EKS-TEN-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	353.2	1.2E-105	243	533	291

Status

Unreviewed

Ensembl Protein

ENSTNIP00000009242

UniProt Accession

H3CLW2;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2 (1 of 2)

Gene Synonyms/Alias

TGFBR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000006473	ENSTNIP00000009242	ENSTNIT00000009413

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

563

Protein Sequence
(FASTA)

AGRLLGRLFP LSGVVAWLRR RGSVGNLLPN RLNLPAGMPG FLPLNQLCKF CDVEPSSCSG 60

TGTCGSSCNI TSICQLPEEV CVAIWRKNET GFFMETLCHD PSKSLYGLML DDHNSSTCVM 120

REKNTTSGTA HVCSCRAEEC NDVLSFSPVV DPTPEDSLVS VVLVSLLPLL VMGVVIGAMF 180

YWYRVHRPRM HSQEWERGIK KRKPKSGGLD CSDVCVIMMD DDGSDSSSTL ANNLNHNTEP 240

LPIELDQLVG KGRFAQVFKA KLKQNASDQF ETVAVKIFPY EEYASWKNEK DIFSNSDLRH 300

ENILHFLTAE EKKAQRQYWL ITAFHARGNL QEYLTHNVIS WEELKILGSS LAQGVSHLHS 360

DRLPCGRPKV AIVHRDLKSS NILVKSDLTC CLCDFGLGLQ LDSSLSVDDL ANSGQVGTAR 420

YMAPEVLEAR LNLENTESFK QADIYSMALV LWETSRCDAV GEVKDYEPAY GSKVREHCVE 480

SMKDNVLRDR RRPEIPDTWL RRQGVAMMCG TIMECWDHDP EARLTAHCVA KRISEMEDEL 540

DKLSSHSSST EKIPEELKIP TEV 563

Nucleotide Sequence
(FASTA)

