EKS-TEN-00127
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00127
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec408.97.8E-123315563249
StatusUnreviewed
Ensembl ProteinENSTNIP00000005810
UniProt AccessionH3CC38;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000003228ENSTNIP00000005810ENSTNIT00000005958
OrganismTetraodon nigroviridis
Functional Description
Protein Length567
Protein Sequence
(FASTA)
KKPMLKGSIE LNKIKCVEIV CCDVPIPCSY KYPFQVFYDN HYLYIFAPDN ECRQRWVQAL 60
KEETKDNNLA TKYHPNIWMD GKWRCCQQTE KLAAGCLVYD PLGFASKKPL PELPDPKVNA 120
DSERIVIAVQ DFLPSGDKDL PLEKDHEYVL INSSNTDWWT VRNGNGDSGF VPSTYVAEKS 180
GGNFERFQWY CKKIMRVQAQ ELLMKEGKEG AFMVRDSSQM GVYTVSVFTK ATGQNGEKDP 240
RVKHYQIRQK EAGAGEYYLA ENFLFSTIPQ LIHYHQHNAA GLITRLRYPV SPSGRCTQQI 300
FDPSNDQWEL DCSELTLGQE IGSGQFGLVL EGQWKKRKVA VKTIREGYMS EDELREEAKV 360
MMKLSHHKLV QFYGMCSQCS PLCLVFEFME NGCLSDYLRA RKGSLSQDLL LSMCVDVSEG 420
MAYLENSNYI HRDLAARNCL VSNNNQVKVS DFGMTRLVFD DQYTSSHCSK FPVKWAAPEV 480
IKYSKFSSKS DIWSFGVLMW EVYSEGRLPY DNRTNAEVVE SLNAGLRLLK PRLAPDAIYV 540
LMEWCWKEKP EDRPCFTILL HELASIS 567
Nucleotide Sequence
(FASTA)
AAAAAGCCCA TGTTGAAGGG CTCCATCGAA CTCAACAAAA TCAAGTGTGT GGAAATTGTT 60
TGCTGCGATG TTCCCATTCC CTGTAGTTAT AAATATCCTT TTCAAGTGTT TTACGACAAC 120
CATTACCTCT ACATTTTTGC CCCAGACAAT GAATGTCGTC AAAGATGGGT CCAAGCTCTC 180
AAAGAGGAGA CAAAGGATAA CAATTTGGCA ACCAAATATC ACCCAAACAT CTGGATGGAC 240
GGTAAATGGA GGTGTTGCCA GCAGACAGAG AAGCTGGCGG CCGGTTGTCT CGTATATGAC 300
CCACTGGGTT TTGCTTCGAA AAAACCACTT CCTGAGCTCC CAGATCCAAA GGTAAATGCA 360
GATTCAGAGA GGATTGTCAT TGCTGTGCAA GATTTCTTGC CGTCTGGAGA CAAAGACTTG 420
CCTCTTGAGA AAGACCACGA GTACGTCCTA ATTAACAGTT CCAACACTGA CTGGTGGACT 480
GTGCGAAACG GCAACGGGGA CAGTGGCTTT GTACCCAGCA CATATGTGGC AGAAAAAAGT 540
GGTGGCAATT TTGAAAGATT TCAATGGTAT TGCAAAAAAA TTATGAGGGT GCAAGCACAG 600
GAGCTGTTAA TGAAAGAGGG CAAAGAAGGT GCATTTATGG TTCGTGACTC GAGCCAGATG 660
GGAGTCTACA CTGTGTCAGT CTTCACAAAG GCAACGGGCC AAAATGGGGA GAAGGATCCA 720
AGGGTGAAAC ATTACCAGAT CAGACAAAAA GAAGCAGGAG CTGGAGAGTA TTACTTGGCA 780
GAAAATTTCT TGTTCAGCAC CATTCCCCAG CTCATTCATT ACCACCAACA CAATGCTGCC 840
GGTCTGATAA CACGCCTGAG ATACCCTGTA TCTCCTAGTG GAAGGTGCAC CCAGCAGATT 900
TTTGATCCTT CCAACGATCA GTGGGAGCTG GACTGCAGTG AACTGACCCT GGGTCAGGAG 960
ATTGGCAGTG GTCAGTTTGG GCTTGTACTG GAAGGTCAAT GGAAGAAGAG GAAAGTGGCG 1020
