EKS-TAG-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	450.4	2.3E-135	56	340	285

Status

Unreviewed

Ensembl Protein

ENSTGUP00000013775

UniProt Accession

H0ZT29;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000013380	ENSTGUP00000013775	ENSTGUT00000013933

Organism

Taeniopygia guttata

Functional Description

Protein Length

420

Protein Sequence
(FASTA)

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60

VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120

EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPMIYVKL YMYQLFRSLA YIHSFGICHR 180

DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240

WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300

WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDKPALF 360

NFTTQELSSN PSLASILIPA HARNQAAAST PTNATAASDV NAGERVQTNS VATASASNST 420

Nucleotide Sequence
(FASTA)

ATGTCCGGGC GGCCCAGGAC CACCTCCTTC GCGGAGAGCT GCAAGCCTGT GCAGCAGCCC 60

TCGGCCTTCG GCAGCATGAA AGTCAGCCGA GACAAAGATG GCAGCAAGGT GACTACAGTA 120

GTGGCAACTC CTGGACAAGG TCCAGACCGA CCACAAGAAG TCAGCTACAC AGACACCAAG 180

GTGATTGGGA ATGGATCTTT TGGTGTTGTG TATCAAGCCA AACTCTGTGA TTCAGGAGAG 240

CTTGTGGCCA TTAAGAAAGT CCTGCAGGAT AAAAGATTTA AGAACAGAGA GCTCCAGATT 300

ATGAGAAAGT TGGATCATTG TAACATTGTC CGATTGCGTT ATTTCTTCTA CTCTAGTGGA 360

GAGAAGAAAG ATGAGGTGTA CCTCAACTTG GTGCTGGACT ATGTTCCTGA AACAGTATAC 420

AGAGTTGCCA GACATTATAG TCGGGCCAAA CAGACACTCC CTATGATTTA TGTCAAGTTG 480

TACATGTATC AGCTGTTCCG GAGTTTAGCC TATATCCATT CCTTTGGGAT CTGCCACCGG 540

GATATAAAAC CACAGAACCT CTTGCTGGAC CCTGATACAG CTGTTCTAAA ACTCTGTGAC 600

TTTGGAAGTG CAAAACAGCT GGTTCGTGGA GAACCCAATG TGTCGTACAT CTGCTCTCGG 660

TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACCGATT ATACCTCCAG TATAGATGTG 720

TGGTCAGCAG GCTGTGTATT GGCTGAACTG TTACTAGGAC AACCGATCTT TCCAGGTGAC 780

AGTGGTGTGG ATCAGTTGGT GGAAATAATC AAGGTTCTGG GAACGCCTAC AAGGGAGCAA 840

ATTAGAGAAA TGAATCCAAA CTATACTGAA TTCAAATTTC CTCAGATTAA GGCACATCCA 900

TGGACTAAGG TCTTCCGGCC CCGCACTCCC CCCGAAGCAA TTGCGCTATG TAGCCGCCTG 960

CTGGAGTACA CCCCCACGGC CCGCCTGACT CCCCTGGAGG CCTGCGCGCA CTCTTTCTTC 1020

GATGAACTAC GGGACCCAAA TGTCAAGTTA CCCAACGGGC GAGATAAACC TGCACTCTTC 1080

AATTTCACCA CTCAAGAACT GTCAAGTAAC CCATCTCTGG CTTCGATCCT CATCCCTGCT 1140

CATGCCCGGA ACCAAGCAGC TGCTTCAACC CCTACAAATG CTACAGCAGC CTCAGATGTT 1200

AACGCAGGAG AACGAGTTCA GACCAATAGT GTAGCTACAG CATCAGCCTC CAACTCCACC 1260

TGA 1263

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  114

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+hs

Q: 115   FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIYVKLYMYQLFRSLAYIHS  174

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 175   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  234

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 235   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  294

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 295   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  340

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPM IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030877	; C:beta-catenin destruction complex
GO:0005813	; C:centrosome
GO:0005829	; C:cytosol
GO:0043198	; C:dendritic shaft
GO:0030426	; C:growth cone
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0044337	; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0016477	; P:cell migration
GO:0006983	; P:ER overload response
GO:0045444	; P:fat cell differentiation
GO:0005977	; P:glycogen metabolic process
GO:0044027	; P:hypermethylation of CpG island
GO:0035556	; P:intracellular signal transduction
GO:0043066	; P:negative regulation of apoptotic process
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0032091	; P:negative regulation of protein binding
GO:0031333	; P:negative regulation of protein complex assembly
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0001954	; P:positive regulation of cell-matrix adhesion
GO:0033138	; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0032092	; P:positive regulation of protein binding
GO:0031334	; P:positive regulation of protein complex assembly
GO:0046827	; P:positive regulation of protein export from nucleus
GO:0032855	; P:positive regulation of Rac GTPase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611	; P:protein export from nucleus
GO:0035372	; P:protein localization to microtubule
GO:0000320	; P:re-entry into mitotic cell cycle
GO:0006349	; P:regulation of gene expression by genetic imprinting
GO:0032886	; P:regulation of microtubule-based process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013