EKS-TAG-00234
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00234
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2518.56.7E-15628380353
StatusUnreviewed
Ensembl ProteinENSTGUP00000017401
UniProt AccessionH1A3D9;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000017113ENSTGUP00000017401ENSTGUT00000017792
OrganismTaeniopygia guttata
Functional Description
Protein Length449
Protein Sequence
(FASTA)
QTVFVGKNKP QKDPLSSFRW QGFKLEEYLI GQPIGKGCSA AVYEAAIPFC PSPRDPALQQ 60
DRASASQGAE GEPVVKHQPK GAFPLAIKMM WNISAGSSSE AILDAMGREL VPATGVALSG 120
EYGAVSGHRY GGAKKLRPHP NIIQVIRAFT SSVPLLPGAF ADYPDVLPLS LNPRGIGHSR 180
TLFLVMKNYP FTLRQYLQEN TPDVRLSTVM ILQLLEGVDH LVRHGIAHRD LKSDNILVEF 240
DSAGCPWLVI TDFGCCLADE SIGLRLPFTS SYVDRGGNGC LMAPEVITAS PGPGTVINYS 300
KADAWAVGAI AYEILGLANP FYGHGDSTLE SRSYQEEQLP SLPKHVPLEV KQVIKMLLQR 360
DPNKRLSARV AANVLHLSLW GDSVVASRTL KPDQMIAWLL CQSAATLLTN RLAEKSQVET 420
KMKMCFLANL EFEDLWAAMF LLLAWRSQS 449
Nucleotide Sequence
(FASTA)
CAGACTGTGT TTGTTGGGAA GAACAAGCCG CAGAAAGATC CCCTGAGCTC CTTCCGCTGG 60
CAGGGCTTCA AGCTGGAGGA GTATCTCATT GGGCAGCCCA TCGGGAAGGG CTGCAGCGCT 120
GCTGTGTACG AGGCAGCGAT TCCCTTCTGT CCCAGCCCTC GGGATCCAGC CCTGCAGCAG 180
GACCGTGCCT CAGCCTCCCA GGGGGCCGAA GGGGAGCCTG TAGTGAAGCA CCAACCGAAA 240
GGGGCTTTTC CCTTAGCTAT CAAAATGATG TGGAACATTT CGGCTGGTTC CTCGAGTGAA 300
GCCATCCTTG ATGCCATGGG CCGAGAGCTG GTCCCAGCCA CAGGCGTTGC CTTGTCCGGG 360
GAGTATGGAG CTGTCTCTGG CCACAGGTAT GGGGGTGCCA AGAAGCTGCG ACCTCATCCG 420
AATATAATCC AGGTGATCCG AGCATTCACA TCCTCTGTCC CTTTGCTGCC TGGAGCCTTT 480
GCTGACTATC CTGATGTCCT CCCACTGAGC CTGAACCCCA GAGGGATCGG TCACAGCCGC 540
ACACTCTTCT TGGTGATGAA GAACTACCCC TTCACGCTGC GCCAGTATCT GCAGGAGAAC 600
ACTCCGGATG TTCGCCTCTC CACAGTGATG ATTCTGCAGC TCTTGGAGGG CGTGGACCAC 660
CTTGTTCGAC ATGGAATAGC ACACAGAGAC CTCAAGTCTG ACAACATCCT GGTTGAATTT 720
GATTCTGCTG GCTGCCCCTG GCTGGTCATC ACCGACTTTG GCTGCTGTTT GGCAGATGAA 780
AGCATCGGCC TGAGGCTGCC CTTCACCAGC TCCTATGTGG ATCGGGGTGG CAACGGCTGC 840
CTTATGGCAC CTGAGGTGAT CACAGCGTCA CCTGGTCCAG GCACGGTGAT CAACTACAGT 900
AAAGCTGATG CTTGGGCTGT TGGAGCAATT GCCTATGAAA TCTTGGGCCT GGCCAATCCT 960
TTCTATGGCC ACGGGGACTC CACTCTGGAA AGCAGAAGTT ACCAGGAGGA GCAGCTGCCA 1020
AGCCTGCCCA AGCACGTGCC CCTCGAGGTG AAGCAGGTGA TAAAGATGCT GCTTCAGAGA 1080
GATCCCAACA AGAGGTTGTC TGCGAGAGTG GCTGCAAACG TGCTGCACCT GAGCCTCTGG 1140
GGTGACAGTG TTGTGGCATC CAGGACCCTG AAACCTGACC AGATGATCGC CTGGCTGCTC 1200
