EKS-TAG-00509

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00509

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	460.4	1.6E-138	68	330	263

Status

Unreviewed

Ensembl Protein

ENSTGUP00000013462

UniProt Accession

H0ZS66;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000013067	ENSTGUP00000013462	ENSTGUT00000013615

Organism

Taeniopygia guttata

Functional Description

Protein Length

1423

Protein Sequence
(FASTA)

GRQRKLESMI RDPRSPVNVE SLLDGLNSLV LDLDYPALRK NKNIDNFLNR YEKIVEKIRA 60

LQMKAEDYDV VKVIGRGAFG EVQLVRHKMT QKVYAMKLLS KFEMIKRSDS AFFWEERDIM 120

AFANSPWVVQ LFCAFQDDKY LYMVMEYMPG GDLVNLMSNY DVPEKWAKFY TAEVVLALDA 180

IHSMGLIHRD VKPDNMLLDK YGHLKLADFG TCMKMDETGM VRCDTAVGTP DYISPEVLKS 240

QGGDGYYGRE CDWWSVGVFL FEMLVGDTPF YADSLVGTYS KIMDHKNSLH FPDDVEISKH 300

AKNLICAFLT DRDVRLGRNG VEEIKHHPFF RSDQWNWDNI RETAAPVVPE LSSDIDSSNF 360

DDIEDDKGDV ETFPIPKAFV GNQLPFIGFT YYRDNLLLSD SSQSCRENES VQSSKNEESK 420

EFQKKLSKLE EQLSNELQAK DELEQKYRST SVRLEKIAKE LDEEITSRKN VESAVRQLER 480

EKALLQHKNT EYQRKAEHEA DKKRNLENEV NSLKDQLEDL KKRNQNSQIS NEKINQLQRQ 540

LDEANSLLRS ESDTAARLRK NQTESTKQIQ QLEINNRELQ DKNCLLENAK LKLEKEYLNL 600

QSALESERRD RSHGSEIISD LQGRISSLEE EVKNGKSALA KLEMEKRQLQ EKLTDLEKEK 660

SNMEIDMTYK FKVMQQNLEQ EEAEHKATKA RLADKNKIYE SIEEAKSEAM KEMEKKLLEE 720

RALKQKVENR LLEAEKQRSM LDCDLKQSQQ KINELLRQKD LLSEDVKNLT LKIEQETQKR 780

CLTQNDLKMQ TQQVNTLRMS EKQLKQENNH LQEIKLSLEK QNNELRKERQ DADGQMKELQ 840

DQLEAEQYFS TLYKTQVREL KEECEEKTKI CKEMQQKIQE LQDERDSLAA QLEITLTKAD 900

SEQLARSIAE EQYSDLEKEK IMKELEIKEM MARHKQELTE KDATIASLEE ANRTLTSDVA 960

NLANEKEELN NKLKEAQEQI TKLKEEEANV GNIKAQFEKQ LLNERTLKTQ AVNKLAEIMN 1020

RKGPVKRGAD TDVRRKEKEN RKLHMELKSE REKLTQMMIK YQKEINEMQA QIAEESQIRI 1080

ELQMTLDSKD SDIEQLRSQL QSLHIGLDNS SIGSGPGEAE ADDGFPVHIT QSHTMESMSF 1140

TYQHSSTSVS IATKPSSSRM LLDSDSDSEE EPLSCSHSPT EVDSTESRLE GWLSMPVRNN 1200

TKKFGWVKKY VIVSSKKILF YDSEQDKEQS NPHMVLDIDK LFHVRPVTQT DVYRADSKEI 1260

PRIFQILYAN EGESKKEQEF PVEPMGEKSN YICHKGHEFI PTLYHFPTNC EACMKPLWHM 1320

FKPPPALECR RCHIKCHKDH MDKKEEIIAP CKVYYDISTA KNLLLLANST EEQQKWVSRL 1380

VKKIPKKPPA PDPFARSSPR TSMKVQPNQS IRRPSRQLPP NKP 1423

Nucleotide Sequence
(FASTA)

