EKS-TEN-00554

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00554

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	485.9	3.4E-146	74	340	267

Status

Unreviewed

Ensembl Protein

ENSTNIP00000007460

UniProt Accession

H3CGT2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000004801	ENSTNIP00000007460	ENSTNIT00000007619

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1687

Protein Sequence
(FASTA)

MSAQVRLKRL EELLLEQKEA GCLSVEALLA LLLCLFSECS QSPLRREKHV ADFLDWVKPF 60

STTVKDLRLH RDDFEMLKVI GRGAFGEVAV VKMKQTERVY AMKILNKWEM LKRAETACFR 120

EERDVLVRGD SQWITTLHYA FQDENFLYLV MDYYVGGDLL TLLSKFEDRL PEDMAKFYLA 180

EMVLAIHSIH QQHYIHRDIK PDNVLLDMNG HIRLADFGSC LRMMEDGTVQ SSVAVGTPDY 240

ISPEILQAME DGMGRYGPEC DWWSLGVCLY EMLYGETPFY AESLVETYGK IMNHEERFQF 300

PSHVSDVSED AKDLIQRLIC SRERRLGLNG ISDFKSHGFF SGIDWDNIRS AEAPYIPDVS 360

SPTDTSNFDV DDDVLKNPEI SPPLSHTGFT GQHLPFVGFT FTTNSCFADG GSISRAEAAP 420

AAAGQQLEAF ERRIRRLEQE KQELNRKLQE STQALQAPRG GALARDKELK KLNEEIERLK 480

QKLADSDRLE HQLEEAVMLQ QDYESSASKL KTLEKQVKML RQEKEEVHKQ LADALERLRS 540

QSKELKEAHS QRKLALQEFS ELSERLADLR SSKQRLSRQL RDKEEEMDAL LQKMDTVRQD 600

IRKTEKIRKD LEAQLDDAKA EASKERKLRE HSELYSKQLE TEVERLKSQQ GRGAPAGTAE 660

SQQEVSRVKA ELDKKILFYE EELLRRDSAL SSEIKNLRKD LHESEGAQLS ANKELLQLRD 720

KLDKAKRDRQ TEMDEAVAAL KEKHEREKNL LTEENRKLTA ENDKICSLVD KLRAQNRQLE 780

DDLQDLSSKK ESVAHWEAQI AEIIQWWVSE ENAGGYLQAL ATKMTEELET LRSSSLGTRP 840

LDPLWKVRRS QKLDMSARLE LQSALDAEIR AKQLVQEELR RVKAANINLE SKVKDSEERI 900

KELEEQMETL KTEMEESHGH HDKGLKLPDF QDSIFDYFNT SPLAPDLTFR VSHHTDRDPS 960

QQESEATPSS PSSSLQDSKG APVPASSPPT SQSVVLTSPK PRAHQLSIKT FSSPTQCTHC 1020

TSLMVGLARQ GYACEVCSFI CHVSCKDHAP CVCPIPAEQS KRPQGIDVQR GIGTAYKGYV 1080

RIPKPSGVKK GWQRVLAVVS DCKLFLYDVP EGKSTQPGVG ASLVLDLREE AFSVSSVLAS 1140

DVIHATRKDV PCIFKITSSQ LIPALSSVSL LVLAESEAEK RKWVRVLEGL QSILSKNLLR 1200

SHHVHVPHEA YDASLPVIKS ALSAAVLDRE RIALGTEDGL FVVEVTRDVI VRAADSKKTY 1260

QIDLIPKEKV VALLCGRNRQ VHLYPWEVLD GAEPTFDVKL TDTKGCQALT TGLLRPGGPA 1320

CLLAAVKRQV QCYEITRSKP HYRRLWEVQA PGPVQWLGMV RERLCVGYPS GFALLGLQGE 1380

TSPVSLVSPA DPSLAFLAQQ PGALHALEVG SSELLLCFSQ LGVYVDSQGK RSRTQELMWP 1440

ATPVAISSNW SHLTVYSEYG VDVFDIHTAD WLQTISLCKI RPLNAEGTLN LLTSEPSRLI 1500

YFSNSCSEGE LTIPDTSDHS RRLMVRTRSK RKFLFKVPEE ERLQQRREML RDPELRSRMI 1560

SNPTNFNHVA HMGPGDGMQA LMDLPLQSAV PSSHEDLAKD RPRPLSSISR QQRSKTHITR 1620

TASGTSDFGG GASSRSILDL DQDLDREPDS DSTKHSTPSN SSNPSSPPSP NSPHRSQLTL 1680

DSMDMEP 1687

Nucleotide Sequence
(FASTA)

