EKS-TAG-00440
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00440
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src441.95.3E-133270516247
StatusUnreviewed
Ensembl ProteinENSTGUP00000012372
UniProt AccessionH0ZP43;
Protein Name
Protein Synonyms/Alias
Gene NameFYN
Gene Synonyms/Alias FYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000011998ENSTGUP00000012372ENSTGUT00000012509
OrganismTaeniopygia guttata
Functional Description
Protein Length534
Protein Sequence
(FASTA)
MGCVQCKDKE ATKLTDERDG SLTQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHATGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF 240
NLTVIATNNT PQTVGLAKDA WEVARDSLFL EQKLGQGCFA EVWRGTWNGN TKVAIKTLKP 300
GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SEEPIYIVTE YMSKGSLLDF LKDGEGRALK 360
LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI CKIADFGLAR LIEDNEYTAR 420
QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMNNR EVLEQVERGY 480
RMPCPQDCPI SLHELMIHCW KKDPEERPTF EYLQGFLEDY FTATEPQYQP GDNL 534
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACTGACGA GAGGGATGGC 60
AGTTTAACTC AAAGCTCAGG CTACCGCTAT GGGACAGATC CTACTCCGCA GCACTATCCT 120
AGCTTTGGTG TGACCTCAAT CCCAAACTAC AACAACTTCC ATGCCACAGG AGGCCAAGGA 180
CTGACCGTGT TTGGTGGAGT CAACTCCTCC TCTCATACAG GGACGCTGCG TACAAGAGGA 240
GGAACAGGTG TAACTCTTTT TGTGGCGCTT TATGACTATG AAGCAAGAAC AGAAGATGAC 300
TTGAGTTTTC ACAAAGGAGA AAAATTCCAG ATACTTAATA GCTCGGAAGG AGACTGGTGG 360
GAAGCCCGTT CCTTGACAAC AGGCGAAACT GGTTACATTC CCAGTAATTA TGTGGCTCCA 420
GTCGATTCCA TCCAAGCAGA GGAGTGGTAC TTTGGCAAGC TTGGCCGAAA AGATGCAGAG 480
AGGCAGCTGC TGTCATTTGG AAACCCCAGA GGTACCTTCT TGATCCGGGA AAGTGAAACT 540
ACCAAAGGTG CCTATTCCCT GTCTATTCGA GACTGGGATG ATATGAAAGG AGATCATGTC 600
AAACATTATA AGATTCGTAA ACTTGACAAT GGTGGATATT ATATCACAAC TCGGGCACAA 660
TTTGAAACTC TTCAGCAGCT GGTTCAGCAT TACTCAGAGA AAGCTGATGG TTTGTGTTTT 720
AACTTAACTG TGATTGCTAC GAATAATACC CCACAAACTG TTGGATTGGC TAAAGATGCA 780
TGGGAAGTTG CACGTGATTC ATTATTTCTG GAACAGAAGC TTGGTCAGGG GTGTTTCGCT 840
GAAGTGTGGC GTGGTACGTG GAATGGAAAT ACTAAAGTGG CTATCAAGAC CCTGAAGCCT 900
GGCACCATGT CTCCAGAATC CTTCTTAGAG GAAGCTCAAA TCATGAAGAA GCTAAAACAT 960
GACAAATTGG TCCAGCTTTA TGCTGTGGTA TCTGAAGAGC CTATCTATAT TGTCACAGAG 1020
TACATGAGTA AAGGAAGTTT GTTAGATTTC TTAAAGGATG GAGAAGGAAG AGCTTTGAAG 1080
TTACCGAACT TGGTGGACAT GGCAGCCCAG GTGGCCGCAG GAATGGCGTA CATCGAGCGG 1140
ATGAATTACA TACACAGAGA TCTGCGGTCT GCAAACATCC TGGTGGGCAA CGGCCTAATA 1200
TGCAAGATTG CTGACTTTGG ATTGGCAAGA CTGATTGAAG ACAATGAATA TACAGCCAGA 1260
CAAGGTGCAA AATTTCCCAT TAAATGGACT GCACCAGAAG CAGCACTGTA TGGAAGGTTC 1320
ACAATAAAGT CAGATGTGTG GTCTTTTGGG ATCCTACTGA CGGAGCTGGT AACAAAAGGG 1380
AGAGTGCCAT ACCCAGGCAT GAATAACCGG GAAGTCTTGG AGCAAGTAGA ACGAGGTTAT 1440
CGGATGCCGT GCCCCCAGGA CTGTCCCATC TCCTTGCATG AGCTTATGAT TCACTGCTGG 1500
AAAAAAGACC CAGAGGAGCG TCCAACTTTT GAATATTTAC AGGGTTTTCT TGAAGACTAC 1560
TTCACTGCAA CAGAACCCCA GTACCAGCCT GGAGACAACC TGTAA 1605
Domain Profile
S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62
         l++klG+G+f evw g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+lyav
Q: 270   LEQKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV  329
         789*********************************************************
S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122
         vse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihrdl
Q: 330   VSE-EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL  388
         **9.********************************************************
S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182
         +++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdvWs
Q: 389   RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS  448
         ************************************************************
S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242
         fGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpeerP
Q: 449   FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP  508
         ************************************************************
S: 243   tfetlqev  250
         tfe+lq +
Q: 509   TFEYLQGF  516
         *****976
Domain Sequence
(FASTA)
LEQKLGQGCF AEVWRGTWNG NTKVAIKTLK PGTMSPESFL EEAQIMKKLK HDKLVQLYAV 60
VSEEPIYIVT EYMSKGSLLD FLKDGEGRAL KLPNLVDMAA QVAAGMAYIE RMNYIHRDLR 120
SANILVGNGL ICKIADFGLA RLIEDNEYTA RQGAKFPIKW TAPEAALYGR FTIKSDVWSF 180
GILLTELVTK GRVPYPGMNN REVLEQVERG YRMPCPQDCP ISLHELMIHC WKKDPEERPT 240
FEYLQGF 247
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00339
EKS-ANC-00354
EKS-BOT-00365
EKS-CAJ-00369
EKS-CAF-00366
EKS-CAP-00398
EKS-CHH-00039
EKS-DAR-00743
EKS-DAN-00035
EKS-FEC-00353
EKS-GAM-00219
EKS-GAG-00309
EKS-GAA-00446
EKS-GOG-00358
EKS-HOS-00371
EKS-ICT-00346
EKS-LAC-00380
EKS-LOA-00374
EKS-MAM-00365
EKS-MEG-00300
EKS-MOD-00354
EKS-MUM-00397
EKS-MUP-00359
EKS-MYL-00364
EKS-NOL-00335
EKS-ORN-00470
EKS-ORA-00320
EKS-ORC-00343
EKS-ORL-00432
EKS-OTG-00370
EKS-PAT-00345
EKS-PES-00325
EKS-POA-00355
EKS-PRC-00071
EKS-PTV-00093
EKS-RAN-00379
EKS-SAH-00336
EKS-SUS-00322
EKS-TAR-00466
EKS-TEN-00462
EKS-TUB-00053
EKS-TUT-00097
EKS-VIP-00051
EKS-XET-00483
EKS-XIM-00460
Gene Ontology
GO:0005768; C:endosome
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050798; P:activated T cell proliferation
GO:0010629; P:negative regulation of gene expression
GO:0042177; P:negative regulation of protein catabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045471; P:response to ethanol
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013