GGCCGCCAGA GGAAGCTGGA GTCCATGATC CGCGACCCGC GCTCCCCGGT CAACGTGGAG 60

AGCCTGCTGG ATGGCTTGAA TTCTTTGGTC CTTGATCTGG ATTATCCAGC GCTGAGGAAG 120

AACAAGAACA TTGATAATTT TTTAAATAGA TATGAGAAGA TTGTGGAAAA AATCCGAGCT 180

TTACAAATGA AAGCTGAAGA CTATGATGTT GTTAAGGTGA TTGGAAGAGG GGCTTTTGGA 240

GAAGTGCAGC TGGTTCGCCA TAAAATGACA CAGAAGGTTT ATGCAATGAA ACTCCTTAGT 300

AAATTTGAAA TGATCAAGAG ATCAGATTCA GCCTTTTTCT GGGAAGAAAG AGATATCATG 360

GCCTTTGCCA ACAGCCCATG GGTGGTTCAG CTATTTTGTG CCTTTCAAGA TGACAAATAT 420

TTGTACATGG TAATGGAATA CATGCCAGGT GGAGATCTTG TAAACCTTAT GAGCAATTAC 480

GATGTGCCTG AGAAATGGGC CAAGTTCTAC ACAGCTGAAG TTGTTCTTGC TCTTGATGCA 540

ATTCACTCCA TGGGCTTGAT ACACAGAGAT GTGAAGCCTG ACAATATGCT TTTAGACAAG 600

TATGGGCATC TGAAGCTGGC AGATTTTGGC ACTTGCATGA AAATGGATGA AACAGGAATG 660

GTGCGTTGCG ACACGGCCGT GGGGACTCCC GACTACATCT CGCCCGAAGT CCTGAAATCG 720

CAGGGGGGTG ATGGCTACTA TGGACGGGAA TGTGACTGGT GGTCTGTAGG GGTTTTCCTT 780

TTTGAGATGT TAGTTGGCGA TACTCCTTTT TATGCAGACT CACTAGTAGG AACATACAGT 840

AAAATTATGG ATCATAAGAA CTCATTGCAT TTCCCTGATG ATGTGGAAAT CTCTAAGCAT 900

GCAAAGAACC TTATCTGTGC CTTTTTAACT GATAGGGATG TGCGACTTGG GAGAAATGGA 960

GTTGAAGAAA TAAAGCATCA CCCTTTCTTC AGAAGTGATC AGTGGAACTG GGACAACATT 1020

CGAGAGACTG CTGCTCCCGT TGTTCCTGAG CTTAGCAGTG ATATAGATAG CAGTAATTTT 1080

GATGACATTG AGGACGACAA GGGAGACGTG GAAACCTTTC CAATCCCCAA AGCCTTCGTG 1140

GGAAACCAGC TGCCTTTCAT AGGATTTACC TATTACAGAG ACAATTTGTT GCTAAGTGAC 1200

TCCTCTCAGT CTTGCAGAGA AAATGAATCT GTGCAATCTA GTAAAAATGA GGAAAGCAAA 1260

GAGTTTCAGA AAAAACTAAG CAAGCTAGAA GAACAGCTCA GTAATGAATT ACAAGCCAAA 1320

GATGAACTAG AACAGAAGTA CAGGTCTACA AGTGTTCGTT TAGAGAAGAT AGCAAAAGAG 1380

CTCGATGAAG AGATAACTTC AAGGAAGAAT GTAGAGTCTG CAGTCCGACA GTTAGAGAGA 1440

GAGAAGGCTC TTCTTCAGCA TAAGAATACG GAATACCAGA GGAAAGCAGA ACATGAAGCA 1500

GATAAGAAAC GTAATTTGGA AAATGAGGTT AACAGTTTAA AAGACCAACT TGAAGATTTA 1560

AAAAAGAGGA ATCAGAACTC TCAAATATCC AATGAAAAAA TCAATCAATT ACAAAGACAG 1620

TTGGATGAAG CCAATTCTTT GCTGCGGTCA GAGTCTGATA CTGCAGCCAG GTTAAGGAAG 1680

AACCAGACAG AAAGCACCAA GCAAATTCAG CAGCTGGAAA TTAATAATAG AGAACTACAA 1740

GATAAGAACT GCCTGCTAGA GAACGCAAAA CTCAAACTGG AGAAGGAGTA TCTCAATCTT 1800

CAGTCAGCTC TAGAATCAGA AAGGAGAGAC CGAAGTCATG GATCAGAGAT TATCAGTGAT 1860

