EKS-TAG-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph508.52.3E-153594851258
StatusUnreviewed
Ensembl ProteinENSTGUP00000013891
UniProt AccessionH0ZTE5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000013491ENSTGUP00000013891ENSTGUT00000014050
OrganismTaeniopygia guttata
Functional Description
Protein Length956
Protein Sequence
(FASTA)
VNLLDSKTIQ GELGWISYPS HGWEEISGVD EHYTPIRTYQ VCNVMDHSQN NWLRTNWIPR 60
NSAQKIYVEL KFTLRDCNSI PLVLGTCKET FNLYYMESDD DHLVKFKEHQ FTKIDTIAAD 120
ESFTQMDLGD RILKLNTEIR EVGPISRKGF YLAFQDVGAC VALVSVRVYF KKCPFTVKNL 180
AMFPDTVPMD SQSLVEVRGS CVNHSKEEEA PKMYCSTEGE WLVPIGKCLC NPGYEERGFA 240
CQACRAGFYK ASAGNVKCAK CPPHSSTYED ASLNCRCEKN YFRSEKDPPS MACTRPPSAP 300
RNVISNINET SVILDWSWPL DTGGRKDVTF NIVCKKCSGG GGRQCEPCSD NVRFLPRQSG 360
LTNTSVTVVD LLAHTNYTFE IDALNGVSAL SSLSRQFAAV SITTNQAAPS PITVIRKDRT 420
SRNSVSLSWQ EPEHPNGIIL DYEVKYYEKQ EQETSYTILR ARGTNVTISG LKPDTTYVFQ 480
IRARTAAGYG TSSRKFEFET SPDSFSISSE NSQVVLIAIS AAVAIILLTV VVYVLIGRFC 540
GYKKSKHGTD EKRLHFGNGH LKLPGLRTYV DPHTYEDPNQ AVHEFAKELD ASNISIDKVV 600
GAGEFGEVCS GRLKLPSKKE ISVAIKTLKV GYTEKQRRDF LGEASIMGQF DHPNIIRLEG 660
VVTKSKPVMI VTEYMENGSL DSFLRKHDAQ FTVIQLVGML RGIASGMKYL SDMGYVHRDL 720
AARNILINSN LVCKVSDFGL SRVLEDDPEA AYTTRGGKIP IRWTSPEAIA YRKFTSASDA 780
CTYGIVLWEV MSYGERPYWE MSNQDVIKAV DEGYRLPPPM DCPAALYQLM LDCWQKDRNN 840
RPKFEQIVSI LDKLIRNPSS LKIITNAAAR PSNLLLDQSN VDISAFRSTG DWLNGFRTGQ 900
CKDIFTGVEY SSCDTIAKIS TDDMKKVGVT VVGPQKKIVS SIKALETHTK NSPVPV 956
Nucleotide Sequence
(FASTA)
GTTAATCTGC TGGATTCAAA AACAATTCAA GGGGAGCTGG GCTGGATCTC CTACCCATCA 60
CATGGGTGGG AAGAGATCAG TGGTGTTGAC GAGCATTACA CTCCAATCAG AACTTACCAA 120
GTGTGCAATG TCATGGATCA CAGCCAGAAC AATTGGCTGC GGACAAACTG GATCCCGCGC 180
AACTCGGCTC AGAAGATCTA CGTGGAGCTC AAGTTCACCC TGAGGGACTG CAACAGCATC 240
CCCCTGGTGC TGGGCACCTG CAAAGAGACC TTCAACCTCT ATTACATGGA GTCCGACGAC 300
GACCACTTGG TCAAGTTCAA GGAGCACCAG TTCACAAAGA TCGACACCAT CGCGGCCGAT 360
GAGAGCTTCA CCCAGATGGA CCTCGGCGAC CGAATCCTCA AGCTGAACAC GGAAATCCGT 420
GAGGTGGGGC CCATCAGCAG GAAGGGCTTC TACCTGGCTT TCCAAGATGT GGGCGCCTGC 480
GTTGCCTTAG TGTCGGTGCG GGTGTACTTC AAGAAGTGCC CTTTCACCGT CAAGAACCTG 540
GCCATGTTCC CAGACACGGT GCCCATGGAC TCCCAGTCAC TGGTGGAGGT GAGGGGCTCC 600
TGTGTCAACC ACTCCAAGGA GGAGGAGGCC CCCAAGATGT ACTGCAGCAC GGAGGGAGAG 660
TGGCTGGTGC CTATCGGGAA GTGCTTGTGC AACCCTGGCT ACGAGGAGAG AGGCTTTGCC 720
TGCCAAGCCT GTCGAGCTGG GTTCTACAAA GCCTCTGCTG GCAATGTGAA GTGTGCCAAA 780
TGCCCCCCTC ACAGCTCCAC TTATGAAGAT GCATCTCTGA ACTGCAGGTG TGAAAAGAAT 840
TACTTTCGCT CTGAGAAAGA CCCTCCATCC ATGGCTTGCA CCAGACCGCC ATCCGCCCCA 900
AGAAACGTCA TCTCCAACAT CAACGAGACC TCCGTTATCC TGGACTGGAG CTGGCCCCTG 960
GACACGGGGG GCAGGAAGGA CGTCACCTTC AACATCGTCT GCAAGAAATG CAGCGGCGGC 1020
GGCGGCAGGC AGTGCGAGCC CTGCAGCGAC AACGTGCGCT TCCTGCCGCG GCAGAGCGGC 1080
CTCACCAACA CCTCGGTCAC CGTGGTGGAC CTGCTGGCAC ACACCAACTA CACCTTCGAG 1140
