EKS-TAG-00191
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00191
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb439.14.5E-132415674260
StatusUnreviewed
Ensembl ProteinENSTGUP00000012886
UniProt AccessionH0ZQJ7;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000012514ENSTGUP00000012886ENSTGUT00000013034
OrganismTaeniopygia guttata
Functional Description
Protein Length786
Protein Sequence
(FASTA)
MEGPSGEAEL PLLTVKHEFP SANLTGHAEK VGIENFELLK VLGTGAYGKV FLVRKVSGHD 60
AGKLYAMKVL KKATIVQKAK TTEHTRTERQ VLEHIRQSPF LVTLHYAFQT DTKLHLILDY 120
INGGELFTHL SHRERFSENE VQIYIGEIVL ALEHLHKLGI IYRDIKLENI LLDSDGHVVL 180
TDFGLSKEFL TDENERAYSF CGTIEYMAPD IVRGGDTGHD KAVDWWSVGV LMYELLTGAS 240
PFTVDGEKNS QAEISRRILK SEPPYPQEMS ALSKDIIQRL LMKDPKKRLG CGPTDADEIK 300
QHPFFQNMNW EDLAAKKIPA PFKPVIRDEL DVSNFAEEFT EMDPTYSPAA TPQTSERIFQ 360
GYSFVAPSIL FKRNAATVDP FQFYVGDERP GATTIARSAM MKDSPFYHHY ELDLKEKPLG 420
EGSFSICRKC LHKKTSQEYA VKIISKRMEA NTQREITALR LCEGHPNVVK LHEVFHDQLH 480
TFLVMELLKG GELLERIQKK KHFSETEASH IMRRLVSAVS HMHDVGVVHR DLKPENLLFT 540
DETDNSEIKI IDFGFARLKP PDNQPLKTPC FTLHYAAPEL LNHNGYDESC DLWSLGVILY 600
TMLSGQVPFQ SQDRSLTCTS ALEIMKKIKK GEFSFEGEAW KNVSEEAKEL IRGLLTVDPN 660
KRIKMSSLRY NEWLQDGSQL SSNPLMTPDN LGSSGAAVHT YVKATFHAFN KYKREGFCLQ 720
NVDKAPLAKR RKMKKTSTST ETRSSSSESS HSSSSHSHGK TTPTKTLQPT NPTDSNNPET 780
IFQFSE 786
Nucleotide Sequence
(FASTA)
ATGGAGGGAC CCTCGGGGGA AGCGGAGCTG CCGCTCCTCA CGGTGAAGCA CGAGTTCCCT 60
TCAGCAAATT TGACAGGCCA TGCAGAGAAA GTTGGCATTG AAAACTTTGA GCTCCTGAAA 120
GTTCTTGGAA CAGGGGCCTA TGGAAAAGTA TTCCTGGTGA GGAAAGTAAG CGGCCATGAT 180
GCTGGAAAAC TGTATGCCAT GAAAGTATTG AAGAAAGCAA CAATAGTTCA AAAAGCCAAA 240
ACAACTGAGC ACACAAGGAC AGAACGACAA GTCTTGGAGC ACATTAGGCA ATCACCGTTT 300
TTGGTCACGT TACATTATGC CTTCCAGACA GATACAAAGC TTCATCTCAT TTTAGACTAT 360
ATAAATGGAG GAGAATTGTT TACTCATCTT TCACACAGAG AGAGATTCTC AGAAAATGAG 420
GTGCAAATTT ACATCGGGGA AATCGTTTTG GCACTTGAAC ATCTCCACAA GTTGGGGATT 480
ATATATCGGG ATATAAAACT TGAGAATATT CTCCTTGATT CTGATGGCCA TGTGGTGCTG 540
ACAGACTTTG GTCTAAGTAA GGAGTTTCTT ACTGATGAGA ACGAGAGAGC ATATTCTTTC 600
TGTGGAACAA TAGAATACAT GGCTCCAGAT ATTGTAAGAG GGGGAGACAC AGGACATGAT 660
AAGGCTGTTG ATTGGTGGAG TGTTGGTGTT CTTATGTATG AATTATTAAC TGGAGCATCG 720
CCATTTACAG TCGACGGAGA GAAGAATTCC CAAGCAGAGA TTTCTAGGAG AATATTAAAA 780
AGTGAGCCAC CTTATCCACA AGAAATGAGT GCTCTGTCTA AGGATATAAT TCAGCGTCTT 840
TTAATGAAAG ACCCCAAGAA GAGGCTAGGT TGTGGTCCCA CTGATGCTGA TGAAATCAAA 900
CAGCATCCCT TTTTCCAGAA TATGAACTGG GAGGACTTAG CTGCCAAAAA AATACCAGCT 960
CCATTTAAAC CAGTAATCAG AGATGAACTG GATGTCAGTA ATTTTGCAGA AGAGTTTACA 1020
GAAATGGATC CAACATACTC TCCTGCAGCA ACCCCTCAGA CTTCAGAAAG AATATTTCAG 1080
GGATATTCTT TCGTTGCACC TTCTATTTTG TTTAAACGCA ATGCAGCTAC AGTAGATCCT 1140
TTTCAGTTTT ATGTGGGGGA TGAGCGACCT GGAGCTACAA CTATTGCCAG AAGTGCTATG 1200
ATGAAGGACT CTCCATTTTA TCATCATTAT GAACTGGATC TGAAAGAGAA ACCATTGGGA 1260
GAAGGAAGTT TTTCCATTTG TCGAAAGTGC TTACACAAGA AAACTAGCCA AGAGTATGCA 1320
