EKS-TEN-00052
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00052
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak308.55.0E-92555812258
StatusUnreviewed
Ensembl ProteinENSTNIP00000007608
UniProt AccessionH3CH80;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2 (1 of 2)
Gene Synonyms/Alias JAK2 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000004943ENSTNIP00000007608ENSTNIT00000007768
OrganismTetraodon nigroviridis
Functional Description
Protein Length1139
Protein Sequence
(FASTA)
VLMACILLTD MEPPTASPTA AHNAPLPPHD PACSLQPKEE PGATCLRVHL YHQVKDGADR 60
GSKGSEGALS FPAGQYVAEE LCVSAAKACG IAPVYFNLFA LMREGDGTWF PPSHVFKASP 120
AASESLQFRL RYYFPGWHNH SSPLYPHRYG TSKGTESPVM DDDVMAYLFS QWRSDFLSGR 180
VPVPGSHEAQ EECLGMAVLD MMRLAREQGQ SPGSICSSTS YKAFLPRCMR ERIREYNFVT 240
RKRIRYRFHR FIQQFGECKV AVGNLKLKYL MSLEMLLPSL YSERFRVTDR KGRQVAIVVT 300
GNGGIQRSMG TEEGAEGLLP QELQTFCDFS EVIDMGVQQA NKEGSSEGRV VTVTKQDNQI 360
LEVEFSLLSE ALSFVSLVDG YYRLVADAHH YLCKEVAPPR LLECLQSYCH GPLSMEFTLS 420
KLRCYGNYQG LYILRCSPRD YDKYYMSFVV GHEGALDYKH CQIVKTEAGH FLLSGAKKSY 480
GSIRDLLHCY RKELRTDGYT FQLSRGCPPS PKDKSNLLVC RNSQGAEVAL APCLHTHNIS 540
QMVFHKIRRE DLVLDNSLGQ GTFTKIFRGV RKELGDYGEV HQMDVVVKIL DKAHCNFSES 600
FYEAASMMSQ LSHKHLLLSY GVCVCGDENM MVQEYGKFGS LDTYLKKKKG CVNITWKLEV 660
AKQLSWAMHY LEDKNLVHGN LCAKNVLLIR EEDRMSGSPP FVKLSDPGIS VGVLPLDVLA 720
DRIPWVPPEC IENPQNLSLA ADKWSFGTTL WEICSGGKKP LSTLDSSKKR LFYEDRHQLP 780
APKWTELANL IHSCMDYEPL HRPSFKAVIR DLNSLFTPDY ELLVDSDIVP NRTRGSGFPW 840
ASESQEPTQF EERHLIFIKQ LGKGNFGSVE MCRYDPLQDS TGEVVAVKKL QHSSTEHLRD 900
FEREIEILKS LHHENIVKYK GVGYSAGRRN LRLIMEYLPY GSLRDYLIKH RERFGPSTLL 960
LYASQICKGM DYLAAKRYIH RDLATRNILV ESEMRVKIGD FGLTKVLPQD KEYYTVREPG 1020
ESPIFWWYAP ESLTESKFSV ASDVWSFGVV LYELFTYSDK NCSPPMVFME RMGKEKQGQM 1080
IVYHLIDLLK QGYRLPTPES CPAEIHAIML ECWNSDLELR PSFKALIHSV EAARGGLSR 1139
Nucleotide Sequence
(FASTA)
GTGCTCATGG CCTGTATCCT GCTGACAGAC ATGGAGCCGC CCACCGCCAG CCCCACAGCT 60
GCCCACAACG CCCCGCTGCC CCCCCACGAC CCGGCCTGCA GCCTCCAGCC CAAAGAGGAG 120
CCAGGCGCCA CCTGCCTGCG CGTCCACCTG TACCACCAGG TGAAGGACGG GGCCGACCGT 180
GGGTCCAAAG GCTCCGAGGG GGCCCTGTCC TTCCCCGCCG GCCAGTACGT GGCCGAGGAG 240
CTGTGCGTCA GCGCCGCCAA GGCCTGCGGC ATCGCTCCCG TGTATTTCAA CCTGTTTGCC 300
TTGATGAGGG AGGGCGACGG CACCTGGTTC CCGCCCAGCC ACGTCTTCAA AGCCAGCCCG 360
GCCGCCAGCG AGAGCCTGCA GTTCCGGCTC AGATACTATT TCCCGGGCTG GCACAACCAC 420
AGCAGCCCGC TCTACCCTCA CCGCTACGGG ACGTCCAAAG GCACGGAGAG CCCCGTGATG 480
GACGACGACG TGATGGCCTA CCTCTTCTCC CAGTGGCGCA GCGACTTCCT GAGCGGGCGG 540
GTCCCCGTCC CGGGCAGCCA CGAGGCCCAG GAGGAGTGTC TGGGCATGGC CGTGCTGGAC 600
ATGATGAGGC TGGCCAGGGA GCAGGGCCAG TCGCCGGGCA GCATCTGCAG CAGCACCAGC 660
TACAAGGCCT TTCTGCCCAG GTGCATGCGG GAGCGGATCC GGGAGTACAA CTTTGTGACC 720
CGGAAGCGGA TCCGCTACCG CTTCCACAGA TTCATCCAGC AGTTCGGCGA GTGCAAGGTC 780