ATGTCGGCTC AGGTGCGCCT GAAGCGGCTG GAGGAGCTGC TGCTGGAGCA GAAGGAGGCC 60

GGCTGCCTGA GCGTGGAGGC GCTGCTCGCC CTGCTGCTCT GCCTCTTCTC CGAGTGCTCC 120

CAGTCCCCGC TCCGGAGGGA GAAGCACGTC GCTGACTTCC TGGACTGGGT GAAGCCGTTC 180

AGCACCACGG TGAAGGACCT GCGGCTGCAC CGAGACGACT TTGAGATGCT GAAGGTGATT 240

GGACGAGGTG CTTTTGGAGA GGTTGCCGTG GTGAAGATGA AGCAGACAGA GAGAGTTTAT 300

GCCATGAAGA TTCTCAATAA GTGGGAGATG CTGAAGAGAG CCGAGACGGC GTGTTTCCGA 360

GAGGAGCGAG ACGTGCTGGT GCGAGGAGAC AGCCAGTGGA TCACTACCCT CCACTACGCC 420

TTCCAGGACG AGAACTTCCT GTACCTGGTG ATGGACTACT ACGTGGGTGG AGACCTGCTG 480

ACCCTGCTCA GTAAGTTTGA GGACCGGCTG CCTGAAGACA TGGCCAAGTT CTACCTGGCT 540

GAGATGGTGC TGGCCATCCA CTCCATCCAC CAGCAGCACT ACATCCACAG AGACATCAAA 600

CCTGACAACG TCCTCCTGGA CATGAACGGC CACATCCGCC TGGCCGACTT TGGCTCCTGT 660

CTGCGCATGA TGGAGGACGG CACGGTTCAG TCCTCGGTGG CGGTGGGAAC TCCAGACTAC 720

ATCTCCCCGG AGATCCTCCA GGCCATGGAG GACGGGATGG GCCGCTACGG GCCCGAGTGT 780

GACTGGTGGT CTCTGGGGGT CTGCCTGTAC GAGATGCTGT ACGGGGAGAC GCCCTTCTAC 840

GCCGAGTCGC TGGTGGAAAC CTACGGGAAG ATCATGAACC ACGAGGAGCG TTTCCAGTTC 900

CCCTCACACG TGTCCGATGT GTCCGAGGAT GCCAAAGATC TGATCCAGCG TCTGATCTGC 960

TCCCGGGAAC GCCGGCTGGG CCTGAACGGC ATCTCAGACT TCAAAAGTCA CGGCTTCTTC 1020

AGCGGGATCG ACTGGGACAA CATCCGCTCG GCCGAGGCGC CCTACATCCC AGACGTGTCC 1080

TCGCCCACGG ACACGTCCAA CTTTGACGTC GATGACGATG TCCTAAAGAA CCCGGAGATC 1140

AGCCCTCCGT TGTCCCACAC GGGTTTCACT GGGCAGCATC TGCCCTTTGT GGGCTTCACC 1200

TTCACCACCA ACAGCTGCTT TGCTGACGGA GGCTCCATCA GCCGAGCGGA GGCCGCTCCG 1260

GCAGCAGCGG GGCAGCAGCT GGAGGCCTTT GAGAGGAGGA TCCGACGGCT GGAGCAGGAG 1320

AAGCAGGAGC TCAACCGCAA GCTGCAGGAG TCCACCCAGG CCCTGCAGGC CCCTCGAGGA 1380

GGAGCTCTGG CCCGGGACAA AGAGCTGAAG AAGCTGAACG AAGAGATCGA ACGACTGAAA 1440

CAGAAGCTGG CAGACTCTGA CCGGCTGGAA CATCAGCTGG AGGAGGCCGT GATGCTCCAG 1500

CAGGACTACG AAAGCTCCGC CTCCAAACTG AAGACGCTGG AGAAGCAGGT GAAGATGCTG 1560

AGGCAGGAGA AGGAGGAAGT CCACAAGCAG CTGGCCGATG CTCTGGAGCG TCTGAGGAGC 1620

CAGTCCAAGG AGCTGAAGGA GGCCCACTCC CAGAGAAAGC TGGCCCTGCA GGAGTTCTCG 1680

GAGCTGTCGG AGCGCTTGGC CGACCTGCGA TCCTCCAAGC AGCGGCTCTC CCGTCAGCTG 1740

AGGGACAAAG AGGAGGAGAT GGACGCGCTG CTGCAGAAAA TGGACACCGT GAGGCAGGAC 1800

ATCCGCAAGA CGGAGAAGAT CCGCAAGGAC CTGGAGGCTC AGCTGGACGA CGCCAAGGCC 1860

GAGGCGTCCA AGGAGAGGAA GCTGCGGGAG CACAGCGAGC TATACTCCAA GCAGCTGGAG 1920

ACGGAAGTGG AGCGTCTGAA GTCTCAGCAG GGCAGAGGAG CGCCGGCGGG GACAGCAGAG 1980

TCCCAGCAGG AAGTGTCCCG GGTGAAGGCG GAGCTTGACA AGAAGATCCT CTTCTACGAG 2040

GAGGAGCTGC TGAGGAGGGA CTCGGCCCTG TCCTCGGAGA TCAAGAACCT GCGGAAAGAC 2100

