EKS-TAG-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	407.2	3.2E-122	192	479	288

Status

Unreviewed

Ensembl Protein

ENSTGUP00000012287

UniProt Accession

H0ZNV8;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011916	ENSTGUP00000012287	ENSTGUT00000012422

Organism

Taeniopygia guttata

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPDV FFCCCEGNMC NERFFYFPEM 120

EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP 180

PPPSPLMGLK PLQLLEIKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG 240

MKHDNILQFI GAEKRGSSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM ALVLWELSRF MSASASPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRECWQKHSG MAMLCETIEE CWDHDAEARL SAGCVEERII 480

QMQKLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTACTAAGTT GGCGTTCGCT GTTTTTCTTA TCTCTTGTTC ATCAGGTGCC 60

ATCCTGGGCA GATCAGAGAC ACAGGAGTGC ATCTATTACA ACGCTAACTG GGAGAAGGAT 120

AAAACCAACC GCAGCGGGAT CGAGCCCTGC TATGGTGATA AAGATAAAAG GAGACACTGC 180

TTTGCTACAT GGAAAAATAT TTCTGGATCA ATTGAAATCG TGAAGCAAGG CTGCTGGCTG 240

GATGACATCA ATTGTTATGA CAGGAATGAT TGCATAGAGA AGAAGGACAG CCCTGATGTG 300

TTTTTCTGTT GCTGTGAGGG CAACATGTGC AACGAGCGCT TCTTCTACTT CCCGGAGATG 360

GAGGTCACGC AGCCAACTTC CAATCCTGTT ACACCGAAGC CACCTCTGTT CAACACCTTG 420

CTGTACTCCT TGGTGCCTAT CATGGGAATT GCAGTGATTG TACTCTTCTC CTTCTGGATG 480

TACAGACATC ACAAGCTGGC CTATCCTCCA GTGCTTGTTC CCACCCAGGA TCCTGGGCCT 540

CCCCCGCCGT CTCCCCTGAT GGGTCTGAAG CCGCTGCAGC TCCTGGAGAT CAAAGCCAGG 600

GGGAGATTTG GGTGTGTGTG GAAAGCTCAG CTGCTCAATG AATACGTTGC AGTCAAAATA 660

TTCCCCATCC AGGACAAGCA GTCGTGGCAG AACGAGTACG AGATCTACAG CCTGCCCGGG 720

ATGAAGCACG ACAACATCCT GCAGTTCATC GGCGCCGAGA AGCGCGGCTC CAGCATCGAC 780

GTGGACCTGT GGCTCATCAC CGCCTTCCAC GAGAAGGGGT CCCTGACAGA TTTCCTGAAG 840

GCCAACGTGG TGTCGTGGAA CGAGCTGTGC CACATCGCCC AGACCATGGC CCGGGGCCTG 900

GCCTACCTGC ACGAGGACAT CCCGGGGCTG AAGGACGGCC ACAAGCCCGC CATCTCCCAC 960

AGGGACATCA AAAGCAAGAA TGTGCTGCTG AAAAACAACC TCACGGCTTG TATTGCTGAT 1020

TTCGGTCTAG CTTTAAAGTT TGAGGCTGGA AAGTCTGCAG GAGACACCCA TGGACAGGTG 1080

GGCACCCGCA GGTACATGGC TCCCGAGGTG CTGGAAGGTG CCATCAACTT CCAAAGGGAC 1140

GCGTTCCTGA GGATAGACAT GTACGCCATG GCCCTGGTGC TCTGGGAATT GTCACGATTC 1200

ATGTCGGCGT CCGCCAGCCC CGTGGACGAG TACATGCTGC CCTTCGAGGA GGAGATCGGC 1260

CAGCACCCCT CCCTGGAGGA CATGCAGGAA GTTGTGGTGC ACAAAAAGAA GAGGCCTGTC 1320

CTAAGGGAGT GTTGGCAGAA GCATTCTGGA ATGGCGATGC TGTGCGAGAC CATCGAGGAG 1380

TGCTGGGATC ACGACGCCGA GGCGCGGCTG TCCGCCGGCT GCGTGGAGGA GAGGATCATC 1440

CAGATGCAGA AACTCACTAA CATTATAACA ACAGAGGACA TCGTGACTGT GGTCACAATG 1500

GTGACAAACG TTGACTTTCC TCCCAAAGAA TCCAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E eiy+++ ++h+nilqfi+

Q: 192   LQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++  ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGSSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y+++LvlWE+ + ++++++ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMALVLWELSRFMSASASPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9*****************9999999************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+

Q: 429   QEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERI  479

         ************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEIYSLPGM KHDNILQFIG 60

AEKRGSSIDV DLWLITAFHE KGSLTDFLKA NVVSWNELCH IAQTMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMA LVLWELSRFM SASASPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RECWQKHSGM AMLCETIEEC WDHDAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013