EKS-TEN-00378

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00378

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	310.2	1.1E-92	754	1016	263

Status

Unreviewed

Ensembl Protein

ENSTNIP00000005385

UniProt Accession

H3CAW4;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000002822	ENSTNIP00000005385	ENSTNIT00000005531
ENSTNIG00000002822	ENSTNIP00000005386	ENSTNIT00000005532
ENSTNIG00000002822	ENSTNIP00000000430	ENSTNIT00000001722

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1050

Protein Sequence
(FASTA)

ISDSRNIFRR FEKSFSLYTG DDPLDPWDKF VDYLEQRTPE GEGRGLSQVF DSLVQRFLNV 60

ERYSDDLRYV NYCIKCASFH PDPVALYTHV YSSGVGHRTA ALHLAWAQQL ELRGMLEQAD 120

AVYQRAVKNQ AQPADTILNE YRQFQTRTKH QTLVSGKKNR NPLQNSQLTN QMASHREHHK 180

LVILAPYVLL SHVLFQASME CSSKPPTIET IITVSRSETS GTSRSSSVQF VSEYLKEELL 240

CEGSELCFEE VRATKYFRQA KVQQEDRTSM KLGKANRTRL NREKEAEVDP SAAWNINAAQ 300

HSSGQEQPCS RGSSRRSLAL RLEGQPLFLH RAAAVPDHRQ EQRNATPEEQ PCAPVPTDTS 360

VLLPTQQMAP PPQDVSSSDS NLSSPPTSVS RDEECRPEPG DRLNMSQGGT GNLSHVTPNT 420

SLGLVQATPS RVLPSPTVNT REALDVIMDM FQAPTLLGDP FSNTSAFPAP EMEAEPAPAH 480

LERALSSEGG GSLLAKPPAA AAFTIFQDDQ DKENSRFSVA APHPPLKPKP IKALAEIPLA 540

KRPNETPPEL TPDESTTWGA GYNSLNSLAA CPNSTTDFAM LAQFVSTPFV CKTPHSSNFF 600

QDEGSMVPSP APSWSRVQLT RRRSVSWPRP PTGSGPLWVR LSAPPPPPPC PCGLRTADVP 660

MTPEPASPAT APPMDAMASP DRGWGLDVSM NPATPPCQSS PVLMSDPWDE QLISQMLSTL 720

TPPLSSHPHY TAWSFGIPAI SPSTTITMGE ACLRVDCVLG QGAFATVYKA TNPTTSDKMV 780

LKVVQKPANP WEFYINTQLD ARLQPAARHL YANIRSAHLF TDGSVLLADL HQYGTLLNAV 840

NIYRSLSEKV MPPPLVLYFT TCILRMVEQL HAISIIHADI KPDNFLLGER FLENQCFEPE 900

NLDHGLVLVD LGQSVDMALF PDSAVFTAKC LTSGFQCTEM LSGRPWNYQT DYFGVAGTVY 960

CMLFGTYMQV TNDGGVWRTN GVFRRIPHSE LWQEFFHALL NVPDCSSPSS LPHLREKLTC 1020

VLQQNYSSSK LRTLKSRLLV QLLERRKTAA 1050

Nucleotide Sequence
(FASTA)

