EPS-TEN-00037

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TEN-00037

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	188.3	2.5E-55	1038	1284	247

Status

Unreviewed

Ensembl Protein

ENSTNIP00000006565

UniProt Accession

H3CMI6;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1 (1 of 2)

Gene Synonyms/Alias

PHLPP1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000003957	ENSTNIP00000009467	ENSTNIT00000009641
ENSTNIG00000003957	ENSTNIP00000006565	ENSTNIT00000006716

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1584

Protein Sequence
(FASTA)

SSSLLLRRRR LKRNLSAAAA TSAVTTACSA KMNSALSSAS LHTRSLDRKT LLKHRQNMQL 60

QPADREWVRS DLHRGSIYVH DRLTPSYPRP VLCTMDTTAG EVALRLSKLC SKSSTVMRIF 120

SKDSPKIDQN GNCNNKYELD DKACKVSQDP SLPCSLPPLE ATDLRDRPGD RLRLLLVENA 180

AWTRRMTRIR RTGSDVESSA FDDLSSGARL SEHRDSLSDY MVLGTEASIL SPSFDSATEA 240

QDMYLSSSDE LELDGPASSA SMDPISQHHM ANDMEPQSRL PHSLSSLTPS SCDDLSSRAC 300

SVGNTPDIQD QLSGPSVVKP GLRARRSEEP WDSNPTLYVQ LHGEAVRRLS PDERPLQIQN 360

DFLFKLGFKD PWRVQEEGLN TEIGSLLRFY AGKPQSIESS ERVQLSGTYN VRKGKLQLPV 420

NRWTRRQVIL CGTCLIVSSV KESQTGKMHI LPLIGGKVEE VKKHNHCLAF SSAGPQSQTY 480

YVSFDSFTEH LRWHRHAAKM VSQRINSVDL SCCSLEQLPP NLFYSQDLTH LNLKHNFLSA 540

DQRLQQLQRY REVSRFSRLR SLNLSNNHLS QFPLAICDIP TLTEVNLSCN YLVSIPCSVG 600

AMTNLQTFLL DGNNLNELPK ELGSLQRLSY LGLSFNHFNH VPQILEQLPC MEKLCMAGNS 660

LETLTLQNFR LLRVKHIDLR HSPVMYKVIG DKIIFIFFCT HIDLIFSCSP VNSLTFHISA 720

ALALFSSIIS FFLVNAFAFL PTELQQLVIS PVPFNLSYMD ISRNHMEALP DWLCEAKKLE 780

VLDVSHNLIA DLPARLLCSN SLRKLSAGHN QLQKLPERVE RPLLEVLDVQ HNQLVELPCN 840

LFLKSDSLRC VNASANKLEH MPPSSLSEES HSVLQELYLT NNRLTDKCVP MLTGHTHLRV 900

LHMAYNHLQT FPASKMAKLE ELEEVDLSGN MLKTVPTTIM NCRRMHTLIA HSNSIEVFPE 960

VMQLMEMKCV DLSCNELSEI TLPENLPPKL QELDLTGNPR LNLDHKTLEQ LNNIRCFRID 1020

PPPTFSSNET TGGPAVWSHG YTEASGIKNK LCVAALSVNS FCGSREALYG VFDGDRNVEV 1080

PYLLQCTMND VLAEEIHKTK SEEDYMTNTF LVMQSRKLGT AGQKLGGSAA LCHIRHDPTD 1140

PGGCFTLTAA NVGKCQAILC RDGKPLPMSL LHNIGLEEEY RRIRQHRAII TEDNKVNGVT 1200

DSTRIMGYSF LYPAVIPCPY VQTVTLTSQD EFFILGSRGL WDAVSPGEAV EAVRNVPDGL 1260

AAAKKLCTLA QGYGCTDSIS AVVVQLSVSE DCCSCCCSEP PQPPPSPGLG PYPSSSSAIK 1320

ERPSDGSLPV PPSSCSEISS EISTSEMSSE VGSTASSDEP PQSSACQYLF PSSELPSARS 1380

CCALHPVCLA GSFQRQLSSA TFSSALSDNG LDSEDEEPIA GVFSNGSRVE VEADVHCLKA 1440

ESSLQKSSPS SSNQEPVLLT LPPPPPPPCT PEPLEEGINL NFSETENGLE RDETWQGTGA 1500

GVADGGKLVG KRRVNGSVAQ QEQSHNLIEV AADAPSKKSG GYFTAPAQPD PDDQFIIPPE 1560

LEEEVKEIMK QHQQRQQKPA GSEQ 1584

Nucleotide Sequence
(FASTA)

