EKS-TEN-00420
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00420
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20325.42.9E-9720283264
StatusUnreviewed
Ensembl ProteinENSTNIP00000009305
UniProt AccessionH3CMF0;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K1 (2 of 2)
Gene Synonyms/Alias MAP4K1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000006534ENSTNIP00000009431ENSTNIT00000009603
ENSTNIG00000006534ENSTNIP00000009305ENSTNIT00000009476
ENSTNIG00000006534ENSTNIP00000009429ENSTNIT00000009601
OrganismTetraodon nigroviridis
Functional Description
Protein Length841
Protein Sequence
(FASTA)
MDHQHRVALD ISTRNPQDDF EILLRVGGGT YGDVYKARNK QNGELAAIKI IKMEPEDDFS 60
VIQQEIIIVK SCKHPNIVAY FGSYIRANKL WICMEFCGGG SLQDVYQVTG PLSEPQIAYT 120
CREMLQGLDY LHGQKKIHRD IKGANVLLND QGEVKLADFG ISAQITATLA RRMSFIGTPY 180
WMAPEVAAVE IKGGYNELCD VWSVGITAIE LAELQPPMFD SPSAAHVVPC RVLFLMSKSG 240
YQPPKLKEKS KWSAQFYNFV KSMLVRNPKK RPSASKMLSH TFLTQPYLNR ELTLDLLEKF 300
HNPEKIRTCL AAEDEDMEVF QSLKRIQSIN KHNRAERTSS DISSWSLQEQ PKGRTSSEEP 360
KYECKSSSDR DFPFVLSPTI KNSSLVASAE EIPPPLPPKP KGRTSSEESV TGEDERLRKP 420
GGLQAPSPLI RTSSETRVRP TFHPRSSRNS GDPATFPVQD SDRSAALVPP ELPPKGIRRR 480
QPMSKAQSSV PNQHPSLLQV YFKKIFHGCP LKINCSTTWE NPANKEQHVV IGAEEGIYTL 540
NLNSSDVTME LLYPGKCTWL YIINNVLMSV SGKSLQLHSH LLKELFDQAR KDHRMVSLPT 600
HRLLPRRCTV TYKIPDTKGC KTCSVAGNVQ RGCVFLCCGL ESSVVLLQWY EPMHKFMLIK 660
NFDFPLPSPL RVFEMVVAPQ EEYPRVCIGV TRGTNTQLPV NVKYINLNSN TSWFTNSGLE 720
MACPEPVQVN QLDSSSLLVL FEKSVHVVGL DGELKSSRHH TTFSHDVESI VYFEETLLAV 780
WRHGWQRKRL GSPEVMEETT DSRKIYRLVQ SDKMIILETH QTEDQSGLSN LYVLEIAENY 840
V 841
Nucleotide Sequence
(FASTA)
ATGGACCACC AGCACCGAGT TGCTCTGGAT ATCTCCACCA GGAACCCCCA GGATGACTTT 60
GAGATCCTGC TGAGAGTCGG AGGAGGAACC TACGGAGACG TTTACAAGGC CCGAAACAAA 120
CAGAATGGAG AGCTGGCGGC CATCAAGATC ATCAAGATGG AACCAGAGGA TGATTTCTCC 180
GTCATCCAGC AGGAAATTAT CATTGTAAAA AGCTGCAAAC ATCCCAACAT CGTGGCCTAT 240
TTTGGCAGCT ACATCAGAGC AAATAAACTG TGGATCTGCA TGGAGTTCTG TGGAGGAGGA 300
TCCCTCCAGG ATGTGTACCA AGTGACTGGA CCTCTGTCTG AGCCCCAGAT CGCGTACACC 360
TGCAGAGAGA TGCTCCAGGG CCTGGACTAT TTACATGGGC AGAAGAAAAT CCACAGAGAC 420
