EKS-TEN-00583

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00583

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	376.6	7.8E-113	57	343	287

Status

Unreviewed

Ensembl Protein

ENSTNIP00000000898

UniProt Accession

H3BY33;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000004124	ENSTNIP00000000898	ENSTNIT00000000791
ENSTNIG00000004124	ENSTNIP00000006741	ENSTNIT00000006892

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

MAAYNGGSSA VAAHHPHHHH QLQHLPPPHM HHHHHHAHHH HQQQPPQQQP QLDIEPDRPI 60

GYGAFGVVWS VTDPRDGKRV ALKKMPNVFQ NLVSCKRVFR ELKMLCFFKH ENVLSALDIL 120

QPPHIDYFEE IYVVTELMQS DLHKIIVSPQ PLSSDHAKVF LYQILRGLKY LHSAGILHRD 180

IKPGNLLVNS NCVLKICDFG LARVEESDEA RHMTQEVVTQ YYRAPEILMG SRHYSNSIDI 240

WSVGCIFAEL LGRRILFQAQ SPIQQLDLIT DLLGTPSMEA MRTACEGARA HILRGPHKQP 300

SLPVLYTLSS QATHEAVHLL CRMLVFDPSK RISAKDALAH PYLDEGRLRY HTCMCKCCYT 360

TSSGRVYTSD FEPVTNPKFD DGFEKNLSSV RQVKEIIHQF ILEQQKGSRV PLCINPQSAA 420

FKSFISSTVA QPSEMPPSPL VWE 443

Nucleotide Sequence
(FASTA)

ATGGCTGCGT ATAACGGAGG CTCCTCGGCC GTGGCTGCCC ATCACCCGCA CCACCACCAC 60

CAGCTGCAGC ACCTGCCGCC CCCCCACATG CACCACCACC ACCACCACGC CCACCACCAC 120

CACCAGCAGC AGCCGCCGCA GCAGCAGCCG CAGCTGGACA TCGAGCCCGA CAGGCCCATC 180

GGATACGGAG CCTTTGGGGT GGTCTGGTCG GTGACGGACC CCAGAGACGG GAAGCGGGTC 240

GCCCTCAAAA AGATGCCCAA TGTCTTCCAA AACCTTGTTT CCTGCAAGAG GGTGTTCCGG 300

GAGCTGAAGA TGCTCTGCTT CTTCAAACAC GAAAACGTTC TCTCTGCGCT GGACATTCTA 360

CAGCCGCCAC ACATCGACTA CTTTGAGGAG ATCTACGTGG TGACCGAGCT GATGCAAAGC 420

GACCTCCATA AGATCATCGT GTCTCCGCAG CCGCTGAGCT CCGACCACGC CAAAGTCTTT 480

CTCTACCAGA TCCTGCGAGG ACTCAAATAC CTTCATTCGG CCGGCATCCT GCACCGGGAC 540

ATCAAGCCGG GGAACCTGCT GGTCAACAGC AACTGTGTGC TGAAGATCTG CGACTTCGGC 600

CTCGCTCGGG TGGAGGAGTC GGACGAGGCG CGGCACATGA CCCAGGAAGT GGTGACGCAG 660

TACTACCGGG CCCCGGAGAT CCTCATGGGG AGTCGCCACT ATTCCAACTC CATTGACATC 720

TGGTCGGTGG GCTGCATCTT CGCCGAGCTG CTGGGCCGCC GCATCCTCTT CCAAGCCCAG 780

AGTCCCATCC AGCAGCTGGA TCTGATCACC GACCTGCTGG GGACTCCGTC CATGGAAGCC 840

ATGAGGACGG CGTGCGAAGG CGCCCGAGCG CACATTCTCA GAGGACCCCA CAAGCAGCCA 900

TCCCTCCCGG TCCTGTACAC GCTGTCCAGC CAAGCCACCC ACGAAGCTGT CCACCTCCTC 960

TGCAGGATGC TGGTGTTCGA TCCATCCAAG CGGATTTCAG CGAAGGACGC CCTGGCCCAC 1020

CCGTACCTGG ACGAGGGCCG CCTGCGCTAC CACACCTGCA TGTGTAAATG CTGCTACACC 1080

ACCTCCTCAG GGCGCGTTTA CACCAGTGAC TTCGAGCCCG TCACCAATCC CAAGTTCGAC 1140

GACGGCTTTG AGAAGAACCT GAGCTCCGTG AGACAGGTCA AAGAAATCAT CCATCAGTTC 1200

ATCCTGGAGC AGCAAAAAGG GAGCCGGGTT CCTCTCTGCA TCAACCCTCA GTCAGCAGCC 1260

TTCAAAAGCT TCATCAGCTC CACGGTGGCT CAGCCGTCTG AGATGCCTCC ATCTCCGCTG 1320

GTGTGGGAGT AG 1332

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kheN+++

Q: 57    DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHENVLSA  116

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 117   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHAKVFLYQILRGLKYLHSAG  175

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar++++++ +++t++v+t++YraPeil+ +++y+

Q: 176   ILHRDIKPGNLLVNSNCVLKICDFGLARVEESDEARHMTQEVVTQYYRAPEILMGSRHYS  235

         ************************************************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +++DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  ar++i +

Q: 236   NSIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSMEAMRTACEG-ARAHILR  294

         ************************************************9996.8888888

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 295   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  343

         87776654467788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHENVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH AKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE SDEARHMTQE VVTQYYRAPE ILMGSRHYSN 180

SIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SMEAMRTACE GARAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013