TTACAAGGTC GAATATCTAG CCTTGAAGAA GAAGTGAAAA ATGGAAAGAG TGCATTAGCC 1920

AAACTGGAAA TGGAGAAAAG ACAATTGCAG GAAAAGCTCA CAGATTTAGA AAAGGAAAAG 1980

AGCAACATGG AAATAGATAT GACATATAAA TTTAAAGTTA TGCAGCAGAA CCTTGAACAA 2040

GAAGAAGCTG AACATAAAGC CACAAAAGCA CGATTAGCAG ACAAAAATAA GATCTATGAG 2100

TCTATAGAGG AAGCAAAATC TGAAGCCATG AAAGAAATGG AAAAGAAACT TTTGGAAGAG 2160

AGAGCTTTAA AGCAGAAAGT AGAAAATCGG CTGTTGGAAG CTGAGAAGCA GCGCTCCATG 2220

TTAGACTGTG ATCTCAAACA ATCGCAACAG AAAATAAATG AGCTCCTTCG GCAGAAGGAT 2280

CTACTGAGTG AGGATGTAAA AAACTTGACA TTAAAAATAG AGCAAGAAAC ACAAAAGCGC 2340

TGTCTCACTC AAAATGACCT CAAGATGCAA ACACAGCAGG TCAACACCTT GAGAATGTCA 2400

GAGAAGCAGT TAAAACAGGA GAACAACCAC CTTCAGGAAA TCAAATTAAG TCTGGAAAAA 2460

CAAAACAATG AACTCCGCAA GGAACGTCAA GATGCAGATG GGCAAATGAA AGAGCTTCAA 2520

GACCAGCTCG AAGCTGAACA ATATTTCTCA ACTCTCTATA AGACACAAGT TCGAGAACTT 2580

AAAGAAGAAT GTGAGGAAAA GACCAAAATC TGTAAAGAAA TGCAGCAAAA GATACAAGAG 2640

TTACAGGATG AGAGAGATTC CTTGGCTGCT CAGCTAGAGA TTACTTTGAC GAAAGCAGAT 2700

TCAGAACAAC TTGCCCGTTC GATTGCTGAA GAACAGTACT CTGATTTGGA AAAAGAGAAG 2760

ATTATGAAAG AGCTGGAGAT TAAAGAGATG ATGGCAAGGC ATAAGCAGGA ACTTACTGAG 2820

AAAGATGCCA CCATAGCCTC ATTGGAGGAA GCAAATAGGA CACTAACTAG TGATGTGGCT 2880

AACCTTGCTA ATGAGAAAGA AGAGCTAAAC AATAAACTGA AGGAAGCACA AGAACAAATT 2940

ACAAAGCTTA AAGAAGAAGA AGCAAATGTA GGAAATATTA AAGCACAATT TGAGAAACAG 3000

TTGTTGAATG AAAGAACATT AAAAACCCAG GCTGTGAATA AATTGGCTGA AATCATGAAT 3060

CGGAAGGGTC CAGTCAAACG CGGAGCTGAC ACTGATGTAC GGCGGAAGGA AAAGGAAAAT 3120

AGGAAGCTGC ATATGGAGCT GAAGTCTGAA CGAGAAAAGT TAACCCAGAT GATGATCAAA 3180

TATCAGAAGG AAATAAATGA AATGCAGGCA CAAATAGCAG AAGAGAGTCA GATAAGGATT 3240

GAACTGCAGA TGACTCTGGA CAGCAAAGAC AGTGATATTG AACAGCTTCG TTCCCAGCTG 3300

CAGTCACTGC ACATTGGGCT GGACAACAGT AGCATAGGCA GTGGACCTGG AGAGGCTGAG 3360

GCAGATGATG GATTCCCTGT CCATATCACT CAATCCCACA CTATGGAATC CATGTCCTTT 3420

ACCTATCAGC ACTCTTCTAC CTCTGTCAGT ATTGCCACTA AGCCTTCCAG TTCTCGCATG 3480

CTTCTTGATT CCGATTCTGA CTCAGAGGAA GAACCTTTGT CTTGTTCCCA CAGCCCTACA 3540

GAAGTTGATA GCACAGAATC AAGATTGGAA GGCTGGCTAT CAATGCCTGT TAGAAATAAC 3600

ACTAAAAAAT TTGGATGGGT TAAAAAGTAT GTAATTGTAA GCAGCAAGAA GATCCTGTTC 3660

TATGACAGCG AACAAGATAA AGAACAGTCT AATCCCCATA TGGTATTGGA TATAGACAAA 3720

