EPS-TEN-00040
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-TEN-00040
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPM/PP2C168.72.2E-49704952249
StatusUnreviewed
Ensembl ProteinENSTNIP00000008984
UniProt AccessionH3CL55;
Protein Name
Protein Synonyms/Alias
Gene NamePHLPP1 (2 of 2)
Gene Synonyms/Alias PHLPP1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000006232ENSTNIP00000008984ENSTNIT00000009155
OrganismTetraodon nigroviridis
Functional Description
Protein Length1164
Protein Sequence
(FASTA)
ALFVQLHGGT VRRLADHERP LQILNEYLSN LGYQDPWRVQ GEGLNPEIGC LIRFYFGKPR 60
SVGGAERVQL SGVFNVRKGK LALPVNRWSK RQVTLSGTCL IVSSVKHAHT GKMHILPLIG 120
GKVEEVRRHS HCLAFSAASS QSQTYYVSYD SYTEHLRWLR TASKMASQRV NSVDLSCCSL 180
EELPPQLFYS QDLTHLNLKN NFMSLHKGVP ALTRFCKLRS LSLSNNALAE FPLVLCDMSS 240
LSELNLSGNQ LSWLPAELGT MHSVRTLLLD GNLLDSLPAE LGSLEGLAYL GLSFNRFSCV 300
PPVLEKLRNL EKLCLAGNQL SALDVAELQW LSVRQVDLRL NRIQTVTGGD PEQLLHLVHL 360
DVRDAGLQEL DVRPLCRLEL LRCDRNSLTL LRVSGHALKS LHASHNELKL LEVQPVPETL 420
TDVDLSWNQL RGVPEGLCDG GRMEVLDISH NRVEELPTSR LMSSRSLRKL LAGWNRVTRL 480
AERVERSQLE VLDLQHNHLT DLPHNLFIKA QSLRHLNASA NRLESLPAAG QSEESCSSLE 540
ELYLTNNSLT DMCVPLLSEH ARLRVLHLAY NQLQSFTASK LARLEQLEEL DLSGNRLRCV 600
PTTVLGCRRL HTLSAHSNCI CTFPEVLQLP DIKCVDLSCN ELSEVTLPEV LPARLQELDL 660
TGNPRLNLDH KSLELLNNIR CFRVDPSPSA PCVSERHGAP AVWSHGYTEA SSAKNKLCVA 720
ALALDSFCGV REALYGVFDG DKNVEVPNLL QCTMGDVLAE ELDRKRRQED YMTSTFLTMQ 780
RKLGTAGQRM GGSAALCHIR HDPVAPSEHG GCFTLKAASV GWCQAVLCRA GRAVPLSLTH 840
TVKDEDEYLR VRRHNAVITE DNKVGGVSGT SRILGYTYLC PSVSPRPHVS TLSLTPQDEF 900
FLLGSRGLWD FLSPDEAVEA VRNVPDALAA AKKLVSLAQS YGCCDSLSAV VVQLSITQDC 960
CCFCHSSPQP FPLGEGVALP AAASSELSSE FSTSEMSSEV GSTASSEEPP SQPEAPASHF 1020
QRQLSGALSD NGADSEDEEP LVGVFSNGSR VEVEADVHCL QRHDSAAPLR EAQPGCRARA 1080
NGSVACQGQN QDLIEEAADV PVRKQGGYFS APAQPDPDDQ LIVPPELEEE VRQEQMQMHN 1140
QQSRCSPAPS PDTAQPDSSF STAP 1164
Nucleotide Sequence
(FASTA)
GCTCTGTTCG TCCAGCTGCA CGGCGGGACG GTGCGCCGGC TCGCCGACCA CGAGAGGCCC 60
CTGCAGATCC TGAACGAGTA CCTGAGCAAC CTGGGCTACC AGGACCCCTG GAGGGTCCAG 120
GGGGAGGGCC TGAACCCCGA GATCGGCTGC CTGATTCGCT TCTACTTTGG AAAGCCTCGC 180