GTAAAAATAA TTAGCAAAAG AATGGAAGCC AACACCCAGA GAGAAATAAC AGCTCTGAGA 1380
CTCTGCGAAG GACATCCAAA TGTAGTGAAG TTACATGAAG TTTTTCATGA CCAGCTTCAC 1440
ACGTTCCTGG TAATGGAATT GCTGAAGGGA GGAGAATTAC TTGAACGTAT TCAGAAAAAG 1500
AAACATTTCA GTGAGACTGA AGCCAGTCAC ATTATGCGCA GACTTGTTTC AGCAGTGAGC 1560
CATATGCATG ATGTAGGAGT AGTCCACAGA GATCTGAAAC CTGAGAATTT ACTATTTACA 1620
GATGAAACTG ATAATTCAGA AATAAAAATA ATTGATTTTG GCTTTGCTCG TTTAAAACCA 1680
CCTGATAATC AGCCTCTTAA GACTCCTTGT TTTACTCTTC ATTATGCTGC CCCAGAGCTC 1740
TTGAATCACA ATGGTTATGA TGAGTCTTGT GATCTGTGGA GTTTGGGGGT TATTTTGTAC 1800
ACGATGCTGT CAGGACAAGT ACCATTTCAG TCTCAAGACA GAAGTTTGAC GTGTACCAGC 1860
GCATTAGAAA TTATGAAGAA AATAAAAAAG GGAGAATTTT CCTTTGAAGG GGAGGCTTGG 1920
AAAAATGTTT CTGAAGAGGC TAAAGAGCTA ATTCGAGGAC TTCTCACAGT GGATCCAAAC 1980
AAAAGGATTA AAATGTCCAG CCTGAGATAC AACGAGTGGC TTCAGGATGG CAGCCAGCTC 2040
TCATCTAACC CTCTAATGAC ACCTGATAAC TTAGGCTCTT CAGGAGCTGC AGTGCACACA 2100
TATGTCAAAG CCACTTTCCA TGCCTTTAAC AAGTACAAAA GGGAAGGATT CTGTCTCCAG 2160
AATGTGGACA AGGCACCTCT TGCAAAAAGA AGGAAAATGA AAAAAACAAG TACAAGCACA 2220
GAGACACGTA GCAGCTCCAG TGAAAGTTCC CATTCTTCTT CCTCTCATTC TCATGGCAAA 2280
ACTACACCCA CAAAGACATT GCAGCCCACA AACCCTACAG ACAGCAATAA CCCAGAAACC 2340
ATCTTCCAGT TCTCTGAA 2358
Domain Profile
S: 3     vkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdv  61
         ++++lG+Gs+s+c++c+hk+t qe+avkii+k+ +++t++ei++l+++e+hpn+v+l++v
Q: 415   KEKPLGEGSFSICRKCLHKKTSQEYAVKIISKRmEANTQREITALRLCEGHPNVVKLHEV  474
         6899*****************************9**************************
S: 62    yddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkp  121
         ++d+++++lv+ellkGGell+ri+kkk+fse+eas+i+r lv+av+++h++Gvvhrdlkp
Q: 475   FHDQLHTFLVMELLKGGELLERIQKKKHFSETEASHIMRRLVSAVSHMHDVGVVHRDLKP  534
         ************************************************************
S: 122   enilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlw  181
         en+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdlw
Q: 535   ENLLFTDETDNSE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDLW  593
         *************.**********************************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+lytml+G+vpf    +++++++a ei++kik+G+fs++Geaw++vseeak+l+++
Q: 594   SLGVILYTMLSGQVPFqsqdRSLTCTSALEIMKKIKKGEFSFEGEAWKNVSEEAKELIRG  653
         ****************9988899*************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+kr+k+++l++++wl
Q: 654   LLTVDPNKRIKMSSLRYNEWL  674
         ********************7
Domain Sequence
(FASTA)
KEKPLGEGSF SICRKCLHKK TSQEYAVKII SKRMEANTQR EITALRLCEG HPNVVKLHEV 60
FHDQLHTFLV MELLKGGELL ERIQKKKHFS ETEASHIMRR LVSAVSHMHD VGVVHRDLKP 120
ENLLFTDETD NSEIKIIDFG FARLKPPDNQ PLKTPCFTLH YAAPELLNHN GYDESCDLWS 180
LGVILYTMLS GQVPFQSQDR SLTCTSALEI MKKIKKGEFS FEGEAWKNVS EEAKELIRGL 240
LTVDPNKRIK MSSLRYNEWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00157
EKS-SUS-00141
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013