ATCAGCGATA GCCGAAATAT TTTTAGACGT TTTGAGAAAA GCTTTAGCCT GTATACGGGA 60

GACGACCCAT TGGATCCATG GGATAAGTTT GTAGATTATC TTGAGCAGAG GACACCGGAG 120

GGAGAGGGTC GTGGCCTGTC TCAGGTCTTT GACAGCCTTG TGCAGAGGTT TTTGAATGTT 180

GAAAGATATT CAGATGACCT CCGATACGTG AACTACTGCA TCAAATGTGC GAGTTTTCAC 240

CCGGACCCCG TGGCCCTGTA CACGCATGTT TACAGTAGCG GAGTCGGGCA CCGGACCGCC 300

GCCCTCCACC TGGCCTGGGC GCAGCAGCTG GAACTCAGGG GGATGCTTGA ACAGGCAGAC 360

GCTGTCTACC AGAGAGCTGT GAAGAACCAA GCCCAGCCTG CTGACACCAT CCTCAATGAG 420

TACAGGCAGT TCCAAACAAG GACTAAACAT CAGACTTTAG TCTCAGGTAA AAAAAACAGA 480

AATCCTTTAC AAAATTCCCA GTTAACCAAT CAGATGGCGT CTCACCGAGA GCATCACAAG 540

CTAGTCATTC TTGCTCCCTA CGTGTTACTA AGTCATGTCC TGTTTCAGGC CTCTATGGAA 600

TGCTCTTCCA AACCTCCCAC CATTGAAACC ATCATCACAG TTTCCCGCTC TGAGACCTCA 660

GGAACCAGCC GGAGCTCCAG TGTCCAGTTT GTGTCCGAGT ACCTGAAGGA AGAGCTGCTC 720

TGCGAGGGCT CCGAGTTGTG CTTCGAGGAG GTCCGCGCCA CCAAATACTT CCGTCAAGCT 780

AAGGTGCAGC AGGAGGATCG GACATCAATG AAGCTGGGGA AGGCCAACCG GACGAGGCTG 840

AACCGGGAGA AGGAGGCTGA GGTGGACCCG TCTGCCGCCT GGAACATCAA CGCTGCCCAG 900

CATTCCTCTG GGCAGGAGCA GCCCTGCAGC CGAGGCAGCA GCCGGCGCTC GCTGGCTCTG 960

AGGCTGGAGG GCCAGCCGCT CTTCCTGCAC CGGGCCGCCG CCGTCCCTGA CCATCGTCAG 1020

GAGCAGAGAA ACGCCACGCC TGAGGAGCAA CCGTGTGCTC CAGTCCCAAC CGACACCAGT 1080

GTCCTGCTAC CCACCCAGCA GATGGCGCCG CCCCCGCAGG ACGTCTCCTC CTCGGACTCT 1140

AATCTCTCCT CTCCACCCAC CTCGGTCTCT AGGGATGAGG AATGTCGTCC TGAACCCGGC 1200

GACAGACTCA ACATGTCACA GGGAGGAACA GGGAACCTGT CCCACGTGAC CCCCAACACC 1260

TCGCTGGGTT TGGTTCAGGC CACACCGTCC CGGGTGCTGC CGTCTCCCAC CGTCAACACG 1320

CGGGAAGCTC TGGATGTCAT CATGGACATG TTCCAGGCAC CCACCCTCCT GGGGGACCCC 1380

TTCAGCAACA CCTCGGCGTT TCCTGCCCCT GAGATGGAGG CGGAGCCTGC ACCAGCACAT 1440

CTTGAACGTG CTCTGTCTTC TGAAGGAGGA GGCTCCTTGT TGGCTAAACC TCCGGCTGCT 1500

GCCGCCTTCA CCATCTTCCA GGACGACCAA GACAAAGAAA ACAGCCGGTT CAGCGTGGCC 1560

GCTCCTCATC CTCCACTCAA ACCTAAACCA ATCAAAGCTC TGGCTGAGAT CCCGCTGGCC 1620

AAAAGACCCA ACGAGACGCC CCCAGAGCTG ACCCCGGATG AGAGCACCAC CTGGGGGGCC 1680

GGCTACAACT CCCTCAACTC CCTGGCGGCG TGCCCCAACA GCACCACCGA CTTCGCCATG 1740

CTGGCCCAGT TTGTGTCCAC GCCGTTCGTC TGCAAGACGC CGCACAGCAG CAACTTCTTC 1800

CAGGATGAAG GATCCATGGT TCCGTCTCCA GCCCCATCAT GGAGCAGAGT CCAGCTGACG 1860

AGACGGCGGT CAGTCAGCTG GCCCCGCCCC CCGACAGGCT CGGGACCATT GTGGGTGAGG 1920

CTCTCTGCTC CACCTCCTCC ACCACCATGC CCGTGTGGGC TCAGGACGGC CGACGTGCCC 1980

ATGACCCCAG AGCCGGCGAG CCCAGCGACA GCGCCACCCA TGGACGCCAT GGCGAGTCCG 2040

GACAGAGGCT GGGGTCTGGA CGTGTCCATG AATCCAGCCA CGCCCCCATG CCAGAGCAGC 2100

CCTGTGCTGA TGTCCGACCC CTGGGACGAG CAGCTGATCT CCCAGATGCT GTCCACGCTG 2160

ACTCCGCCCC TCAGCTCTCA CCCGCATTAC ACGGCCTGGT CCTTCGGCAT CCCTGCCATC 2220

AGCCCGAGCA CGACCATCAC CATGGGAGAG GCGTGTCTGC GGGTGGACTG CGTGCTGGGA 2280