ATCAAGGGTG CCAATGTCCT TCTCAACGAT CAGGGCGAGG TCAAGCTGGC TGACTTTGGG 480
ATCTCGGCCC AGATCACAGC CACGCTGGCT CGGCGGATGT CCTTCATCGG AACACCGTAC 540
TGGATGGCGC CAGAGGTGGC GGCCGTAGAG ATTAAAGGCG GTTATAATGA ATTGTGCGAC 600
GTCTGGTCAG TGGGCATCAC AGCCATAGAG CTGGCAGAGC TTCAGCCCCC CATGTTTGAT 660
AGTCCATCCG CTGCGCATGT GGTTCCCTGC AGGGTCCTGT TCCTCATGTC CAAAAGCGGT 720
TATCAGCCCC CGAAACTGAA GGAAAAGTCC AAATGGTCCG CTCAGTTTTA TAACTTTGTA 780
AAGTCCATGT TGGTGAGGAA CCCGAAGAAG AGACCCAGCG CCTCCAAGAT GCTGTCGCAC 840
ACGTTTCTGA CGCAGCCGTA CCTGAACAGG GAGCTGACCC TGGACCTGCT GGAGAAGTTT 900
CACAATCCTG AGAAAATCCG AACTTGCCTG GCGGCAGAGG ATGAAGACAT GGAGGTTTTT 960
CAATCATTAA AACGGATTCA GTCCATCAAC AAACACAACC GTGCAGAGAG AACAAGCTCT 1020
GACATCAGCT CTTGGTCGCT TCAGGAACAG CCCAAAGGCC GGACGAGCTC CGAGGAACCT 1080
AAATACGAAT GTAAGTCTTC ATCTGACCGT GACTTTCCTT TTGTCCTCAG TCCGACGATA 1140
AAAAACAGCA GCTTGGTCGC TTCAGCTGAA GAAATTCCAC CTCCGCTTCC CCCGAAGCCC 1200
AAAGGCCGGA CGAGCTCCGA GGAAAGCGTG ACAGGGGAGG ACGAGCGGCT GAGGAAGCCG 1260
GGCGGCCTGC AGGCTCCCTC CCCCCTCATC AGGACCTCCA GCGAGACCCG TGTCAGACCC 1320
ACCTTCCATC CGAGATCCTC ACGCAACTCC GGTGACCCTG CAACCTTCCC TGTCCAGGAC 1380
AGCGACAGAT CGGCGGCCCT CGTTCCCCCT GAGCTTCCCC CGAAAGGCAT ACGCCGGCGA 1440
CAGCCGATGT CAAAGGCTCA GAGCTCCGTT CCCAACCAGC ATCCCTCTCT GCTGCAGGTC 1500
TACTTCAAAA AGATCTTTCA TGGCTGTCCT CTGAAAATTA ACTGCTCTAC AACCTGGGAA 1560
AACCCCGCCA ACAAAGAGCA GCATGTAGTC ATCGGTGCAG AGGAAGGAAT TTACACCCTC 1620
AACCTCAACA GCTCTGATGT CACCATGGAG CTGCTGTATC CTGGAAAGTG TACCTGGCTG 1680
TACATCATTA ATAATGTCCT CATGTCCGTG TCAGGTAAAT CGCTGCAGCT TCACTCTCAT 1740
TTACTGAAGG AGCTGTTTGA CCAGGCTCGG AAAGACCACC GCATGGTCTC CCTGCCCACT 1800
CACAGGCTGC TACCGAGGAG ATGCACTGTG ACGTATAAAA TACCCGACAC CAAAGGCTGC 1860
AAAACCTGCT CAGTCGCAGG GAATGTGCAG CGAGGGTGTG TGTTTTTATG CTGCGGCCTA 1920
GAGTCCAGCG TGGTGCTCCT GCAGTGGTAC GAGCCTATGC ACAAGTTCAT GCTCATCAAG 1980
AACTTCGACT TCCCCTTGCC CAGCCCTTTG CGGGTGTTTG AGATGGTGGT GGCCCCCCAG 2040
GAGGAGTACC CCCGGGTGTG TATTGGTGTC ACCAGAGGCA CCAACACTCA GCTCCCTGTC 2100
AACGTAAAGT ACATCAACCT CAACTCCAAC ACGTCCTGGT TCACCAACTC CGGCCTGGAG 2160
ATGGCGTGTC CAGAGCCAGT TCAAGTAAAC CAGCTGGACA GCAGCTCACT ACTGGTCCTT 2220
