EKS-TEN-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.6	1.4E-134	200	512	313

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010091

UniProt Accession

H3CPA8;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007287	ENSTNIP00000010091	ENSTNIT00000010271

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

582

Protein Sequence
(FASTA)

MIISRKPEGP IATARHADGL YDSYMRTDHI LKDEADTGPS GLPPMPKHTV VSNKTVIRDQ 60

VTVRGGQLKV KYLYEDSTNN RKISAITTAT AQSGGPALPK ERSVDSSESS KAPSESAGAG 120

SGGTSVKMCG PLTPDQALRL YRSQLTPLEQ GEIQAYPDVY FVGPNAKKRP AVSGGTNNSG 180

YDDEQGGYIH VAHDHLAYRY EFLKIIGKGS FGQVKVYDHK LQQHLALKMV RNEKRFHRQA 240

QEEIRILEHL RKQDRNGTMN VVHMLENFTF RNHICMTFEL LSMNLYELIK RNKFQGFSLP 300

LVRKFAHSIL QCLEALSRHR IIHCDLKPEN ILLKQQGRSG IKVIDFGSSC FEHQRVYTYI 360

QSRFYRAPEV ILGSRYGLPI DMWSFGCILA ELLTGYPLFP GEDEGDQLAC VMELLGMPPQ 420

KVLEQAKRAK NFINSKGHPR YCGANTLPTG ATVLTGSRSR RGKMRGPPGS KEWSAALKGC 480

EDPTFTDFIK KCLDWDPSTR LTPSQALRHP WLYRRLPKPL PGTDKSPGVV KRLPEHHSTS 540

FPSILAKGGP VLGTTADKLR SNMMGDSGEA IPLRTVLPKL VS 582

Nucleotide Sequence
(FASTA)