TCGGTGGGCG GAGCCGAGCG CGTGCAGCTG TCGGGGGTGT TTAACGTGCG GAAGGGCAAG 240
CTGGCGCTGC CGGTGAACCG CTGGTCCAAG CGCCAAGTCA CCCTGAGTGG AACCTGCCTC 300
ATCGTTTCCT CCGTCAAGCA CGCCCACACC GGAAAGATGC ACATCCTCCC GCTCATCGGA 360
GGAAAGGTGG AGGAGGTGAG GAGACACAGC CACTGTCTGG CCTTCAGCGC CGCCTCCTCC 420
CAGAGTCAGA CCTACTACGT CAGCTACGAC TCCTACACGG AGCACCTCCG CTGGCTCAGG 480
ACGGCCTCCA AGATGGCCTC CCAGAGGGTG AACTCGGTGG ACCTGTCCTG CTGCAGCCTG 540
GAGGAGCTGC CCCCGCAGCT CTTCTACAGC CAGGACCTGA CGCACCTCAA CCTGAAGAAC 600
AACTTCATGT CGCTGCACAA AGGTGTTCCA GCGCTCACCA GGTTCTGTAA GCTGAGGAGT 660
CTCAGCCTGT CCAATAACGC CCTGGCAGAG TTTCCTCTGG TGCTGTGCGA CATGTCTTCG 720
CTCTCGGAGC TCAACCTGTC TGGAAACCAG CTGTCCTGGC TCCCCGCTGA GCTGGGAACC 780
ATGCACAGCG TGCGGACTCT CCTCCTGGAC GGGAACCTCC TCGATTCCCT GCCGGCTGAG 840
CTGGGCTCCC TGGAGGGCCT GGCCTACCTG GGCTTGTCCT TCAACCGCTT CAGCTGTGTG 900
CCGCCGGTCC TGGAGAAGCT GCGGAACCTG GAGAAGCTCT GCCTGGCCGG GAACCAGCTG 960
TCGGCCCTGG ACGTGGCTGA GTTGCAGTGG CTGTCTGTCC GCCAGGTGGA CCTCAGGCTG 1020
AACCGGATCC AGACGGTGAC GGGTGGAGAC CCGGAGCAGC TGCTCCACCT TGTCCACCTG 1080
GACGTGAGGG ACGCTGGTCT TCAGGAGCTG GACGTGCGTC CTCTGTGCCG GTTGGAGCTC 1140
CTCCGCTGTG ACAGGAACTC CCTCACCCTG CTCAGAGTGA GCGGCCACGC CCTCAAGAGC 1200
TTGCACGCCT CGCACAACGA GCTGAAGCTG CTGGAGGTGC AGCCGGTGCC AGAGACGCTG 1260
ACCGATGTGG ACCTGTCCTG GAACCAGCTG CGAGGCGTCC CAGAGGGGCT GTGTGACGGC 1320
GGCCGGATGG AGGTTCTGGA CATCAGCCAC AACCGTGTGG AGGAGCTGCC TACAAGCAGG 1380
CTGATGTCCA GCCGGAGTTT GAGGAAACTG CTGGCAGGCT GGAACCGAGT GACCCGGCTG 1440
GCTGAGCGGG TGGAGCGGTC CCAGCTGGAG GTCCTGGACC TGCAGCACAA CCACCTGACG 1500
GATCTGCCGC ACAACCTCTT CATCAAAGCG CAGAGCCTGC GCCACCTCAA CGCCTCAGCC 1560
AACCGGCTGG AGAGCCTCCC TGCAGCCGGC CAATCAGAGG AGAGCTGCAG CAGCCTGGAG 1620
GAGCTCTACC TGACCAACAA CAGCCTGACG GACATGTGCG TCCCCCTGCT GAGCGAGCAC 1680
GCCCGCCTCA GGGTGCTGCA CCTGGCCTAC AACCAGCTGC AGAGCTTCAC CGCCAGTAAA 1740
CTGGCCCGGC TGGAGCAGCT GGAGGAGCTG GACCTGAGCG GCAACAGGCT GAGGTGCGTG 1800
CCCACCACCG TCCTCGGCTG TCGGCGCCTG CACACGCTCT CCGCCCACTC CAACTGCATC 1860
TGCACCTTCC CCGAGGTCCT GCAGCTGCCT GACATCAAGT GTGTGGACCT GAGCTGCAAC 1920
