EPS-TEN-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TEN-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	198.1	2.5E-58	88	340	253

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010470

UniProt Accession

H3CQD6;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007655	ENSTNIP00000010470	ENSTNIT00000010651

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

425

Protein Sequence
(FASTA)

NCPCSLAAAL ARATADSVLQ TDLSIHHLNK TAEDGADPVP LKHERQQQSK LESVKLARLV 60

FNRLFELCCL WMKELPFRRR PQPYYETSIH AIKNMRRKME DKHVIIPDFN TLFNVQDQEE 120

QAYFAVFDGH GGVDAAIYAA NHLHVNLVRQ ESFSHDPSEA LCRAFKLTDE GFVKKARREQ 180

LRCGTTGVVT FLRGRTLYVA WLGDSQVILV RRGQVVELMK PHKPDREDEK QRIEALGGCV 240

IWFGTWRVNG SLSVSRAIGD SEHKPYICGD ATNVFPLDGW EDYLILACDG FWDTVSPDEA 300

VRVVSDHLQE NSGDTTMVAH KLVASARDAG SSDNITVIVV FLRDRARRRP PPPAARVERG 360

GEGGSTADIG GKSRGGWPLQ QCSAPADLGY EDRTDSFTDR TSLSLGPSLE GRLFLNRAPL 420

AAIFP 425

Nucleotide Sequence
(FASTA)

AACTGCCCCT GCTCCCTGGC TGCAGCCTTG GCCCGAGCCA CAGCCGACAG CGTCCTGCAG 60

ACCGACCTCT CCATCCACCA CCTCAACAAG ACCGCGGAGG ACGGCGCTGA CCCAGTACCA 120

CTCAAACATG AGAGGCAACA ACAGTCAAAG TTGGAGTCGG TGAAGCTGGC TCGGCTGGTG 180

TTCAACAGGC TCTTTGAGTT GTGCTGCCTG TGGATGAAGG AGCTGCCCTT CCGCCGCCGG 240

CCGCAGCCGT ACTATGAAAC GTCCATCCAC GCCATCAAGA ACATGAGGCG CAAGATGGAG 300

GACAAGCACG TCATCATCCC CGACTTCAAC ACGCTCTTCA ACGTTCAGGA TCAGGAGGAG 360

CAGGCCTATT TCGCTGTGTT CGACGGCCAC GGCGGCGTGG ACGCTGCCAT TTACGCCGCC 420

AACCACCTGC ACGTGAACCT GGTGCGGCAG GAGTCCTTCA GCCACGACCC CAGCGAGGCG 480

CTCTGCCGCG CCTTCAAGCT CACCGACGAG GGCTTCGTGA AGAAGGCCAG GCGGGAGCAA 540

CTGCGCTGCG GCACCACGGG CGTGGTCACC TTCCTGCGGG GCCGGACGCT GTACGTGGCC 600

TGGCTGGGGG ACTCCCAGGT CATCCTGGTG CGGAGAGGGC AGGTGGTGGA GCTGATGAAG 660

CCGCACAAGC CGGACAGAGA GGACGAGAAG CAGCGGATCG AGGCTTTGGG AGGCTGCGTC 720

ATCTGGTTCG GCACCTGGAG GGTTAACGGC AGCCTGTCTG TGTCCAGAGC CATAGGCGAC 780

TCGGAGCACA AACCCTACAT CTGCGGCGAC GCGACCAACG TGTTCCCGCT GGACGGCTGG 840

GAGGACTACC TGATCCTGGC CTGCGACGGC TTCTGGGACA CGGTGAGTCC GGACGAGGCG 900

GTGCGGGTGG TGAGCGACCA CCTGCAGGAG AACAGCGGCG ACACCACCAT GGTGGCCCAC 960

AAGCTGGTGG CCTCGGCCCG CGACGCCGGC TCCAGCGACA ACATCACCGT CATCGTGGTC 1020

TTCCTGCGGG ACCGCGCTCG CCGCCGCCCG CCACCACCAG CGGCCAGGGT GGAGCGCGGC 1080

GGCGAGGGAG GCAGCACAGC GGACATCGGC GGGAAAAGCC GCGGCGGCTG GCCCCTGCAG 1140

CAGTGCTCGG CGCCCGCCGA CCTGGGCTAC GAAGACCGGA CGGACTCCTT CACGGACAGA 1200

ACCAGCCTCA GTCTGGGGCC TTCGCTGGAG GGCCGCCTCT TCCTCAACCG GGCGCCCCTG 1260

GCGGCCATCT TCCCC 1275

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++ + p+f    + +d+   a+f+v+DGhgg ++a +++++lh  l

Q: 88    SIHAIKNMRRKMEDKHVIIPDFNTLFNVQDQeeQAYFAVFDGHGGVDAAIYAANHLHVNL  147

         567899***************9876655555559**************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++ +     + + ++al +aF+ tde +  +++++ ++ ++G+t vv  +++ +lyva

Q: 148   VRQES----FSHDPSEALCRAFKLTDEGF--VKKARREQLRCGTTGVVTFLRGRTLYVAW  201

         ***77....5677888999**********..8888788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         +GdS+++L r g++vel + Hkp+redE++Rie+ gg vi   g  Rv+G+L vsRa+Gd

Q: 202   LGDSQVILVRRGQVVELMKPHKPDREDEKQRIEALGGCVIWF-GTwRVNGSLSVSRAIGD  260

         ****************************************66.777**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  +  + +++l+  +++liLa+DG wd+vs+ eav++v d+l+ ++ +++ +a

Q: 261   SEHKPYICGD-ATNVFPLDGWEDYLILACDGFWDTVSPDEAVRVVSDHLQeNSGDTTMVA  319

         ******9776.9************************************9945668899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 320   HKLVASARDAGSSDNITVIVV  340

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVIIP DFNTLFNVQD QEEQAYFAVF DGHGGVDAAI YAANHLHVNL 60

VRQESFSHDP SEALCRAFKL TDEGFVKKAR REQLRCGTTG VVTFLRGRTL YVAWLGDSQV 120

ILVRRGQVVE LMKPHKPDRE DEKQRIEALG GCVIWFGTWR VNGSLSVSRA IGDSEHKPYI 180

CGDATNVFPL DGWEDYLILA CDGFWDTVSP DEAVRVVSDH LQENSGDTTM VAHKLVASAR 240

DAGSSDNITV IVV 253

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013