EKS-TAG-00254
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00254
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl549.77.7E-166217468252
StatusUnreviewed
Ensembl ProteinENSTGUP00000017671
UniProt AccessionH1A456;
Protein Name
Protein Synonyms/Alias
Gene NameABL2
Gene Synonyms/Alias ABL2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000017391ENSTGUP00000017671ENSTGUT00000018074
OrganismTaeniopygia guttata
Functional Description
Protein Length1102
Protein Sequence
(FASTA)
SSEALHRPYG CDVEPQALNE AIRWSSKENL LGATESDPNL FVALYDFVAS GDNTLSITKG 60
EKLRVLGYNQ NGEWSEVRSK NGQGWVPSNY ITPVNSLEKH SWYHGPVSRS AAEYLLSSLI 120
NGSFLVRESE SSPGQLSISL RYEGRVYHYR INTTSDGKVY VTAESRFSTL AELVHHHSTV 180
ADGLVTTLHY PAPKCNKPTV YGVSPIHDKW EMERTDITMK HKLGGGQYGE VYVGVWKKYN 240
LTVAVKTLKE DTMEVEEFLK EAAVMKEIKH PNLVQLLGVC TLEPPFYIVT EYMPYGNLLD 300
YLRECNREEV SAVVLLYMAT QISSAMEYLE KKNFIHRDLA ARNCLVGENH VVKVADFGLS 360
RLMTGDTYTA HAGAKFPIKW TAPESLAYNT FSIKSDVWAF GVLLWEIATY GMSPYPGIDL 420
SQVYDLLEKG YRMEQPEGCP PKVYELMRAC WKWNPPDRPS FAETHQAFET MFHDSSISEE 480
VAEELGRTAS SSSIVPYLPR LPMLPSKTRT LKKQAENKEN IEGTQDTVEH SASSSAPGFI 540
RSTQPTGGSP ALPHKQRDKS PSSLLEDAKE TTFTRDRKGG FFSSFMKKRN APTPPKRSSS 600
FREMENQPHK KYELTGNFSS VASLQHVDGF SFAPAQQDTS LAPPKCYGGG FVQRTFYSEE 660
GTGPSSAGAV STGGGWSGIT GFFTPRLIKK TLGLRAGKPT GNEEASKPFP RSNSTSSMSS 720
GLPEQDRMAM TLPRNSQRSK IQLERTVSTS SQPDESTERA SDLIPKRFEE GPALTRERPK 780
AKLLPRGATA LPFRTPSTSE EKEGPGLVAA PKGKEKNSGP RQGALEDGER PGWSSPLKAA 840
AILPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL LSEHQVTSSG DRDRPRRVKP 900
KCAPPPPPVM RLLQQPAACS DAAEELSGVA GAQHGLESSE GSKKAAAAAA PVGGKSGRPA 960
LPPPQVPLSS SSTSPVKMAN GTAGAKVALR KTKQAAEKIP ADKISKEALL ECAGLLSSAI 1020
AEPTPNSQLV DTGHQLLDYC SGYVDCIPHT RNKFAFREAV SKLELSLQEL QVSSTAAGVH 1080
GANPVLNNLL SCVQEISDVV QR 1102
Nucleotide Sequence
(FASTA)
TCCTCAGAGG CCCTGCACCG CCCCTACGGC TGCGACGTCG AGCCCCAGGC ACTGAACGAA 60
GCCATCAGAT GGAGCTCCAA GGAGAACCTG CTTGGAGCCA CTGAGAGCGA TCCCAATCTC 120
TTTGTTGCAC TTTACGATTT TGTAGCGAGT GGTGACAACA CACTCAGCAT CACCAAAGGT 180
GAGAAGTTGC GAGTCCTGGG TTACAACCAG AATGGTGAAT GGAGTGAGGT ACGTTCGAAG 240
AATGGGCAGG GCTGGGTACC AAGCAACTAC ATCACTCCAG TGAACAGCCT GGAGAAGCAC 300
TCGTGGTACC ACGGGCCGGT GTCCCGCAGT GCAGCAGAGT ATCTGCTCAG CAGCCTCATC 360
AATGGCAGCT TCCTGGTGCG GGAGAGCGAG AGCAGCCCAG GGCAGCTGTC CATCTCGCTC 420
AGGTACGAAG GACGTGTTTA CCACTACAGG ATCAACACCA CCTCGGATGG CAAGGTCTAT 480
GTGACAGCAG AAAGCCGTTT CAGCACCCTG GCAGAGCTGG TGCACCATCA CTCGACAGTG 540