TTTGAAAAGT CGGTGCACGT CGTTGGCCTG GACGGAGAGC TGAAGAGCAG CAGACACCAC 2280
ACCACCTTCT CTCACGACGT CGAGTCTATA GTATATTTTG AAGAAACGCT GTTGGCAGTG 2340
TGGCGTCACG GCTGGCAGAG GAAAAGACTG GGTTCTCCTG AGGTGATGGA GGAAACCACC 2400
GACTCCAGGA AAATCTACAG ACTGGTGCAG TCAGACAAGA TGATCATCCT GGAGACTCAT 2460
CAAACGGAGG ATCAGTCGGG GCTCTCCAAC CTCTACGTCC TGGAAATCGC AGAGAACTAC 2520
GTC 2523
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +e+l ++g G++g+vy+ar+k++gel+aik+i++e +++ + +q+ei ++k++khpniv+
Q: 20    FEILLRVGGGTYGDVYKARNKQNGELAAIKIIKMEPEDDFSVIQQEIIIVKSCKHPNIVA  79
         788999******************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+++ ++lw++me++ gGsl+d+++  ++ +l+E qiay +re+l++L+ylH +k+i
Q: 80    YFGSYIRANKLWICMEFCGGGSLQDVYQ--VTGPLSEPQIAYTCREMLQGLDYLHGQKKI  137
         ****************************..******************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++n+Ll+++geVkL+dfg++aq+++t ++r +++gtpywmAPEv a+e + gY+e
Q: 138   HRDIKGANVLLNDQGEVKLADFGISAQITATLARRMSFIGTPYWMAPEVAAVEiKGGYNE  197
         *****************************************************999****
S: 180   kaDiwslGItaielaegepPfkdle......plkallkilkne..ppklkskkkfskefk  231
          +D+ws+GItaielae +pP++d +      p ++l++++k+   ppklk+k+k+s +f 
Q: 198   LCDVWSVGITAIELAELQPPMFDSPsaahvvPCRVLFLMSKSGyqPPKLKEKSKWSAQFY  257
         *********************986433333378999*999998889**************
S: 232   efvekclqknpekRpsasellkhkFl  257
         +fv+++l +np+kRpsas++l+h+Fl
Q: 258   NFVKSMLVRNPKKRPSASKMLSHTFL  283
         *************************7
Domain Sequence
(FASTA)
FEILLRVGGG TYGDVYKARN KQNGELAAIK IIKMEPEDDF SVIQQEIIIV KSCKHPNIVA 60
YFGSYIRANK LWICMEFCGG GSLQDVYQVT GPLSEPQIAY TCREMLQGLD YLHGQKKIHR 120
DIKGANVLLN DQGEVKLADF GISAQITATL ARRMSFIGTP YWMAPEVAAV EIKGGYNELC 180
DVWSVGITAI ELAELQPPMF DSPSAAHVVP CRVLFLMSKS GYQPPKLKEK SKWSAQFYNF 240
VKSMLVRNPK KRPSASKMLS HTFL 264
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00309
EKS-CAP-00354
EKS-CII-00179
EKS-GAA-00394
EKS-ICT-00303
EKS-MYL-00318
EKS-ORL-00387
EKS-SUS-00281
EKS-XET-00387
EKS-XIM-00401
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013