EKS-TAG-00443

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00443

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	430.2	2.1E-129	180	428	249

Status

Unreviewed

Ensembl Protein

ENSTGUP00000013694

UniProt Accession

H0ZSU8;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000013299	ENSTGUP00000013694	ENSTGUT00000013851

Organism

Taeniopygia guttata

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

VIALYDFPAS NDRDLELVKG EKLQVLSKEG DWWLAKSLNS GRKGYIPSNF VAQVDSLEQE 60

KWYFRTLSRK DAERLLLSSG NKVGSFLVRE SETTKDAYSL SVRDNSSAHG DIIKHYRIRS 120

LDGGGYYISP RMTFSSLPEL IHHYSREGDG LCQRLTAPCT SLVPQRPWAK DEWEIPREAL 180

KLVKKLGSGQ FGEVWMGYYK NNIKVAVKTM KEGSMDPDAF LAEANLMKKL QHNKLVRLYA 240

VVTKQPIYIV TEYMANGCLL DFLKTEEGSQ LNLPKLIDIS AQVAEGMAYI ERMNFIHRDL 300

RAANILVSET LCCKIADFGL ARLIENEYLA QEGAKFPIKW TAPEAINYGV FTIKSDVWSF 360

GILLTEIITF GRIPYPGMTN PEVIRNLERG YRMPCPESCP GELYSIILKC WRSIPEERPT 420

FEYLQSVLED FYTSTEKQYE PEP 443

Nucleotide Sequence
(FASTA)

GTGATTGCAC TGTATGATTT TCCTGCCTCA AATGACCGTG ACCTGGAGCT GGTCAAAGGA 60

GAGAAACTCC AGGTCCTCTC CAAGGAGGGG GACTGGTGGC TGGCAAAGTC CCTCAATAGT 120

GGGAGGAAAG GATACATCCC CAGCAACTTC GTGGCACAAG TGGACAGCTT GGAACAGGAA 180

AAGTGGTATT TTAGAACTCT GAGCAGAAAA GATGCTGAAC GGCTGCTGTT GTCTTCTGGG 240

AACAAAGTTG GCTCTTTCCT TGTCCGGGAG AGTGAAACCA CCAAAGACGC TTATTCCCTG 300

TCCGTGAGGG ACAACAGCTC CGCTCACGGG GACATCATCA AACACTACAG GATCCGCTCC 360

CTGGACGGAG GGGGGTACTA CATCTCCCCC AGGATGACTT TCTCCAGCCT GCCAGAGCTC 420

ATCCATCATT ACAGCCGTGA AGGGGATGGG CTGTGCCAGC GCCTCACAGC TCCCTGCACA 480

TCCCTGGTTC CCCAGAGACC CTGGGCCAAG GACGAGTGGG AGATCCCTCG GGAGGCCCTG 540

AAGCTCGTGA AGAAGCTGGG CAGTGGGCAG TTTGGGGAAG TGTGGATGGG CTACTACAAG 600

AACAACATCA AGGTGGCTGT GAAGACCATG AAGGAGGGCA GCATGGATCC TGACGCCTTC 660

CTGGCAGAGG CAAACCTGAT GAAGAAGCTG CAGCACAACA AACTGGTCCG GCTGTACGCC 720

GTGGTCACCA AGCAGCCCAT CTACATCGTG ACAGAGTACA TGGCCAATGG GTGTTTGCTG 780

GATTTCCTGA AGACAGAAGA AGGGAGCCAA CTGAATCTCC CCAAACTCAT TGATATCTCT 840

GCTCAGGTGG CAGAGGGCAT GGCCTACATC GAGCGCATGA ACTTCATCCA CCGGGACCTG 900

AGGGCCGCCA ACATCCTCGT CTCGGAGACG CTGTGCTGCA AAATCGCCGA TTTCGGCCTG 960

GCCAGGCTCA TCGAGAACGA GTACCTGGCA CAGGAAGGTG CCAAATTTCC CATCAAATGG 1020

ACAGCTCCAG AGGCCATTAA CTATGGGGTT TTCACCATCA AATCTGACGT GTGGTCATTC 1080

GGGATCCTCC TGACAGAGAT CATCACCTTC GGCAGGATTC CTTATCCAGG AATGACCAAC 1140

CCCGAGGTGA TTCGCAACCT GGAGCGGGGT TACCGCATGC CCTGCCCGGA GTCGTGTCCC 1200

GGGGAGCTCT ACAGCATCAT CCTCAAGTGC TGGCGCAGCA TCCCCGAGGA GCGCCCCACC 1260

TTCGAGTACC TGCAGTCGGT GCTCGAGGAC TTCTACACCT CCACGGAGAA GCAATACGAG 1320

CCCGAGCCG 1329

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g++k+++kvavkt+keg+++p+afl+ea+++kkl+h+klv+ly

Q: 180   LKLVKKLGSGQFGEVWMGYYKNNIKVAVKTMKEGSMDPDAFLAEANLMKKLQHNKLVRLY  239

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ +Piyivte+ma+G+lldflk+eeg++l+lpkl+d++aqvaeGmay+e++n+ihr

Q: 240   AVVTK-QPIYIVTEYMANGCLLDFLKTEEGSQLNLPKLIDISAQVAEGMAYIERMNFIHR  298

         ****9.9*****************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlarli ++ey a+egak+PikWtaPeai++g+ftiksdv

Q: 299   DLRAANILVSETLCCKIADFGLARLI-ENEYLAQEGAKFPIKWTAPEAINYGVFTIKSDV  357

         **************************.799******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+t G++PypGmtn ev++++ergyr+p+pe+cp ely+++l+cw++ pee

Q: 358   WSFGILLTEIITFGRIPYPGMTNPEVIRNLERGYRMPCPESCPGELYSIILKCWRSIPEE  417

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 418   RPTFEYLQSVL  428

         ********986

Domain Sequence
(FASTA)

LKLVKKLGSG QFGEVWMGYY KNNIKVAVKT MKEGSMDPDA FLAEANLMKK LQHNKLVRLY 60

AVVTKQPIYI VTEYMANGCL LDFLKTEEGS QLNLPKLIDI SAQVAEGMAY IERMNFIHRD 120

LRAANILVSE TLCCKIADFG LARLIENEYL AQEGAKFPIK WTAPEAINYG VFTIKSDVWS 180

FGILLTEIIT FGRIPYPGMT NPEVIRNLER GYRMPCPESC PGELYSIILK CWRSIPEERP 240

TFEYLQSVL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013