EPS-TEN-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TEN-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	266.8	2.7E-79	23	288	266

Status

Unreviewed

Ensembl Protein

ENSTNIP00000008010

UniProt Accession

H3CID2;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B (1 of 2)

Gene Synonyms/Alias

PPM1B (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000005327	ENSTNIP00000008010	ENSTNIT00000008172

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKT EKHSAHGEGN ALRYGLSSMQ GWRVEMEDAH TAVVGLPHGL ADWSFFAVYD 60

GHAGSRVANY CSAHLLEHIL SGGADFSSES SSIEGVKDGI RSGFLNIDEY MRSFSDLRQG 120

LDRSGSTAVC VLLSPTHLYF INCGDSRAVL SRDSQVGFST QDHKPCNPRE KERIQKAGGS 180

VMIQRVNGSL AVSRALGDYD YKCVDGKGPT EQLVSPEPEV CVLERVAEGD EFVVLACDGI 240

WDVMSNEELC DFVRSRLLVC DDLEKVCNSV VDTCLHKGSR DNMSVVLVCF PGAPKVSEEA 300

LKKEEELDKY LEARVEELLG SCGEAGVPDL VSVLRSIGAE NIPNLPPGGG LISKRSVIEA 360

VYNKLNPHKE EEGSASELED PW 382

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TCCTGGACAA GCCCAAGACG GAGAAGCACA GCGCCCACGG CGAGGGGAAC 60

GCCCTCCGCT ACGGCCTCAG CTCCATGCAG GGCTGGCGGG TGGAGATGGA GGACGCGCAC 120

ACGGCCGTGG TCGGCCTCCC CCACGGACTG GCCGACTGGT CCTTCTTCGC CGTCTACGAC 180

GGCCACGCGG GCTCCCGGGT GGCCAACTAC TGCTCCGCCC ACCTGCTGGA ACACATCTTG 240

TCCGGAGGCG CCGACTTCAG CTCGGAGTCC AGCTCCATCG AGGGCGTGAA GGACGGCATC 300

CGCTCCGGCT TCCTCAACAT CGACGAGTAC ATGCGCAGCT TCTCCGACCT GAGGCAGGGC 360

CTGGACCGCA GCGGCTCCAC CGCCGTGTGC GTGCTGCTCA GCCCCACCCA CCTCTACTTC 420

ATTAACTGCG GCGACTCTCG GGCCGTGCTG AGCCGAGACT CCCAGGTGGG CTTCTCCACC 480

CAGGACCACA AGCCCTGCAA CCCCCGCGAG AAGGAGCGCA TCCAGAAGGC CGGCGGCTCG 540

GTCATGATCC AGAGGGTGAA CGGCTCCCTG GCCGTGTCCC GGGCCCTGGG GGACTACGAC 600

TACAAGTGTG TGGACGGCAA GGGCCCCACG GAGCAGCTGG TGAGCCCCGA GCCCGAGGTG 660

TGTGTGCTGG AGCGGGTGGC CGAGGGGGAC GAGTTCGTGG TGCTGGCCTG CGACGGCATC 720

TGGGACGTCA TGTCCAACGA GGAGCTGTGC GACTTCGTCC GCTCCCGGCT GCTGGTGTGC 780

GACGACCTGG AGAAGGTCTG CAACTCGGTG GTGGACACGT GTCTGCACAA GGGGAGCAGG 840

GACAACATGA GCGTGGTGTT GGTGTGTTTC CCCGGAGCCC CCAAGGTCTC AGAGGAGGCG 900

CTGAAGAAGG AGGAGGAGCT GGACAAATAC CTGGAGGCCC GCGTGGAAGA GCTGCTGGGG 960

AGCTGCGGGG AGGCCGGGGT CCCCGACCTG GTGTCTGTCC TGAGGAGCAT CGGAGCAGAG 1020

AACATCCCCA ACCTCCCGCC CGGAGGAGGC CTGATCAGCA AACGGAGTGT GATCGAGGCA 1080

GTCTACAACA AGCTGAACCC TCACAAAGAA GAGGAAGGGA GCGCCAGCGA GCTGGAGGAC 1140

CCCTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++         ++ff+vyDGh+gs+va++cs +l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGLPHG---LADWSFFAVYDGHAGSRVANYCSAHLLEHI  79

         69****************985444443...444***********************9999

S: 62    aeele...sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

                 s++s+ + vk+ ++++Fl++de ++ +++ ++  d+sGstav++l+++++ly

Q: 80    LSGGAdfsSESSSIEGVKDGIRSGFLNIDEYMRSFSDLRQGLDRSGSTAVCVLLSPTHLY  139

         887556667778888999******************************************

S: 119   vanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRal  178

         ++n+GdSravL+r+ ++   ++dHkp +++E+eRi++aggsv+ +   Rv+G+LavsRal

Q: 140   FINCGDSRAVLSRDSQVGFSTQDHKPCNPREKERIQKAGGSVMIQ---RVNGSLAVSRAL  196

         *********************************************...************

S: 179   Gdlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeavslvrdv  228

         Gd+++k         ++v+pePev + ++  + def++La+DG+wdv+snee++++vr++

Q: 197   GDYDYKcvdgkgpteQLVSPEPEVCVLERvAEGDEFVVLACDGIWDVMSNEELCDFVRSR  256

         ***************************99788899*************************

S: 229   lekkeaeqeaakkLvklalargskdnvsaivv  260

         l   ++++++++++v+++l++gs+dn+s+++v

Q: 257   LLVCDDLEKVCNSVVDTCLHKGSRDNMSVVLV  288

         ***************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGLPHGLAD WSFFAVYDGH AGSRVANYCS AHLLEHILSG 60

GADFSSESSS IEGVKDGIRS GFLNIDEYMR SFSDLRQGLD RSGSTAVCVL LSPTHLYFIN 120

CGDSRAVLSR DSQVGFSTQD HKPCNPREKE RIQKAGGSVM IQRVNGSLAV SRALGDYDYK 180

CVDGKGPTEQ LVSPEPEVCV LERVAEGDEF VVLACDGIWD VMSNEELCDF VRSRLLVCDD 240

LEKVCNSVVD TCLHKGSRDN MSVVLV 266

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013