EKS-TEN-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	363.0	8.3E-109	72	323	252

Status

Unreviewed

Ensembl Protein

ENSTNIP00000009209

UniProt Accession

H3CLT0;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000006441	ENSTNIP00000009209	ENSTNIT00000009380

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1231

Protein Sequence
(FASTA)

MAAVSSGGAA GSAAAAITHS SRTTHAGMGS QNRVQPPSGL NHSSRTSAAA GCLTNPGHTS 60

ATRPPPARVG HYEIERTIGK GNFAVVKLAT HIITKAKVAI KIVDKSQLDD ENLKKIFREV 120

QIMKLLKHPH IIRLYQVMET ERMIYLVTEY ASGGEIFDHL VAHGRMAEKD ARKKFKQIVA 180

AVYFCHCRNI VHRDLKAENL LLDHNLNIKI ADFGFSNMFS KGQLLKTWCG SPPYAAPELF 240

EGKEYDGPKV DIWSLGVVLY VLVCGALPFD GSTLQNLRAR VLSGKFRIPF FMSTDCEYLI 300

RHMLVLEPSR RLTMEQICKN KWMRQGDPDP EFDRLIAECE QVKTEREMEL ISEQVLIAMS 360

EMGLDRERTI QSLQTDVYDH YSAIYSLLAD RLKKHKTLPV VLPTPRPISY PTDSQGNPVS 420

MTVPHVQLIN PENQIVEPDG SMALDSDEGE EPSPEAMARY LSMRRTTVGV PDQRAEMQED 480

LQKLPPGFPR GAVPQPSFPP LAPVMGPMHT LMPTQSLQPT QQLEYKEQSL LQPPTLQLLN 540

GMGPLGRRAS DGGANIQLHA QLLKRPRGPS PLVASPHPIA AVAPVDEEGS DGEPDQEAVQ 600

SHQRSSYKDC NTLHLPMERF SPVRRFSDGA ATIQAFKAHL ENSSLIKKLK QECEELQKKY 660

AAQQDEQFLE HTQQQHILYQ QEQQILHQQI QGLSLGHVES QPSHLTHQLQ RLRIQPSSPP 720

PTHPSNHLFR QPNQSPPPGS AAIMQAHAGP SSVQYQHGAP VLYQAQSGSP PATGLPRVSL 780

PTSQQGPAAH TPVPLAPGVV TIQVQEVELA GGAQRQAAFL ATPGGHRVLG KQLSADNAES 840

HSRSLGRFTS GYEQVQFNPQ LFSGDSASHG TPAMVGTYSP YLQGASLKVP GLEGFQSGVV 900

GTGSYGTPST LQQALLSPTP LDYRPPQQHV TPTLQGLLSP RHSLTGHADP RLPLQDLAAL 960

LKRQSPRSCQ GTPTPPSGTP QDYGEMLLLR QLSQGESLDP PQASPGGQHY HHLLQIRPPD 1020

LQSPQHPTQP PGPSLPHSES MEEDETPAGY HHPHDGLLTK AGEGNELLGP PRGGTPPYSS 1080

PTHRHAAYIR SAPAPRESEH VECRPPGQTM EVPDHNGVGY LRGPQGEAYR SRGQLQRHHT 1140

IQTCDDAYDQ ADSMSGMSLL AGKALSSARM SDILSQTSLT GSQQLQQRQE SVCDVDGELH 1200

AAACYPSSCT SDMLLTYKPP DLQYSMEQAG V 1231

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTCAAGCGG AGGTGCTGCT GGGTCTGCCG CGGCCGCGAT TACGCATTCT 60

TCCCGAACGA CCCACGCAGG CATGGGCTCC CAGAACCGAG TCCAGCCACC CTCCGGCCTT 120

AACCACTCCA GTCGAACCAG CGCGGCCGCT GGGTGCTTGA CCAATCCCGG CCACACTTCG 180

GCCACCAGGC CCCCCCCTGC CCGTGTGGGC CACTATGAAA TCGAGCGGAC CATCGGCAAG 240

GGAAATTTTG CGGTTGTCAA ACTAGCCACA CACATCATTA CCAAAGCAAA GGTGGCTATA 300

AAGATCGTCG ACAAGAGCCA GCTGGATGAT GAGAACCTGA AAAAGATCTT CAGAGAGGTG 360

CAAATCATGA AGTTGCTCAA GCACCCCCAC ATCATCCGCC TCTATCAGGT GATGGAGACG 420

GAGAGAATGA TCTATCTGGT AACAGAATAC GCCAGCGGGG GAGAGATTTT TGACCATTTG 480

GTGGCTCATG GTCGTATGGC AGAAAAGGAC GCCAGGAAGA AGTTCAAGCA GATTGTTGCC 540

