EKS-TEN-00445

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00445

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	190.6	4.0E-56	260	468	209

Status

Unreviewed

Ensembl Protein

ENSTNIP00000003626

UniProt Accession

H3C5V6;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2 (1 of 2)

Gene Synonyms/Alias

EIF2AK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000000327	ENSTNIP00000003079	ENSTNIT00000001797
ENSTNIG00000000327	ENSTNIP00000003626	ENSTNIT00000003057

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

468

Protein Sequence
(FASTA)

YISLLNEQAQ KEGWSLRYEE VGCDGLDHFR TFKIVTIIND RAFPEGVAVG KTKKEAKEEA 60

AKLVYNEICG SEKSDMIKSL SVTTADTERN YISLINEHCQ KKGFSHSFVM VDRQGPSHGP 120

QFYYQLSIDG HKYPVGEGKT AKEARQNAAQ LACLKVVSIY TSFNITYISL CFLSKNCESG 180

IRCSVCSASG GHASEASTRF FRLAVHFPNA HGNSKENKST LFRNRLTSMA RFQRARKQRQ 240

GKKVLKSNQC FVFQRFTSEF DSISRLGSGG YGHVFKARNK LLGSEMAVKI VLCDEKALRE 300

AQALSDLDHC NIIRYYTCWL EDSGYDRRSP PYQDSSLKYL YIQMELCSTE NLKLWIEKMN 360

HNQNQERKKK SLSIFRQIVS GVEYIHSRNL IHRDLKPENI MFSKKEKEKV KIGDFGLVTV 420

GAFEAKNLEE RTVYKGTPWY MPPEQKDKKT YDQKVDIFPL GLIYFELL 468

Nucleotide Sequence
(FASTA)

TATATATCCT TATTGAACGA GCAAGCACAA AAAGAAGGGT GGTCCCTACG CTATGAAGAA 60

GTTGGATGTG ATGGTCTCGA TCACTTCAGA ACGTTCAAGA TAGTCACCAT CATAAATGAC 120

CGAGCTTTTC CTGAAGGTGT TGCTGTGGGG AAAACGAAGA AAGAAGCTAA AGAGGAAGCT 180

GCCAAGCTGG TGTACAATGA GATCTGTGGC AGTGAGAAGA GCGACATGAT AAAAAGTTTG 240

AGTGTGACGA CCGCTGACAC AGAGAGAAAT TACATCAGTC TCATCAACGA GCATTGTCAG 300

AAGAAGGGGT TCTCACACTC TTTCGTCATG GTGGATAGGC AGGGACCGTC ACACGGGCCT 360

CAGTTTTACT ACCAACTCTC GATCGATGGT CACAAATACC CCGTAGGCGA GGGCAAGACC 420

GCCAAGGAGG CCAGACAGAA TGCAGCGCAG CTGGCCTGTT TAAAAGTTGT CAGCATTTAC 480

ACAAGCTTCA ATATCACGTA TATATCCCTG TGTTTTCTCA GCAAAAACTG TGAGAGTGGG 540

ATCAGGTGCA GTGTTTGCTC GGCCTCAGGC GGTCATGCTT CAGAAGCCTC AACACGTTTT 600

TTCAGACTTG CAGTACATTT CCCAAATGCT CATGGAAACA GCAAAGAGAA TAAATCCACT 660

TTATTCAGGA ATCGCCTGAC TTCAATGGCC AGATTTCAGC GAGCGAGAAA ACAACGCCAA 720

GGTAAGAAAG TCCTAAAATC TAACCAATGT TTCGTTTTCC AAAGGTTTAC ATCAGAGTTT 780

GACTCGATCA GTCGCCTGGG AAGTGGAGGC TATGGTCACG TTTTCAAGGC CAGAAACAAA 840

CTGCTCGGTT CGGAGATGGC TGTAAAAATT GTCCTGTGTG ACGAGAAGGC TCTACGGGAG 900

GCCCAGGCGT TATCGGACCT CGATCACTGC AATATTATTC GGTACTACAC CTGCTGGTTG 960

GAGGATTCAG GATACGATCG CCGTTCACCG CCATACCAGG ATTCATCACT CAAGTACCTC 1020

TATATCCAGA TGGAGCTGTG TTCCACTGAA AACCTCAAGT TATGGATAGA AAAAATGAAT 1080

CATAATCAAA ACCAGGAGAG GAAAAAGAAA AGTCTTTCAA TTTTCCGACA AATAGTCAGT 1140

GGAGTTGAGT ACATCCACTC CAGGAATTTA ATCCACAGGG ATCTGAAGCC TGAAAACATC 1200

ATGTTTAGCA AAAAGGAAAA GGAAAAGGTA AAGATCGGAG ACTTTGGCCT GGTCACCGTT 1260

GGAGCCTTTG AGGCTAAGAA TTTGGAGGAG AGAACGGTGT ACAAAGGAAC CCCCTGGTAC 1320

ATGCCCCCCG AACAAAAAGA CAAGAAAACG TACGACCAGA AAGTGGATAT ATTTCCTTTG 1380

GGCTTGATTT ATTTTGAGCT CCTT 1404

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         f+ i  lG+Gg+g V+ka+nkl + e+a+k + +++      k++re++aL+ l+h ni+

Q: 260   FDSISRLGSGGYGHVFKARNKLLGSEMAVKIVLCDE------KALREAQALSDLDHCNII  313

         677899***********************9988887......78****************

S: 61    rYfaawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderk  120

         rY+++wle+                   s   ++s+ k+lyiqmelc+ e+Lk wi++ +

Q: 314   RYYTCWLEDSGYDR-------------RSPPYQDSSLKYLYIQMELCSTENLKLWIEKMN  360

         ********988544.............34445556678******************9876

S: 121   llesrselvm..rlfkqllegleylHskgliHrdLkpsniFldsdd..qvKigDFgLata  176

          ++++++      +f+q+++g+ey+Hs+ liHrdLkp ni++++++  +vKigDFgL+t

Q: 361   HNQNQERKKKslSIFRQIVSGVEYIHSRNLIHRDLKPENIMFSKKEkeKVKIGDFGLVTV  420

         444333333334******************************9544459**********9

S: 177   laealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLl  233

          a + k+          +++t   gt  ym Peq  k++Y++kvDif LGli feLl

Q: 421   GAFEAKN---------LEERTVYKGTPWYMPPEQKDKKTYDQKVDIFPLGLIYFELL  468

         6555443.........346799*********************************96

Domain Sequence
(FASTA)

FDSISRLGSG GYGHVFKARN KLLGSEMAVK IVLCDEKALR EAQALSDLDH CNIIRYYTCW 60

LEDSGYDRRS PPYQDSSLKY LYIQMELCST ENLKLWIEKM NHNQNQERKK KSLSIFRQIV 120

SGVEYIHSRN LIHRDLKPEN IMFSKKEKEK VKIGDFGLVT VGAFEAKNLE ERTVYKGTPW 180

YMPPEQKDKK TYDQKVDIFP LGLIYFELL 209

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013