EKS-TAG-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak281.75.8E-8443301259
StatusUnreviewed
Ensembl ProteinENSTGUP00000017439
UniProt AccessionH1A3H7;
Protein Name
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000017135ENSTGUP00000017439ENSTGUT00000017835
OrganismTaeniopygia guttata
Functional Description
Protein Length589
Protein Sequence
(FASTA)
PPEKSNLLIV RSGVPCPPGS PPAPQRRSLQ QMMFHKIDPQ SLTRGESLGQ GSFTQIYKGV 60
KREQDEEDGP RQTPVVLKVM DSSHRNCLES FLEAASTMSQ LSCKHLVLLH GVSLGKDSVM 120
VQEYVRHGPL DLYVRKNRGM VTTGWKLTVA KQLAYALNYL EDKKIPHGNV SAKKVLLARE 180
GDTARGSPPF IKLNDPGVSV TVLARDTLGS RIPWVAPECV SNPGSLALPA DKWGFGATLW 240
EIFSGGNMPL SLLEPQRKLE FYQGCQQLPA PKWPELAVLV AQCMEYEPQR RPCFRALIRD 300
LNSLITSDYE LLSDLSPVDV TLRDGFWGHD SLAMSQDPEH FQERHLKYIS LLGKGFRERE 360
LCRYDPLGDS TGDCGGEELQ QDSAKEFGFE RRSNPALVQH DFIVRTGCCY SLECAGMRLV 420
MKFLPQGCLR DFLQKNQPRL EHGTLLLYAW QICKGMEYLG AQRCVHRDLA SRNILVESDS 480
HVKIGDFGLA KLLPQDKDYY VVREPGQSPV FWYAPESLAD NIFSCASDAW SFGVLLYELF 540
TYSSKSRSPS EEFLRMMGTA RPAQIICHLL ELLKDNRRLP APTGCPSEV 589
Nucleotide Sequence
(FASTA)
CCCCCAGAGA AGTCCAACCT GCTGATTGTT CGGAGCGGGG TCCCCTGTCC CCCTGGCTCC 60
CCTCCTGCCC CCCAGCGCCG CAGCCTCCAG CAGATGATGT TCCACAAGAT CGACCCCCAG 120
AGCCTGACAC GGGGTGAGAG CCTGGGCCAG GGCTCCTTCA CCCAGATCTA CAAAGGCGTC 180
AAAAGGGAAC AGGACGAGGA GGACGGACCC CGCCAGACCC CGGTGGTGCT CAAGGTCATG 240
GACAGCAGCC ACCGCAACTG CCTGGAGTCC TTCCTGGAGG CCGCCAGCAC CATGAGCCAG 300
CTCTCGTGCA AACACCTGGT GCTGCTACAC GGCGTCAGCC TCGGAAAGGA CAGTGTGATG 360
GTGCAGGAGT ACGTCCGGCA TGGGCCCCTG GACCTGTACG TGCGCAAGAA CCGGGGCATG 420
GTGACCACTG GCTGGAAGCT GACGGTGGCC AAGCAGTTGG CCTATGCCCT CAACTACCTG 480
GAGGACAAGA AGATCCCGCA CGGGAATGTC TCTGCTAAGA AGGTCCTGCT GGCGCGGGAG 540
GGGGACACAG CCAGGGGGAG CCCCCCCTTC ATCAAACTCA ACGACCCCGG GGTCAGCGTC 600
ACCGTCCTGG CCCGGGACAC TCTGGGTTCG AGGATCCCAT GGGTGGCCCC CGAGTGTGTC 660
AGCAACCCCG GGAGCCTGGC GCTGCCGGCC GACAAGTGGG GCTTCGGAGC CACCCTCTGG 720
GAGATCTTCA GTGGGGGGAA CATGCCCCTG AGCCTGCTGG AGCCCCAGAG GAAGCTGGAA 780
TTCTACCAGG GATGCCAGCA GCTCCCGGCT CCCAAGTGGC CGGAGCTGGC CGTGCTGGTG 840
GCCCAGTGCA TGGAGTACGA GCCCCAGCGC CGGCCCTGCT TCCGCGCCCT CATCCGCGAC 900
CTCAACAGCC TCATCACCTC TGACTACGAG CTGCTCTCGG ACCTGTCCCC CGTGGATGTG 960
ACGCTCCGGG ACGGCTTCTG GGGACACGAT TCCCTCGCCA TGAGCCAGGA TCCCGAGCAC 1020
TTCCAGGAGC GACACCTCAA GTACATCTCG CTGCTGGGCA AGGGATTTCG GGAGCGTGAG 1080
CTGTGCCGCT ACGACCCCCT GGGGGACAGC ACGGGCGACT GTGGCGGTGA AGAGCTGCAG 1140
