EKS-TEN-00513

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00513

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	500.3	3.5E-150	590	914	325

Status

Unreviewed

Ensembl Protein

ENSTNIP00000006719

UniProt Accession

H3CEP5;

Protein Name

Protein Synonyms/Alias

Gene Name

KIT (2 of 2)

Gene Synonyms/Alias

KIT (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000004103	ENSTNIP00000006719	ENSTNIT00000006870

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

971

Protein Sequence
(FASTA)

ISYELICNIS IIDVRIQAGL AVCWKPVITP SGPHVVVSKR GRMELRCHDN ATTSGTPSRR 60

EAEGWQGEVE EGGAKLIKVS SVQPYHMGRY MCVNNNTMEH SSIYVYVKDP QNVFQRTIVN 120

VILERAGENC IIPCLVTDPE VSHLALETCD GQPLPSGMKY HSNLQRGVII HNVRKNYEGC 180

YVCVGRLHGV KVVSSQYTVD VLLVPEVPPV IVLSEKDTVI LRKGERFEIT CSSTNVNLNF 240

SLKWDFPSTA KPEESFASHI LSSSRGYQLA ASLSIPAVSR SDSGPYRCYA LNERGGSATE 300

LQLDVREQGF FTMLGSPGPI QAYVKEGESL SLRVEFDAYP APSSWSWSHS GKQLLNTTEH 360

VITVHRHNYR YLSELRLVRV LSTEGGIYKF SANNEDDSTE RYFHVFVNSK PVIVAQEGPV 420

DGQVRCIAAG YPVPKISWYF CKMPHKRCSH LPNATQWDVP DAPTITESVF GRSEVESRLN 480

VSHKEYSHFH TLECVASTEG EEAFTLFSIS ERLVPHKLFT PLLSGMVATG ILLSLILMVL 540

FYKYVQKPKF QIQWKVIESI HGNSYIYIDP TQLPYDSKWE FPRQKLRFAG KTLGSGAFGK 600

VVRATAYGLC SADTVTTVAV KMLKPNAHST EKEALMSELK VLTYLGNHMN IVNLLGACTL 660

GGPILVITEY CCYGDLLNFL RKKRESFLNS KAGDNYYNVS SRPKPTREEM GLGYVPMRPS 720

EKERSSSSDF NSVKIWFSFV KPSFISKLED ADELSLDAED LLSFSFQVAK GMEYITSKNC 780

IHRDLAARNV LLTHGRVAKI CDFGLARDIT TDANYVLRGN ARLPVKWMSP ESIFDCVYTF 840

ESDVWSYGIL LWEIFSLGNS PYPGMRVDSA FYRMIQEGHK MSRPEFAPVE MYDIMLSCWS 900

HDPLKRPSFR KLVEQTEVLL SENTKNVYLR LSNYTGHPEQ QRAPSRRLSS VCSTTAPTQP 960

LLQSTADVFL D 971

Nucleotide Sequence
(FASTA)