GCAGATGGCC TGGTGACAAC TCTGCATTAC CCAGCACCCA AGTGCAATAA GCCCACCGTG 600
TATGGAGTGT CCCCCATCCA TGACAAGTGG GAGATGGAGC GCACCGACAT CACCATGAAG 660
CACAAGCTCG GGGGAGGGCA GTACGGAGAG GTCTACGTGG GGGTCTGGAA GAAATACAAT 720
CTCACAGTGG CTGTGAAAAC GTTAAAGGAA GATACCATGG AGGTGGAAGA GTTCTTGAAA 780
GAAGCTGCTG TGATGAAGGA GATCAAGCAT CCAAATCTAG TGCAGTTGTT AGGTGTGTGC 840
ACCCTGGAGC CCCCATTTTA CATTGTGACA GAGTACATGC CCTATGGGAA CCTGCTGGAC 900
TACCTGCGCG AGTGCAACCG CGAGGAGGTC AGCGCTGTCG TGCTGCTCTA CATGGCCACC 960
CAGATCTCCT CTGCCATGGA GTACCTGGAG AAGAAGAACT TCATCCACAG GGACCTGGCA 1020
GCACGGAACT GCTTAGTTGG AGAAAACCAC GTGGTGAAGG TGGCTGACTT TGGCTTGAGT 1080
CGACTCATGA CTGGTGATAC CTACACAGCC CATGCTGGGG CCAAGTTCCC AATCAAATGG 1140
ACAGCTCCTG AGAGCCTGGC CTACAACACC TTTTCAATCA AATCAGATGT GTGGGCCTTT 1200
GGGGTGCTGT TATGGGAAAT TGCTACTTAT GGGATGTCAC CATACCCAGG CATTGACCTC 1260
TCTCAGGTGT ATGATCTGCT GGAAAAGGGC TATCGGATGG AGCAACCAGA GGGGTGCCCT 1320
CCCAAGGTGT ATGAACTGAT GAGAGCATGC TGGAAGTGGA ACCCACCAGA CCGACCTTCC 1380
TTTGCTGAGA CCCACCAGGC TTTTGAAACC ATGTTCCACG ACTCGAGCAT CTCGGAGGAG 1440
GTAGCAGAGG AGCTTGGAAG AACAGCCTCG TCCTCATCCA TCGTTCCTTA CCTGCCCCGC 1500
TTACCCATGC TTCCCTCCAA AACACGAACA CTGAAGAAAC AGGCAGAGAA CAAGGAGAAC 1560
ATTGAGGGAA CACAGGACAC TGTGGAGCAC TCAGCATCCA GCTCAGCACC AGGTTTCATC 1620
AGAAGCACGC AGCCAACAGG CGGGTCCCCC GCGCTGCCCC ACAAGCAGAG GGACAAGTCC 1680
CCCAGCAGCC TCCTGGAGGA TGCCAAAGAG ACCACGTTCA CCAGGGACAG GAAAGGGGGC 1740
TTCTTCAGCT CCTTCATGAA GAAGAGGAAC GCTCCCACGC CCCCCAAGCG CAGCAGCTCC 1800
TTCCGGGAGA TGGAGAACCA GCCCCATAAG AAATACGAGC TGACGGGTAA CTTTTCCTCT 1860
GTTGCTTCCT TGCAGCACGT GGACGGGTTC TCCTTTGCTC CCGCGCAGCA GGACACGAGC 1920
CTGGCTCCCC CCAAGTGCTA CGGAGGGGGC TTTGTGCAGA GGACCTTCTA CAGCGAGGAG 1980
GGCACTGGGC CCAGCAGTGC TGGGGCTGTG AGCACTGGTG GAGGGTGGTC GGGCATCACT 2040
GGCTTCTTCA CTCCACGCTT GATTAAAAAG ACGCTGGGTT TACGAGCAGG AAAACCCACT 2100
GGCAATGAAG AAGCTTCAAA GCCTTTTCCA AGGTCAAACT CTACATCTTC CATGTCCTCA 2160
GGGCTTCCAG AGCAGGATAG GATGGCAATG ACCCTTCCCA GAAATTCCCA GAGGTCAAAA 2220
ATTCAGCTGG AACGGACTGT GTCCACCTCC TCCCAGCCTG ATGAGAGCAC AGAGAGGGCC 2280
AGTGACCTGA TTCCCAAAAG GTTTGAAGAG GGCCCTGCTT TGACCAGAGA GAGACCAAAA 2340
GCAAAACTCT TGCCAAGAGG TGCCACAGCA CTCCCTTTTC GAACTCCCTC CACGTCAGAA 2400
GAAAAGGAGG GTCCAGGGCT AGTGGCAGCT CCTAAGGGCA AGGAAAAAAA CAGTGGCCCA 2460
CGACAAGGGG CCCTTGAGGA TGGCGAGAGG CCGGGGTGGT CATCTCCGCT AAAGGCTGCA 2520
GCAATACTTC CAACCACTCA TAACCACAAA GTGCCAGTCC TAATCTCACC CACTCTAAAA 2580
CACACTCCAG CAGACGTGCA GCTCATTGGC ACAGACTCTC AGGGTAATAA ATTTAAGCTC 2640
TTATCTGAGC ATCAGGTCAC TTCTTCCGGC GACAGGGACC GGCCCAGACG GGTAAAACCA 2700
