EKS-TEN-00104
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00104
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk537.96.5E-162583865283
StatusUnreviewed
Ensembl ProteinENSTNIP00000000393
UniProt AccessionH3CAA2;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000002621ENSTNIP00000000393ENSTNIT00000003997
ENSTNIG00000002621ENSTNIP00000005174ENSTNIT00000005320
OrganismTetraodon nigroviridis
Functional Description
Protein Length879
Protein Sequence
(FASTA)
MSHVVNLRLL YPKVHELPFS SSLPSAPRII TLLETLDVLT DHNATFICEV ESRPPADVTW 60
TKNNHPIMYY DPRYVTQAQG QMLTVPHVRE SDSGEYCCIA TNGVGEPAKS CGALQLKMTE 120
PQIKRHPTNL TLLVESKAVL PCVTLGNPKP DVTWLKDDEL IKISDRVTIL DYGALKIHNV 180
RKEDAGQYRC VARNSFGLSI SKPVTIEVQV PARILQVPKE SKVAYGGLVS LQCNATGNPV 240
PTITWLENGN TISGASVDEA LSGDVIQSVL KVRVSKPALY TCLASNRHSA GANTVKASAR 300
VTVAEWRLYK GAAGYCSGYR GDVCRAILQD DQLVFFNSSL PDPEDLQEYL VQSLWPALEG 360
LGAACGPAMH SLLCHSAFPD CNPSGFGPAP KPVCREHCLA VKELYCQREW AVLEGSASAQ 420
SGLFRSATGS SRPSSLLPNC QALPSLHADP DICTHVPFTD IKTDQITNVI PELKNSRNYC 480
RNPGGTPRVL PPTTVSHPAY SMSVIVIVLS ALAAAVLFTI VILACRRQRK QWRNRKRVME 540
TPTLSALPSE LLLDRLHPNP MYQRVPLLLN SKLLALEYPR NNIQYVRDIG EGAFGRVFQA 600
SRAPGLLPME SFTMVAVKML KEEASADMQN DFQREAALMA QFDHPNIVKL LGVCAVGKPM 660
CLMFEYMAHG DLNEFLRRRS PDQSVRTISR ASLSGRSFTS ELEAGLLSCA DQLSISKQIA 720
AGMAYLSERK FVHRDLATRN CLVGEEMVVK IADFGLSRNI YSADYYKANE NDAIPIRWMP 780
PESIFYNRYT TESDIWAYGV VLWEIFSHGM QPYYGMGHEE VIYYVRDGHI LSCPENCPLE 840
LYNLMRLCWS SQPPERPSFS SIHRILERMH QNTLNTDTE 879
Nucleotide Sequence
(FASTA)
ATGAGTCACG TCGTCAATCT CAGGCTCTTG TATCCTAAAG TCCATGAACT CCCATTTTCA 60
TCCTCTCTCC CATCAGCTCC GCGTATCATC ACTTTATTGG AGACCCTGGA TGTTCTGACG 120
GATCACAACG CCACCTTCAT CTGCGAGGTG GAGTCCCGCC CCCCTGCTGA CGTCACATGG 180
ACCAAGAATA ACCACCCGAT TATGTACTAC GACCCCAGGT ACGTCACGCA GGCGCAGGGT 240
CAGATGCTAA CCGTGCCTCA CGTCAGGGAG TCAGACAGTG GCGAATACTG CTGCATCGCC 300
ACCAACGGCG TCGGCGAGCC GGCTAAGAGC TGCGGAGCTC TGCAGCTCAA GATGACAGAG 360
CCGCAGATCA AACGCCATCC CACCAACCTG ACCCTGCTGG TGGAGTCCAA AGCTGTGTTG 420
CCCTGCGTTA CCCTCGGCAA CCCCAAACCG GACGTCACCT GGCTGAAAGA CGATGAGCTC 480
ATCAAGATCA GCGACCGCGT TACTATTCTG GATTACGGAG CCTTGAAGAT CCACAATGTC 540
CGGAAGGAGG ACGCGGGCCA GTACCGCTGC GTGGCCAGGA ACAGCTTCGG TTTGTCCATT 600