CTCTTCCATG TCCGACCAGT CACTCAGACT GATGTGTACA GAGCAGATTC CAAGGAAATT 3780

CCTAGGATAT TCCAGATCCT ATATGCTAAT GAAGGAGAGA GCAAAAAGGA ACAGGAATTT 3840

CCTGTGGAGC CCATGGGAGA GAAGTCAAAT TACATTTGTC ACAAAGGACA TGAGTTCATA 3900

CCTACTCTTT ACCACTTCCC AACCAATTGT GAAGCTTGTA TGAAGCCCCT GTGGCACATG 3960

TTCAAACCTC CTCCTGCTCT GGAATGTCGC CGCTGCCATA TCAAATGTCA CAAAGATCAC 4020

ATGGATAAAA AGGAAGAGAT TATAGCGCCC TGCAAAGTGT ACTATGATAT TTCTACGGCA 4080

AAGAATCTAC TACTGTTAGC TAATTCAACA GAAGAACAGC AAAAATGGGT GAGCCGACTG 4140

GTGAAAAAAA TACCCAAGAA GCCTCCAGCA CCAGATCCCT TTGCTCGATC TTCACCCAGA 4200

ACTTCCATGA AGGTACAGCC AAACCAGTCC ATCAGACGAC CAAGTCGACA GCTCCCTCCA 4260

AACAAACCA 4269

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         ++++kviGrGafgev++vr+k t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 68    YDVVKVIGRGAFGEVQLVRHKMTQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  127

         799*********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql++afqd+kyly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g

Q: 128   VVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  185

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+

Q: 186   LIHRDVKPDNMLLDKYGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLKSQG-GD  244

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fp+d+++s++ak+l

Q: 245   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPDDVEISKHAKNL  304

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+r+ rlgr+g+e++k+hpff

Q: 305   ICAFLTDRDVRLGRNGVEEIKHHPFF  330

         *************************9

Domain Sequence
(FASTA)

YDVVKVIGRG AFGEVQLVRH KMTQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFCAFQD DKYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120

HRDVKPDNML LDKYGHLKLA DFGTCMKMDE TGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLHFPDDVEI SKHAKNLICA 240

FLTDRDVRLG RNGVEEIKHH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0051298	; P:centrosome duplication
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0016525	; P:negative regulation of angiogenesis
GO:0010825	; P:positive regulation of centrosome duplication
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013