EKS-TEN-00185

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00185

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	534.6	4.5E-161	579	855	277

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010448

UniProt Accession

H3CQB4;

Protein Name

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007633	ENSTNIP00000010448	ENSTNIT00000010629

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

923

Protein Sequence
(FASTA)

MSRVTFCALL LCLVDRISAR VIDEARTKDL RVFKPLVVPG FPENTTAVVG GQAKLVCKVH 60

RPLSTKVQWL KREASVSGQT PEAPPRPREL TPLQSNASKV YMLNLHNVTM EDAGEYICMA 120

ENPTGQMMQS AWLEVLPDVL KDLSEDTAEH LLLEPGNVLK LRCDISTRPG MAFNWYKDGI 180

RVLPMPRVQI RGAIIEIADV TYEDSGVYVC VLRGHKEPTR NFTITVADSL GSGDDDEDNN 240

LEDSSAEIEN DQVYLSKGPY WTHIQRMEKK LYAVPAGNTV KFRCPAMGSP MPSIRWLKNG 300

REFRGEHRIG GIKLRHQHWS LVMESVVPSD RGNYTCVVEN KYGSIFHSYV LDVLERSPHR 360

PILQAGLPAN TTAVVGSDVQ LHCKVYSDAQ PHIQWLKHIE RNGSSYSPDG TPYVQILKTG 420

SLNMSDVEVL YLSKVTMEDA GEYTCLAGNS IGYAHQSAWL NVISEEEAAD AMDSMETKYT 480

DIIIYVCGFL ALIMATIIVV LCRMQAQPRG EPFDALPVQK LSKFPLRRQY SLESNSSGKS 540

SASLMRVARL SSSCSPMLAG VLEFELPYDP DWEFPRENLT LGKPLGEGCF GQVVRAEAFG 600

INKDSPDQAT TVAVKMLKDD ATDKDLADLI SEMELMKVMD KHKNIINLLG VCTQDGPLYV 660

LVEYASKGSL REYLRARRPP GMDYTFDVTK VPEEQLTFKD LLSCAYQVAR GMEYLASKRC 720

IHRDLAARNV LVTEDNVMKI ADFGLARGVH QIDYYKKTTN GRLPVKWMAP EALFDRVYTH 780

QSDVWSFGVL MWETFTLGGS PYPGIPVEEL FKLLKEGHRM DKPSNCTHEL YMMMRECWHA 840

VPSQRPTFKQ LVEELDRVLL SISDETSGSP APFEQYSPSC EDTSSSCSSD NDSVFTHDAL 900

STEPCLLGYH DVRSRIDVNT ALR 923

Nucleotide Sequence
(FASTA)