GAGCTGAGCG AGGTGACCCT GCCGGAGGTT CTTCCGGCCC GGCTGCAGGA GCTGGACCTG 1980
ACCGGGAACC CTCGGCTCAA CCTGGACCAC AAGAGCCTGG AGCTCCTGAA CAACATCAGG 2040
TGCTTCAGGG TGGACCCGTC GCCTTCGGCG CCGTGCGTGA GCGAGCGCCA CGGCGCTCCC 2100
GCCGTCTGGA GCCACGGCTA CACCGAAGCC TCCTCGGCGA AGAACAAGCT GTGCGTGGCG 2160
GCGCTGGCTC TGGACAGCTT CTGCGGGGTC CGCGAGGCGC TCTACGGCGT GTTTGACGGG 2220
GACAAGAACG TGGAGGTTCC CAACCTGCTG CAGTGCACCA TGGGAGACGT GCTGGCGGAG 2280
GAGCTGGACA GGAAGCGGCG GCAGGAGGAC TACATGACCA GCACCTTCCT CACCATGCAG 2340
AGGAAGCTGG GCACGGCGGG GCAGCGGATG GGAGGCTCGG CGGCGCTCTG TCACATCAGA 2400
CACGACCCGG TGGCGCCCAG CGAGCACGGC GGCTGCTTCA CGCTGAAGGC GGCCAGCGTG 2460
GGCTGGTGCC AGGCCGTGCT GTGCCGCGCC GGCAGAGCGG TGCCGCTGTC GCTCACCCAC 2520
ACGGTGAAGG ACGAGGACGA GTACCTGAGG GTCCGCCGGC ACAACGCCGT CATCACCGAG 2580
GATAACAAGG TGGGCGGAGT CAGCGGCACC AGCCGGATCC TGGGCTACAC CTACCTCTGC 2640
CCGTCTGTCT CGCCGCGACC GCACGTCAGC ACGCTCAGCC TCACGCCGCA GGACGAGTTC 2700
TTCCTGCTGG GCAGCCGGGG GCTGTGGGAC TTCCTGTCCC CCGACGAGGC GGTGGAGGCG 2760
GTCCGCAACG TCCCCGACGC CCTGGCGGCC GCCAAGAAGC TGGTGAGCCT GGCTCAGAGC 2820
TACGGCTGCT GCGACAGCCT GAGCGCCGTG GTGGTGCAGC TCAGCATCAC CCAGGACTGC 2880
TGCTGCTTCT GCCACAGCAG CCCGCAGCCC TTCCCGCTGG GGGAGGGCGT GGCGCTGCCC 2940
GCCGCCGCCT CCTCCGAGCT GAGCAGCGAG TTCAGCACCT CGGAGATGAG CAGCGAGGTG 3000
GGCTCCACGG CGTCCTCGGA GGAGCCGCCG TCGCAGCCCG AGGCCCCCGC CTCCCACTTC 3060
CAGAGGCAGC TGTCGGGAGC GCTGTCGGAC AACGGCGCCG ACAGCGAGGA CGAGGAGCCG 3120
CTGGTGGGCG TCTTCTCCAA CGGCAGCCGT GTGGAGGTGG AGGCCGACGT GCACTGCCTG 3180
CAGCGCCACG ACAGCGCCGC TCCTCTGAGG GAGGCGCAGC CGGGCTGCAG GGCCCGAGCC 3240
AACGGCTCGG TGGCGTGCCA GGGACAGAAC CAGGACCTCA TCGAGGAGGC GGCCGACGTC 3300
CCCGTCAGGA AGCAGGGGGG GTACTTCAGC GCCCCCGCCC AGCCGGACCC TGACGACCAG 3360
CTCATCGTCC CCCCGGAGCT GGAGGAGGAG GTGCGCCAGG AACAAATGCA AATGCACAAC 3420
CAGCAAAGCC GCTGTAGCCC CGCCCCCAGC CCGGACACCG CCCAACCAGA CTCCTCCTTT 3480
TCTACAGCCC CC 3492
Domain Profile
S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61
         ++g+++ +  +n+++ a+ + ++f+  +e     a++gv+DG+++ ev + +++++ ++l
Q: 704   SHGYTEASSAKNKLCVAALALDSFCGVRE-----ALYGVFDGDKNVEVPNLLQCTMGDVL  758
         67899999999999999999888888766.....59************************
