EKS-TAG-00444

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00444

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	413.3	3.0E-124	220	472	253

Status

Unreviewed

Ensembl Protein

ENSTGUP00000012321

UniProt Accession

H0ZNZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011957	ENSTGUP00000012321	ENSTGUT00000012457

Organism

Taeniopygia guttata

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

PDLQAGQKDL ESKIKEKPLP PLPGQDLANI CNFVALFDYD ARTEDDLSFR AGDKLEVLSA 60

SHEGWWYAKL LLPEGSACPG RKLTGYIPAN YIAADQSIEA EPWFFGSTKR ADAERQLLYP 120

ENKEGAFLIR ESESLKGEYS LSVFDGTSVK HYRIKRMDGS FFLTKRKTFK TLNKLVDYYS 180

KNNDGLCVLL RQPCLKMQTP ATFDLSYKTV DQWEIDRRSL KLVKKLGSGQ FGEVWEGLWN 240

NTIPVAIKTL KPGSMDPKDF LREAQIMKNL RHPKLIQLYA VCTLEDPIYI ITELMRYGSL 300

LEYLKKDGGS QISLTHQIDM AAQVASGMAY LESQNYIHRD LAARNVLVGE HNVYKVADFG 360

LARVFKVESE KVYEARTETK LPVKWTAPEA IRYNRFSIKS DVWSFGILLF EIITYGQMPY 420

QGMPGHQVIQ LLDNGYRLPQ PETCPAALYK MMEQCWSAEA DERPTFEALN DQLENYFTSE 480

LY 482

Nucleotide Sequence
(FASTA)

CCTGACCTCC AAGCAGGACA GAAGGACTTA GAGAGTAAGA TAAAAGAGAA ACCTTTACCT 60

CCACTGCCTG GCCAGGATCT AGCAAACATT TGCAACTTTG TGGCACTGTT TGACTATGAT 120

GCTCGCACTG AGGATGACTT GAGCTTCCGA GCTGGGGATA AGCTGGAAGT GCTGAGTGCA 180

TCCCATGAGG GATGGTGGTA CGCGAAGCTC CTCCTGCCAG AGGGGTCAGC CTGTCCTGGC 240

CGCAAGCTCA CAGGCTACAT CCCTGCCAAC TACATAGCTG CTGACCAGAG CATTGAAGCT 300

GAGCCATGGT TCTTTGGCTC AACCAAACGA GCAGATGCCG AGAGACAACT GTTGTACCCT 360

GAAAACAAGG AAGGAGCCTT CCTAATCCGA GAAAGCGAAA GTCTAAAAGG CGAATACTCA 420

CTCTCAGTTT TTGATGGTAC ATCTGTGAAG CACTACAGGA TCAAAAGGAT GGATGGAAGC 480

TTTTTCCTAA CCAAAAGGAA AACTTTTAAA ACTTTGAATA AGTTGGTTGA CTATTACAGC 540

AAGAACAATG ATGGCCTCTG CGTGTTGCTC AGGCAACCAT GCCTAAAGAT GCAAACTCCT 600

GCTACTTTTG ATTTGTCTTA CAAAACTGTT GATCAGTGGG AGATAGACCG ACGATCTCTG 660

AAATTGGTGA AAAAATTAGG ATCTGGTCAG TTTGGTGAAG TATGGGAAGG ACTGTGGAAT 720

AATACCATCC CCGTGGCAAT CAAAACATTA AAACCAGGTT CAATGGATCC AAAGGACTTT 780

CTGAGGGAAG CACAAATAAT GAAGAACTTG AGACATCCAA AGCTTATACA GCTTTATGCT 840

GTCTGCACTT TGGAGGACCC AATTTATATT ATTACCGAGC TGATGAGATA TGGAAGTCTC 900

CTAGAATACC TTAAAAAAGA TGGGGGCTCT CAAATCTCCC TGACACATCA AATAGACATG 960

GCTGCTCAGG TGGCTTCTGG GATGGCATAC CTTGAATCTC AGAACTATAT CCATCGGGAT 1020

CTGGCAGCCA GGAATGTTCT TGTTGGTGAG CATAATGTTT ACAAAGTGGC AGACTTTGGA 1080

CTTGCAAGGG TTTTTAAGGT AGAAAGTGAA AAAGTGTATG AAGCTAGGAC AGAAACAAAA 1140

CTCCCAGTGA AATGGACAGC CCCAGAGGCA ATCCGCTACA ACAGATTCAG CATTAAATCA 1200

GATGTCTGGT CCTTTGGGAT TCTCCTGTTT GAAATAATCA CCTATGGGCA GATGCCTTAT 1260

CAGGGTATGC CGGGACACCA GGTGATCCAG CTGCTGGACA ATGGGTACAG ACTTCCTCAG 1320

CCAGAGACGT GCCCAGCAGC ACTCTACAAG ATGATGGAGC AGTGCTGGAG CGCGGAGGCC 1380

GATGAGCGTC CCACCTTTGA GGCCCTCAAC GATCAGCTGG AGAACTACTT CACCAGCGAG 1440

CTCTAT 1446

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g+w+++++va+ktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 220   LKLVKKLGSGQFGEVWEGLWNNTIPVAIKTLKPGSMDPKDFLREAQIMKNLRHPKLIQLY  279

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm+ Gsll++lk++ g++++l++++d+aaqva+Gmayle++n+ihr

Q: 280   AVCTLEDPIYIITELMRYGSLLEYLKKDGGSQISLTHQIDMAAQVASGMAYLESQNYIHR  339

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar+++   ++ y+a++++klP+kWtaPeai++++f+ik

Q: 340   DLAARNVLVGEHNVYKVADFGLARVFKvesEKVYEARTETKLPVKWTAPEAIRYNRFSIK  399

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+G++Py+Gm  ++v++ +++gyrlp+pe+cp+ ly+++++cw+++

Q: 400   SDVWSFGILLFEIITYGQMPYQGMPGHQVIQLLDNGYRLPQPETCPAALYKMMEQCWSAE  459

         ************************************************************

S: 238   peerPtfetlqev  250

         ++erPtfe+l+ +

Q: 460   ADERPTFEALNDQ  472

         *********9876

Domain Sequence
(FASTA)

LKLVKKLGSG QFGEVWEGLW NNTIPVAIKT LKPGSMDPKD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRYGS LLEYLKKDGG SQISLTHQID MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNVYKVADF GLARVFKVES EKVYEARTET KLPVKWTAPE AIRYNRFSIK 180

SDVWSFGILL FEIITYGQMP YQGMPGHQVI QLLDNGYRLP QPETCPAALY KMMEQCWSAE 240

ADERPTFEAL NDQ 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013