TCCAGCTCTC TCCTGTTGCG ACGGAGGCGC CTGAAGCGCA ACCTCTCCGC CGCTGCGGCC 60

ACCTCAGCTG TCACCACCGC CTGTAGCGCC AAGATGAACT CGGCCCTGTC CTCTGCGTCC 120

TTGCACACTC GGAGTTTGGA CCGAAAGACT CTGTTGAAAC ACCGACAGAA CATGCAGCTG 180

CAGCCCGCCG ATCGCGAGTG GGTGAGATCG GACCTCCATC GGGGTTCCAT TTATGTCCAC 240

GACAGACTGA CGCCTTCGTA CCCCAGACCG GTTCTTTGCA CTATGGACAC CACGGCCGGC 300

GAGGTGGCTC TTCGTCTGAG CAAACTCTGC AGTAAGTCCA GCACGGTTAT GCGCATTTTC 360

TCTAAAGATA GCCCCAAGAT TGACCAAAAT GGCAACTGCA ACAACAAATA TGAATTGGAC 420

GATAAAGCGT GCAAGGTGAG CCAAGACCCA AGCCTACCAT GCAGCCTGCC TCCCCTGGAA 480

GCCACCGATT TGAGGGACCG TCCTGGTGAC AGGCTGAGGC TGCTGCTGGT GGAGAATGCA 540

GCATGGACAC GCAGAATGAC GAGGATTCGG AGAACAGGCT CAGATGTGGA GAGCAGCGCG 600

TTTGATGACC TGAGCTCCGG AGCCCGGCTC AGCGAGCACA GGGACTCTCT GAGCGATTAC 660

ATGGTCCTGG GCACAGAGGC CTCCATCCTC AGCCCCTCCT TTGACAGTGC CACGGAGGCC 720

CAGGACATGT ATCTCAGTTC TTCGGATGAA CTGGAGCTCG ATGGTCCTGC TTCGAGTGCT 780

AGCATGGATC CCATCTCTCA ACATCACATG GCAAATGATA TGGAGCCGCA GAGCAGACTC 840

CCACACAGCC TGAGCAGCTT AACACCCAGC AGCTGCGACG ACTTGTCGTC AAGAGCCTGT 900

TCTGTAGGTA ATACACCTGA CATCCAAGAC CAGCTCTCTG GCCCAAGTGT TGTAAAACCA 960

GGGCTGAGAG CCAGGCGCAG TGAAGAACCC TGGGATTCCA ACCCCACACT GTATGTACAG 1020

CTGCACGGTG AAGCCGTCAG GAGGCTTAGT CCAGATGAAA GGCCGCTGCA GATCCAAAAC 1080

GACTTTCTTT TCAAGCTTGG GTTTAAGGAC CCCTGGAGAG TTCAAGAGGA AGGCCTTAAC 1140

ACAGAAATTG GTTCCTTGTT ACGTTTCTAT GCAGGGAAGC CCCAAAGCAT TGAGAGCTCA 1200

GAACGGGTCC AGCTGTCGGG CACTTATAAC GTTCGGAAAG GGAAGCTCCA GCTGCCGGTG 1260

AACCGCTGGA CCAGACGTCA GGTCATTCTG TGTGGCACCT GTCTCATCGT CTCCTCAGTC 1320

AAAGAGAGCC AAACGGGGAA AATGCACATC TTGCCGCTCA TCGGAGGAAA GGTAGAGGAG 1380

GTGAAGAAGC ACAATCACTG CTTGGCTTTC AGCTCAGCGG GGCCTCAGAG TCAAACCTAC 1440

TACGTCAGCT TTGACAGCTT CACGGAGCAC CTGCGCTGGC ATCGACACGC TGCCAAGATG 1500

GTGTCCCAGA GGATCAACTC TGTGGATTTG TCCTGCTGCA GCCTCGAGCA GCTCCCCCCC 1560

AACCTGTTCT ACAGCCAGGA CCTCACTCAC CTCAATCTTA AACACAACTT TCTGTCTGCG 1620

GATCAGCGAT TGCAGCAGCT GCAGAGGTAC CGTGAGGTTT CCAGGTTTTC TCGCCTGCGG 1680

AGCCTCAACC TGTCCAACAA CCACCTCAGT CAGTTTCCTC TGGCCATTTG TGACATTCCC 1740

ACACTGACGG AAGTCAACCT TAGCTGCAAC TACCTGGTCT CCATCCCATG TTCTGTGGGA 1800

GCGATGACAA ATTTGCAGAC TTTCCTTCTG GATGGTAACA ACCTGAATGA ACTGCCCAAG 1860

GAGCTCGGTT CCCTCCAGAG GCTGAGCTAC TTAGGCCTTT CTTTCAACCA TTTCAACCAT 1920

GTGCCCCAAA TCCTGGAGCA GTTGCCCTGC ATGGAGAAGC TGTGCATGGC TGGAAACAGC 1980

