EKS-TEN-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	482.7	2.1E-145	605	864	260

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010634

UniProt Accession

H3CQV0;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB3

Gene Synonyms/Alias

EPHB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007814	ENSTNIP00000010634	ENSTNIT00000010815

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

884

Protein Sequence
(FASTA)

LWVCSLVVPA VLAVEETLMD SRWATTELAW TTFPKSQWEE VSGYDDSMSP IRTYQVCNVR 60

QPNQNNWLRT DFVPRKGVLR VYVELKFSVR DCASIPNIPG SCKETFNLFY YESDGDTATD 120

ASPQWRENPY VKVDTIAPDE SFSLLEAGRI NTKVRSFGPL SKAGFYLAFQ DLGACMSLIS 180

VRVFFKKCST TIANFAVFPE TATGAEATSL VIAPGACVSN AMEVSVPLKL YCNGDGEWMV 240

PVGSCTCVSG YEPSPDNTQC QACFPGTFKP KLGDGSCTLC PANSHSSVRG SSVCSCRSGF 300

HRADSDPSES VCTTIPSAPR NLISSVNETS LSLEWDEPED TGGRSDLVYN VVCKKCLWDR 360

SPCTRCDDNV DVAPRRLGLR QRKVVVRNLQ AHTRYSFEVQ AVNGVSRSRP SPSFSTVNIT 420

TNQAAPSAVP TVHLMRSTAD TLSLSWLPPD KPNGVILDYE IKYHERGKAM SHTVTAQHSS 480

ARVEGLRAAT PYVVQVRART VAGYGRYSNP MDFSTSLHSD PQKSVQDQLP LIVGSASAGL 540

VVIVALVVIA VVCLKKQRGG SELEYTEKLQ QYISPGVKVY IDPFTYEDPN DAVHEFAKEI 600

DISCVKIEEV IGAAGEFGEV CRGRLKQAGR REMVVAIKTL KAGYTERQRR DFLAEASIMG 660

QFDHPNVIRL EGVLTRSCPV LIITEFMENG ALDSFLRLND GRFTMTQLVG MLRGVAAGMK 720

YLSDMNYVHR DLAARNILVN SNLVCKVSDF GLSRFLDDTS ADPTYTSSQG GKIPIRWTAP 780

EAIAFRKFTT ASDVWSYGIV MWEVVSYGER PYWDMSNQDV MTAVEQDYRL PPPMDCPMVL 840

HQLMLECWMK ERNLRPKFSR IVGTLDKLLR NAACLKMVTS SYSG 884

Nucleotide Sequence
(FASTA)

