EKS-TEN-00515
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00515
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR426.97.5E-128560879320
StatusUnreviewed
Ensembl ProteinENSTNIP00000010424
UniProt AccessionH3CQ90;
Protein Name
Protein Synonyms/Alias
Gene NamePDGFRB (2 of 2)
Gene Synonyms/Alias PDGFRB (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000007610ENSTNIP00000010424ENSTNIT00000010605
OrganismTetraodon nigroviridis
Functional Description
Protein Length961
Protein Sequence
(FASTA)
GVFLVLPEGV LSLELLPSSS EVLLNPSDNF TVVCSGWSQV SWLLPEEILV EGVEVEDQGS 60
VSTLNIFNAS WKHSGRYLCE EGLSSQSKRV DIFIPGRGPE EWFPPTGLGV VMRENEEGTI 120
PCVVSDPQLS VSLYKRTDRK AVGGLRYEPG RGFTGPLNDT SYLCVASDGR QQVDSQVYYV 180
FSVIVPKVME VDLTASSRVL KQGELLTVNC TVQDTEMVYF NWDFPRKQII EPLMDFLPNR 240
IRSFLNISEA TVADSGVYAC TVQTSMKGRR VTHTDACLSA DQGYVYLWPS GETNVSSLLH 300
HTVEFSVEVD AHPAPTVRWT KDNQTVQKDT TSVTTTHLTG TRYVSTLKLV RVRLDQSGSY 360
GAAAHNQDAE EEVLFHLEVK VPPKIIALSE VRNKVMLCIS EGAPPPSVTW YSCQNSHRCS 420
NVTDSWRRVS EGGAVQENVT KLETRGVTQV HSALTLQSLS SLSAVRCEAS NSAGRRARDL 480
RIQSASLFSQ VAVLAAVLVL VFIAVVFLIV LILLWRKKPQ YEVRWKVIQS VSLDGQQYTY 540
LDPAHLPYNS TWEVPRDNIV LGQVLGSGVF GRVVEANVSG LLHSHSTTKV AVKMVKGNSG 600
AVQSLMSELK VLVHLGPHLN IVNLLGACTR KGPVYLITEF CRHGDLSGYL ERNRHTFLQG 660
DKQTKSDADG GYMDMNKEES VEYVTRTKLS YADIEPAAYE TPYTPADQRE AMLLLSDSPL 720
LTLHDLLSFS FQVAKAMDFL SSRNCLHRDL AARNVLVCEG KLAKVCDFGL ARDLTRDQNY 780
VAKGNTFLPV KWMSPESIFQ SVYSCQSDVW SYGILLWEIF SLGGSPYPDL PLTQEFYSAL 840
KRGYRMNPPE HAPQNISDLM KRCWEEKPQA RPAFSSLVAS VGNMLTDDYK KRYHSLAENF 900
LKGEQPAVAR SRAAGDQNGE TEAKGLSLSS TQQNLQCRSG TDALCCLQSS RFLRWTSTDR 960
R 961
Nucleotide Sequence
(FASTA)
GGTGTGTTCC TGGTTCTCCC TGAAGGTGTC CTCAGCCTGG AGCTGCTTCC CTCCTCCTCC 60
GAAGTCCTCC TCAATCCCAG CGACAACTTC ACGGTGGTGT GCTCTGGCTG GAGTCAGGTG 120
TCCTGGCTCC TACCCGAGGA GATATTGGTG GAGGGTGTGG AGGTGGAGGA CCAGGGCTCC 180
GTCAGCACCC TGAACATCTT CAACGCAAGC TGGAAACATT CCGGGAGATA CCTGTGTGAG 240
GAGGGCCTGT CGTCTCAGAG CAAACGGGTG GACATCTTCA TACCTGGGCG AGGTCCGGAG 300
GAGTGGTTCC CCCCCACAGG TCTGGGGGTG GTGATGAGGG AAAATGAGGA AGGCACCATT 360
CCCTGTGTGG TGTCCGATCC GCAGCTCTCC GTGTCTCTGT ACAAACGCAC CGACAGAAAG 420
GCGGTCGGCG GCTTGAGGTA CGAGCCGGGC CGGGGCTTCA CCGGCCCCCT GAACGACACT 480
TCCTACCTGT GTGTGGCCTC CGATGGGCGG CAGCAGGTGG ACTCTCAGGT CTACTATGTC 540
TTCAGCGTCA TAGTCCCCAA GGTGATGGAG GTGGACCTGA CGGCCTCCAG CAGAGTGTTG 600
