EKS-TEN-00551

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00551

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Syk	441.2	1.1E-132	367	614	248

Status

Unreviewed

Ensembl Protein

ENSTNIP00000009903

UniProt Accession

H3CNS0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

SYK

Gene Synonyms/Alias

SYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007102	ENSTNIP00000009903	ENSTNIT00000010081

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

PGDTMADNVS ALPFFYGNIT REEAEDYLQL AGMADGLYLL RQSRNNLGGF ALSVSSSGRS 60

YHYSIERQAN ETYAIPGGKS HQDPVDVIDY HSQVMDGLVT LLKKPCNRPK NVKPKVGLFE 120

DIKEKLIREY VQQTWNLQGA GLELAIISQR PQLEKRIAIT AHERMVWFHG AITREGSEPR 180

LQNGSRINGR FLVRQRDTNG SYALCLLHEG QVMHYRVDRD QAGKLSIPEG KKFDTLWQLV 240

EHYSYKPDGL LHVLTEPCPR PDGDNVGPLL PRDHPSLKSS FPANSSTKSE RLPYRAPSRC 300

SLPAPPSVCR ANACASCRKN QGQGGPGDPV TGIQAYAMPM DTEVYESPYA DPDELRSSTV 360

DRSQLFLEDG ELGSGNFGTV MKGIYKMKKT EKTVAVKILK NDEDNLSVRE EMLREANVMQ 420

QLDNPYIVRM IGICEAENLM LVMELAELGP LHKFLQKHKQ ISMKNITELV HQVSVGMKYL 480

EEHNFVHRDL AARNVLLVTQ HYAKISDFGL SKAVAEDKSY YKAKGHGKWP VKWYAPECIN 540

YFKFSSKSDV WSFGVLMWEA FSFGQKPYRG MKGNEVMQMI ESGQRMEAPA NCPSEMSDLM 600

QACWTYKVED RPSFSVVEPR LREYYYDIAH 630

Nucleotide Sequence
(FASTA)