ATGATTATCA GCAGAAAACC AGAGGGCCCA ATAGCAACAG CGCGGCACGC TGACGGTCTG 60

TACGACTCCT ACATGAGGAC AGACCACATC CTCAAAGATG AAGCAGATAC TGGTCCGTCA 120

GGGCTGCCCC CCATGCCCAA ACACACTGTT GTCAGTAACA AGACGGTCAT AAGGGACCAG 180

GTGACTGTCC GAGGCGGCCA GCTGAAGGTC AAATACCTGT ACGAGGACTC CACCAACAAC 240

CGAAAGATCA GCGCTATTAC CACGGCAACC GCCCAGAGCG GCGGGCCCGC CTTGCCCAAG 300

GAGCGCAGCG TGGACAGCAG CGAGTCCAGC AAGGCTCCCA GTGAGTCCGC CGGAGCAGGG 360

AGCGGCGGGA CCAGCGTGAA GATGTGTGGC CCCCTCACCC CCGACCAGGC TCTGAGGCTG 420

TACCGCTCAC AGCTCACCCC TCTGGAGCAG GGCGAGATCC AGGCGTACCC GGACGTCTAC 480

TTCGTGGGGC CCAACGCCAA GAAGAGGCCC GCCGTGTCTG GCGGCACCAA CAACTCCGGC 540

TACGACGACG AGCAGGGCGG ATACATCCAC GTGGCTCATG ATCACCTGGC CTATCGCTAT 600

GAGTTCCTCA AGATTATCGG AAAAGGCAGT TTCGGTCAGG TCAAAGTGTA CGACCACAAA 660

CTGCAGCAGC ACCTGGCTCT GAAAATGGTG CGCAACGAGA AGCGGTTCCA CCGGCAGGCG 720

CAGGAGGAGA TCCGCATCCT GGAGCACCTG CGCAAGCAGG ACCGCAACGG CACCATGAAC 780

GTGGTGCACA TGCTGGAAAA CTTCACCTTC CGGAACCACA TTTGCATGAC CTTTGAGCTG 840

CTGAGCATGA ACCTGTACGA GCTCATCAAG CGGAACAAGT TCCAGGGCTT CAGCTTGCCG 900

CTGGTCAGGA AGTTTGCACA CTCCATCCTG CAGTGCCTGG AGGCCTTGAG TCGGCACAGG 960

ATCATCCACT GCGACCTGAA ACCGGAGAAC ATCCTGCTGA AGCAGCAGGG GCGCAGCGGC 1020

ATTAAGGTGA TTGACTTTGG CTCCAGCTGT TTTGAACACC AGCGGGTGTA CACCTACATC 1080

CAGTCTCGCT TCTACCGAGC TCCGGAGGTG ATCCTGGGCT CCCGGTACGG CCTTCCCATC 1140

GACATGTGGA GTTTCGGCTG CATTCTGGCC GAGCTGCTGA CGGGCTACCC CTTGTTTCCC 1200

GGGGAGGACG AGGGCGACCA GTTGGCCTGC GTCATGGAGC TGCTGGGCAT GCCTCCACAG 1260

AAGGTCCTGG AACAGGCCAA ACGAGCCAAG AACTTCATCA ACTCCAAAGG CCACCCCCGC 1320

TACTGCGGAG CCAACACCCT GCCCACAGGG GCCACGGTGC TGACGGGCTC CCGCTCTCGT 1380

CGCGGCAAGA TGAGAGGCCC CCCGGGCAGC AAGGAGTGGA GCGCTGCGCT CAAAGGCTGC 1440

GAGGACCCCA CCTTTACGGA CTTCATAAAG AAGTGCTTGG ACTGGGATCC CTCCACGCGC 1500

CTCACCCCCA GCCAGGCCCT CAGACACCCC TGGCTGTACC GGCGCCTCCC TAAGCCTCTT 1560

CCTGGGACCG ACAAGAGCCC GGGCGTGGTG AAGCGTCTCC CGGAGCACCA CAGCACCTCC 1620

TTCCCCTCTA TCCTGGCGAA GGGGGGTCCC GTCCTGGGTA CCACAGCTGA CAAACTAAGG 1680

AGCAATATGA TGGGAGATTC TGGGGAGGCC ATCCCTCTGC GCACAGTCCT ACCGAAACTT 1740

GTCTCTTAG 1749

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye l++igkGsfgqV k++d+k ++++a+k+++n+krf+rqaqeE++iLe+l+k+d++ +

Q: 200   YEFLKIIGKGSFGQV-KVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLRKQDRNGT  258

         999***********7.9*******************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nvv++le f+frnh+c++fells+nLyel+k+nkf+g+sl lvrk+a++il++L++L++

Q: 259   MNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSR  318

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 319   HRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGSRYG  377

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

           iDmWS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+k+le+ak+ak+f+++k+

Q: 378   LPIDMWSFGCILAELLTGYPLFPGEDEGDQLACVMELLGMPPQKVLEQAKRAKNFINSKG  437

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+  ++  + +++l+ ++++++k r +p+ske++ alk +ed +f+d++k++l++dp

Q: 438   HPRYCGANTLPTGATVLTGSRSRRGKMRGPPGSKEWSAALKGCEDPTFTDFIKKCLDWDP  497

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 498   STRLTPSQALRHPWL  512

         **************6

Domain Sequence
(FASTA)

YEFLKIIGKG SFGQVKVYDH KLQQHLALKM VRNEKRFHRQ AQEEIRILEH LRKQDRNGTM 60

NVVHMLENFT FRNHICMTFE LLSMNLYELI KRNKFQGFSL PLVRKFAHSI LQCLEALSRH 120

RIIHCDLKPE NILLKQQGRS GIKVIDFGSS CFEHQRVYTY IQSRFYRAPE VILGSRYGLP 180

IDMWSFGCIL AELLTGYPLF PGEDEGDQLA CVMELLGMPP QKVLEQAKRA KNFINSKGHP 240

RYCGANTLPT GATVLTGSRS RRGKMRGPPG SKEWSAALKG CEDPTFTDFI KKCLDWDPST 300

RLTPSQALRH PWL 313

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013