EKS-TEN-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	329.9	1.2E-98	206	472	267

Status

Unreviewed

Ensembl Protein

ENSTNIP00000007060

UniProt Accession

H3CFN3;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK2

Gene Synonyms/Alias

CHEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000004423	ENSTNIP00000007060	ENSTNIT00000007217

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

531

Protein Sequence
(FASTA)

MSEERPPEGG PSQSTQSTQS TLSPSQDTAS CSQSKPQSQP ASSSSSGPTT SSQSSSGSGT 60

LSSVDTIPVT LPSVPEEPEA EPWGRLLPMA RGFRSHDCVE DQYLFGRDSK CNYVLDDPDN 120

RGSRKFQIYS KKHFRIYRQE GCEVFVEDYS NNGTFVDGIL IGKNRKLPLV NNAVLALSER 180

RNKVFVYIDL MSHDQSSLPK ELQEKYLLTR QIGTGVCGEV KLAFERSSCR KYAVKIIKKK 240

NFQSEGTATR NAQTEIEILQ RIDHPCLIKT LDFYQTDDSY YIVLELMEGG ELFHRVKSRQ 300

QLSESVTKLY FYQMLRAVQR AQYLHSNGII HRDLKPENIL LSSQERTRIC QVTDFNQSRI 360

LEETMLMRTL CGTPSYLAPE VFTQASTSGY GLAVDAWSLG VLLFVCLGGY PPFHEGFGNV 420

SISEQIIGGE FTMVPSKWRH VSDQAKDVVR KLLVVDPSRR MSIDQALEHP WLQDQAMLAT 480

AHRLMHPPDA TAVATEAGPD PGSPRRKRGR DEEEQEEHPA KRNRGPTAVL L 531

Nucleotide Sequence
(FASTA)

