EKS-TAG-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	450.8	1.7E-135	206	493	288

Status

Unreviewed

Ensembl Protein

ENSTGUP00000012554

UniProt Accession

H0ZPM2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000012182	ENSTGUP00000012554	ENSTGUT00000012693

Organism

Taeniopygia guttata

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

VVDGVMILPV LMVMAFPSPS WQDDEQKLKM VPYECVCEGI SCGNGDRCQG QRCFASLSIN 60

DGAKVYQKGC FQVYEQRKMT CKTPPSPNQA VECCQGHLCN MNITAQLPSS KGESLAQQQC 120

VLREGLCVVH VDFAMCCLIA VLIIRRIQKN HMERLNSRDA EYGTIEGLIA SNVGDSTLAD 180

LLDHSCTSGS GSGLPFLVQR TVARQITLVE CVGKGRYGEV WRGQWQGENV AVKIFSSRDE 240

KSWFRETELY NTVLLRHENI LGFIASDMTS RNSSTQLWLI THYHEMGSLY DYLQLTTLDT 300

VSCLRIVLSI ASGLAHLHIE IFGTQGKPAI SHRDLKSKNI LVKKNGQCCI ADLGLAVMHS 360

QSTNQLDVGN NPRVGTKRYM APEVLDETIQ ADCFDSYKRV DIWAFGLVLW EVARRMVSNG 420

IVEDYKPPFY DLVPNDPSFE DMRKVVCVDQ QRPNIPNRWF SDPTLTSLAK LMKECWYQNP 480

SARLTALRIK KTLTKIDNSL DKLKADC 507

Nucleotide Sequence
(FASTA)

GTGGTTGATG GAGTTATGAT TCTCCCTGTA CTGATGGTGA TGGCGTTCCC ATCCCCGAGC 60

TGGCAAGATG ATGAACAGAA GCTCAAGATG GTCCCCTACG AATGTGTGTG TGAAGGCATA 120

TCCTGTGGGA ACGGGGATCG GTGCCAAGGC CAGCGCTGCT TTGCTTCCCT GAGCATTAAT 180

GACGGGGCCA AGGTTTACCA GAAGGGCTGC TTCCAGGTCT ATGAGCAACG CAAAATGACG 240

TGCAAAACGC CTCCGTCCCC CAACCAGGCC GTGGAGTGCT GCCAGGGACA CCTGTGCAAC 300

ATGAACATCA CTGCGCAGCT GCCCTCGTCC AAAGGTGAGA GCTTAGCTCA GCAGCAGTGC 360

GTTCTGAGAG AGGGGCTGTG TGTTGTGCAT GTGGACTTTG CCATGTGCTG CCTAATAGCT 420

GTGCTGATCA TACGGAGAAT ACAGAAAAAC CACATGGAGA GGCTCAATTC TAGGGATGCA 480

GAATATGGCA CAATCGAGGG CCTCATTGCC TCGAACGTGG GGGACAGCAC GTTGGCAGAT 540

TTGTTGGACC ATTCCTGCAC ATCTGGAAGT GGCTCTGGAC TTCCTTTCTT GGTGCAAAGA 600

ACGGTGGCTC GCCAGATCAC ACTTGTGGAG TGTGTAGGAA AGGGCCGTTA TGGAGAAGTT 660

TGGAGGGGTC AGTGGCAAGG AGAAAATGTT GCTGTGAAGA TCTTCTCTTC TAGGGATGAA 720

AAGTCCTGGT TCAGGGAAAC TGAGCTGTAC AACACTGTAC TGCTGCGGCA CGAGAATATT 780

TTAGGTTTTA TTGCGTCTGA TATGACTTCC AGGAACTCCA GCACGCAGCT GTGGCTGATC 840

ACACACTACC ACGAGATGGG CTCCCTGTAC GACTACCTGC AGCTGACCAC ACTGGACACA 900

GTGAGCTGCC TGCGCATCGT GCTGTCCATC GCCAGCGGCC TGGCGCACCT GCACATCGAG 960

ATCTTCGGCA CGCAGGGCAA GCCGGCCATC TCCCACCGCG ACCTCAAGAG CAAGAACATC 1020

CTGGTCAAGA AGAACGGGCA GTGCTGCATC GCCGACCTGG GCCTTGCAGT GATGCATTCC 1080

CAAAGCACAA ACCAGTTGGA TGTGGGGAAC AATCCCCGTG TGGGCACCAA GCGCTACATG 1140

GCTCCGGAGG TGCTGGACGA GACCATCCAG GCAGACTGCT TTGACTCCTA CAAGCGGGTG 1200

GACATCTGGG CCTTTGGGCT GGTGCTGTGG GAGGTGGCCA GGCGCATGGT CAGCAACGGA 1260

ATCGTGGAAG ACTACAAACC ACCCTTTTAT GACTTGGTTC CGAACGATCC CAGTTTTGAA 1320

GACATGAGGA AAGTGGTCTG TGTGGATCAG CAGAGGCCCA ACATTCCCAA CAGATGGTTC 1380

TCAGACCCGA CGTTGACGTC CCTCGCCAAG CTGATGAAGG AGTGCTGGTA CCAGAACCCC 1440

TCGGCCAGAC TGACAGCCCT GCGCATCAAA AAGACTTTGA CCAAAATTGA CAATTCCTTA 1500

GACAAACTGA AAGCTGACTG TTGA 1524

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 206   ITLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  265

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 266   SDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  325

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 326   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  383

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+++ ++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++ v++dPs+e+m

Q: 384   VLDETIQADCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDLVPNDPSFEDM  442

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 443   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  493

         *************************************************97

Domain Sequence
(FASTA)

ITLVECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAISHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQADCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDLVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0030509	; P:BMP signaling pathway
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013