EKS-TEN-00576

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00576

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	414.4	2.5E-124	64	359	296

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010341

UniProt Accession

H3CCC1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007532	ENSTNIP00000005893	ENSTNIT00000006041
ENSTNIG00000007532	ENSTNIP00000010341	ENSTNIT00000010522

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSRHFLYNCS QPILDVKIAF CQGFGQQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA GYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKSLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPSPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDCLFPA DSEHNKLKAS QARDLLSKML IIDPAKRISV DEALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHSIDEW KELIYKEVMN FEERTKNGVV KGQPSPSGAA 420

VNSSESLPPS SSINDISSMS TDQTLASDTD SSLETSAGPL GCCR 464

Nucleotide Sequence
(FASTA)

ATGAGCAGAC ATTTCTTATA TAACTGCAGC CAACCAATCC TGGATGTGAA GATTGCCTTT 60

TGTCAGGGTT TCGGACAACA AGTGGATGTA TCATATATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAAG TGGACAACCA GTTTTACAGC GTGGAGGTGG GGGACTCCAC CTTCACAGTC 180

CTAAAACGCT ACCAGAATTT GAAGCCCATC GGCTCCGGAG CTCAGGGAAT AGTCTGTGCA 240

GGCTACGACG CTGTCCTGGA CAGAAATGTG GCCATCAAGA AGCTGAGCAG ACCCTTCCAG 300

AACCAGACCC ACGCCAAGAG GGCGTACCGG GAGTTGGTGC TCATGAAATG CGTCAACCAC 360

AAAAATATCA TCAGTTTATT AAACGTCTTC ACACCACAGA AATCATTAGA GGAATTCCAG 420

GATGTCTATC TGGTCATGGA GCTGATGGAC GCCAACCTGT GCCAGGTGAT TCAGATGGAG 480

CTCGACCACG AGAGAATGTC CTACCTGCTC TACCAGATGT TGTGCGGCAT CAAACATCTG 540

CACTCAGCCG GCATTATTCA CAGGGACCTC AAACCAAGCA ATATAGTGGT AAAGTCCGAC 600

TGCACCCTGA AAATCCTGGA CTTTGGCCTC GCTCGGACTG CAGGCACCAG CTTCATGATG 660

ACCCCCTACG TGGTGACGAG ATACTACAGA GCCCCCGAGG TGATCCTCGG CATGGGTTAC 720

AAGGAGAACG TGGATATTTG GTCGGTGGGG TGCATTATGG GAGAAATGGT GCGCCACAAA 780

ATCCTCTTCC CTGGGCGGGA CTACATCGAC CAGTGGAATA AGGTGATCGA GCAGCTGGGA 840

ACGCCCTCAC CAGAGTTCAT GAAGAAGCTT CAGCCCACTG TGAGGAACTA CGTGGAGAAC 900

AGGCCGAAGT ACGCCGGCCT CACCTTTCCC AAACTGTTCC CGGACTGCCT TTTCCCTGCT 960

GACTCGGAGC ACAACAAACT CAAAGCTAGC CAGGCCAGAG ACCTGCTGTC TAAGATGCTG 1020

ATCATTGACC CCGCCAAAAG AATATCGGTG GACGAGGCCT TACAGCACCC CTACATTAAC 1080

GTGTGGTACG ATCCAGCTGA GGTGGAGGCG CCCCCTCCAC AGATCTATGA CAAACAGCTG 1140

GATGAAAGAG AACACTCCAT TGACGAATGG AAAGAACTCA TTTACAAAGA GGTGATGAAC 1200

TTTGAGGAGA GAACGAAAAA TGGCGTTGTG AAGGGACAGC CTTCACCTTC AGGTGCAGCC 1260

GTGAACAGCA GCGAAAGCCT CCCTCCCTCC TCCTCCATCA ACGACATCTC CTCCATGTCC 1320

ACGGACCAGA CCCTGGCATC AGACACCGAC AGCAGCCTGG AGACCTCGGC AGGACCACTG 1380

GGGTGTTGCA GGTGA 1395

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++ +d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAGYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtps ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPSPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+L++dp kRisv+eaL+hpY

Q: 299   ENRPKYAGLTFPKLFPDclfpadsehnklKASQARDLLSKMLIIDPAKRISVDEALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAGYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPS PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDCLFPADSE HNKLKASQAR DLLSKMLIID PAKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013