TCAAAGCCCG TCACCATCGA GGTTCAGGTT CCCGCTCGAA TTCTGCAGGT TCCCAAAGAG 660
AGCAAGGTGG CCTACGGCGG CCTGGTCTCC CTGCAGTGCA ACGCCACGGG AAACCCGGTG 720
CCCACCATCA CCTGGCTGGA AAACGGGAAC ACGATCTCCG GCGCGTCGGT GGACGAGGCT 780
CTGTCTGGGG ACGTGATCCA GTCCGTCCTG AAAGTGAGGG TCAGCAAACC GGCTCTGTAC 840
ACCTGCCTGG CGTCCAACAG GCACAGCGCC GGCGCCAACA CCGTCAAGGC CAGCGCCAGA 900
GTCACCGTGG CAGAATGGCG ACTCTACAAA GGAGCCGCCG GCTACTGCAG CGGTTACCGT 960
GGAGACGTGT GTCGCGCCAT CCTGCAAGAC GACCAGCTGG TTTTCTTCAA CTCGTCGCTG 1020
CCGGACCCCG AGGACCTGCA GGAGTACCTG GTTCAGAGCC TGTGGCCGGC GCTGGAGGGG 1080
CTGGGGGCAG CGTGTGGCCC CGCCATGCAC TCGTTGCTCT GTCACAGCGC CTTCCCAGAC 1140
TGTAACCCCT CAGGCTTCGG ACCCGCACCC AAACCGGTCT GCAGGGAACA CTGCCTCGCT 1200
GTGAAGGAGC TGTACTGTCA GAGAGAGTGG GCGGTCCTGG AGGGCAGCGC CTCGGCCCAG 1260
TCCGGCCTGT TCCGCTCTGC CACCGGTTCC AGCAGGCCCA GTTCGCTGCT GCCCAACTGC 1320
CAGGCCTTAC CCAGTCTTCA CGCTGACCCC GACATCTGCA CGCACGTCCC CTTCACAGAC 1380
ATCAAGACCG ACCAGATCAC AAATGTGATT CCAGAGTTGA AGAACTCCAG GAACTACTGC 1440
AGGAACCCCG GGGGGACGCC GCGCGTCCTG CCCCCCACCA CCGTGTCCCA CCCAGCCTAC 1500
TCCATGTCCG TCATCGTCAT CGTCCTGTCC GCCCTGGCGG CAGCCGTCCT CTTCACCATC 1560
GTCATCCTGG CCTGCCGCAG GCAGAGGAAG CAGTGGAGGA ACCGGAAGAG AGTGATGGAG 1620
ACCCCGACGC TGAGCGCCCT GCCCTCAGAG CTGCTGCTGG ATCGGCTCCA CCCCAACCCC 1680
ATGTACCAGC GCGTTCCCCT GCTGCTGAAC TCAAAGCTGC TGGCGCTCGA GTATCCTCGG 1740
AACAACATCC AGTACGTCCG CGACATCGGA GAGGGAGCCT TCGGACGCGT CTTCCAGGCC 1800
AGCAGAGCTC CAGGCCTGCT GCCGATGGAG TCGTTCACGA TGGTGGCTGT GAAGATGCTG 1860
AAGGAGGAGG CATCAGCTGA TATGCAAAAT GACTTCCAGA GAGAGGCGGC ACTCATGGCC 1920
CAGTTTGACC ATCCGAATAT TGTCAAACTA CTAGGTGTGT GTGCAGTGGG CAAACCAATG 1980
TGTCTGATGT TCGAGTACAT GGCCCACGGT GACCTCAACG AGTTCCTTCG CCGCCGATCC 2040
CCGGATCAGT CGGTGCGCAC CATCAGCCGA GCCAGCCTAT CAGGTCGCAG CTTCACGTCG 2100
GAGCTGGAGG CGGGGCTTCT CTCCTGCGCC GATCAGCTGT CCATTTCTAA GCAGATCGCT 2160
GCGGGGATGG CCTACCTGTC GGAGCGCAAG TTCGTGCACC GGGACTTGGC CACGCGGAAC 2220
TGCCTGGTGG GGGAGGAGAT GGTGGTGAAG ATCGCCGACT TCGGCCTCTC CAGGAACATC 2280
TACTCAGCTG ATTACTACAA AGCTAACGAG AACGACGCCA TCCCCATTCG CTGGATGCCC 2340
CCGGAGTCCA TCTTCTACAA CCGCTACACC ACCGAGTCGG ACATCTGGGC CTACGGCGTG 2400
GTGCTGTGGG AGATCTTCTC TCACGGGATG CAGCCGTACT ACGGGATGGG CCACGAGGAG 2460
GTCATCTACT ACGTGAGGGA CGGCCACATC CTGTCCTGTC CTGAGAACTG TCCCCTGGAG 2520
