EKS-TEN-00544

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00544

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	439.5	3.2E-132	127	379	253

Status

Unreviewed

Ensembl Protein

ENSTNIP00000009848

UniProt Accession

H3CNL6;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKA

Gene Synonyms/Alias

AURKA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007048	ENSTNIP00000009848	ENSTNIT00000010026

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MDSASKLKLA KDVKHLRPES SGEGPKRIPV SQQPEMAVVT PTPYQRVLGV SNGPQRVQRP 60

VSHQKPLAHQ IPPKANVPKA TQEAAKQPEP EKLPNKPAKN DSEKASASKP LTVRFCPLRT 120

RWSLENFDIG RPLGKGKFGN VYLARERQSK FILALKVLFK KQLEKAGVEH QLRREVEIQS 180

HLRHPNILRL YGYFHDPSRV YLILEFAPKG ELYGELQRCG SFPEDRSATY IMELADALNY 240

CHSKKVIHRD IKPENLLLGA TGELKIADFG WSVHTPSSRR STLCGTLDYL PPEMIEGKTH 300

DEKVDLWSLG VLCYEFLVGK PPFEAKTHEE TYRRISRVEY TYPAHTNISD GAKDLVSRLL 360

KHNPMHRLPV QGVLAHPWVV QCSTKKPTTV TTEQPSKEKS 400

Nucleotide Sequence
(FASTA)

ATGGACTCTG CTTCCAAACT CAAGTTGGCA AAAGATGTGA AACATCTGCG GCCTGAATCA 60

AGTGGCGAAG GGCCCAAACG GATCCCCGTG TCACAGCAAC CAGAGATGGC AGTGGTCACA 120

CCAACGCCCT ATCAGCGTGT CCTAGGTGTG TCCAATGGAC CTCAGCGCGT TCAGCGGCCT 180

GTCAGCCACC AGAAGCCACT TGCTCATCAA ATTCCACCCA AGGCAAATGT GCCCAAGGCC 240

ACCCAGGAAG CAGCCAAGCA GCCCGAGCCA GAAAAACTAC CAAACAAACC GGCCAAAAAT 300

GACTCTGAAA AGGCGTCTGC ATCAAAGCCT TTAACTGTGC GGTTCTGCCC ACTCAGGACA 360

CGCTGGAGCC TGGAAAACTT TGACATCGGC CGACCCCTGG GAAAGGGTAA ATTTGGCAAC 420

GTCTATCTGG CTCGAGAGCG GCAGAGTAAG TTCATCTTGG CCCTGAAGGT GCTCTTCAAG 480

AAACAGCTGG AGAAGGCCGG TGTGGAGCAC CAGCTGAGGA GAGAGGTGGA GATCCAGTCT 540

CATCTCAGGC ACCCTAACAT TCTCCGTCTC TACGGTTACT TCCACGACCC GTCTCGTGTG 600

TATCTCATCC TTGAGTTTGC ACCCAAAGGT GAGCTGTATG GTGAGCTGCA GCGTTGTGGA 660

AGTTTCCCAG AAGACAGAAG TGCCACATAC ATCATGGAAC TGGCCGATGC CCTCAACTAC 720

TGTCACTCTA AGAAGGTGAT CCACAGGGAC ATCAAACCAG AAAACCTGTT GCTGGGGGCC 780

ACCGGAGAGC TGAAGATTGC AGATTTCGGC TGGTCCGTTC ATACGCCTTC CTCCAGGAGG 840

TCCACGCTCT GTGGAACGCT GGACTACCTG CCTCCAGAGA TGATAGAGGG AAAAACCCAC 900

GATGAAAAGG TGGACCTGTG GAGTCTCGGG GTCCTTTGTT ATGAGTTCCT TGTTGGGAAA 960

CCGCCGTTTG AAGCAAAAAC TCACGAGGAG ACCTATCGAA GGATATCGAG GGTGGAGTAC 1020

ACCTACCCTG CACACACAAA CATCAGTGAT GGAGCCAAAG ATTTGGTTTC CAGGCTGCTG 1080

AAGCACAACC CCATGCACAG GTTGCCTGTC CAGGGAGTCC TTGCCCACCC CTGGGTGGTC 1140

CAGTGTTCCA CCAAAAAACC CACAACCGTG ACCACCGAAC AGCCCAGCAA GGAAAAGTCC 1200

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         f+iGr+lGkGkfGnvylare++skfi+alkvlfk+qlek+gve+qlrre+eiqshl+hpn

Q: 127   FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKKQLEKAGVEHQLRREVEIQSHLRHPN  186

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrlygyfhd +rvylile+ap+Gely elq+   + e r+a+yi eladal+y+h+kkv

Q: 187   ILRLYGYFHDPSRVYLILEFAPKGELYGELQRCGSFPEDRSATYIMELADALNYCHSKKV  246

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg +gelk+adfGwsvh+pss+r tlcGtldylppem+eg+++dekvdl

Q: 247   IHRDIKPENLLLGATGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDL  306

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpss..vskgakdliskllkkepke  238

         w+lGvlcye+lvGkppfe+++++ety+ri++v++++p++  +s+gakdl+s+llk++p +

Q: 307   WSLGVLCYEFLVGKPPFEAKTHEETYRRISRVEYTYPAHtnISDGAKDLVSRLLKHNPMH  366

         *************************************753499*****************

S: 239   rltladvlahpwi  251

         rl+++ vlahpw+

Q: 367   RLPVQGVLAHPWV  379

         ************8

Domain Sequence
(FASTA)

FDIGRPLGKG KFGNVYLARE RQSKFILALK VLFKKQLEKA GVEHQLRREV EIQSHLRHPN 60

ILRLYGYFHD PSRVYLILEF APKGELYGEL QRCGSFPEDR SATYIMELAD ALNYCHSKKV 120

IHRDIKPENL LLGATGELKI ADFGWSVHTP SSRRSTLCGT LDYLPPEMIE GKTHDEKVDL 180

WSLGVLCYEF LVGKPPFEAK THEETYRRIS RVEYTYPAHT NISDGAKDLV SRLLKHNPMH 240

RLPVQGVLAH PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013