EKS-TEN-00472

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00472

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	360.0	6.9E-108	173	426	254

Status

Unreviewed

Ensembl Protein

ENSTNIP00000002569

UniProt Accession

H3C955;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000002299	ENSTNIP00000004777	ENSTNIT00000004922
ENSTNIG00000002299	ENSTNIP00000002569	ENSTNIT00000004098

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

ALFDFEARSD AELTVKEGDK LSVLEKRGDY VLAKKLTGSL ESGLLPANYV ALLQDEFAKH 60

KWYYGNINRV KAEKLLLASQ NKDGSFLVRI SESHSDEYTI SARSEGKVFH FRIQRSSIGA 120

YFVSDRISFA TLGELISYYQ RNNRSLGVLL EEPCAQQREL FDMEPWERPR EEFRLLRKLG 180

EGHFGEVWEA LWSTENRRVA IKTLKQEDTK QDEFVKEVQA LKSLHHPKLI QLLAMCSRGE 240

PVYIVTELMT KGSLKAYLAC GSAAEGQVLT SAHLIYMGSQ IAEGMAYLED RNIVHRDLAA 300

RNILVGEDLV CKVADFGLAR IIKDSVYTAS RNTKIPVRWT APEAAIHQRF SVKSDVWSFG 360

VLLYEMMSRG KMPYEGKNNK EVLDLLASGF RLPCPTRCPQ NIYRMMMGCW AAEPSKRPSF 420

HALHSQLDAI Y 431

Nucleotide Sequence
(FASTA)

GCGCTCTTCG ACTTCGAGGC CCGCAGCGAC GCCGAGCTGA CGGTGAAGGA GGGCGACAAG 60

CTGTCGGTGC TGGAGAAGCG CGGCGACTAC GTGCTGGCCA AGAAGCTGAC CGGGTCCCTG 120

GAGTCCGGCC TCCTGCCCGC CAACTACGTG GCCCTGCTCC AGGACGAGTT CGCCAAGCAC 180

AAGTGGTACT ACGGCAACAT AAACCGCGTG AAAGCCGAGA AGCTGCTGCT GGCGTCCCAG 240

AACAAAGATG GCTCCTTCCT GGTCCGCATC AGCGAGAGCC ACAGCGACGA GTACACCATC 300

TCCGCCCGCA GCGAGGGGAA GGTGTTCCAC TTCCGGATCC AGCGCTCCTC CATCGGGGCC 360

TACTTCGTGT CCGATAGGAT CTCCTTCGCC ACGCTGGGCG AGCTCATCTC CTACTACCAG 420

AGGAACAACC GCAGCCTGGG GGTGCTGCTG GAGGAACCCT GTGCTCAGCA GCGGGAACTC 480

TTCGACATGG AGCCGTGGGA GCGGCCCCGC GAGGAGTTCC GCCTCCTGAG GAAGCTGGGA 540

GAGGGCCACT TCGGGGAGGT GTGGGAGGCC CTGTGGAGCA CCGAGAACAG GAGGGTGGCC 600

ATCAAAACCC TGAAGCAAGA GGACACGAAG CAGGACGAGT TTGTGAAGGA GGTCCAGGCC 660

CTGAAGAGCC TCCACCACCC CAAGCTGATC CAGCTCCTGG CCATGTGCTC CAGAGGAGAG 720

CCCGTCTACA TCGTCACCGA GCTCATGACC AAAGGGAGCC TCAAGGCCTA CCTGGCCTGT 780

GGTTCAGCGG CTGAAGGCCA GGTGCTGACG TCGGCTCACC TGATCTACAT GGGCAGCCAG 840

ATCGCCGAGG GGATGGCCTA CCTGGAGGAC AGGAACATCG TGCACAGGGA CCTGGCCGCC 900

AGGAACATCC TGGTGGGAGA AGATCTGGTC TGCAAGGTGG CCGACTTCGG TCTGGCTCGC 960

ATCATTAAGG ACAGCGTGTA CACGGCTAGC CGCAACACCA AGATCCCCGT CAGGTGGACG 1020

GCGCCGGAAG CCGCCATTCA CCAGCGGTTC TCCGTCAAGT CGGACGTCTG GTCCTTCGGG 1080

GTTCTGCTCT ACGAGATGAT GTCACGCGGC AAAATGCCTT ACGAAGGAAA GAACAACAAG 1140

GAGGTTCTGG ACCTGCTGGC GTCCGGGTTC CGGCTGCCGT GTCCCACCCG CTGCCCCCAG 1200

AACATCTACC GCATGATGAT GGGCTGCTGG GCGGCCGAGC CCTCCAAGAG GCCCTCCTTC 1260

CACGCCCTGC ACAGCCAGCT GGACGCCATC TAC 1293

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkg.svkvavktlkegtlspeafleeaqilkklrheklvkl  59

         ++l++klGeG+fGevw+++w + + +va+ktlk+++ ++++f++e+q+lk+l+h+kl++l

Q: 173   FRLLRKLGEGHFGEVWEALWSTeNRRVAIKTLKQEDTKQDEFVKEVQALKSLHHPKLIQL  232

         5899****************862578**********************************

S: 60    yavvseeePiyivtelmakGslldflk...eeegkklklpklvdlaaqvaeGmayleekn  116

         +a++s++eP+yivtelm+kGsl ++l      eg+ l+  +l+ + +q+aeGmayle++n

Q: 233   LAMCSRGEPVYIVTELMTKGSLKAYLAcgsAAEGQVLTSAHLIYMGSQIAEGMAYLEDRN  292

         **************************7444678999999*********************

S: 117   lihrdlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkfti  176

         ++hrdlaarn+lvge+lv+kvadfGlar+i+d+ yta++++k+P++WtaPea+  ++f++

Q: 293   IVHRDLAARNILVGEDLVCKVADFGLARIIKDSVYTASRNTKIPVRWTAPEAAIHQRFSV  352

         ************************************************************

S: 177   ksdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkk  236

         ksdvWsfG+ll+e++++Gk+Py+G +n+evl+ +  g+rlp+p++cp+++y++++ cw +

Q: 353   KSDVWSFGVLLYEMMSRGKMPYEGKNNKEVLDLLASGFRLPCPTRCPQNIYRMMMGCWAA  412

         ************************************************************

S: 237   dpeerPtfetlqev  250

         +p++rP+f++l+++

Q: 413   EPSKRPSFHALHSQ  426

         **********9986

Domain Sequence
(FASTA)

FRLLRKLGEG HFGEVWEALW STENRRVAIK TLKQEDTKQD EFVKEVQALK SLHHPKLIQL 60

LAMCSRGEPV YIVTELMTKG SLKAYLACGS AAEGQVLTSA HLIYMGSQIA EGMAYLEDRN 120

IVHRDLAARN ILVGEDLVCK VADFGLARII KDSVYTASRN TKIPVRWTAP EAAIHQRFSV 180

KSDVWSFGVL LYEMMSRGKM PYEGKNNKEV LDLLASGFRL PCPTRCPQNI YRMMMGCWAA 240

EPSKRPSFHA LHSQ 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013