CCAGGAGACA CCATGGCCGA CAACGTCAGC GCGCTACCCT TCTTCTACGG CAACATCACC 60

AGGGAGGAGG CGGAGGACTA CCTGCAGCTG GCCGGCATGG CCGACGGTCT GTACCTGCTG 120

CGCCAGAGCC GGAACAACCT GGGAGGCTTC GCGCTCTCCG TCTCCTCCTC GGGCCGCTCC 180

TACCATTACA GCATCGAAAG GCAGGCCAAC GAAACCTACG CCATCCCTGG GGGGAAGAGC 240

CACCAGGACC CGGTGGACGT CATCGACTAC CACTCCCAGG TGATGGACGG TCTGGTGACG 300

CTGCTGAAGA AGCCCTGCAA CCGGCCCAAG AACGTGAAGC CCAAGGTGGG CCTCTTTGAG 360

GACATCAAGG AGAAACTGAT CCGGGAGTAC GTGCAGCAGA CGTGGAACCT GCAGGGAGCA 420

GGTCTGGAGC TGGCCATCAT CAGCCAGAGG CCTCAGCTGG AGAAGAGGAT CGCCATCACG 480

GCGCACGAGA GGATGGTCTG GTTCCACGGA GCCATCACGC GGGAGGGCTC CGAGCCCAGG 540

CTCCAAAACG GCAGCCGCAT CAACGGGAGG TTCCTGGTCC GTCAGAGGGA CACAAACGGG 600

TCGTACGCTC TGTGTCTGCT GCACGAAGGA CAGGTGATGC ATTACCGCGT CGACCGGGAC 660

CAAGCCGGGA AGCTGTCCAT TCCAGAGGGA AAGAAGTTCG ACACCCTGTG GCAGCTGGTT 720

GAGCATTATT CCTACAAGCC TGACGGTCTG CTGCACGTCC TGACCGAACC CTGTCCAAGA 780

CCTGACGGAG ACAACGTTGG ACCCCTCCTC CCGAGAGACC ACCCTTCGCT GAAGTCCTCC 840

TTTCCAGCAA ACTCCTCTAC AAAGTCAGAA CGACTTCCAT ACCGGGCCCC ATCAAGGTGC 900

AGCCTCCCGG CTCCTCCGTC TGTGTGCCGC GCTAACGCCT GCGCTTCCTG TCGGAAGAAC 960

CAGGGCCAGG GAGGTCCTGG AGACCCCGTC ACTGGAATCC AGGCGTACGC GATGCCCATG 1020

GACACGGAGG TGTACGAGAG CCCCTACGCT GACCCCGACG AGCTGAGGAG CTCCACGGTG 1080

GATCGCAGCC AGCTCTTCCT GGAGGACGGG GAACTGGGGT CGGGGAACTT CGGGACCGTC 1140

ATGAAGGGCA TCTACAAGAT GAAGAAGACG GAGAAGACGG TGGCCGTCAA AATCCTGAAG 1200

AACGACGAGG ACAACCTGTC GGTGCGCGAG GAGATGCTGC GGGAGGCCAA CGTCATGCAG 1260

CAGCTGGACA ACCCCTACAT CGTCCGCATG ATCGGCATCT GCGAGGCCGA GAACCTGATG 1320

CTGGTCATGG AGCTGGCCGA GCTGGGACCG CTGCACAAGT TCCTGCAAAA GCACAAGCAG 1380

ATCAGCATGA AGAACATCAC GGAGCTGGTG CACCAGGTGT CCGTGGGGAT GAAGTACCTG 1440

GAGGAACACA ACTTTGTGCA CCGGGACCTC GCCGCCAGGA ACGTCCTGCT GGTCACGCAG 1500

CACTACGCCA AGATCAGCGA CTTCGGCCTG TCCAAGGCCG TGGCCGAGGA CAAGAGCTAC 1560

TACAAGGCCA AGGGTCATGG GAAGTGGCCG GTCAAATGGT ACGCTCCGGA GTGCATCAAC 1620

TACTTCAAAT TCTCCTCCAA GAGTGATGTT TGGAGCTTTG GGGTGCTGAT GTGGGAGGCC 1680

TTCTCCTTTG GCCAGAAACC ATACCGGGGT ATGAAAGGTA ACGAGGTGAT GCAGATGATC 1740

GAGAGCGGGC AGCGGATGGA GGCTCCAGCC AACTGTCCCT CAGAGATGTC TGACCTCATG 1800

CAGGCCTGCT GGACCTACAA GGTGGAGGAC AGGCCCAGCT TCAGCGTGGT GGAGCCCAGG 1860

CTGCGGGAGT ATTACTACGA CATCGCTCAC TGA 1893

Domain Profile

S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlk.eadekadkdellreasvmqqldnky  60

         +ed elGsGnfG+v kG+y+mkk++++va+k+lk + d+ + ++e+lrea+vmqqldn+y

Q: 367   LEDGELGSGNFGTVMKGIYKMKKTEKTVAVKILKnDEDNLSVREEMLREANVMQQLDNPY  426

         789*******************************66677799******************

S: 61    ivrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknf  120

         ivr+iGi++ae lmlvmelaelGpl+k+l+++++ i+ kn+ elvhqv++Gmkylee+nf

Q: 427   IVRMIGICEAENLMLVMELAELGPLHKFLQKHKQ-ISMKNITELVHQVSVGMKYLEEHNF  485

         ******************************9999.*************************

S: 121   vhrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfs  180

         vhrdlaarnvllv++hyakisdfGlska+  d+syyka+ +Gkwpvkwyapecin+ kfs

Q: 486   VHRDLAARNVLLVTQHYAKISDFGLSKAVAEDKSYYKAKGHGKWPVKWYAPECINYFKFS  545

         ************************************************************

S: 181   sksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwk  240

         sksdvwsfGv++weafs+Gqkpy+++kg ev++++e+G+r+e+pa+cp+e+ +lm+ cw+

Q: 546   SKSDVWSFGVLMWEAFSFGQKPYRGMKGNEVMQMIESGQRMEAPANCPSEMSDLMQACWT  605

         ************************************************************

S: 241   ykvedrpdf  249

         ykvedrp+f

Q: 606   YKVEDRPSF  614

         *******99

Domain Sequence
(FASTA)

LEDGELGSGN FGTVMKGIYK MKKTEKTVAV KILKNDEDNL SVREEMLREA NVMQQLDNPY 60

IVRMIGICEA ENLMLVMELA ELGPLHKFLQ KHKQISMKNI TELVHQVSVG MKYLEEHNFV 120

HRDLAARNVL LVTQHYAKIS DFGLSKAVAE DKSYYKAKGH GKWPVKWYAP ECINYFKFSS 180

KSDVWSFGVL MWEAFSFGQK PYRGMKGNEV MQMIESGQRM EAPANCPSEM SDLMQACWTY 240

KVEDRPSF 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR023420	; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR012234	; Tyr_kinase_non-rcpt_SYK/ZAP70.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 2.

SMARTs

SM00252	; SH2; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 2.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013