GCCGTTTATT TCTGCCATTG CCGCAACATT GTCCACAGAG ACCTAAAGGC TGAAAATCTG 600

CTTTTGGACC ACAATCTCAA TATCAAAATA GCAGATTTTG GCTTCAGTAA CATGTTTTCA 660

AAAGGACAGC TCCTGAAGAC GTGGTGCGGC AGTCCGCCTT ACGCTGCGCC CGAGTTGTTT 720

GAAGGCAAAG AGTACGACGG GCCTAAAGTA GACATATGGA GCTTAGGTGT GGTTTTATAC 780

GTGCTGGTCT GTGGCGCTCT GCCCTTTGAT GGCAGCACTC TACAAAACCT GCGAGCGCGG 840

GTCCTCAGTG GCAAATTCCG CATCCCCTTC TTCATGTCCA CAGACTGTGA GTACCTGATC 900

AGACACATGT TAGTGCTGGA ACCCAGCAGA CGGCTGACCA TGGAGCAGAT CTGTAAGAAC 960

AAGTGGATGA GGCAGGGAGA CCCTGACCCG GAGTTCGACA GGCTGATAGC AGAATGTGAG 1020

CAGGTGAAGA CGGAGAGAGA GATGGAGCTC ATCAGTGAGC AGGTTCTCAT TGCCATGTCT 1080

GAGATGGGAC TGGACCGCGA ACGCACCATC CAGTCCTTAC AAACAGACGT CTACGATCAC 1140

TACAGCGCCA TCTACAGTCT GCTGGCGGAC CGCCTCAAGA AACACAAGAC CCTGCCTGTT 1200

GTGCTGCCGA CGCCGCGGCC CATCAGCTAC CCTACGGATT CACAGGGCAA TCCTGTTAGC 1260

ATGACTGTTC CCCACGTCCA GCTCATCAAC CCAGAAAACC AGATTGTTGA GCCGGACGGC 1320

AGCATGGCAC TAGACAGCGA TGAGGGAGAA GAACCTTCTC CCGAGGCCAT GGCTCGTTAC 1380

CTTTCCATGA GGCGGACAAC TGTGGGGGTA CCAGACCAAA GGGCAGAGAT GCAGGAAGAC 1440

TTACAGAAGC TGCCTCCAGG ATTCCCACGT GGTGCAGTGC CCCAGCCCTC ATTCCCCCCT 1500

CTGGCCCCAG TCATGGGGCC AATGCACACT CTGATGCCCA CGCAGAGTTT ACAACCCACA 1560

CAGCAACTGG AATACAAGGA GCAGTCCCTG TTACAGCCAC CAACCCTACA GCTGCTTAAT 1620

GGCATGGGGC CGCTGGGCCG CAGAGCTTCT GATGGAGGAG CTAATATTCA GCTACACGCT 1680

CAGCTGCTCA AGAGGCCCCG GGGGCCTTCC CCACTTGTTG CCAGCCCGCA CCCAATCGCT 1740

GCTGTCGCAC CCGTGGATGA AGAGGGTTCG GATGGAGAGC CGGACCAAGA GGCAGTACAG 1800

AGCCACCAAA GGTCCAGCTA CAAGGACTGC AATACCCTTC ACCTGCCCAT GGAGCGCTTC 1860

TCACCGGTCC GACGCTTTTC CGATGGAGCA GCCACAATCC AGGCTTTCAA GGCCCACCTG 1920

GAGAATAGCA GTCTCATCAA AAAGCTCAAA CAGGAATGTG AGGAGCTTCA GAAGAAGTAT 1980

GCTGCTCAGC AGGACGAGCA GTTTCTGGAG CACACCCAGC AGCAGCACAT CCTGTACCAG 2040

CAAGAGCAAC AAATCCTCCA CCAGCAAATC CAAGGTCTGT CGCTAGGCCA CGTAGAGAGC 2100

CAGCCCAGTC ACCTGACCCA CCAGCTCCAG AGATTACGTA TTCAGCCCTC CAGCCCTCCG 2160

CCAACACATC CCAGCAACCA CCTCTTCAGA CAGCCTAACC AGAGTCCTCC ACCTGGCTCT 2220

GCAGCCATAA TGCAGGCGCA TGCGGGTCCC TCCTCGGTCC AGTACCAGCA CGGTGCTCCG 2280

GTGCTCTACC AGGCTCAGAG TGGGAGCCCA CCTGCAACAG GCTTACCAAG AGTCTCCTTA 2340

CCAACCAGTC AGCAAGGGCC CGCCGCTCAC ACCCCCGTCC CACTGGCCCC GGGCGTAGTG 2400

ACCATTCAGG TCCAGGAGGT GGAGCTGGCG GGTGGAGCCC AAAGGCAGGC CGCCTTCCTG 2460

GCCACGCCGG GAGGTCACAG GGTCCTCGGG AAGCAGCTGA GCGCTGACAA TGCCGAGTCT 2520

CACAGTCGCA GCCTCGGCCG CTTCACCTCG GGTTACGAAC AGGTCCAGTT CAACCCCCAG 2580

CTGTTCTCCG GCGACAGCGC CTCTCACGGG ACCCCGGCCA TGGTGGGCAC CTACAGCCCT 2640