AAACAGGGGG AGCTTCTGAC TGTCAACTGT ACTGTCCAGG ACACTGAGAT GGTCTACTTC 660
AACTGGGACT TTCCCCGCAA ACAGATCATC GAACCCCTGA TGGACTTCCT GCCCAATCGG 720
ATCCGCTCCT TCCTCAACAT CTCCGAGGCA ACAGTGGCTG ATTCGGGTGT TTATGCGTGC 780
ACGGTGCAGA CAAGCATGAA AGGTCGCAGA GTCACACACA CTGATGCCTG TCTCTCTGCA 840
GATCAAGGGT ACGTCTACCT GTGGCCTTCA GGTGAGACCA ACGTCTCGTC TCTCCTTCAT 900
CACACGGTGG AGTTTAGCGT TGAGGTCGAC GCCCATCCTG CTCCCACCGT CCGCTGGACC 960
AAAGACAACC AGACGGTCCA GAAGGACACC ACCTCTGTCA CCACCACACA CCTGACAGGA 1020
ACCAGGTATG TGAGCACACT GAAGCTGGTC CGGGTCCGGT TGGATCAAAG CGGATCTTAC 1080
GGAGCCGCTG CTCACAACCA GGATGCTGAG GAGGAGGTCC TGTTCCACCT GGAGGTCAAA 1140
GTGCCCCCAA AGATCATAGC CCTGTCAGAG GTCAGGAATA AGGTCATGCT CTGTATCAGC 1200
GAGGGAGCTC CGCCCCCATC TGTCACCTGG TACAGCTGTC AGAATTCCCA CAGGTGCAGC 1260
AACGTGACGG ACAGCTGGAG GCGTGTCTCA GAGGGCGGGG CTGTCCAGGA GAACGTCACC 1320
AAACTGGAAA CCCGAGGAGT CACCCAGGTG CACAGCGCAC TGACGCTGCA GAGCCTCTCG 1380
TCTCTGTCGG CCGTCCGCTG CGAAGCGTCC AACTCGGCGG GACGGCGAGC GCGAGACCTG 1440
CGCATCCAGA GTGCCTCTCT CTTTTCCCAG GTGGCGGTTT TGGCAGCGGT TCTTGTCCTG 1500
GTCTTCATCG CTGTTGTCTT CCTCATTGTC CTCATCCTCC TCTGGAGAAA AAAACCTCAG 1560
TACGAAGTCC GTTGGAAGGT GATCCAGTCG GTCAGTCTGG ACGGACAGCA GTACACCTAC 1620
CTGGACCCCG CCCACCTGCC CTACAACTCC ACCTGGGAGG TGCCGCGGGA CAACATCGTC 1680
CTGGGTCAGG TGTTGGGATC CGGCGTGTTC GGCCGTGTGG TGGAGGCCAA CGTCTCTGGT 1740
CTGCTTCACT CTCATTCCAC CACCAAAGTG GCCGTCAAGA TGGTCAAAGG CAACAGTGGC 1800
GCGGTTCAGT CTCTGATGTC AGAGCTGAAG GTCCTGGTTC ATCTCGGCCC TCACCTGAAC 1860
ATCGTCAACC TGCTGGGAGC GTGCACGAGA AAAGGGCCTG TCTATCTGAT CACTGAGTTC 1920
TGTCGTCACG GCGACCTGTC GGGCTATCTG GAGAGGAACA GACACACCTT CCTGCAGGGT 1980
GACAAGCAGA CAAAAAGCGA CGCTGACGGA GGCTACATGG ACATGAACAA GGAGGAGAGC 2040
GTGGAGTACG TCACCAGGAC CAAGCTAAGC TACGCTGACA TTGAACCGGC TGCTTACGAG 2100
ACTCCATACA CACCAGCAGA CCAGCGGGAG GCGATGCTCC TCCTCAGCGA CTCTCCTCTT 2160
CTGACTCTCC ATGACCTCCT CAGCTTCTCC TTCCAGGTTG CTAAGGCCAT GGACTTCCTC 2220
TCCTCCAGAA ACTGTCTCCA CAGAGATCTG GCTGCCAGGA ACGTGCTGGT CTGCGAGGGG 2280
AAGCTGGCCA AGGTCTGCGA CTTCGGTTTG GCCAGAGATC TGACCAGGGA CCAGAACTAC 2340
GTCGCCAAGG GCAACACCTT CCTTCCTGTG AAGTGGATGT CACCGGAGAG CATCTTCCAG 2400
AGCGTTTACA GCTGCCAGAG TGACGTCTGG TCCTATGGAA TTCTGCTGTG GGAGATTTTC 2460
TCTCTCGGTG GCAGCCCGTA CCCGGACCTC CCGCTGACCC AGGAGTTCTA CTCGGCTCTG 2520
AAGAGAGGAT ACAGGATGAA TCCGCCCGAA CACGCGCCGC AGAACATTTC TGACCTGATG 2580
AAACGCTGCT GGGAGGAGAA ACCTCAGGCC AGACCCGCCT TCTCCTCGCT AGTTGCCTCC 2640