GTAAAAACGA TCAGAGAAGG GTACATGTCG GAAGACGAAC TGCGGGAGGA GGCCAAAGTT 1080
ATGATGAAGC TGTCACACCA CAAGCTGGTT CAGTTCTATG GCATGTGCAG CCAGTGTTCT 1140
CCCCTGTGCT TGGTGTTTGA GTTCATGGAG AACGGCTGTC TTTCCGACTA CCTGCGAGCC 1200
AGGAAAGGCA GCTTGTCTCA GGACCTGCTG TTGAGCATGT GTGTAGACGT CAGTGAGGGG 1260
ATGGCCTACC TGGAGAACTC CAATTACATC CACAGAGATC TGGCTGCCAG GAACTGTCTT 1320
GTTTCAAATA ACAACCAGGT GAAAGTGTCT GACTTTGGTA TGACCAGGTT GGTGTTCGAT 1380
GATCAGTACA CGAGCTCTCA CTGTTCCAAG TTCCCTGTCA AGTGGGCGGC ACCGGAGGTC 1440
ATCAAATACT CCAAGTTCAG CAGCAAATCG GACATCTGGT CATTTGGTGT GCTCATGTGG 1500
GAGGTGTACA GTGAGGGCCG CCTTCCTTAT GACAACCGCA CCAACGCGGA GGTGGTAGAA 1560
AGCCTGAACG CAGGCCTCCG GCTCCTGAAG CCACGCTTGG CTCCAGATGC CATCTATGTG 1620
CTTATGGAGT GGTGCTGGAA GGAGAAACCT GAAGACCGCC CCTGCTTCAC CATTTTGCTG 1680
CACGAGCTGG CCTCCATCTC CTGA 1704
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         ltl +e+gsgqfg+v  g+w+   +va+k+i+eg mse+++ eeakvmmklsh+klvq+y
Q: 315   LTLGQEIGSGQFGLVLEGQWKK-RKVAVKTIREGYMSEDELREEAKVMMKLSHHKLVQFY  373
         67889***************96.69***********************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         g+c++  p+++v+e++engcl++ylr +k++l+++lll+mc dv+egm+yle++++ihrd
Q: 374   GMCSQCSPLCLVFEFMENGCLSDYLRARKGSLSQDLLLSMCVDVSEGMAYLENSNYIHRD  433
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv++++ vkvsdfg++r v+ddqy+ss  +kfpvkw++pev++ysk+ssksd+w
Q: 434   LAARNCLVSNNNQVKVSDFGMTRLVFDDQYTSSHCSKFPVKWAAPEVIKYSKFSSKSDIW  493
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwev+seg+lpy++++n+evve+++ glrl +p+la++ +y +m+ cwkekpe+r
Q: 494   SFGVLMWEVYSEGRLPYDNRTNAEVVESLNAGLRLLKPRLAPDAIYVLMEWCWKEKPEDR  553
         ************************************************************
S: 241   ptfkellsal  250
         p+f+ ll++l
Q: 554   PCFTILLHEL  563
         *******987
Domain Sequence
(FASTA)
LTLGQEIGSG QFGLVLEGQW KKRKVAVKTI REGYMSEDEL REEAKVMMKL SHHKLVQFYG 60
MCSQCSPLCL VFEFMENGCL SDYLRARKGS LSQDLLLSMC VDVSEGMAYL ENSNYIHRDL 120
AARNCLVSNN NQVKVSDFGM TRLVFDDQYT SSHCSKFPVK WAAPEVIKYS KFSSKSDIWS 180
FGVLMWEVYS EGRLPYDNRT NAEVVESLNA GLRLLKPRLA PDAIYVLMEW CWKEKPEDRP 240
CFTILLHEL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORN-00134
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-XET-00091
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013