EKS-TEN-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	439.1	5.7E-132	13	297	285

Status

Unreviewed

Ensembl Protein

ENSTNIP00000009137

UniProt Accession

H3CLK7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5 (1 of 2)

Gene Synonyms/Alias

CDKL5 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000006372	ENSTNIP00000009136	ENSTNIT00000009307
ENSTNIG00000006372	ENSTNIP00000009137	ENSTNIT00000009308

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

810

Protein Sequence
(FASTA)

MKNPDIGDVM NKFEVLGIVG EGAYGVVLKC RHKETNEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EELPNGVPTD KARSYIYQLI 120

RAIHWCHKHD IVHRDIKPEN LLISSDDVLK LCDFGFARSL SEGTDANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYN 240

NPRFHGLRFP AVNHHQTLER RYLGIIGGGL LDLLKNLLLL TPTERFLTEQ CLNHHAFQTL 300

RLVERSGPPT PTPVRSSKRK PHHGDNTTPS RSPSSQTQST VLYRGHRSSS RECSSLPRHE 360

DLHPNNDAFL NGSMTAAINL SPTLHPKNYQ PQVYNHSTSC SMDLASSNLP HLLSPGESKS 420

KCDFDLNLGS KVPDGPGAKY LNSNFRSQQN RHSFVEGKTN TLQSGDKHSR HGYMEAHSSM 480

PSSKFAYLNL SKSYGTLSDA KSVGNLNDVH LYADEPTSRY FPSSCLDLTA PSSPAARRMD 540

RLGLVASGRG STRSDRESNT LDSSHRRSSI RLKASEEAKS PDGLDPGDSG MERSHAHSLS 600

SPREPLAYSQ GYTSPFSSQQ RPHRHSMYVR RDHQRTHGAE EGLAVGQGLP TRAKSLQLLS 660

PQLSEQTPTE VTHSRPPIRD STRDNTASFH TQRQNSEVGL YHDQQAEDGG SSKENRNIYS 720

ESMPRRVGSF YRVPSPRPDN SFHDSRGQSR DSGLSSDGSR LTNHSKRQPG FDPWTGPDTV 780

VLNPSEPSKE KEKQGFFRAI KKKKKKSQMV 810

Nucleotide Sequence
(FASTA)

ATGAAGAACC CCGACATTGG TGATGTGATG AATAAATTTG AAGTCCTTGG GATCGTGGGT 60

GAAGGTGCTT ACGGTGTTGT TTTGAAGTGT CGTCACAAGG AGACAAATGA AATAGTGGCC 120

ATTAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTTA AGGAAACAAC ACTGCGGGAG 180