ATCGACGCGC TCAACGGCGT CTCGGCGCTC AGCAGCCTCT CCAGGCAGTT CGCTGCTGTC 1200
AGCATCACCA CTAACCAGGC TGCTCCATCC CCCATCACAG TCATAAGGAA GGACAGGACG 1260
TCCAGGAACA GCGTGTCCCT CTCCTGGCAG GAGCCCGAGC ATCCCAACGG GATCATCTTG 1320
GACTACGAGG TCAAATACTA CGAAAAGCAG GAACAAGAGA CAAGCTATAC TATTCTGAGA 1380
GCCAGGGGCA CCAACGTGAC CATCAGTGGG CTCAAGCCTG ACACCACCTA TGTCTTCCAA 1440
ATCCGAGCCC GGACTGCAGC CGGATACGGG ACCAGCAGCC GCAAATTTGA GTTTGAGACC 1500
AGCCCAGACT CCTTCTCCAT CTCCAGTGAG AACAGCCAAG TGGTGCTGAT TGCCATTTCA 1560
GCAGCAGTGG CCATCATTCT GCTCACAGTG GTGGTGTATG TCTTGATTGG GAGATTCTGT 1620
GGATACAAGA AGTCTAAACA TGGCACTGAT GAGAAAAGGC TGCATTTTGG GAATGGCCAT 1680
TTAAAGCTCC CAGGTCTGAG AACTTACGTA GATCCACACA CGTATGAGGA TCCCAACCAA 1740
GCGGTGCATG AATTTGCCAA GGAACTGGAT GCTTCCAATA TATCCATTGA TAAAGTAGTT 1800
GGAGCAGGAG AATTTGGAGA AGTGTGCAGT GGACGCCTGA AGCTGCCTTC TAAAAAGGAA 1860
ATTTCAGTGG CCATCAAAAC CCTGAAAGTT GGCTACACAG AAAAGCAGAG GAGGGACTTC 1920
CTGGGAGAAG CCAGCATCAT GGGCCAGTTT GACCACCCCA ACATCATCCG ACTGGAGGGA 1980
GTTGTCACTA AAAGTAAACC AGTTATGATT GTTACTGAAT ACATGGAAAA TGGTTCCTTG 2040
GACAGCTTCC TACGAAAGCA TGATGCCCAG TTCACAGTCA TCCAGCTGGT GGGCATGCTC 2100
CGAGGGATCG CCTCTGGCAT GAAGTACCTG TCGGACATGG GTTACGTGCA CCGGGATTTG 2160
GCTGCTCGTA ACATCCTCAT CAACAGCAAC CTGGTGTGCA AAGTCTCAGA TTTTGGTCTC 2220
TCTCGTGTAC TGGAGGATGA CCCAGAAGCT GCTTACACCA CAAGGGGGGG CAAGATTCCC 2280
ATCCGATGGA CGTCTCCAGA AGCTATTGCC TATCGCAAGT TCACGTCAGC CAGCGACGCC 2340
TGTACCTATG GGATTGTCCT CTGGGAGGTG ATGTCTTATG GGGAGAGACC CTACTGGGAG 2400
ATGTCCAACC AGGATGTGAT TAAGGCTGTG GATGAAGGGT ACCGCTTGCC ACCTCCCATG 2460
GACTGCCCAG CTGCCTTGTA TCAGCTGATG CTGGACTGCT GGCAGAAGGA CAGAAACAAC 2520
AGACCCAAGT TTGAGCAGAT TGTCAGCATC CTGGATAAGC TGATCCGTAA TCCCAGCAGT 2580
CTGAAAATAA TCACCAACGC GGCGGCAAGG CCATCAAATC TCCTCCTGGA CCAAAGCAAC 2640
GTTGACATTT CAGCCTTCCG CTCCACGGGT GATTGGCTCA ATGGATTTCG GACAGGGCAG 2700
TGCAAGGACA TCTTCACGGG GGTGGAGTAC AGCTCCTGTG ACACCATAGC CAAGATTTCC 2760
ACAGATGACA TGAAGAAAGT TGGCGTTACA GTGGTGGGCC CTCAAAAGAA GATTGTCAGC 2820
AGTATCAAAG CTCTAGAAAC TCATACAAAG AACAGCCCTG TTCCTGTGTA A 2871
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 594   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  653
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 654   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  713
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 714   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  773
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasd+ +yGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 774   FTSASDACTYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  833
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 834   WQKDRNNRPKFEQIVSIL  851
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDACTY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013