CTGGAAACAC TCACTCTGCA GAACTTCCGA CTGCTTCGTG TCAAGCACAT TGATCTGAGG 2040

CATTCTCCCG TGATGTACAA AGTTATAGGA GACAAAATTA TTTTTATTTT TTTCTGTACA 2100

CACATAGATT TAATTTTCTC ATGCTCTCCT GTGAATTCAT TAACTTTTCA CATCAGTGCT 2160

GCACTTGCAT TATTCTCCTC CATCATCTCG TTCTTTCTTG TTAATGCATT TGCATTTCTC 2220

CCCACAGAGT TGCAGCAACT GGTTATCAGT CCCGTGCCCT TCAATCTCAG TTACATGGAC 2280

ATTTCGAGGA ACCATATGGA GGCCTTGCCA GACTGGCTGT GTGAAGCTAA GAAACTAGAA 2340

GTTCTAGACG TGAGCCATAA CCTAATCGCT GATCTCCCAG CACGGTTGCT CTGCAGCAAC 2400

AGTCTGAGGA AGCTGAGTGC AGGACACAAC CAGCTGCAGA AACTGCCTGA AAGGGTAGAG 2460

CGCCCTCTGC TGGAAGTCTT GGACGTACAG CACAACCAAC TGGTGGAGCT GCCCTGCAAC 2520

CTGTTCCTCA AATCTGACAG CTTAAGGTGT GTAAACGCTT CGGCAAATAA GCTGGAGCAC 2580

ATGCCACCAT CCAGCCTGTC AGAGGAGAGC CACAGCGTTC TGCAGGAACT CTACCTCACC 2640

AATAACCGGC TCACCGATAA GTGTGTGCCC ATGCTGACAG GCCACACACA CCTTCGTGTT 2700

CTGCATATGG CTTACAACCA TCTCCAGACT TTCCCAGCCA GTAAAATGGC CAAGCTGGAG 2760

GAGTTGGAGG AGGTGGACCT GAGCGGAAAC ATGCTGAAGA CTGTGCCCAC CACCATCATG 2820

AACTGTCGGC GAATGCACAC GCTTATCGCC CACTCCAACT CTATCGAGGT CTTTCCAGAA 2880

GTCATGCAAC TGATGGAGAT GAAATGTGTG GATCTGAGCT GCAATGAACT GAGCGAGATC 2940

ACCCTGCCTG AAAATCTGCC TCCGAAGCTT CAGGAGCTGG ACCTGACAGG AAATCCTCGT 3000

TTGAACCTGG ACCACAAAAC TCTGGAGCAA CTCAATAATA TTCGCTGCTT CCGTATTGAT 3060

CCACCACCAA CCTTTTCATC GAACGAGACA ACTGGTGGGC CTGCTGTGTG GAGCCATGGT 3120

TACACAGAGG CCTCGGGCAT CAAGAACAAA TTGTGTGTGG CAGCTCTGTC TGTAAACAGC 3180

TTCTGCGGGA GTCGGGAGGC TCTGTACGGC GTGTTCGATG GAGACAGGAA CGTGGAAGTG 3240

CCCTACCTTT TGCAGTGCAC GATGAACGAT GTGTTGGCTG AAGAAATACA CAAGACCAAG 3300

AGCGAAGAGG ATTACATGAC TAACACCTTC CTGGTCATGC AAAGTAGAAA ACTTGGAACT 3360

GCAGGGCAGA AACTGGGTGG CTCAGCAGCT CTGTGTCACA TCCGCCATGA CCCCACTGAC 3420

CCCGGGGGGT GCTTCACACT CACAGCAGCT AATGTGGGCA AGTGCCAGGC CATCCTGTGC 3480

CGTGACGGGA AACCCTTACC GATGTCCCTG CTTCACAACA TTGGGCTGGA GGAGGAGTAC 3540

CGCAGGATCA GGCAGCACAG GGCCATCATT ACCGAGGATA ACAAGGTCAA TGGTGTGACC 3600

GATTCCACGC GAATCATGGG CTACTCCTTC CTCTACCCGG CTGTCATTCC CTGTCCCTAC 3660

GTGCAGACAG TCACTCTCAC CTCTCAGGAT GAATTCTTCA TTCTGGGTAG CCGTGGCCTC 3720

TGGGACGCTG TGTCCCCTGG AGAGGCTGTG GAGGCGGTCC GAAACGTCCC CGATGGCCTG 3780

GCTGCTGCTA AGAAACTGTG TACGCTGGCG CAGGGTTACG GCTGCACAGA CAGCATCAGT 3840

GCTGTTGTCG TCCAGCTGAG CGTGAGTGAA GACTGCTGCT CTTGCTGCTG TTCTGAGCCT 3900

CCTCAGCCAC CCCCAAGCCC AGGCTTGGGC CCCTATCCGT CATCTTCCTC TGCCATCAAA 3960