TGCCAGTCTG CAGCCACCCT GCTCACCAAC AGGCTGGCGG AGAAGAGCCA GGTAGAAACC 1260
AAAATGAAGA TGTGCTTCTT GGCAAACCTC GAGTTTGAAG ACCTCTGGGC AGCAATGTTC 1320
CTGTTGCTGG CCTGGAGAAG TCAATCT 1347
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeidqesavaakkfpl  60
         ylig+ +gkgc+aavyea ++  ++  + a +       +++ +++++ +++  + +fpl
Q: 28    YLIGQPIGKGCSAAVYEAAIPFCPSPRDPALQQDRA--SASQGAEGEPVVKHQPKGAFPL  85
         99********************99988877665544..455567899999999999****
S: 61    aiklmfnieadssseallksmsqelvpasrvaldgeygav.......pkllakhPnivrv  113
         aik+m+ni+a+sssea+l++m++elvpa+ val+geygav        k+l +hPni++v
Q: 86    AIKMMWNISAGSSSEAILDAMGRELVPATGVALSGEYGAVsghryggAKKLRPHPNIIQV  145
         ***********************************************899**********
S: 114   lrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrstr  173
         +raf++sv+llP+a++dyPd+lp  l+p+g+g+++tl+lvmk+y+ tlr+yl++++++ r
Q: 146   IRAFTSSVPLLPGAFADYPDVLPLSLNPRGIGHSRTLFLVMKNYPFTLRQYLQENTPDVR  205
         ************************************************************
S: 174   laalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdglr  233
         l++++++qlle+vdhlv+hg+ahrdlksdnilve+d+ ++P+lvi+dfGCclad+++glr
Q: 206   LSTVMILQLLEGVDHLVRHGIAHRDLKSDNILVEFDSAGCPWLVITDFGCCLADESIGLR  265
         ************************************************************
S: 234   lpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfygeg  293
         lp++ss+vd+GGn++lmaPe+ ta pGp +viny+kad+WavGa+ayei+gl+nPfyg+g
Q: 266   LPFTSSYVDRGGNGCLMAPEVITASPGPGTVINYSKADAWAVGAIAYEILGLANPFYGHG  325
         ************************************************************
S: 294   kaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
           +les+syqe+qlP+lp+ vp e++q++  ll+r+++kr sa++aanvl+lsl+
Q: 326   DSTLESRSYQEEQLPSLPKHVPLEVKQVIKMLLQRDPNKRLSARVAANVLHLSLW  380
         ******************************************************9
Domain Sequence
(FASTA)
YLIGQPIGKG CSAAVYEAAI PFCPSPRDPA LQQDRASASQ GAEGEPVVKH QPKGAFPLAI 60
KMMWNISAGS SSEAILDAMG RELVPATGVA LSGEYGAVSG HRYGGAKKLR PHPNIIQVIR 120
AFTSSVPLLP GAFADYPDVL PLSLNPRGIG HSRTLFLVMK NYPFTLRQYL QENTPDVRLS 180
TVMILQLLEG VDHLVRHGIA HRDLKSDNIL VEFDSAGCPW LVITDFGCCL ADESIGLRLP 240
FTSSYVDRGG NGCLMAPEVI TASPGPGTVI NYSKADAWAV GAIAYEILGL ANPFYGHGDS 300
TLESRSYQEE QLPSLPKHVP LEVKQVIKML LQRDPNKRLS ARVAANVLHL SLW 353
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013