GCCGTTGGCA ACCTCAAACT CAAGTACCTG ATGAGCCTGG AGATGCTCCT GCCTTCGCTC 840
TACTCGGAGC GCTTCCGGGT CACCGACCGC AAGGGGCGCC AGGTGGCCAT CGTGGTCACG 900
GGCAACGGCG GCATCCAGCG CTCCATGGGG ACGGAGGAGG GGGCCGAGGG GCTCCTGCCG 960
CAGGAGCTGC AGACCTTCTG CGACTTCTCG GAGGTGATCG ACATGGGCGT CCAACAGGCC 1020
AACAAGGAGG GATCGTCGGA GGGCCGCGTG GTCACCGTCA CCAAGCAGGA CAACCAGATT 1080
CTGGAGGTGG AGTTCAGCCT GCTGTCGGAG GCGCTGTCCT TCGTCTCCCT GGTGGACGGA 1140
TACTACCGCC TGGTGGCCGA CGCCCACCAC TACCTCTGCA AAGAGGTGGC TCCGCCCCGG 1200
CTTCTGGAGT GCCTGCAGAG CTACTGTCAC GGCCCTCTGT CGATGGAGTT CACGCTCAGT 1260
AAGCTGCGTT GCTACGGCAA CTACCAAGGC CTGTACATCC TCCGCTGCAG CCCCAGGGAC 1320
TACGACAAGT ACTACATGTC CTTTGTGGTG GGGCACGAAG GAGCGCTGGA CTACAAACAC 1380
TGCCAGATCG TCAAGACGGA GGCCGGACAC TTCCTCCTGA GCGGCGCCAA GAAGAGCTAC 1440
GGCTCCATCA GGGACCTCCT GCACTGCTAC AGGAAGGAGC TGCGCACCGA CGGCTACACC 1500
TTCCAGCTCA GCAGGGGTTG CCCCCCCAGC CCGAAAGATA AATCCAACCT GCTGGTGTGC 1560
AGGAACAGCC AGGGAGCAGA GGTGGCTCTG GCTCCGTGTC TGCACACACA CAACATCAGC 1620
CAGATGGTCT TCCACAAGAT CCGAAGAGAG GACCTGGTCC TGGACAACAG TCTGGGCCAG 1680
GGCACCTTCA CCAAGATCTT CCGCGGCGTG AGGAAGGAGC TGGGGGACTA CGGGGAGGTG 1740
CACCAGATGG ACGTGGTGGT AAAGATCCTG GACAAGGCGC ACTGCAACTT CTCTGAGTCC 1800
TTCTACGAGG CCGCCAGTAT GATGAGCCAA CTCTCCCACA AGCACCTGCT CCTCAGCTAC 1860
GGTGTTTGTG TCTGTGGCGA CGAGAACATG ATGGTGCAGG AGTATGGCAA GTTCGGCTCG 1920
CTCGACACCT ACCTGAAGAA GAAGAAGGGC TGTGTGAACA TCACCTGGAA GCTGGAGGTG 1980
GCCAAGCAGC TGTCCTGGGC CATGCACTAC CTGGAGGACA AGAACCTGGT TCACGGAAAC 2040
CTCTGTGCCA AGAACGTCCT GCTGATCCGA GAGGAGGACC GGATGTCGGG AAGCCCGCCC 2100
TTCGTCAAGC TGAGCGACCC GGGCATCAGC GTCGGCGTGC TGCCCCTAGA CGTTCTAGCC 2160
GACCGCATCC CCTGGGTGCC CCCCGAGTGC ATCGAAAACC CCCAGAACTT GAGTTTGGCC 2220
GCGGACAAGT GGAGCTTCGG GACCACGCTG TGGGAGATCT GCAGCGGCGG AAAAAAGCCG 2280
CTGAGCACGC TGGACAGCTC CAAGAAGCGC CTGTTTTACG AGGACAGACA CCAGCTGCCG 2340
GCTCCGAAAT GGACCGAGCT GGCCAACCTG ATCCACAGCT GCATGGACTA CGAGCCGCTG 2400
CACCGGCCCT CCTTCAAGGC CGTCATCAGA GACCTCAACA GCCTCTTCAC GCCAGATTAC 2460
GAGCTGCTGG TGGACAGCGA CATCGTCCCC AACAGGACCA GAGGCTCGGG CTTCCCGTGG 2520
GCGTCGGAGA GCCAGGAACC CACCCAGTTT GAGGAGAGAC ACCTCATCTT TATCAAGCAG 2580
CTGGGAAAAG GAAACTTTGG CAGCGTGGAG ATGTGCAGGT ACGACCCGCT GCAGGACAGC 2640
ACGGGAGAGG TGGTGGCCGT GAAGAAGCTG CAGCACAGCT CCACCGAGCA CCTGCGAGAC 2700
TTCGAGCGGG AAATCGAGAT CCTGAAGTCC CTCCACCACG AGAACATCGT CAAGTATAAA 2760
GGAGTGGGCT ACAGCGCCGG ACGGAGGAAC CTGCGCCTGA TCATGGAGTA TCTGCCCTAC 2820
GGCAGCCTCA GAGATTATCT CATCAAACAC AGGGAACGCT TCGGACCCAG CACGCTGCTG 2880
CTCTACGCCT CGCAGATTTG CAAGGGAATG GATTATCTGG CTGCCAAGCG GTACATCCAC 2940
AGAGACCTGG CCACACGCAA CATCCTGGTG GAGAGCGAGA TGAGGGTGAA AATCGGAGAT 3000
TTTGGCCTGA CCAAAGTGCT GCCGCAGGAC AAGGAGTACT ACACAGTGAG GGAGCCGGGA 3060
GAGAGCCCCA TCTTCTGGTG GTACGCTCCC GAGTCCCTCA CCGAGAGCAA GTTCTCCGTG 3120