GAGAGGCCTT CAGATGGCTC TCTCCCTGTT CCGCCGTCTT CCTGCAGTGA AATCAGCAGC 4020

GAGATCAGCA CCAGTGAGAT GAGCAGCGAG GTGGGCTCCA CAGCGTCATC TGACGAACCT 4080

CCTCAGAGCT CCGCCTGCCA GTATCTGTTC CCAAGTTCAG AGCTGCCCTC AGCACGCAGC 4140

TGTTGTGCCC TCCACCCTGT CTGCTTAGCG GGATCCTTTC AGAGGCAGCT GTCTAGTGCA 4200

ACCTTCTCCA GCGCCCTGTC TGACAACGGG TTGGACAGCG AGGACGAGGA GCCCATCGCG 4260

GGCGTTTTCT CAAACGGAAG CCGCGTGGAA GTAGAAGCAG ATGTCCACTG CCTTAAAGCC 4320

GAATCCTCTC TCCAAAAATC ATCACCCTCA TCCTCCAACC AGGAGCCAGT ACTGTTAACA 4380

TTACCCCCAC CTCCTCCGCC GCCTTGCACC CCAGAGCCCC TGGAGGAGGG GATCAACTTG 4440

AACTTCAGCG AGACAGAGAA TGGGCTGGAG AGAGACGAGA CGTGGCAGGG AACTGGAGCT 4500

GGAGTCGCAG ACGGAGGAAA GTTGGTCGGT AAAAGGAGGG TCAACGGATC CGTGGCGCAG 4560

CAGGAGCAGA GCCACAACCT CATCGAGGTG GCTGCCGACG CTCCTTCGAA AAAGTCCGGA 4620

GGATACTTCA CAGCTCCCGC CCAGCCCGAT CCCGACGACC AATTCATCAT CCCACCAGAG 4680

CTGGAGGAGG AGGTGAAGGA AATCATGAAG CAGCATCAGC AGAGGCAGCA GAAGCCTGCG 4740

GGAAGCGAGC AG 4752

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s+++f+ s+e+     ++gv+DG+++ ev + +++++ ++l

Q: 1038  SHGYTEASGIKNKLCVAALSVNSFCGSREA-----LYGVFDGDRNVEVPYLLQCTMNDVL  1092

         6899**********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aee+     +++  +++++++Fl ++++        ++ +k G +a +++i+++

Q: 1093  AEEIH----KTKSEEDYMTNTFLVMQSRK-----LGTAGQKLGGSAALCHIRHDptdpgg  1143

         ***99....8999999**********988.....7889**********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG+++a+Lcr+gk++++s  H++  e+E++Ri+++ + +++++  +v+Gv+

Q: 1144  cfTLTAANVGKCQAILCRDGKPLPMSLLHNIGLEEEYRRIRQHRAIITEDN--KVNGVTD  1201

         ********************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R +G  +l+p v+p P v+ ++lts+def+iL+s Glwd vs+ eav++vr+v +

Q: 1202  STRIMGYSFLYPAVIPCPYVQTVTLTSQDEFFILGSRGLWDAVSPGEAVEAVRNVPD---  1258

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

            +aakkL++la+ +g++d++sa+vv

Q: 1259  -GLAAAKKLCTLAQGYGCTDSISAVVV  1284

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGI KNKLCVAALS VNSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDVLAEEIH 60

KTKSEEDYMT NTFLVMQSRK LGTAGQKLGG SAALCHIRHD PTDPGGCFTL TAANVGKCQA 120

ILCRDGKPLP MSLLHNIGLE EEYRRIRQHR AIITEDNKVN GVTDSTRIMG YSFLYPAVIP 180

CPYVQTVTLT SQDEFFILGS RGLWDAVSPG EAVEAVRNVP DGLAAAKKLC TLAQGYGCTD 240

SISAVVV 247

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>