t+GkvvkicdfGlard+m+d
Q: 694   FNVLTFEDLLCFSFQVAKGMEFLESKSCIHRDLAARNILVTHGKVVKICDFGLARDVMND  753
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         sny+v+Gnarlpvkwmapes+f+  yt+ksdvwsyGillweifslG++pypg+ vd++fy
Q: 754   SNYIVRGNARLPVKWMAPESLFERTYTMKSDVWSYGILLWEIFSLGVNPYPGIQVDTNFY  813
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         kli++G++m+qp yat+++y +m++cw+ +++krpsf+ lv+
Q: 814   KLIQSGFKMDQPYYATKDVYCLMRSCWALDSRKRPSFSYLVS  855
         **************************************9986
Domain Sequence
(FASTA)
LEFGQVLGSG AFGKVVTATA YGINNAGDSV QVAVKMLKEK PDTAEEDALM SELKMMTHIG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHWTLTDIFK QQNFSFYHNI 120
HQDQNSREDE CETMQRSQNI NVTLGSNGIV LFSEEVLEYK NTHLYFVSDE EDFNVLTFED 180
LLCFSFQVAK GMEFLESKSC IHRDLAARNI LVTHGKVVKI CDFGLARDVM NDSNYIVRGN 240
ARLPVKWMAP ESLFERTYTM KSDVWSYGIL LWEIFSLGVN PYPGIQVDTN FYKLIQSGFK 300
MDQPYYATKD VYCLMRSCWA LDSRKRPSFS YLVS 334
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAR-00506
EKS-TEN-00504
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013