CTGCACGAGT CCGAGGGGGC GCAGCTGAGC GCCAACAAGG AGCTGCTGCA GCTACGAGAC 2160

AAGCTGGACA AGGCCAAGAG GGACAGACAG ACGGAGATGG ACGAAGCCGT CGCGGCTCTG 2220

AAGGAGAAAC ACGAGCGAGA GAAAAACCTG CTGACGGAGG AAAACCGCAA ATTGACGGCT 2280

GAAAACGACA AGATCTGCTC GTTGGTGGAC AAGCTGAGGG CTCAGAACCG GCAGCTGGAG 2340

GACGACCTCC AGGACCTGTC GTCCAAGAAG GAGAGCGTTG CTCACTGGGA GGCCCAGATC 2400

GCAGAGATCA TCCAGTGGTG GGTGAGTGAG GAGAATGCTG GAGGCTACCT CCAGGCTTTG 2460

GCCACCAAGA TGACAGAAGA GCTAGAAACA CTTCGAAGTT CCAGCCTGGG AACCAGACCT 2520

CTGGACCCCC TCTGGAAGGT GCGTCGCAGT CAGAAGTTGG ACATGTCGGC CCGGCTGGAG 2580

CTTCAGTCGG CTCTGGACGC TGAGATCAGA GCCAAGCAGC TGGTCCAGGA GGAACTGCGT 2640

CGGGTCAAAG CTGCCAACAT CAACCTAGAG AGTAAGGTGA AAGATTCCGA GGAGAGGATC 2700

AAGGAGCTGG AGGAGCAGAT GGAGACCCTG AAGACAGAGA TGGAGGAGAG CCACGGCCAC 2760

CACGACAAAG GCCTGAAGCT TCCAGACTTC CAGGACTCCA TCTTTGATTA CTTCAACACA 2820

TCTCCTCTGG CTCCTGACCT GACCTTCAGA GTGAGTCACC ACACGGACCG AGACCCCAGC 2880

CAGCAGGAGT CTGAGGCCAC GCCCTCCTCG CCCTCCTCCA GTCTCCAGGA CAGTAAAGGA 2940

GCTCCCGTCC CAGCAAGCTC CCCCCCCACA TCCCAGAGCG TCGTGCTGAC ATCACCAAAG 3000

CCCAGAGCTC ATCAGCTGAG CATCAAGACC TTCTCCAGCC CCACCCAGTG CACACACTGC 3060

ACCTCCCTGA TGGTCGGGCT CGCAAGGCAG GGATACGCTT GTGAAGTGTG TTCCTTCATC 3120

TGCCACGTTT CCTGCAAAGA CCACGCCCCC TGTGTGTGTC CAATCCCGGC TGAGCAGTCC 3180

AAAAGGCCGC AGGGCATCGA CGTTCAGCGG GGCATCGGCA CCGCCTACAA GGGTTATGTC 3240

CGGATCCCGA AGCCCAGCGG CGTGAAGAAG GGCTGGCAGC GGGTGCTGGC CGTGGTCTCC 3300

GACTGTAAGC TGTTCCTCTA CGATGTTCCT GAAGGCAAGT CCACCCAGCC AGGTGTGGGG 3360

GCCAGTCTGG TGCTGGATCT GAGGGAGGAG GCCTTTTCCG TCAGCTCCGT GCTGGCCTCG 3420

GACGTCATCC ACGCCACCAG GAAGGACGTC CCCTGCATTT TCAAGATCAC GTCCTCGCAG 3480

CTCATCCCGG CGCTGTCCTC CGTGTCCCTG TTGGTGCTGG CCGAGAGCGA GGCGGAGAAG 3540

AGGAAGTGGG TCAGGGTTCT GGAAGGTCTT CAGAGCATCC TGAGCAAGAA CCTGCTGAGA 3600

AGCCATCATG TCCACGTTCC CCATGAAGCT TATGACGCCT CCCTTCCCGT CATCAAGTCG 3660

GCTCTGTCCG CCGCCGTCCT CGATCGGGAG AGAATCGCCC TGGGAACAGA AGACGGGCTG 3720

TTCGTGGTGG AGGTGACCAG AGACGTGATC GTCCGAGCGG CCGACAGCAA GAAGACCTAT 3780

CAGATCGACC TGATCCCCAA GGAGAAGGTG GTGGCGCTGC TGTGTGGGCG CAACCGGCAG 3840

GTCCACCTTT ACCCCTGGGA GGTTCTGGAC GGGGCCGAGC CCACATTCGA CGTGAAGCTG 3900

ACCGACACCA AAGGCTGCCA GGCCCTGACC ACGGGGCTGC TCCGCCCTGG AGGCCCCGCC 3960

TGTTTGCTGG CGGCCGTCAA GCGTCAGGTC CAGTGTTATG AGATCACTCG CAGCAAGCCC 4020

CACTACCGGA GGCTGTGGGA GGTGCAGGCC CCGGGGCCCG TGCAGTGGTT GGGGATGGTG 4080

AGGGAGCGCC TCTGCGTGGG CTACCCTTCG GGCTTCGCTC TGCTGGGCCT GCAGGGGGAG 4140