CTCAAGATGC TCCGCACCCT CAAGCAGGAA AATATTGTGG AGCTGAAGGA GGCCTTCCGG 240

AGACGAGGGA AGCTCTACCT TGTCTTTGAG TATGTGGAAA AGAACATGCT GGAGCTGCTG 300

GAGGAGCTAC CAAATGGCGT ACCAACAGAC AAAGCACGCA GCTACATCTA CCAGTTAATC 360

AGAGCAATTC ACTGGTGCCA CAAGCACGAC ATAGTTCACC GGGATATAAA GCCTGAGAAC 420

CTTCTCATCA GCTCAGATGA TGTTCTCAAA TTATGCGACT TTGGCTTTGC ACGCAGTCTC 480

TCAGAGGGAA CCGATGCTAA TTACACCGAG TATGTGGCCA CTAGATGGTA CCGCTCTCCA 540

GAGCTCCTGC TTGGGGCTCC GTACGGAAAG GCGGTGGACA TGTGGTCAGT GGGCTGTATA 600

CTAGGAGAGC TGAGCGACGG GCAGCCTCTA TTCCCAGGAG AGAGCGAGAT TGACCAGCTC 660

TTTACCATCC AGAAAGTGCT AGGCCCCCTA CCATCAGAAC AGATGAAGCT CTTTTATAAT 720

AACCCCCGCT TCCATGGGCT GAGGTTTCCT GCGGTGAACC ACCATCAGAC CTTAGAGAGA 780

AGATACCTGG GGATCATTGG TGGAGGCCTT CTGGATCTGC TCAAGAACCT GCTGCTGCTG 840

ACCCCGACGG AACGCTTTCT CACCGAGCAG TGTTTGAACC ACCACGCCTT CCAGACCCTG 900

CGGCTGGTGG AGCGGTCCGG CCCACCCACA CCTACACCTG TACGCTCCTC CAAGAGAAAA 960

CCTCACCATG GAGACAACAC CACCCCCAGC AGGTCACCAT CCAGTCAGAC ACAGAGTACT 1020

GTCCTATATA GAGGTCACCG CTCGAGCAGC AGAGAATGTT CCAGCTTGCC TCGTCATGAA 1080

GACCTCCACC CCAACAACGA CGCTTTTCTC AATGGCAGCA TGACTGCAGC CATCAATCTC 1140

AGTCCCACTC TGCATCCGAA GAACTACCAG CCGCAGGTCT ACAACCACTC CACCTCGTGC 1200

AGCATGGACC TGGCCAGCAG CAACCTGCCC CATCTGCTTA GCCCTGGTGA ATCCAAGAGC 1260

AAGTGCGACT TTGACTTGAA CCTTGGGTCA AAGGTTCCCG ACGGCCCGGG AGCCAAGTAC 1320

CTGAACTCCA ACTTCCGTTC ACAGCAGAAC CGCCATTCCT TTGTGGAGGG GAAGACCAAC 1380

ACGCTACAGT CAGGAGATAA ACACAGTCGC CACGGCTACA TGGAAGCCCA CAGCTCCATG 1440

CCATCTTCTA AGTTTGCCTA TTTGAACTTG TCCAAGAGCT ACGGAACACT CAGCGATGCC 1500

AAGTCCGTGG GGAATTTAAA CGATGTGCAT CTTTATGCCG ATGAGCCTAC ATCTCGCTAT 1560

TTTCCCTCGA GCTGCCTGGA CCTCACGGCT CCGAGCAGCC CCGCAGCCCG CCGCATGGAC 1620

AGACTGGGGC TCGTCGCCAG CGGAAGAGGG AGCACGCGCT CGGACAGAGA GAGCAACACG 1680

CTGGACTCAT CGCACAGGCG CTCCTCAATC CGTCTGAAGG CCTCAGAGGA GGCCAAGTCC 1740

CCGGACGGCC TGGACCCCGG AGACAGCGGC ATGGAGAGGA GCCACGCCCA CTCGCTGTCC 1800

TCGCCACGCG AACCTCTGGC CTACAGTCAG GGATACACCA GCCCCTTCTC CTCCCAGCAG 1860

CGGCCCCACC GCCACTCCAT GTACGTGCGG AGAGACCACC AGCGGACACA CGGGGCAGAG 1920

GAGGGGCTGG CGGTGGGGCA GGGCTTGCCC ACCAGAGCCA AGAGCCTGCA GCTGCTGTCT 1980

CCGCAGCTGA GCGAGCAGAC ACCCACTGAG GTCACCCACA GCAGACCCCC AATAAGGGAC 2040

TCCACCAGGG ACAACACTGC GTCTTTTCAC ACACAGCGGC AAAATAGCGA GGTGGGCTTG 2100

TATCATGACC AGCAAGCGGA AGATGGGGGC TCCTCAAAAG AAAACCGCAA CATCTACAGT 2160

GAATCCATGC CCAGGAGGGT GGGCAGCTTC TACAGAGTCC CTTCTCCCCG GCCAGACAAC 2220

TCCTTTCATG ACAGCAGAGG CCAGAGCCGG GATTCAGGTT TGTCCTCGGA TGGAAGCAGA 2280

TTGACAAACC ACTCAAAACG CCAGCCGGGA TTTGACCCTT GGACTGGCCC AGACACGGTT 2340

GTGCTGAACC CCTCGGAGCC ATCCAAAGAA AAAGAAAAGC AGGGTTTCTT CAGGGCTATA 2400

AAGAAGAAAA AGAAAAAATC CCAAATGGTA 2430

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEVLGIVGEGAYGVVLKCRHKETNEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le+ pnGv++++ ++++yq+++ai++chk++i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGVPTDKARSYIYQLIRAIHWCHKHDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis ++v+klcdfGfar l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISSDDVLKLCDFGFARSLSeGTDANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************978899*******************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYNNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++ ++le++y   +   lldllk++l l p+er+++e++l+h+ f

Q: 252   VNHHQTLERRYLgIIGGGLLDLLKNLLLLTPTERFLTEQCLNHHAF  297

         ***********9778899*************************987

Domain Sequence
(FASTA)

FEVLGIVGEG AYGVVLKCRH KETNEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE LPNGVPTDKA RSYIYQLIRA IHWCHKHDIV 120

HRDIKPENLL ISSDDVLKLC DFGFARSLSE GTDANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYNNP RFHGLRFPAV 240

NHHQTLERRY LGIIGGGLLD LLKNLLLLTP TERFLTEQCL NHHAF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013