GTGGGCAACA TGCTGACCGA CGACTACAAA AAGCGTTACC ACAGCCTGGC TGAGAACTTC 2700
CTGAAAGGAG AACAACCGGC TGTCGCTCGA TCCAGAGCTG CTGGAGACCA GAATGGAGAG 2760
ACGGAGGCCA AAGGTCTTTC ATTGTCCTCC ACTCAGCAGA ACCTTCAATG CAGATCTGGT 2820
ACAGACGCTC TGTGTTGTCT GCAGAGTTCC CGCTTTCTCA GGTGGACGTC CACAGATCGG 2880
AGG 2883
Domain Profile
S: 2     elGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlGe  61
         +lG+vlGsG fG+vvea   Gl +s+++ kvavkm+k ++     ++lmselk+l hlG+
Q: 560   VLGQVLGSGVFGRVVEANVSGLLHSHSTTKVAVKMVKGNS--GAVQSLMSELKVLVHLGP  617
         79**********************************9865..56799*************
S: 62    henivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldskal  121
         h+nivnllGact+ Gp+y+ite+c++Gdl  yl+r+r++fl+    k+++++++  + ++
Q: 618   HLNIVNLLGACTRKGPVYLITEFCRHGDLSGYLERNRHTFLQGD--KQTKSDADGGYMDM  675
         *****************************************654..44444444445444
S: 122   ladkslrsksslssesseeyvd.lkkdvsdvssskadklasekkksalerevkaaleeed  180
          +            e+s eyv   k +++d++++ +++++          +++a+l   d
Q: 676   NK------------EESVEYVTrTKLSYADIEPAAYETPYTPA------DQREAMLLLSD  717
         22............22233333134457777778888777655......33344556667
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         s  l+l+dllsfs+qvak m+fl+s+nc+hrdlaarnvl++eGk++k+cdfGlard+++d
Q: 718   SPLLTLHDLLSFSFQVAKAMDFLSSRNCLHRDLAARNVLVCEGKLAKVCDFGLARDLTRD  777
         9***********************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
          nyv+kGn++lpvkwm+pesif+s+y+ +sdvwsyGillweifslG++pyp+l++ ++fy
Q: 778   QNYVAKGNTFLPVKWMSPESIFQSVYSCQSDVWSYGILLWEIFSLGGSPYPDLPLTQEFY  837
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
          ++k+Gyrm+ p++a+++i ++m++cwe++p+ rp+f+ lv 
Q: 838   SALKRGYRMNPPEHAPQNISDLMKRCWEEKPQARPAFSSLVA  879
         **************************************9985
Domain Sequence
(FASTA)
VLGQVLGSGV FGRVVEANVS GLLHSHSTTK VAVKMVKGNS GAVQSLMSEL KVLVHLGPHL 60
NIVNLLGACT RKGPVYLITE FCRHGDLSGY LERNRHTFLQ GDKQTKSDAD GGYMDMNKEE 120
SVEYVTRTKL SYADIEPAAY ETPYTPADQR EAMLLLSDSP LLTLHDLLSF SFQVAKAMDF 180
LSSRNCLHRD LAARNVLVCE GKLAKVCDFG LARDLTRDQN YVAKGNTFLP VKWMSPESIF 240
QSVYSCQSDV WSYGILLWEI FSLGGSPYPD LPLTQEFYSA LKRGYRMNPP EHAPQNISDL 300
MKRCWEEKPQ ARPAFSSLVA 320
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-ORN-00518
EKS-TAR-00513
EKS-XIM-00508
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013