CAAGGAGCCT TCGCCACCGT GTACAAGGCC ACCAACCCCA CCACCTCGGA CAAGATGGTG 2340

CTGAAGGTAG TCCAGAAACC GGCCAATCCA TGGGAGTTTT ACATCAACAC GCAGCTGGAC 2400

GCGCGGCTGC AGCCCGCCGC TCGCCACCTC TACGCCAACA TCCGCTCAGC TCACCTGTTC 2460

ACCGACGGCA GCGTCCTGCT GGCCGACCTC CACCAATACG GCACCCTGCT GAACGCAGTG 2520

AACATCTACA GAAGCCTGAG CGAGAAGGTG ATGCCGCCGC CGCTCGTCCT CTACTTCACC 2580

ACCTGCATCC TGCGCATGGT GGAGCAGCTG CACGCCATCA GCATCATCCA CGCCGACATC 2640

AAGCCCGACA ACTTCCTGTT GGGAGAGAGG TTCCTGGAGA ACCAGTGCTT TGAGCCGGAG 2700

AACCTGGACC ACGGCCTGGT CCTGGTGGAC CTGGGCCAGA GCGTGGACAT GGCGCTCTTC 2760

CCGGACAGCG CCGTCTTCAC CGCCAAGTGT CTGACGTCGG GCTTCCAGTG CACTGAGATG 2820

CTGAGCGGGA GACCGTGGAA CTACCAGACG GATTATTTTG GCGTGGCAGG GACGGTGTAC 2880

TGCATGCTGT TTGGGACCTA CATGCAGGTG ACCAATGATG GCGGCGTGTG GAGGACCAAC 2940

GGCGTGTTCA GAAGAATTCC CCACAGCGAG CTGTGGCAGG AGTTTTTCCA CGCTCTGCTG 3000

AACGTCCCGG ACTGCTCCTC GCCGTCGAGC CTGCCCCACC TCCGGGAGAA GCTGACGTGT 3060

GTCCTGCAGC AGAACTACAG CAGCAGCAAG CTGAGGACGC TGAAGAGCCG TCTGCTGGTG 3120

CAGCTGCTGG AGCGCCGCAA GACGGCGGCC 3150

Domain Profile

S: 2     eiekeigeGayakvykaehdsksgelvalK.vekpansWefYIclqlkeRlkeeellksi  60

          ++  +g+Ga+a+vyka+ +  +  +++lK v+kpan+WefYI++ql  Rl+ +   + +

Q: 754   RVDCVLGQGAFATVYKAT-NPTTSDKMVLKvVQKPANPWEFYINTQLDARLQ-PAARHLY  811

         57889*************.67778888888469*******************.779****

S: 61    ieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiveklH  120

         ++i sa+lf+d+s+l+ ++++ygtll+++n +++ ++kvm+  lv+++++ +l++ve+lH

Q: 812   ANIRSAHLFTDGSVLLADLHQYGTLLNAVNIYRSLSEKVMPPPLVLYFTTCILRMVEQLH  871

         ************************************************************

S: 121   eveIiHgDlkPdnfllgnrimdkad..kdkeekglkliDfgrsiDmkllpdgtkfkgkak  178

         ++ IiH+D+kPdnfllg+r+ ++++   ++ ++gl l+D+g+s+Dm l+pd+  f++k+

Q: 872   AISIIHADIKPDNFLLGERFLENQCfePENLDHGLVLVDLGQSVDMALFPDSAVFTAKCL  931

         ***********************99434566799**************************

S: 179   tdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkkel  238

         t++f+c+eml+g++w+Yq+D+fg+a++++++lfg+y++v+++gg w+ +  ++r +++el

Q: 932   TSGFQCTEMLSGRPWNYQTDYFGVAGTVYCMLFGTYMQVTNDGGVWRTNGVFRRIPHSEL  991

         ************************************************************

S: 239   wekiferlLNisdastlpsleelve  263

         w+++f+ lLN++d+s+ +sl +l+e

Q: 992   WQEFFHALLNVPDCSSPSSLPHLRE  1016

         ****************888888885

Domain Sequence
(FASTA)

RVDCVLGQGA FATVYKATNP TTSDKMVLKV VQKPANPWEF YINTQLDARL QPAARHLYAN 60

IRSAHLFTDG SVLLADLHQY GTLLNAVNIY RSLSEKVMPP PLVLYFTTCI LRMVEQLHAI 120

SIIHADIKPD NFLLGERFLE NQCFEPENLD HGLVLVDLGQ SVDMALFPDS AVFTAKCLTS 180

GFQCTEMLSG RPWNYQTDYF GVAGTVYCML FGTYMQVTND GGVWRTNGVF RRIPHSELWQ 240

EFFHALLNVP DCSSPSSLPH LRE 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013