CTCTACAACC TGATGCGCCT CTGCTGGAGC AGCCAGCCGC CCGAGCGGCC CAGTTTCAGC 2580
AGCATCCACA GGATCCTGGA GCGAATGCAC CAAAACACGC TGAACACGGA CACCGAG 2637
Domain Profile
S: 1     ieyvrdlgegafgrvfqa.rapgllpyeefllvavkmlkeeasadmqadfereaallaef  59
         i+yvrd+gegafgrvfqa rapgllp e f++vavkmlkeeasadmq df+reaal+a+f
Q: 583   IQYVRDIGEGAFGRVFQAsRAPGLLPMESFTMVAVKMLKEEASADMQNDFQREAALMAQF  642
         79***************879****************************************
S: 60    dnpnivkllgvcavgkpmcllfeymaygdlneflrslspy.tvcslshsdlslraqvssp  118
         d+pnivkllgvcavgkpmcl+feyma+gdlneflr  sp  +v ++s++ ls r+ +s  
Q: 643   DHPNIVKLLGVCAVGKPMCLMFEYMAHGDLNEFLRRRSPDqSVRTISRASLSGRSFTSEL  702
         ***************************************626789***************
S: 119   drlplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiys  178
         +   ls+a++l+i++q+aagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iys
Q: 703   EAGLLSCADQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYS  762
         ************************************************************
S: 179   adyykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheevi  238
         adyyka+endaipirwmp+esi+ynryt+esd+waygvvlweifs+++qpyyg+ heevi
Q: 763   ADYYKANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSHGMQPYYGMGHEEVI  822
         ************************************************************
S: 239   kyvrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         +yvrdg il+cpen+plely+lmrlcws +p +rpsf+sihri
Q: 823   YYVRDGHILSCPENCPLELYNLMRLCWSSQPPERPSFSSIHRI  865
         *****************************************98
Domain Sequence
(FASTA)
IQYVRDIGEG AFGRVFQASR APGLLPMESF TMVAVKMLKE EASADMQNDF QREAALMAQF 60
DHPNIVKLLG VCAVGKPMCL MFEYMAHGDL NEFLRRRSPD QSVRTISRAS LSGRSFTSEL 120
EAGLLSCADQ LSISKQIAAG MAYLSERKFV HRDLATRNCL VGEEMVVKIA DFGLSRNIYS 180
ADYYKANEND AIPIRWMPPE SIFYNRYTTE SDIWAYGVVL WEIFSHGMQP YYGMGHEEVI 240
YYVRDGHILS CPENCPLELY NLMRLCWSSQ PPERPSFSSI HRI 283
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000001; Kringle.
IPR013806; Kringle-like.
IPR018056; Kringle_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 3.
PF00051; Kringle; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00130; KR; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013