CAGGATTCGG CCAAGGAATT CGGATTTGAG CGGAGATCAA ATCCTGCACT CGTGCAGCAC 1200
GACTTCATCG TCCGTACCGG GTGTTGCTAC AGCCTGGAAT GCGCGGGGAT GCGGCTGGTG 1260
ATGAAGTTCT TGCCCCAAGG CTGCCTGCGG GATTTCCTGC AGAAGAACCA GCCCCGCCTG 1320
GAGCACGGCA CGCTGCTCCT TTACGCCTGG CAGATCTGCA AGGGCATGGA ATACCTGGGG 1380
GCGCAGCGCT GCGTGCACCG GGACCTGGCG AGCAGGAACA TCCTGGTGGA GAGCGACAGC 1440
CACGTCAAGA TCGGCGACTT CGGGCTGGCC AAGCTGCTCC CGCAGGACAA GGATTACTAC 1500
GTGGTGCGGG AGCCCGGCCA GAGCCCTGTT TTCTGGTACG CTCCGGAATC CCTGGCTGAC 1560
AACATCTTCT CCTGCGCCTC CGACGCCTGG AGCTTCGGGG TGCTCCTCTA CGAGCTCTTC 1620
ACCTACAGCT CCAAGAGCAG GAGCCCCTCG GAGGAATTCC TGCGGATGAT GGGCACCGCG 1680
AGGCCGGCGC AGATCATTTG CCACCTGCTG GAGCTCCTCA AGGACAACCG GCGGCTCCCG 1740
GCTCCCACCG GCTGTCCCTC GGAGGTG 1767
Domain Profile
S: 2     kqiesLgkgtftkvfevred...aegdsteee.valkvLkesgedisrdfkreaeilsql  57
         ++ esLg+g+ft+++++ ++   +e+  ++   v+lkv+++s++++ ++f ++a+++sql
Q: 43    TRGESLGQGSFTQIYKGVKReqdEEDGPRQ-TpVVLKVMDSSHRNCLESFLEAASTMSQL  101
         6789*************9963313333334.26***************************
S: 58    shehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         s +h+v l+gv++ +++  +V+eyv++G+Ld y rk++  +++ ++l vakqla+a++YL
Q: 102   SCKHLVLLHGVSLGKDSV-MVQEYVRHGPLDLYVRKNRGMVTTGWKLTVAKQLAYALNYL  160
         ****************96.*****************************************
S: 118   edkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripw  175
         edkk+ h++v+a++vL++re++   g+ppf+kl dpg++ +v      l+r+   sripw
Q: 161   EDKKIPHGNVSAKKVLLAREGDtaRGSPPFIKLNDPGVSVTV------LARDTLGSRIPW  214
         *********************988899***************......************
S: 176   lapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpk  235
         +apec+s+  +l + +d+W+Fg+tl+e+  +s g++pl+  +++rkle+++  ++lp+pk
Q: 215   VAPECVSNPGSLALPADKWGFGATLWEI--FSGGNMPLSLLEPQRKLEFYQGCQQLPAPK  272
         ****************************..******************************
S: 236   cpaelaelmtnclsyepsqrpsFrailedl  265
         +p ela+l+ +c++yep++rp Fra+++dl
Q: 273   WP-ELAVLVAQCMEYEPQRRPCFRALIRDL  301
         **.*************************98
Domain Sequence
(FASTA)
TRGESLGQGS FTQIYKGVKR EQDEEDGPRQ TPVVLKVMDS SHRNCLESFL EAASTMSQLS 60
CKHLVLLHGV SLGKDSVMVQ EYVRHGPLDL YVRKNRGMVT TGWKLTVAKQ LAYALNYLED 120
KKIPHGNVSA KKVLLAREGD TARGSPPFIK LNDPGVSVTV LARDTLGSRI PWVAPECVSN 180
PGSLALPADK WGFGATLWEI FSGGNMPLSL LEPQRKLEFY QGCQQLPAPK WPELAVLVAQ 240
CMEYEPQRRP CFRALIRDL 259
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013