ATGTCTGAGG AGCGTCCGCC TGAGGGGGGC CCGTCCCAGT CCACCCAGTC CACCCAGTCC 60

ACCCTGTCTC CATCCCAGGA CACGGCGTCC TGCTCCCAGT CCAAACCTCA GTCTCAGCCT 120

GCCTCCAGTT CTTCTAGTGG ACCAACCACA AGCAGCCAGT CCTCCAGCGG GTCGGGGACG 180

CTGAGCAGCG TGGACACCAT CCCGGTCACC CTCCCGTCTG TCCCGGAGGA GCCGGAGGCG 240

GAACCCTGGG GGCGCCTGCT GCCCATGGCC CGAGGCTTCA GGAGCCACGA CTGTGTGGAG 300

GATCAGTACC TGTTTGGACG GGACTCCAAG TGTAACTACG TCCTGGACGA TCCGGACAAC 360

AGAGGCTCCC GGAAGTTCCA GATCTACAGC AAGAAACACT TCAGGATCTA CAGACAGGAG 420

GGCTGCGAGG TGTTTGTGGA GGACTACAGT AATAACGGCA CCTTTGTTGA TGGGATCCTG 480

ATTGGGAAGA ACAGGAAGCT CCCTCTGGTC AACAACGCCG TGCTCGCTCT GTCCGAGCGG 540

CGGAACAAAG TCTTTGTCTA CATTGACCTG ATGTCACATG ATCAGTCCAG TTTACCCAAA 600

GAGCTGCAGG AGAAGTACCT GCTGACTCGG CAGATCGGCA CAGGGGTTTG TGGTGAGGTG 660

AAGTTGGCTT TTGAGAGATC ATCCTGCAGA AAATATGCAG TGAAAATAAT CAAGAAGAAG 720

AACTTCCAGT CTGAAGGGAC AGCAACACGA AACGCACAAA CGGAGATCGA GATTCTGCAG 780

AGAATCGACC ACCCTTGCCT CATTAAAACC CTGGACTTCT ACCAGACAGA CGACAGCTAT 840

TACATCGTGT TGGAGCTGAT GGAGGGGGGG GAGCTCTTCC ACAGAGTCAA GTCTCGGCAG 900

CAGCTTTCCG AGTCCGTCAC CAAACTTTAC TTCTATCAGA TGCTGAGAGC TGTCCAGCGC 960

GCGCAGTACC TCCACAGTAA TGGGATCATC CACAGAGACC TGAAACCAGA GAACATCCTG 1020

CTGTCCTCCC AGGAGCGCAC GCGCATCTGC CAGGTGACAG ACTTCAACCA GTCCCGGATC 1080

CTGGAGGAGA CCATGCTGAT GAGGACTCTG TGCGGGACCC CGTCCTACCT GGCTCCTGAG 1140

GTCTTCACGC AGGCGTCCAC CAGTGGCTAC GGGCTGGCGG TGGACGCCTG GAGCCTGGGC 1200

GTGCTGCTCT TCGTCTGTCT CGGGGGTTAC CCTCCGTTCC ACGAAGGTTT TGGGAACGTG 1260

TCCATCAGCG AGCAGATCAT CGGCGGCGAG TTCACCATGG TCCCGTCCAA GTGGAGACAC 1320

GTCTCCGATC AGGCTAAAGA CGTCGTGAGG AAGCTGCTGG TGGTGGACCC CAGTCGCAGG 1380

ATGAGCATTG ACCAGGCCCT GGAGCACCCC TGGTTGCAGG ATCAGGCCAT GTTGGCCACG 1440

GCTCACAGGC TCATGCACCC CCCGGATGCT ACTGCTGTTG CCACGGAGGC GGGCCCTGAC 1500

CCAGGAAGTC CCAGGAGGAA ACGAGGAAGA GATGAGGAAG AACAGGAGGA GCATCCGGCC 1560

AAACGTAACC GCGGCCCCAC CGCCGTCCTG CTGTAG 1596

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrksirssreikkakeveeeveilkkl  60

         y+l +++G+G +g+vkla+e++ ++k+avki++k++    ++e + +++ ++e+eil+++

Q: 206   YLLTRQIGTGVCGEVKLAFERSSCRKYAVKIIKKKN---FQSEGTATRNAQTEIEILQRI  262

         7899******************************99...56677788999**********

S: 61    shPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltav...k  117

         +hP+++k  d++++++s+y+vlel+egGel+++v ++++l+e+++kl+f+q+l av   +

Q: 263   DHPCLIKTLDFYQTDDSYYIVLELMEGGELFHRVKSRQQLSESVTKLYFYQMLRAVqraQ  322

         *******************************************************95545

S: 118   ylhekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevl  177

         ylh++giihrDlkPeniLls++e   + ++tDf ++++l+e+ lm+tlCGtpsy+aPev

Q: 323   YLHSNGIIHRDLKPENILLSSQERTRICQVTDFNQSRILEETMLMRTLCGTPSYLAPEVF  382

         ************************************************************

S: 178   vkkgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkis  237

         ++  +++y  +vD WslGv+lfv+l GypPf e  ++vs++eqi  g++++ ++kw+++s

Q: 383   TQASTSGYGLAVDAWSLGVLLFVCLGGYPPFHEGFGNVSISEQIIGGEFTMVPSKWRHVS  442

         ************************************************************

S: 238   eeakdlikklLvvdPeerlsieealnhpWl  267

         ++akd+++klLvvdP++r+si++al+hpWl

Q: 443   DQAKDVVRKLLVVDPSRRMSIDQALEHPWL  472

         *****************************8

Domain Sequence
(FASTA)

YLLTRQIGTG VCGEVKLAFE RSSCRKYAVK IIKKKNFQSE GTATRNAQTE IEILQRIDHP 60

CLIKTLDFYQ TDDSYYIVLE LMEGGELFHR VKSRQQLSES VTKLYFYQML RAVQRAQYLH 120

SNGIIHRDLK PENILLSSQE RTRICQVTDF NQSRILEETM LMRTLCGTPS YLAPEVFTQA 180

STSGYGLAVD AWSLGVLLFV CLGGYPPFHE GFGNVSISEQ IIGGEFTMVP SKWRHVSDQA 240

KDVVRKLLVV DPSRRMSIDQ ALEHPWL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006974	; P:response to DNA damage stimulus

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013