EKS-TAG-00036

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00036

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	408.8	7.6E-123	35	301	267

Status

Unreviewed

Ensembl Protein

ENSTGUP00000013079

UniProt Accession

H0ZR37;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK1

Gene Synonyms/Alias

VRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000012702	ENSTGUP00000013079	ENSTGUT00000013228

Organism

Taeniopygia guttata

Functional Description

Protein Length

412

Protein Sequence
(FASTA)

MPNKKTAGKR APAKTKLAEL FGLGEVLADT SRKEWKLGVP VGQGGFGRLY LADVNSSKSV 60

GSDAPYVAKV EPSQNGPLFT ELKFYMRAAK PDEIQKWTKS HKLKYLGVPR YWGSGLHERN 120

GKSYRFMIMD RFGRDLQKMF EENAKQFSHK TVLQLGLRIL DILEYVHEHE YVHGDIKASN 180

LLLSYKNPNQ VYLVDYGLAY RYCPDGVHKV YKEDPKRCHD GTIEYTSIDA HKGVAPSRRG 240

DLEILGYCMI HWLSGHLPWE DNLKDPNFVR DSKISCRDNI SILMDKCFPG KNKPDEIAKY 300

MEKVKVLSYE EKPAYQHFRE ILLQGLKAIG QKDDGVLDFG LAENGDVQRK PLQKKRRQAA 360

AAASESTEAK MEDQGSPKKK KVATSNAIAA RTQKMTSPKP KKSTATRKRV QK 412

Nucleotide Sequence
(FASTA)

ATGCCAAATA AGAAAACGGC TGGAAAAAGA GCACCTGCAA AAACGAAACT TGCTGAATTG 60

TTTGGTCTGG GGGAGGTTCT AGCAGATACA TCAAGAAAAG AATGGAAATT AGGTGTCCCT 120

GTAGGGCAGG GAGGCTTTGG ACGCCTATAC CTTGCTGATG TTAATTCTTC AAAGTCGGTT 180

GGCAGTGATG CCCCTTATGT TGCAAAAGTG GAACCCAGCC AGAATGGACC TCTTTTTACT 240

GAGTTAAAGT TCTACATGCG AGCTGCTAAG CCAGATGAAA TTCAGAAGTG GACTAAGTCC 300

CATAAACTGA AATATTTAGG TGTACCAAGA TATTGGGGTT CTGGCTTGCA TGAAAGGAAT 360

GGAAAAAGCT ATCGATTTAT GATAATGGAC CGATTTGGCA GAGATCTCCA GAAGATGTTT 420

GAAGAGAATG CAAAGCAATT TTCTCATAAA ACTGTACTAC AATTAGGCCT GAGAATACTT 480

GATATTCTGG AATATGTCCA TGAGCATGAA TATGTGCATG GAGACATCAA GGCCTCAAAC 540

CTCCTTCTGA GTTACAAGAA CCCTAATCAG GTGTACTTGG TGGATTATGG ACTTGCCTAC 600

CGATACTGTC CTGATGGAGT TCACAAAGTA TATAAGGAAG ATCCTAAAAG GTGCCATGAT 660

GGAACTATTG AATATACCAG TATTGATGCA CACAAGGGTG TGGCACCATC AAGACGTGGT 720

GATCTGGAGA TCTTGGGTTA CTGTATGATT CATTGGCTTA GTGGCCATCT ACCATGGGAA 780

GATAATTTGA AAGATCCAAA TTTTGTCAGA GACTCAAAAA TAAGTTGTAG AGATAATATT 840

TCAATTTTGA TGGACAAATG CTTTCCTGGG AAAAATAAAC CAGATGAAAT AGCCAAATAT 900

ATGGAAAAGG TGAAGGTACT TAGTTATGAA GAGAAACCTG CTTATCAGCA TTTCCGAGAA 960

ATACTTCTGC AAGGTCTCAA GGCCATTGGA CAAAAAGATG ATGGTGTGCT TGACTTTGGC 1020

TTGGCAGAGA ATGGAGACGT TCAAAGAAAA CCCCTGCAAA AGAAAAGAAG ACAGGCGGCA 1080

GCTGCAGCCA GTGAGAGTAC TGAGGCAAAA ATGGAAGATC AAGGAAGTCC AAAGAAAAAG 1140

AAAGTTGCTA CTTCTAATGC AATTGCTGCC AGAACCCAGA AGATGACCTC ACCAAAACCC 1200

AAGAAAAGCA CAGCAACCAG AAAGAGAGTC CAGAAGTAA 1239

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wklg ++g+ggfG++yla  +++k++++da +v kvep++nGpLf+elkfy+raak+++i

Q: 35    WKLGVPVGQGGFGRLYLAdvNSSKSVGSDAPYVAKVEPSQNGPLFTELKFYMRAAKPDEI  94

         9*****************9999**************************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw+k +klk+lg+P +++sGlhe +g++yRf++++r+grdLqk+ e+n+k++s+ktvlq

Q: 95    QKWTKSHKLKYLGVPRYWGSGLHERNGKSYRFMIMDRFGRDLQKMFEENAKQFSHKTVLQ  154

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycp+g+hk yked

Q: 155   LGLRILDILEYVHEHEYVHGDIKASNLLLSYKNPNQVYLVDYGLAYRYCPDGVHKVYKED  214

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGt+e+ts+DaHkGvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp+ v+++k

Q: 215   PKRCHDGTIEYTSIDAHKGVAPSRRGDLEILGYCMIHWLSGHLPWEDNLKDPNFVRDSKI  274

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

            d+++ l++k+++ k+++ e+aky+

Q: 275   SCRDNISILMDKCFPGKNKPDEIAKYM  301

         **************************8

Domain Sequence
(FASTA)

WKLGVPVGQG GFGRLYLADV NSSKSVGSDA PYVAKVEPSQ NGPLFTELKF YMRAAKPDEI 60

QKWTKSHKLK YLGVPRYWGS GLHERNGKSY RFMIMDRFGR DLQKMFEENA KQFSHKTVLQ 120

LGLRILDILE YVHEHEYVHG DIKASNLLLS YKNPNQVYLV DYGLAYRYCP DGVHKVYKED 180

PKRCHDGTIE YTSIDAHKGV APSRRGDLEI LGYCMIHWLS GHLPWEDNLK DPNFVRDSKI 240

SCRDNISILM DKCFPGKNKP DEIAKYM 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013