ATGTCCAGGG TCACCTTTTG CGCTCTGCTG CTGTGTTTAG TGGACAGGAT CTCAGCTCGT 60

GTCATCGACG AAGCGCGGAC CAAAGATCTT AGGGTGTTCA AGCCCCTGGT GGTGCCGGGC 120

TTCCCAGAAA ACACCACAGC AGTGGTCGGT GGCCAGGCCA AGCTGGTGTG TAAAGTCCAC 180

CGGCCGTTGT CCACCAAGGT CCAGTGGCTG AAGAGGGAGG CCAGCGTGTC TGGACAGACC 240

CCAGAAGCAC CGCCGCGCCC CCGCGAACTG ACACCCCTGC AGAGCAATGC ATCCAAGGTG 300

TACATGCTAA ACCTGCACAA CGTCACTATG GAGGACGCAG GAGAGTACAT CTGCATGGCC 360

GAGAACCCCA CAGGGCAGAT GATGCAGTCC GCCTGGCTGG AGGTCCTGCC TGATGTTCTG 420

AAAGACTTGA GCGAAGACAC GGCAGAGCAC CTCCTGCTGG AGCCGGGGAA CGTCCTCAAG 480

CTGCGCTGCG ACATCAGCAC CAGGCCCGGC ATGGCCTTCA ACTGGTACAA GGACGGAATC 540

CGGGTCCTGC CCATGCCCCG CGTTCAGATC CGCGGCGCCA TCATAGAAAT CGCAGACGTG 600

ACCTACGAGG ACTCGGGAGT TTATGTTTGT GTCCTCAGGG GCCACAAAGA GCCCACCAGA 660

AACTTCACCA TCACCGTGGC AGATTCACTG GGATCAGGTG ATGATGATGA GGATAACAAC 720

TTGGAAGACT CATCGGCAGA GATAGAGAAC GACCAGGTTT ACCTCTCCAA AGGTCCCTAC 780

TGGACTCACA TCCAGCGTAT GGAGAAGAAG CTCTACGCTG TTCCTGCCGG AAACACGGTG 840

AAGTTTCGCT GCCCGGCAAT GGGCAGCCCC ATGCCGAGCA TCAGGTGGCT CAAAAACGGG 900

CGTGAGTTTA GGGGAGAGCA CCGCATTGGA GGAATCAAGC TAAGACATCA GCATTGGAGT 960

TTGGTAATGG AGAGCGTGGT ACCTTCAGAC AGAGGAAACT ACACCTGTGT GGTGGAGAAC 1020

AAGTACGGGT CCATCTTTCA CAGCTACGTC CTCGACGTCC TTGAGCGTTC TCCACACCGG 1080

CCTATCCTCC AGGCTGGTCT GCCTGCAAAT ACCACAGCGG TGGTGGGCAG TGACGTCCAG 1140

CTACACTGTA AGGTCTACAG CGATGCCCAG CCTCACATTC AGTGGCTCAA GCACATAGAA 1200

AGGAACGGGA GCAGCTACAG CCCTGACGGA ACACCCTACG TTCAAATACT CAAGACTGGC 1260

AGTTTGAACA TGTCGGACGT GGAGGTGCTC TACCTGTCTA AAGTCACCAT GGAGGATGCA 1320

GGAGAGTACA CCTGCCTGGC GGGCAATTCA ATTGGGTACG CTCATCAGTC TGCCTGGCTC 1380

AATGTCATTT CAGAAGAGGA AGCAGCAGAC GCTATGGACT CCATGGAAAC CAAATACACC 1440

GACATCATCA TCTACGTCTG TGGTTTCCTG GCTCTGATTA TGGCCACCAT CATCGTGGTG 1500

CTGTGCCGGA TGCAGGCGCA GCCCAGAGGT GAACCGTTCG ATGCTCTTCC CGTACAGAAG 1560

CTGTCCAAGT TTCCTCTTCG CAGACAGTAT TCACTGGAGT CCAACTCATC AGGAAAGTCC 1620

AGCGCTTCAC TGATGAGAGT GGCTCGCCTC TCGTCCAGCT GCTCCCCCAT GCTGGCTGGC 1680

GTTTTGGAGT TTGAGTTGCC CTATGACCCA GACTGGGAGT TCCCCAGGGA GAATTTAACG 1740

CTGGGCAAAC CTCTGGGAGA GGGCTGCTTC GGACAAGTGG TCCGAGCCGA GGCCTTCGGC 1800

ATCAACAAGG ACTCCCCAGA TCAAGCCACC ACTGTGGCGG TAAAGATGCT AAAAGATGAT 1860

GCCACAGACA AAGATCTGGC TGACCTCATA TCAGAAATGG AGCTGATGAA GGTGATGGAT 1920

AAACACAAGA ACATCATCAA CTTACTGGGA GTTTGCACCC AAGACGGCCC TCTGTATGTG 1980

CTGGTGGAGT ACGCCTCCAA AGGGAGTCTG AGGGAGTACC TACGGGCACG GAGGCCCCCA 2040

GGCATGGACT ACACTTTTGA TGTGACCAAG GTGCCTGAAG AGCAGCTCAC CTTCAAAGAC 2100

CTGCTGTCCT GTGCCTACCA GGTTGCCAGA GGGATGGAGT ACCTTGCATC TAAAAGGTGT 2160

ATTCACAGAG ATCTGGCTGC AAGAAATGTC CTGGTTACAG AGGACAACGT GATGAAGATC 2220

GCTGACTTTG GCCTGGCGAG GGGCGTCCAT CAAATTGACT ATTACAAGAA AACTACCAAT 2280

GGACGGCTGC CGGTCAAGTG GATGGCACCT GAAGCCTTGT TTGACAGAGT CTACACACAC 2340

CAGAGTGACG TGTGGTCCTT CGGCGTTCTG ATGTGGGAGA CCTTCACGCT GGGTGGCTCG 2400

CCCTACCCGG GCATCCCTGT GGAGGAGCTC TTCAAGCTGC TGAAGGAGGG ACACCGCATG 2460

GATAAACCCT CCAACTGCAC GCATGAACTA TACATGATGA TGCGTGAGTG CTGGCATGCT 2520

GTCCCCAGCC AGAGGCCGAC CTTCAAACAG CTGGTGGAGG AGTTGGACAG AGTGCTGCTG 2580

TCCATCTCTG ACGAGACTTC TGGTTCGCCT GCTCCCTTCG AGCAGTACTC CCCATCCTGT 2640

GAGGACACCT CCAGCTCCTG CTCATCTGAT AACGACTCCG TTTTTACCCA CGATGCCTTG 2700

TCCACCGAGC CCTGCCTCCT TGGCTACCAC GACGTACGCT CTCGGATAGA TGTGAACACG 2760

GCACTGCGGT AG 2772

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g++kd +++++tvavkmlk+datdkdladl+seme++k+

Q: 579   LTLGKPLGEGCFGQVVRAEAFGINKDSPDQATTVAVKMLKDDATDKDLADLISEMELMKV  638

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d +k++eeqlt+

Q: 639   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTF  698

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdl+s+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 699   KDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  758

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+we +tlGgspypgi+veelfkllkeGh

Q: 759   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWETFTLGGSPYPGIPVEELFKLLKEGH  818

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mrecwha++s+rptfkqlve+l

Q: 819   RMDKPSNCTHELYMMMRECWHAVPSQRPTFKQLVEEL  855

         ***********************************86

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVRAEA FGINKDSPDQ ATTVAVKMLK DDATDKDLAD LISEMELMKV 60

MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGMDYTFDV TKVPEEQLTF 120

KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWETFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPSNCTH ELYMMMRECW HAVPSQRPTF KQLVEEL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013