AAGTGTGCTC CACCTCCACC GCCGGTGATG CGGCTCCTCC AGCAGCCAGC TGCCTGCTCG 2760
GATGCAGCAG AAGAGCTGAG CGGCGTGGCA GGAGCGCAGC ACGGACTGGA ATCCAGCGAA 2820
GGGAGTAAGA AGGCGGCAGC AGCAGCAGCA CCTGTCGGTG GAAAATCTGG GAGGCCTGCG 2880
TTGCCTCCGC CCCAAGTGCC TCTGTCATCG TCTTCCACCT CCCCAGTGAA AATGGCCAAT 2940
GGCACGGCCG GCGCCAAGGT TGCGCTGAGA AAGACCAAAC AGGCGGCTGA GAAGATCCCC 3000
GCAGACAAGA TCAGCAAGGA AGCGCTGCTG GAGTGCGCGG GTCTCCTCTC CAGCGCCATC 3060
GCCGAGCCCA CGCCCAACAG CCAGCTGGTG GACACGGGGC ACCAGCTGCT GGATTACTGC 3120
TCAGGCTACG TGGACTGCAT CCCGCACACG CGCAACAAAT TTGCCTTCCG GGAAGCCGTG 3180
AGCAAACTGG AACTCAGCCT GCAGGAGCTG CAGGTGTCCT CGACAGCTGC TGGCGTCCAT 3240
GGGGCGAACC CCGTCCTTAA TAACTTATTG TCATGTGTCC AAGAAATCAG TGATGTGGTG 3300
CAAAGGTAG 3309
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevy+gvwkky+ltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 217   ITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  276
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih
Q: 277   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVSAVVLLYMATQISSAMEYLEKKNFIH  336
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd
Q: 337   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  396
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkw+p 
Q: 397   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWNPP  456
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfae+hqa+
Q: 457   DRPSFAETHQAF  468
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYVGVW KKYNLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVSAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWNPP 240
DRPSFAETHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00219
EKS-ANC-00229
EKS-BOT-00258
EKS-CAJ-00244
EKS-CAF-00246
EKS-CAP-00294
EKS-DAR-00594
EKS-EQC-00231
EKS-FEC-00245
EKS-GAG-00199
EKS-GOG-00257
EKS-HOS-00246
EKS-ICT-00226
EKS-LAC-00271
EKS-LOA-00269
EKS-MAM-00260
EKS-MEG-00205
EKS-MOD-00238
EKS-MUM-00243
EKS-MUP-00257
EKS-MYL-00238
EKS-NOL-00239
EKS-ORN-00336
EKS-ORA-00228
EKS-ORC-00245
EKS-OTG-00265
EKS-PAT-00227
EKS-PES-00230
EKS-POA-00231
EKS-RAN-00273
EKS-SAH-00244
EKS-SUS-00224
EKS-TEN-00296
EKS-TUT-00027
EKS-XET-00313
EKS-XIM-00329
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0051017; P:actin filament bundle assembly
GO:0071300; P:cellular response to retinoic acid
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0051353; P:positive regulation of oxidoreductase activity
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013