EKS-TEN-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	415.0	1.1E-124	245	498	254

Status

Unreviewed

Ensembl Protein

ENSTNIP00000007835

UniProt Accession

H3CHV7;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000005162	ENSTNIP00000007835	ENSTNIT00000007996

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MEIQKRLSAC WNSFLVCFKK PTQSGENEQK RATVLANVGA TTEPDSRVIR PPVPASTSRG 60

FYVALYDYSA RTEEDLSFNT GDTLEALDRS TGDWWYARAV SGVSANKQGY IPANYVAPVE 120

SIDAEPWYFP DTKRLDAEKL LLSEGNQHGA FLIRNCESQK GELSLSVLDN GRVKHYKLRK 180

AENGHYFVSR TKTFPTLKQL VEHYASQADG LCACLGEPCK KMEVPQTHGL SYNTVDQWEI 240

DRKSIKLLRK LGAGQFGEVF EGLWNDTTPV AVKTLKPGTM DPEDFLREAQ IMKRLRHAKL 300

IQLYAVCTLE DPIYIITELM KYGSLLDYLQ KNKGTTLQIS DQIEMAAQVA SGMAFLELQN 360

YIHRDLAARN VLVGENNICK VADFGLARVF MKDNENVYEA REGTKFPVKW TAPEAIHSNK 420

FSIKSDVWSF GILLYEIMTF GQMPYPTMTN LQVVQKVPQG YRMPCPPSCP KVLYDIMTEC 480

WKEDEQDRPT FETLQWKLED FFDLDVTSYD DASRY 515

Nucleotide Sequence
(FASTA)

ATGGAGATTC AAAAGAGACT TTCCGCATGC TGGAACTCCT TCCTGGTGTG TTTTAAAAAG 60

CCGACCCAGT CAGGAGAAAA TGAGCAGAAG CGGGCCACCG TTCTGGCAAA TGTCGGAGCG 120

ACCACAGAAC CGGACTCTCG TGTCATAAGG CCTCCGGTGC CTGCGTCGAC GTCCAGAGGG 180

TTCTATGTGG CCCTGTACGA TTACTCTGCT CGTACCGAGG AGGACCTGAG TTTTAACACC 240

GGGGACACGT TGGAAGCCCT GGACAGGAGC ACCGGGGACT GGTGGTATGC CCGAGCAGTG 300

AGCGGAGTGT CAGCCAACAA ACAGGGGTAC ATTCCTGCCA ACTACGTGGC CCCCGTGGAG 360

AGTATCGATG CGGAACCGTG GTATTTTCCC GACACCAAGA GGCTGGACGC AGAGAAGTTG 420

CTGCTGTCTG AGGGAAATCA GCATGGTGCT TTCCTCATTA GAAACTGCGA AAGCCAAAAA 480

GGAGAGCTTT CCCTCTCAGT GCTGGACAAT GGGAGGGTGA AGCATTACAA GCTGAGAAAG 540

GCAGAGAATG GACACTACTT TGTGTCGAGG ACCAAAACCT TTCCTACACT GAAGCAGCTG 600

GTGGAACATT ACGCCAGTCA GGCTGATGGT CTGTGTGCAT GTCTGGGTGA ACCGTGCAAG 660

AAGATGGAGG TTCCTCAAAC TCATGGCCTG TCGTACAACA CCGTGGACCA ATGGGAGATT 720

GACCGCAAAT CCATCAAACT GCTAAGGAAG CTGGGAGCCG GTCAGTTTGG AGAAGTGTTT 780

GAGGGTCTCT GGAATGACAC CACACCAGTA GCAGTGAAGA CCCTCAAACC TGGTACAATG 840

GATCCCGAGG ACTTCCTGAG AGAGGCTCAG ATCATGAAGA GGCTACGGCA TGCCAAACTG 900

ATCCAGCTGT ATGCCGTATG CACTCTGGAG GATCCGATCT ACATCATCAC AGAGCTGATG 960

AAGTACGGCA GCCTGCTGGA TTACCTCCAA AAAAATAAAG GGACCACACT GCAAATATCC 1020

GACCAGATCG AGATGGCCGC CCAGGTGGCT TCCGGCATGG CTTTCCTGGA GTTACAGAAT 1080

TACATCCACA GAGACCTGGC AGCCCGGAAT GTTTTGGTGG GCGAGAACAA CATTTGCAAA 1140

GTTGCCGACT TTGGGCTCGC AAGAGTCTTC ATGAAAGATA ATGAAAATGT GTACGAGGCC 1200

AGAGAAGGAA CTAAGTTCCC TGTGAAGTGG ACCGCTCCAG AGGCTATCCA CAGCAACAAG 1260

TTCTCCATTA AATCGGATGT CTGGTCTTTC GGGATTTTAC TTTACGAGAT CATGACGTTC 1320

GGACAGATGC CTTACCCAAC CATGACCAAT CTGCAGGTGG TCCAGAAGGT CCCGCAGGGC 1380

TACAGGATGC CATGTCCTCC CAGCTGCCCT AAAGTCCTGT ATGACATCAT GACGGAGTGC 1440

TGGAAGGAGG ACGAACAGGA CCGGCCCACG TTTGAGACCC TGCAGTGGAA GCTAGAGGAC 1500

TTTTTCGACT TGGACGTGAC ATCTTACGAT GACGCCAGCC GTTATTAG 1548

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +kl++klG+GqfGev++g+w+++++vavktlk+gt++pe+fl+eaqi+k+lrh kl++ly

Q: 245   IKLLRKLGAGQFGEVFEGLWNDTTPVAVKTLKPGTMDPEDFLREAQIMKRLRHAKLIQLY  304

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm+ Gslld+l++++g++l++++++++aaqva+Gma+le +n+ihr

Q: 305   AVCTLEDPIYIITELMKYGSLLDYLQKNKGTTLQISDQIEMAAQVASGMAFLELQNYIHR  364

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar++    ++ y+a+eg+k+P+kWtaPeai+ +kf+ik

Q: 365   DLAARNVLVGENNICKVADFGLARVFMkdnENVYEAREGTKFPVKWTAPEAIHSNKFSIK  424

         ************************764455788***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t G++Pyp mtn +v+++v +gyr+p+p +cp+ ly++++ecwk+d

Q: 425   SDVWSFGILLYEIMTFGQMPYPTMTNLQVVQKVPQGYRMPCPPSCPKVLYDIMTECWKED  484

         ************************************************************

S: 238   peerPtfetlqevl  251

          ++rPtfetlq++l

Q: 485   EQDRPTFETLQWKL  498

         ***********986

Domain Sequence
(FASTA)

IKLLRKLGAG QFGEVFEGLW NDTTPVAVKT LKPGTMDPED FLREAQIMKR LRHAKLIQLY 60

AVCTLEDPIY IITELMKYGS LLDYLQKNKG TTLQISDQIE MAAQVASGMA FLELQNYIHR 120

DLAARNVLVG ENNICKVADF GLARVFMKDN ENVYEAREGT KFPVKWTAPE AIHSNKFSIK 180

SDVWSFGILL YEIMTFGQMP YPTMTNLQVV QKVPQGYRMP CPPSCPKVLY DIMTECWKED 240

EQDRPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013