EKS-TEN-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	351.2	3.7E-105	122	380	259

Status

Unreviewed

Ensembl Protein

ENSTNIP00000006496

UniProt Accession

H3CE22;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K11

Gene Synonyms/Alias

MAP3K11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000003891	ENSTNIP00000006496	ENSTNIT00000006646

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

796

Protein Sequence
(FASTA)

MEPLKNIFSR GPLSSWKNLE QSQKGNFINP VWTALFDYEA SCKDELTLRK GDLVEVLSLD 60

SEISGDEGWW AGKVNNKVGI FPSNYGSFNP NGYGKLPGNG VVPELGPAVV GDFDVVDFRE 120

LSLQEIIGVG GFGKVYRGTW RGELVAVKAA RQDPDEDISV TAQNVKQEAR LFSMLTHPNI 180

IALKGVCLQE PNLCLIMEYA SGGPLSRALA GRRIPPHILV NWAVQIAKGM LYLHSEAIVP 240

VIHRDLKSNN ILLAEAIENE CMEDLTLKIT DFGLAREWHK TTKMSTAGTY AWMAPEVIKS 300

STFSKGSDVW SYGVLLWELL TGEAPYKGID GLAVAYGVAV NKLTLPIPST CPEPFAQLMA 360

ECWDQDPHRR PNFSSILTQL TALERQVKEE MPQDSFHSLQ EDWKLEIQDM FDELRAKEKE 420

LRCREEELKR AALEQKSHEE FLRQREQQLA QWEQDVFERE LSLLILHLNQ NQEKPNVKKR 480

KGTFKKHKLK GKNGEISMPQ DFIHKITVQA SPGPEKRRNS PDLGLGSPPS FGPRLRAFQR 540

TEQGEPGKMW ALEAPSHKQA NGDLRLGPHW RPQSPKSPKS PKVLRLSPQE SGNNNGELSD 600

DFEAYRPSTP TPPAQNGIPG AISSNRSGSP RPERGSLGSN IGGTHRALLG SGSLLASVGL 660

GRCLDIPPRV PPRTNASSLG DRTPSEPEIC SAKPLVSDPP DLPLQYQDIK PLPLSPPPPV 720

PRDRSSHRKQ QCLHSPQSPR TPLRHGWGSP EAGPEAQLSG TRGSPKTGRL EVNVIPRPRP 780

SPVRPRIDPW SFISAG 796

Nucleotide Sequence
(FASTA)