GCCTCCGACG TTTGGAGCTT CGGCGTCGTC CTCTACGAGC TCTTCACCTA CAGCGACAAG 3180
AACTGCAGCC CACCCATGGT GTTTATGGAG AGAATGGGGA AGGAGAAACA AGGCCAGATG 3240
ATCGTGTACC ACCTGATCGA CCTGCTGAAG CAGGGCTACA GGTTGCCCAC TCCTGAAAGC 3300
TGTCCAGCAG AGATTCACGC CATCATGCTG GAGTGCTGGA ACAGCGACCT GGAGCTGCGA 3360
CCTTCCTTCA AGGCCCTGAT CCACAGCGTG GAGGCCGCGC GAGGCGGCCT GAGCAGATGA 3420
Domain Profile
S: 4     iesLgkgtftkvfevred...aegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
          +sLg+gtftk+f++ ++   ++g+ ++  v++k+L++++ + s++f+++a+++sqlsh+
Q: 555   DNSLGQGTFTKIFRGVRKelgDYGEVHQMDVVVKILDKAHCNFSESFYEAASMMSQLSHK  614
         689************997566778888888******************************
S: 61    hivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLedk  120
         h++  +gvcv+++en +V+ey + GsLd+yL+kkk +++++++l+vakql +am+YLedk
Q: 615   HLLLSYGVCVCGDENMMVQEYGKFGSLDTYLKKKKGCVNITWKLEVAKQLSWAMHYLEDK  674
         ************************************************************
S: 121   klvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripwlap  178
         +lvh++++a+nvL+ re++  +g+ppfvklsdpg++  v      l+ +   +ripw++p
Q: 675   NLVHGNLCAKNVLLIREEDrmSGSPPFVKLSDPGISVGV------LPLDVLADRIPWVPP  728
         ****************9998999****************......***************
S: 179   eclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkcpa  238
         ec+++ +nls+a+d+WsFg+tl+e+  cs g++pl++ ++++k  ++e++++lp+pk++ 
Q: 729   ECIENPQNLSLAADKWSFGTTLWEI--CSGGKKPLSTLDSSKKRLFYEDRHQLPAPKWT-  785
         *************************..********************************.
S: 239   elaelmtnclsyepsqrpsFrailedl  265
         ela+l++ c++yep +rpsF+a+++dl
Q: 786   ELANLIHSCMDYEPLHRPSFKAVIRDL  812
         *************************98
Domain Sequence
(FASTA)
DNSLGQGTFT KIFRGVRKEL GDYGEVHQMD VVVKILDKAH CNFSESFYEA ASMMSQLSHK 60
HLLLSYGVCV CGDENMMVQE YGKFGSLDTY LKKKKGCVNI TWKLEVAKQL SWAMHYLEDK 120
NLVHGNLCAK NVLLIREEDR MSGSPPFVKL SDPGISVGVL PLDVLADRIP WVPPECIENP 180
QNLSLAADKW SFGTTLWEIC SGGKKPLSTL DSSKKRLFYE DRHQLPAPKW TELANLIHSC 240
MDYEPLHRPS FKAVIRDL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00041
EKS-EQC-00028
EKS-FEC-00028
EKS-GAG-00025
EKS-GAA-00047
EKS-GOG-00030
EKS-ICT-00030
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00047
EKS-ORL-00044
EKS-OTG-00031
EKS-PAT-00029
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00027
EKS-TAG-00028
EKS-XET-00030
EKS-XIM-00045
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0048514; P:blood vessel morphogenesis
GO:0030218; P:erythrocyte differentiation
GO:0007259; P:JAK-STAT cascade
GO:0046427; P:positive regulation of JAK-STAT cascade
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0060215; P:primitive hemopoiesis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013