ACGTCCCCCG TCAGCCTGGT CAGTCCTGCC GACCCGTCCC TGGCCTTCCT GGCCCAGCAG 4200

CCCGGAGCCT TGCACGCCCT GGAGGTGGGC TCCTCGGAGC TGCTGCTCTG CTTCAGCCAG 4260

CTCGGCGTCT ACGTGGACTC GCAGGGCAAG CGCTCCAGGA CCCAGGAGCT GATGTGGCCC 4320

GCCACGCCAG TCGCAATCAG TTCCAACTGG TCCCACCTGA CCGTCTACAG CGAGTACGGC 4380

GTGGACGTCT TTGACATCCA CACGGCTGAC TGGCTCCAGA CCATCTCCCT CTGCAAGATC 4440

CGACCTCTCA ACGCGGAGGG GACCCTGAAC CTGCTGACGT CAGAACCTTC TCGCCTCATC 4500

TACTTCAGCA ACTCGTGCTC AGAGGGGGAG CTGACCATCC CAGACACGTC CGACCACAGC 4560

AGGAGGTTGA TGGTCCGAAC GCGAAGCAAG AGAAAGTTCC TCTTCAAGGT TCCTGAGGAA 4620

GAGCGCCTCC AGCAGCGAAG GGAGATGCTC CGGGACCCTG AGCTCAGGTC CAGGATGATC 4680

TCCAACCCCA CCAACTTCAA CCACGTGGCC CACATGGGCC CCGGTGACGG CATGCAGGCT 4740

CTGATGGACC TCCCTCTGCA GAGCGCGGTG CCTTCGTCTC ACGAGGACTT GGCCAAGGAC 4800

AGGCCCCGCC CACTCTCCAG TATCTCTCGG CAACAGCGGA GTAAGACGCA CATCACCCGC 4860

ACGGCCTCAG GTACGTCAGA TTTTGGGGGA GGAGCTTCAT CGCGCAGTAT CCTGGACCTA 4920

GATCAGGACC TGGACCGGGA GCCGGACTCG GACTCCACCA AACACTCGAC CCCCTCCAAC 4980

AGCTCCAACC CCAGCAGCCC CCCCAGCCCC AACTCGCCCC ACCGCAGCCA GCTGACCCTG 5040

GACAGCATGG ACATGGAGCC CTGA 5064

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fe+lkviGrGafgevavv++k+te+vyamkil+k+e+lkrae+a+freerdvlv++ds+w

Q: 74    FEMLKVIGRGAFGEVAVVKMKQTERVYAMKILNKWEMLKRAETACFREERDVLVRGDSQW  133

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde++lylvm+y+vGGdlltllsk+ed+lpe++a+fylae+vla++s+h+ +

Q: 134   ITTLHYAFQDENFLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIHSIHQQH  193

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         y+hrdikpdn+lld++Ghi+ladfGscl+++edgtv+ssvavGtpdyispe+l+a+e+g+

Q: 194   YIHRDIKPDNVLLDMNGHIRLADFGSCLRMMEDGTVQSSVAVGTPDYISPEILQAMEDGM  253

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv+lye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vse+akd

Q: 254   GRYGPECDWWSLGVCLYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVsDVSEDAKD  313

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg +gi+d+k+h ff

Q: 314   LIQRLICSRERRLGLNGISDFKSHGFF  340

         **************************9

Domain Sequence
(FASTA)

FEMLKVIGRG AFGEVAVVKM KQTERVYAMK ILNKWEMLKR AETACFREER DVLVRGDSQW 60

ITTLHYAFQD ENFLYLVMDY YVGGDLLTLL SKFEDRLPED MAKFYLAEMV LAIHSIHQQH 120

YIHRDIKPDN VLLDMNGHIR LADFGSCLRM MEDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GRYGPECDWW SLGVCLYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VSDVSEDAKD 240

LIQRLICSRE RRLGLNGISD FKSHGFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013