ATGGAGCCGC TGAAGAACAT ATTCAGCCGT GGCCCGCTGT CCAGCTGGAA AAATTTGGAA 60

CAGTCACAAA AAGGGAACTT CATTAACCCG GTGTGGACCG CGCTGTTTGA CTACGAAGCG 120

TCCTGCAAGG ATGAGCTCAC CTTGCGGAAA GGTGATCTAG TGGAGGTTCT CTCCCTGGAC 180

TCTGAGATAT CAGGGGATGA GGGCTGGTGG GCTGGAAAGG TTAACAACAA AGTTGGCATC 240

TTCCCGTCCA ACTACGGCTC CTTCAACCCA AATGGATACG GGAAGCTTCC GGGCAACGGC 300

GTTGTGCCCG AGCTCGGCCC AGCGGTGGTC GGTGACTTTG ATGTGGTGGA TTTCCGAGAA 360

CTGAGCCTAC AGGAGATCAT TGGAGTTGGG GGCTTTGGGA AAGTATATCG CGGTACATGG 420

CGGGGGGAGC TGGTGGCGGT GAAGGCCGCC CGGCAGGATC CGGACGAAGA CATCAGCGTG 480

ACGGCGCAGA ACGTCAAGCA AGAGGCGCGA TTGTTTTCCA TGCTAACCCA TCCGAACATC 540

ATCGCGCTGA AAGGGGTCTG CCTGCAGGAG CCCAACCTGT GCCTGATCAT GGAATATGCT 600

TCTGGTGGTC CACTGAGCCG GGCACTGGCT GGACGCCGCA TCCCGCCGCA CATCCTGGTC 660

AACTGGGCGG TGCAGATTGC CAAAGGGATG CTGTACCTGC ACAGCGAGGC TATCGTCCCC 720

GTCATCCATC GCGACCTCAA GTCCAACAAC ATCCTCCTGG CTGAAGCCAT CGAGAACGAG 780

TGCATGGAAG ACCTAACGCT CAAGATCACC GACTTTGGCC TGGCGAGAGA GTGGCATAAA 840

ACCACTAAAA TGAGCACGGC GGGCACCTAC GCCTGGATGG CCCCCGAGGT GATCAAGTCC 900

TCCACTTTTT CAAAAGGAAG CGACGTCTGG AGCTACGGCG TTCTGCTCTG GGAACTGCTT 960

ACTGGCGAGG CACCGTACAA AGGGATCGAC GGACTCGCCG TCGCCTACGG GGTTGCCGTC 1020

AACAAGCTGA CCCTGCCCAT CCCTTCCACA TGTCCGGAAC CCTTCGCTCA GCTCATGGCC 1080

GAGTGCTGGG ACCAGGACCC TCACCGCAGA CCTAATTTCA GCTCCATCCT CACTCAACTC 1140

ACAGCCCTGG AGAGGCAGGT GAAGGAGGAG ATGCCGCAGG ACTCCTTTCA CTCCCTGCAG 1200

GAGGACTGGA AGCTGGAGAT TCAAGACATG TTTGATGAAC TTCGAGCAAA AGAGAAGGAG 1260

CTACGGTGTC GCGAGGAGGA ACTGAAACGA GCGGCCTTGG AACAAAAGTC CCACGAAGAG 1320

TTCCTGCGGC AACGAGAGCA GCAGCTGGCC CAGTGGGAGC AGGACGTGTT TGAGCGCGAA 1380

CTCAGCCTCC TCATCCTGCA CCTCAACCAG AACCAGGAAA AACCCAACGT GAAGAAAAGG 1440

AAGGGCACGT TCAAAAAGCA CAAGCTCAAG GGCAAGAACG GCGAGATCAG CATGCCCCAA 1500

GATTTCATCC ACAAGATCAC AGTGCAGGCG TCGCCGGGCC CGGAGAAACG ACGGAACTCT 1560

CCCGATTTGG GTTTGGGATC GCCGCCTTCC TTCGGGCCTC GTTTACGTGC CTTTCAGCGT 1620

ACAGAACAAG GAGAGCCGGG CAAAATGTGG GCCCTAGAAG CCCCCTCACA CAAACAAGCT 1680

AACGGCGACC TGAGACTGGG CCCCCACTGG AGACCCCAGA GCCCCAAAAG TCCCAAAAGC 1740

CCCAAAGTGC TGCGCCTTAG TCCCCAGGAA AGTGGCAACA ACAACGGAGA ACTCAGCGAT 1800

GATTTTGAGG CGTACAGGCC CTCCACTCCG ACCCCTCCTG CCCAGAATGG TATCCCAGGC 1860

GCTATTTCCA GTAACCGCTC TGGCTCCCCA AGGCCGGAGA GGGGTTCCCT TGGCAGCAAC 1920

ATTGGGGGCA CCCACCGCGC CCTGCTTGGC AGCGGCTCCC TGCTGGCCTC TGTAGGACTC 1980

GGCCGCTGCC TGGATATTCC CCCAAGGGTG CCCCCTCGAA CAAACGCCTC TTCCCTCGGC 2040

GATCGCACTC CTTCAGAGCC GGAGATCTGT TCTGCCAAGC CCCTGGTTTC AGACCCCCCC 2100

GATTTACCTC TACAGTATCA AGACATAAAA CCTTTGCCCC TATCGCCTCC TCCTCCAGTC 2160

CCTCGCGACA GGAGCAGCCA TCGAAAGCAG CAGTGCCTGC ACAGTCCGCA GAGCCCAAGG 2220

ACACCCCTGC GGCACGGCTG GGGCAGCCCT GAAGCAGGCC CTGAAGCTCA GCTTTCAGGT 2280

ACCAGAGGGA GTCCCAAGAC CGGCCGCCTG GAGGTCAACG TCATCCCCCG TCCTCGTCCA 2340

TCTCCCGTTC GCCCTCGCAT CGACCCCTGG AGCTTCATCT CGGCCGGC 2388

Domain Profile

S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59

         +l+e+ig g fgkvy+++wr++ vavK++r++  e  + +++++++ea+l+s+l hpnii

Q: 122   SLQEIIGVGGFGKVYRGTWRGELVAVKAARQDPDEdiSVTAQNVKQEARLFSMLTHPNII  181

         5789****************************99988999********************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +l+Gvcl+epnl+l+mey++gg Ls++l++   r+i+++ lv+wa+qiA+Gm YLhsea

Q: 182   ALKGVCLQEPNLCLIMEYASGGPLSRALAG---RRIPPHILVNWAVQIAKGMLYLHSEAI  238

         ******************************...9**************************

S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172

         +++ihrdLks+n+Ll       ++e++tlki+dFG are++k+tkms+agt+awmaPEv+

Q: 239   VPVIHRDLKSNNILLaeaieneCMEDLTLKITDFGLAREWHKTTKMSTAGTYAWMAPEVI  298

         ************************************************************

S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232

         k++++s+ sDvwSygv+LWellt+e Pyk+++ la+ay+va+++l+lpips+cpe++++L

Q: 299   KSSTFSKGSDVWSYGVLLWELLTGEAPYKGIDGLAVAYGVAVNKLTLPIPSTCPEPFAQL  358

         ************************************************************

S: 233   mkecwnedpekRpsfseivksl  254

         m ecw++dp++Rp+fs+i+++l

Q: 359   MAECWDQDPHRRPNFSSILTQL  380

         ******************9876

Domain Sequence
(FASTA)

SLQEIIGVGG FGKVYRGTWR GELVAVKAAR QDPDEDISVT AQNVKQEARL FSMLTHPNII 60

ALKGVCLQEP NLCLIMEYAS GGPLSRALAG RRIPPHILVN WAVQIAKGML YLHSEAIVPV 120

IHRDLKSNNI LLAEAIENEC MEDLTLKITD FGLAREWHKT TKMSTAGTYA WMAPEVIKSS 180

TFSKGSDVWS YGVLLWELLT GEAPYKGIDG LAVAYGVAVN KLTLPIPSTC PEPFAQLMAE 240

CWDQDPHRRP NFSSILTQL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013