GCTGGCCGCC TGCTTGGTCG ACTCTTTCCT CTTTCCGGGG TGGTTGCCTG GCTCCGCCGT 60

CGCGGATCTG TGGGAAACCT CCTCCCTAAT CGCCTGAACC TTCCTGCAGG TATGCCCGGC 120

TTTCTGCCCT TAAATCAGCT CTGCAAGTTC TGCGACGTGG AGCCCTCCAG CTGCAGCGGG 180

ACGGGGACCT GCGGGTCCAG CTGCAACATC ACCTCCATCT GCCAGCTGCC TGAAGAAGTC 240

TGCGTGGCCA TCTGGAGGAA GAACGAGACG GGATTCTTCA TGGAGACGCT GTGTCACGAC 300

CCTTCCAAGT CTCTTTACGG CTTGATGCTA GATGATCACA ACAGCTCCAC CTGCGTGATG 360

AGGGAGAAGA ACACGACCAG CGGGACGGCT CACGTCTGCT CCTGCAGGGC GGAGGAGTGC 420

AACGACGTTC TGAGCTTCTC CCCTGTCGTG GATCCGACCC CTGAAGACTC TCTGGTGTCG 480

GTGGTTCTGG TGAGCCTGCT CCCCCTGCTG GTGATGGGCG TCGTCATCGG CGCCATGTTC 540

TACTGGTACC GCGTGCACCG GCCCCGCATG CACAGCCAGG AGTGGGAGAG GGGCATCAAG 600

AAACGCAAGC CCAAAAGCGG CGGCCTGGAC TGCAGCGACG TCTGCGTCAT CATGATGGAC 660

GACGACGGGT CCGACAGCAG CTCCACGCTC GCCAACAACC TGAACCACAA CACGGAGCCG 720

CTGCCCATAG AGCTGGATCA GCTGGTGGGA AAGGGCCGCT TCGCGCAGGT GTTCAAGGCC 780

AAGCTGAAGC AGAACGCATC TGATCAGTTC GAAACGGTGG CCGTGAAGAT CTTCCCGTAC 840

GAGGAATACG CGTCCTGGAA GAACGAGAAG GACATCTTCT CCAATTCGGA CCTGCGGCAC 900

GAGAACATCC TCCACTTCCT TACAGCCGAG GAGAAGAAGG CCCAGAGGCA GTACTGGCTC 960

ATCACCGCCT TCCACGCCAG AGGGAACCTG CAGGAATACC TGACGCATAA TGTGATCAGC 1020

TGGGAGGAGC TTAAGATCCT GGGGAGCTCC TTAGCCCAGG GAGTGTCCCA CCTCCACAGT 1080

GACCGCCTCC CCTGCGGACG CCCGAAGGTG GCCATCGTCC ACCGTGACCT CAAGAGCTCC 1140

AACATCCTGG TGAAGAGCGA CCTGACGTGC TGCCTGTGCG ACTTCGGCCT GGGCTTGCAG 1200

CTGGACAGCA GCCTGTCGGT GGATGACCTG GCCAATAGCG GACAGGTGGG TACGGCCCGG 1260

TACATGGCTC CCGAGGTGCT GGAGGCCCGG CTGAACCTGG AAAACACCGA GTCCTTCAAG 1320

CAGGCCGATA TCTACTCCAT GGCGCTGGTG CTGTGGGAGA CATCGAGGTG CGACGCTGTC 1380

GGAGAGGTGA AGGACTACGA GCCTGCCTAC GGCTCCAAGG TGCGAGAGCA CTGTGTGGAG 1440

AGCATGAAGG ACAACGTGCT GAGAGACAGA AGACGGCCCG AGATCCCCGA CACCTGGCTC 1500

AGACGCCAGG GCGTGGCGAT GATGTGCGGC ACCATCATGG AATGCTGGGA CCACGACCCC 1560

GAGGCCCGGC TCACGGCCCA CTGCGTCGCC AAGCGCATCT CAGAGATGGA AGACGAGTTG 1620

GACAAACTGT CCAGCCACAG CTCGTCCACC GAGAAGATCC CCGAGGAGCT GAAGATCCCT 1680

ACGGAAGTG 1689

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr+++V+kakl++      e+vAvKif++e+ aswk+Ek+i+++  lrhen

Q: 243   IELDQLVGKGRFAQVFKAKLKQnasdqfETVAVKIFPYEEYASWKNEKDIFSNSDLRHEN  302

         67899****************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         il+f++a++k+   + +++l+t++h +g+L++yL+++++++eel  l +sla+G++hLH+

Q: 303   ILHFLTAEEKK--AQRQYWLITAFHARGNLQEYLTHNVISWEELKILGSSLAQGVSHLHS  360

         ********987..568********************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + +  +g+ K ai+HRDlks Nilvk+dltcc++D+GL l+l+++ ++ dla++ qvGt

Q: 361   D-RLPCGRPKVAIVHRDLKSSNILVKSDLTCCLCDFGLGLQLDSSLSVDDLANSGQVGTA  419

         *.577899****************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle +lnl+++e+fk+aD+Ys++LvlWE  sRc++  +ev++y++++ ++v+++

Q: 420   RYMAPEVLEARLNLENTESFKQADIYSMALVLWET-SRCDA-VGEVKDYEPAYGSKVREH  477

         **********************************5.8***9.999************998

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

          ++e+mk+ v++++ rP+ip++w + + +++++ ++ ecWd+dpeaRlta++v+kr+

Q: 478   -CVESMKDNVLRDRRRPEIPDTWLRRQGVAMMCGTIMECWDHDPEARLTAHCVAKRI  533

         .79***************************************************986

Domain Sequence
(FASTA)

IELDQLVGKG RFAQVFKAKL KQNASDQFET VAVKIFPYEE YASWKNEKDI FSNSDLRHEN 60

ILHFLTAEEK KAQRQYWLIT AFHARGNLQE YLTHNVISWE ELKILGSSLA QGVSHLHSDR 120

LPCGRPKVAI VHRDLKSSNI LVKSDLTCCL CDFGLGLQLD SSLSVDDLAN SGQVGTARYM 180

APEVLEARLN LENTESFKQA DIYSMALVLW ETSRCDAVGE VKDYEPAYGS KVREHCVESM 240

KDNVLRDRRR PEIPDTWLRR QGVAMMCGTI MECWDHDPEA RLTAHCVAKR I 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Pelodiscus sinensis"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013