S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115
         aeel+    ++r+ +++++++Fl+++++l       ++ +++G +a +++i+++      
Q: 759   AEELD----RKRRQEDYMTSTFLTMQRKL------GTAGQRMGGSAALCHIRHDpvapse  808
         ***98....9999999*************......999**************99999***
S: 116   .....klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlG  170
              +l  a vG ++avLcr g av+ls +H+++ edE+ R++++ + +++++  +v G
Q: 809   hggcfTLKAASVGWCQAVLCRAGRAVPLSLTHTVKDEDEYLRVRRHNAVITEDN--KVGG  866
         ***999999*************************************97777777..****
S: 171   vLavsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle  230
         v   sR lG +yl p v+p+P+v+   lt++def+ L+s Glwd +s+ eav++vr+v +
Q: 867   VSGTSRILGYTYLCPSVSPRPHVSTLSLTPQDEFFLLGSRGLWDFLSPDEAVEAVRNVPD  926
         ************************************************************
S: 231   kkeaeqeaakkLvklalargskdnvsaivv  260
             + +aakkLv la+++g+ d++sa+vv
Q: 927   ----ALAAAKKLVSLAQSYGCCDSLSAVVV  952
         ....************************97
Domain Sequence
(FASTA)
SHGYTEASSA KNKLCVAALA LDSFCGVREA LYGVFDGDKN VEVPNLLQCT MGDVLAEELD 60
RKRRQEDYMT STFLTMQRKL GTAGQRMGGS AALCHIRHDP VAPSEHGGCF TLKAASVGWC 120
QAVLCRAGRA VPLSLTHTVK DEDEYLRVRR HNAVITEDNK VGGVSGTSRI LGYTYLCPSV 180
SPRPHVSTLS LTPQDEFFLL GSRGLWDFLS PDEAVEAVRN VPDALAAAKK LVSLAQSYGC 240
CDSLSAVVV 249
KeywordComplete proteome; Leucine-rich repeat; Reference proteome; Repeat.
Sequence SourceEnsembl
Orthology
Ortholog group
Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EPS-GAM-00030
EPS-GAA-00048
EPS-ORN-00041
EPS-TAR-00050
EPS-XIM-00054
Gene Ontology
GO:0003824; F:catalytic activity
GO:0005543; F:phospholipid binding
GO:0008152; P:metabolic process
GO:0007165; P:signal transduction
KEGG
InterPros
IPR001611; Leu-rich_rpt.
IPR003591; Leu-rich_rpt_typical-subtyp.
IPR001849; Pleckstrin_homology.
IPR001932; PP2C-like.
IPR000159; Ras-assoc.
Pfam
PF00560; LRR_1; 1.
PF00481; PP2C; 1.
SMARTs
SM00369; LRR_TYP; 1.
SM00332; PP2Cc; 1.
Prosites
PS51450; LRR; 18.
PS50003; PH_DOMAIN; 1.
PS50200; RA; 1.
Prints
Created Date20-Feb-2013