EKS-TEN-00402

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00402

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.6	9.1E-107	266	517	252

Status

Unreviewed

Ensembl Protein

ENSTNIP00000006351

UniProt Accession

H3CDM8;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK1

Gene Synonyms/Alias

PAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000003751	ENSTNIP00000006351	ENSTNIT00000006500

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MSDNGEVEDK PPAPPMRNTS TMIGSSIKDP APLNHSSKPL PPNPEDKKKK ERSIRFILTG 60

GGDKTYKKKE RPEISLPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120

QAVLDVLKFY DSKETANSQK YMSFTDKSID TYCSSTTSSS KAVSETPAIA TVSEDEDEDE 180

AEPPPVIAPR PEHTKSIYTR SVIEPLSVPP TKDAATSPIS PPGASPAPGP SAARPLDKTR 240

KKKMSDEEIL EKLRTIVSVG DPKKKYSHFE KIGQGASGTV YTAIDIATGQ EVAIKQMNLQ 300

QQPKKELIIN EILVMRENKN PNIVNYLDSY LVGDELWVVM EYLAGGSLTD VVTETCMDEA 360

QIAAVCRECL QALEFLHSNQ VIHRDIKSDN ILLGMDGSVK LTDFGFCAQI TPEQSKRSTM 420

VGTPYWMAPE VVTRKAYGPK VDIWSLGIMA IEMIEGEPPY LNENPLRALY LIATNGTPEL 480

QHPEKLTTIF RDFLNQCLEM DVEKRGSAKE LLQHQFLKMA KPLSSLTPLI VAAKEVAKNN 540

R 541

Nucleotide Sequence
(FASTA)

ATGTCTGATA ATGGGGAGGT CGAGGACAAG CCCCCAGCCC CACCCATGCG GAACACCAGC 60

ACCATGATCG GCTCCTCCAT CAAGGACCCC GCCCCTCTCA ACCACAGCTC AAAGCCCCTC 120

CCGCCCAACC CAGAAGACAA GAAGAAAAAA GAGCGGTCCA TCCGCTTCAT CCTGACGGGA 180

GGAGGTGATA AAACCTATAA GAAGAAGGAG CGTCCAGAAA TTTCTCTACC GTCCGATTTC 240

GAACACACCA TCCATGTTGG CTTTGACGCC GTGACAGGAG AGTTTACCGG GATGCCAGAG 300

CAGTGGGCCC GACTCTTGCA GACATCCAAC ATCACCAAAC TGGAGCAGAA GAAGAATCCT 360

CAAGCTGTCC TCGATGTTTT AAAGTTTTAT GACTCAAAAG AAACGGCCAA CAGCCAGAAG 420

TATATGAGCT TTACAGATAA AAGCATAGAC ACCTACTGCT CATCCACAAC ATCGAGCTCC 480

AAGGCTGTGT CTGAGACGCC TGCCATAGCA ACCGTATCTG AGGACGAAGA TGAGGATGAG 540

GCCGAGCCGC CGCCGGTGAT CGCGCCGCGA CCCGAACACA CTAAATCAAT ATACACCCGT 600

TCTGTGATCG AGCCCCTCTC CGTTCCCCCG ACTAAAGACG CCGCCACTTC CCCCATCTCT 660

CCCCCCGGTG CAAGCCCCGC CCCCGGGCCC TCCGCAGCCC GCCCCCTGGA CAAAACCAGG 720

AAGAAGAAAA TGTCGGATGA GGAGATTCTG GAAAAACTAC GGACAATTGT AAGCGTGGGA 780

GACCCTAAAA AGAAATATAG TCATTTTGAG AAAATTGGAC AAGGAGCATC TGGAACTGTT 840

TACACAGCCA TTGACATTGC TACAGGGCAG GAGGTTGCTA TTAAACAGAT GAACCTGCAG 900

CAGCAGCCTA AGAAGGAACT GATCATCAAC GAGATTCTCG TGATGAGGGA AAATAAAAAC 960

CCAAACATAG TCAACTACCT GGACAGTTAC CTGGTGGGCG ACGAGCTCTG GGTGGTGATG 1020

GAGTATCTGG CTGGAGGATC TTTAACGGAC GTGGTCACAG AAACCTGCAT GGACGAAGCC 1080

CAGATAGCAG CTGTGTGCAG GGAGTGTCTG CAAGCGTTGG AGTTCCTCCA CTCGAACCAG 1140

GTGATCCACC GAGACATCAA GAGCGACAAC ATCCTGCTGG GCATGGACGG CTCCGTCAAA 1200

CTGACTGACT TTGGATTCTG CGCCCAGATC ACTCCTGAAC AGAGTAAACG GAGTACAATG 1260

GTGGGAACGC CATACTGGAT GGCTCCGGAG GTGGTGACCC GCAAAGCCTA CGGCCCCAAA 1320

GTGGACATCT GGTCCCTTGG TATCATGGCC ATAGAGATGA TCGAAGGGGA GCCGCCGTAC 1380

CTGAATGAAA ACCCACTCAG GGCGCTGTAT CTCATAGCAA CCAATGGCAC GCCGGAGCTG 1440

CAGCATCCGG AGAAGCTGAC GACGATATTC AGGGACTTTT TGAATCAATG TCTGGAGATG 1500

GACGTGGAGA AGCGCGGCTC AGCCAAAGAG CTGCTACAGC ATCAGTTTCT GAAGATGGCC 1560

AAGCCCCTCT CCAGCTTGAC TCCGCTCATC GTCGCAGCCA AGGAGGTTGC CAAGAACAAC 1620

CGCTAG 1626

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 266   YSHFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  325

         7899********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lHs++vi

Q: 326   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHSNQVI  382

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 383   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  440

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+++ f++f+++cl+

Q: 441   VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQHPEKLTTIFRDFLNQCLEM  500

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 501   DVEKRGSAKELLQHQFL  517

         ****************7

Domain Sequence
(FASTA)

YSHFEKIGQG ASGTVYTAID IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMIE GEPPYLNENP LRALYLIATN GTPELQHPEK LTTIFRDFLN QCLEMDVEKR 240

GSAKELLQHQ FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013