ATTTCATATG AATTGATCTG CAATATTTCG ATCATCGATG TAAGAATACA AGCTGGTTTA 60

GCTGTGTGCT GGAAACCAGT CATCACCCCC AGTGGGCCTC ATGTAGTTGT TTCCAAGAGG 120

GGGAGGATGG AGCTGCGTTG CCATGACAAT GCCACCACAT CTGGCACACC TTCCAGGAGA 180

GAGGCCGAAG GCTGGCAGGG AGAGGTGGAA GAGGGCGGAG CCAAGCTTAT CAAGGTGTCG 240

TCGGTACAAC CATACCACAT GGGTCGTTAC ATGTGTGTCA ACAACAACAC AATGGAGCAC 300

AGCTCCATCT ACGTATATGT GAAAGACCCC CAGAATGTGT TTCAGCGCAC CATAGTAAAC 360

GTCATCCTGG AGCGCGCTGG GGAGAACTGC ATCATTCCCT GTCTCGTCAC CGATCCCGAG 420

GTCAGCCATT TAGCTTTGGA GACCTGCGAT GGGCAACCTT TGCCCTCCGG TATGAAATAT 480

CACAGCAACC TGCAGCGTGG CGTCATCATC CACAACGTGA GAAAAAACTA CGAGGGCTGT 540

TACGTGTGTG TGGGACGACT TCATGGTGTC AAAGTGGTAT CAAGCCAGTA CACCGTGGAT 600

GTATTACTCG TGCCAGAGGT GCCTCCGGTA ATCGTGCTGT CTGAGAAAGA CACTGTTATC 660

CTGAGGAAAG GCGAACGGTT CGAGATCACC TGCAGCTCCA CCAACGTGAA CCTGAACTTC 720

AGTCTCAAGT GGGATTTTCC TTCCACAGCG AAACCTGAAG AGTCGTTCGC ATCACACATC 780

CTGTCCAGTT CCAGGGGTTA CCAACTCGCC GCCTCGCTTT CCATCCCGGC TGTCAGTCGA 840

TCAGACTCGG GCCCCTACCG GTGCTACGCC CTCAATGAGA GAGGTGGCAG CGCTACCGAG 900

CTGCAGCTGG ATGTCCGCGA ACAGGGATTC TTTACCATGT TGGGTAGCCC CGGTCCCATC 960

CAGGCTTATG TTAAAGAAGG GGAGAGCCTG AGTCTCAGAG TAGAGTTTGA CGCCTACCCT 1020

GCTCCCAGCT CCTGGTCTTG GTCCCACAGT GGCAAACAGC TGTTGAACAC CACCGAGCAC 1080

GTGATTACTG TCCATCGCCA CAACTATAGG TACCTCAGCG AGCTTAGACT CGTGCGGGTC 1140

CTCAGCACCG AGGGAGGAAT TTATAAATTC TCGGCCAATA ATGAGGATGA CTCCACCGAA 1200

CGCTATTTTC ACGTGTTTGT CAACAGTAAG CCAGTTATTG TCGCTCAGGA AGGGCCCGTT 1260

GACGGACAGG TGCGCTGCAT CGCTGCAGGT TACCCGGTTC CCAAAATCAG CTGGTACTTC 1320

TGTAAGATGC CCCACAAAAG GTGTTCACAC CTGCCCAATG CCACCCAATG GGACGTTCCC 1380

GACGCCCCCA CCATTACGGA GTCTGTATTT GGCAGGAGTG AGGTGGAGAG CCGGCTAAAT 1440

GTGAGCCACA AGGAGTACTC TCATTTTCAC ACACTGGAGT GCGTGGCGAG CACAGAGGGT 1500

GAAGAGGCCT TCACCCTGTT CTCTATCAGC GAGCGCCTGG TCCCTCATAA ACTCTTCACT 1560

CCTCTTCTCA GCGGCATGGT GGCCACAGGC ATCCTTCTGA GCCTCATCCT AATGGTGCTG 1620

TTCTATAAAT ACGTGCAGAA ACCCAAATTC CAAATACAAT GGAAGGTGAT TGAAAGTATC 1680

CACGGCAACA GCTACATTTA TATCGACCCA ACCCAGTTGC CGTACGACTC AAAATGGGAG 1740

TTTCCTCGAC AGAAGCTTCG TTTTGCAGGC AAAACATTAG GCTCCGGAGC TTTTGGAAAG 1800

GTGGTGCGAG CCACAGCTTA TGGACTCTGT TCAGCAGACA CTGTTACAAC TGTTGCGGTT 1860

AAAATGCTTA AACCAAATGC CCATTCTACG GAAAAGGAGG CGCTGATGTC AGAGCTGAAG 1920

GTTCTCACTT ACCTCGGCAA CCATATGAAT ATCGTGAACC TGCTGGGGGC CTGCACGCTC 1980

GGAGGCCCAA TTTTAGTGAT CACAGAATAC TGTTGCTATG GCGACCTGCT TAACTTCCTG 2040

CGAAAGAAAA GAGAGTCCTT CCTGAATTCC AAAGCGGGTG ATAACTACTA TAACGTCTCC 2100

AGCCGGCCAA AACCTACAAG AGAGGAGATG GGTTTGGGGT ACGTGCCGAT GCGCCCCTCC 2160

GAGAAAGAAA GGTCTTCCTC ATCGGATTTC AACAGTGTCA AAATCTGGTT TTCGTTTGTT 2220

AAACCCAGCT TTATCTCTAA ACTAGAGGAT GCAGATGAGC TGTCCCTGGA TGCAGAAGAC 2280

CTCCTCAGCT TCTCTTTCCA GGTGGCCAAA GGAATGGAGT ACATCACATC CAAGAATTGT 2340

ATCCACAGGG ATCTTGCAGC CAGAAACGTT CTGTTGACTC ATGGCAGGGT GGCAAAAATC 2400