TACCTGCAAG GGGCCTCCCT CAAGGTCCCA GGCCTGGAAG GCTTCCAGAG CGGGGTGGTG 2700

GGCACCGGCA GCTACGGCAC CCCCTCCACA CTACAGCAGG CTCTGCTCTC TCCCACTCCT 2760

CTGGACTACC GCCCGCCCCA GCAGCACGTC ACCCCCACCC TGCAGGGCCT GCTCTCCCCT 2820

CGCCATTCTT TGACGGGCCA CGCTGACCCC CGGCTGCCCC TGCAGGACTT GGCCGCCCTG 2880

CTGAAGAGAC AGAGCCCCCG CTCGTGCCAG GGCACCCCCA CGCCACCCAG TGGTACGCCC 2940

CAGGACTATG GAGAAATGCT GCTGTTGCGC CAGCTGAGCC AGGGCGAAAG TTTAGACCCC 3000

CCCCAAGCCT CCCCCGGGGG CCAGCATTAC CACCATCTCC TCCAGATACG GCCCCCAGAC 3060

CTCCAGTCGC CCCAGCACCC GACCCAGCCG CCGGGCCCCA GCCTGCCTCA CTCCGAGAGC 3120

ATGGAGGAGG ACGAGACGCC AGCGGGCTAC CACCACCCGC ACGACGGGCT GCTGACCAAG 3180

GCTGGTGAAG GTAACGAGCT GCTGGGGCCC CCCAGGGGAG GCACCCCGCC CTACAGCTCC 3240

CCCACCCACA GGCACGCAGC TTATATCAGG AGCGCGCCAG CACCCAGAGA ATCGGAGCAC 3300

GTGGAGTGCA GACCACCGGG ACAGACCATG GAGGTCCCCG ATCACAACGG CGTGGGCTAC 3360

CTGCGGGGCC CTCAGGGCGA GGCCTACAGG TCCCGGGGCC AACTGCAGCG CCACCACACC 3420

ATCCAGACGT GCGACGACGC CTACGACCAG GCGGACTCCA TGTCAGGGAT GAGCCTGTTG 3480

GCGGGGAAGG CCCTCAGTTC CGCTCGCATG TCCGACATCC TCAGTCAGAC GTCGCTGACG 3540

GGGAGCCAGC AGCTACAACA GCGCCAAGAG TCAGTATGTG ACGTGGACGG GGAGCTCCAT 3600

GCGGCCGCCT GCTACCCCTC CTCCTGCACC AGTGATATGC TTCTGACCTA CAAGCCCCCT 3660

GACCTGCAGT ACAGCATGGA GCAGGCTGGA GTCTAG 3696

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g+f+ Vkla+h  tk kva+Ki++k++l++e+l+ki+rE++i+k lkhp+i

Q: 72    YEIERTIGKGNFAVVKLATHIITKAKVAIKIVDKSQLDDENLKKIFREVQIMKLLKHPHI  131

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l++v+et++++ylv+eyasgge+fd+++++gr+ ek+ark fkq+v+av ++h ++iv

Q: 132   IRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKDARKKFKQIVAAVYFCHCRNIV  191

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++n+f++g+ll+t+cGsppYaaPel++gk+Y+gpkvD

Q: 192   HRDLKAENLLLDHNLNIKIADFGFSNMFSKGQLLKTWCGSPPYAAPELFEGKEYDGPKVD  251

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd+++l++l++++l+gk++ip+ +s+++e L+r++Lv +p++R

Q: 252   IWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTDCEYLIRHMLVLEPSRR  311

         ************************************************************

S: 241   atieeilkhewl  252

         +t+e+i k++w+

Q: 312   LTMEQICKNKWM  323

         ***********8

Domain Sequence
(FASTA)

YEIERTIGKG NFAVVKLATH IITKAKVAIK IVDKSQLDDE NLKKIFREVQ IMKLLKHPHI 60

IRLYQVMETE RMIYLVTEYA SGGEIFDHLV AHGRMAEKDA RKKFKQIVAA VYFCHCRNIV 120

HRDLKAENLL LDHNLNIKIA DFGFSNMFSK GQLLKTWCGS PPYAAPELFE GKEYDGPKVD 180

IWSLGVVLYV LVCGALPFDG STLQNLRARV LSGKFRIPFF MSTDCEYLIR HMLVLEPSRR 240

LTMEQICKNK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013