TGTGATTTCG GTTTGGCTCG AGACATCACA ACCGACGCCA ACTACGTGCT TCGGGGCAAT 2460

GCTCGTCTGC CGGTGAAGTG GATGTCTCCG GAGAGCATTT TTGACTGCGT GTACACGTTC 2520

GAGAGTGACG TCTGGTCTTA CGGCATCTTG CTTTGGGAAA TCTTCTCTCT GGGTAACAGC 2580

CCGTACCCGG GAATGAGAGT GGACTCGGCA TTTTACAGGA TGATTCAAGA AGGTCACAAG 2640

ATGAGCAGGC CTGAGTTTGC TCCAGTCGAG ATGTACGATA TAATGTTGTC CTGTTGGAGT 2700

CATGATCCTT TGAAAAGACC TTCATTCAGA AAACTGGTGG AACAAACCGA GGTACTGCTG 2760

TCAGAAAACA CAAAGAACGT TTACCTGAGA CTGAGCAACT ACACCGGTCA TCCAGAACAG 2820

CAAAGGGCGC CATCCCGCAG ACTGAGCTCA GTCTGCAGCA CTACAGCTCC CACCCAGCCT 2880

TTACTGCAAA GCACAGCTGA CGTCTTTCTA GAC 2913

Domain Profile

S: 4     GkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlGehe  63

         Gk+lGsGafGkvv atayGl  +d+v +vavkmlk++a+s+ekealmselk+l++lG+h+

Q: 590   GKTLGSGAFGKVVRATAYGLCSADTVTTVAVKMLKPNAHSTEKEALMSELKVLTYLGNHM  649

         9***********************************************************

S: 64    nivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldskalla  123

         nivnllGact gGpi+viteyccyGdlln+lr+kresfl+   +k    + + +++

Q: 650   NIVNLLGACTLGGPILVITEYCCYGDLLNFLRKKRESFLN---SK----AGDNYYNVSSR  702

         ***************************************3...33....34444442222

S: 124   dkslrsksslssesseeyvdlkkdvsdvssskadklasek.kksalerevkaaleeedse  182

          k +r       e    yv ++++    ++s+++ ++s k   s+++ +  ++le+ d+

Q: 703   PKPTRE------EMGLGYVPMRPSE--KERSSSSDFNSVKiWFSFVKPSFISKLEDADEL  754

         333333......33457******44..444444555554415799999999*********

S: 183   vleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkdsn  242

         +l+ edllsfs+qvakGme++ sknc+hrdlaarnvllt+G+v+kicdfGlardi++d+n

Q: 755   SLDAEDLLSFSFQVAKGMEYITSKNCIHRDLAARNVLLTHGRVAKICDFGLARDITTDAN  814

         ************************************************************

S: 243   yvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfykl  302

         yv +Gnarlpvkwm+pesifd++yt++sdvwsyGillweifslG +pypg+ vds fy++

Q: 815   YVLRGNARLPVKWMSPESIFDCVYTFESDVWSYGILLWEIFSLGNSPYPGMRVDSAFYRM  874

         ************************************************************

S: 303   ikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         i+eG++m++p++a+ e+y+im +cw ++p krpsf++lve

Q: 875   IQEGHKMSRPEFAPVEMYDIMLSCWSHDPLKRPSFRKLVE  914

         *************************************986

Domain Sequence
(FASTA)

GKTLGSGAFG KVVRATAYGL CSADTVTTVA VKMLKPNAHS TEKEALMSEL KVLTYLGNHM 60

NIVNLLGACT LGGPILVITE YCCYGDLLNF LRKKRESFLN SKAGDNYYNV SSRPKPTREE 120

MGLGYVPMRP SEKERSSSSD FNSVKIWFSF VKPSFISKLE DADELSLDAE DLLSFSFQVA 180

KGMEYITSKN CIHRDLAARN VLLTHGRVAK ICDFGLARDI TTDANYVLRG NARLPVKWMS 240

PESIFDCVYT FESDVWSYGI LLWEIFSLGN SPYPGMRVDS AFYRMIQEGH KMSRPEFAPV 300

EMYDIMLSCW SHDPLKRPSF RKLVE 325

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013