CTGTGGGTGT GCAGCCTCGT CGTGCCCGCG GTGCTGGCGG TGGAAGAAAC CCTTATGGAC 60

AGTCGGTGGG CGACTACAGA GCTGGCGTGG ACGACGTTCC CAAAGAGTCA GTGGGAGGAG 120

GTCAGCGGCT ACGACGACTC CATGAGCCCC ATCAGGACCT ACCAGGTCTG CAACGTGCGG 180

CAGCCCAACC AGAACAACTG GCTCAGGACG GACTTCGTCC CCCGCAAAGG CGTGCTGCGC 240

GTCTACGTGG AGCTCAAGTT CTCGGTGCGC GACTGCGCCA GCATCCCCAA CATCCCCGGC 300

TCCTGCAAGG AGACCTTCAA CCTCTTCTAC TACGAGTCGG ACGGGGACAC GGCCACCGAC 360

GCCAGCCCGC AGTGGAGGGA GAACCCCTAC GTGAAGGTGG ACACCATCGC CCCCGACGAG 420

AGCTTCTCCC TGCTGGAGGC GGGCCGGATC AACACCAAAG TGCGGAGCTT CGGGCCCCTC 480

TCCAAGGCGG GCTTCTACCT GGCCTTCCAG GACCTGGGGG CCTGCATGTC GCTCATCTCC 540

GTCAGGGTCT TCTTCAAGAA GTGCTCCACC ACCATCGCAA ACTTCGCCGT CTTCCCCGAG 600

ACGGCCACGG GGGCAGAGGC CACCTCCCTG GTGATCGCCC CGGGGGCGTG CGTCAGCAAC 660

GCCATGGAGG TGTCCGTCCC CCTCAAGCTC TACTGCAACG GCGACGGCGA GTGGATGGTT 720

CCGGTGGGCT CCTGCACCTG CGTGTCGGGC TACGAGCCCT CGCCGGACAA CACGCAGTGC 780

CAGGCCTGCT TTCCCGGAAC CTTCAAGCCC AAACTGGGAG ACGGCTCCTG CACCCTCTGC 840

CCGGCCAACA GCCACAGCAG CGTGCGGGGC TCCAGCGTCT GCTCCTGCCG GAGCGGCTTC 900

CACCGGGCCG ACAGCGACCC CTCCGAGTCC GTCTGCACCA CCATCCCCTC GGCGCCGCGC 960

AACCTCATCT CCAGCGTGAA CGAGACCTCG CTGTCGCTGG AGTGGGACGA GCCCGAGGAC 1020

ACCGGCGGCA GGAGCGACCT GGTCTACAAC GTGGTGTGCA AGAAGTGCCT GTGGGACCGC 1080

AGCCCGTGCA CGCGCTGCGA CGACAACGTG GACGTGGCGC CCCGCAGGCT GGGGCTGAGA 1140

CAGCGGAAGG TGGTGGTGAG GAACCTGCAG GCGCACACCC GCTACAGCTT CGAGGTGCAG 1200

GCCGTCAACG GCGTCTCCAG AAGTCGGCCT TCGCCCAGCT TCTCCACCGT CAACATCACC 1260

ACCAACCAGG CCGCGCCCTC GGCCGTGCCC ACCGTCCACC TGATGAGATC CACGGCCGAC 1320

ACGCTCAGCC TGTCCTGGCT GCCCCCGGAC AAACCCAACG GCGTCATCCT GGACTATGAG 1380

ATCAAATACC ACGAGAGGGG CAAAGCCATG TCCCACACCG TCACCGCCCA GCACAGCTCG 1440

GCCAGGGTGG AGGGGCTGCG GGCCGCCACG CCCTACGTGG TGCAGGTGCG GGCGCGCACC 1500

GTGGCCGGGT ACGGCCGCTA CAGCAACCCC ATGGACTTCA GCACCAGCCT CCACAGTGAC 1560

CCTCAGAAGT CTGTGCAGGA CCAGCTGCCC CTCATCGTAG GCTCCGCCTC CGCGGGCCTG 1620

GTGGTCATCG TGGCCCTGGT GGTCATCGCC GTCGTCTGCC TGAAGAAGCA GCGCGGCGGC 1680

TCGGAGCTGG AGTACACGGA GAAGCTGCAG CAGTACATCT CCCCAGGGGT CAAAGTGTAC 1740

ATCGACCCCT TCACCTACGA GGACCCCAAC GACGCCGTGC ACGAGTTCGC CAAGGAGATC 1800

GACATCTCCT GCGTGAAGAT CGAGGAGGTC ATCGGCGCAG CAGGTGAGTT CGGCGAGGTG 1860

TGCCGCGGCC GCCTCAAGCA GGCCGGCCGC CGGGAGATGG TGGTGGCCAT CAAGACGCTG 1920

AAGGCAGGCT ACACGGAGCG CCAGAGGCGG GACTTCCTGG CCGAGGCCTC CATCATGGGC 1980

CAGTTCGACC ACCCCAACGT GATCCGGCTG GAGGGCGTCC TGACGCGCAG CTGCCCCGTC 2040

CTCATCATCA CCGAGTTCAT GGAGAACGGA GCGCTGGACT CCTTCCTCAG GCTGAACGAC 2100

GGACGCTTCA CCATGACGCA GCTGGTGGGG ATGCTGCGCG GCGTCGCCGC GGGGATGAAG 2160

TACCTGTCGG ACATGAACTA CGTCCACCGA GACCTCGCCG CTCGCAACAT CCTGGTCAAC 2220

AGCAACCTGG TCTGCAAGGT CTCCGACTTC GGCCTGTCGC GGTTCCTGGA CGACACGTCT 2280

GCAGACCCCA CTTACACCAG CTCCCAGGGG GGGAAGATCC CCATCCGGTG GACGGCTCCA 2340

GAAGCCATCG CCTTCAGGAA ATTCACCACC GCCAGTGACG TGTGGAGCTA CGGCATCGTG 2400

ATGTGGGAGG TGGTGTCCTA CGGGGAGAGG CCTTACTGGG ACATGAGCAA CCAGGACGTG 2460

ATGACGGCGG TGGAGCAGGA CTACCGGCTG CCTCCGCCCA TGGACTGTCC CATGGTGCTG 2520

CACCAGCTGA TGCTGGAGTG CTGGATGAAG GAGCGCAACC TGAGGCCCAA GTTCTCCCGC 2580

ATCGTCGGCA CCCTGGACAA GCTGCTGCGC AACGCCGCCT GCCTGAAGAT GGTGACCAGC 2640

AGCTACTCGG GGTGA 2655

Domain Profile

S: 1     vkiekviGa.GefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdh  59

         vkie+viGa GefGevc+Grlk++g+re++vaiktlkag+te+qrrdfl+easi+Gqfdh

Q: 605   VKIEEVIGAaGEFGEVCRGRLKQAGRREMVVAIKTLKAGYTERQRRDFLAEASIMGQFDH  664

         79*****9549*************************************************

S: 60    pniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsd  119

         pn+irleGv+t+s pv+i+te+mengaldsflr +dg+ft+ qlvgmlrG+a+gmkylsd

Q: 665   PNVIRLEGVLTRSCPVLIITEFMENGALDSFLRLNDGRFTMTQLVGMLRGVAAGMKYLSD  724

         ************************************************************

S: 120   mgyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaia  177

         m+yvhrdlaarnilvnsnlvckvsdfGlsr+l+d s +++yt+s ggkipirwtapeaia

Q: 725   MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLDDTSaDPTYTSSqGGKIPIRWTAPEAIA  784

         ********************************99999*****877***************

S: 178   yrkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlm  237

         +rkft+asdvwsyGiv+wev+syGerpywdmsnqdv++a+e++yrlpppmdcp+ l+qlm

Q: 785   FRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQDYRLPPPMDCPMVLHQLM  844

         ************************************************************

S: 238   ldcwqkdraerpkfeqivsi  257

         l+cw k+r+ rpkf++iv +

Q: 845   LECWMKERNLRPKFSRIVGT  864

         *****************976

Domain Sequence
(FASTA)

VKIEEVIGAA GEFGEVCRGR LKQAGRREMV VAIKTLKAGY TERQRRDFLA EASIMGQFDH 60

PNVIRLEGVL TRSCPVLIIT EFMENGALDS FLRLNDGRFT MTQLVGMLRG VAAGMKYLSD 120

MNYVHRDLAA RNILVNSNLV CKVSDFGLSR FLDDTSADPT YTSSQGGKIP IRWTAPEAIA 180

FRKFTTASDV WSYGIVMWEV VSYGERPYWD MSNQDVMTAV EQDYRLPPPM DCPMVLHQLM 240

LECWMKERNL RPKFSRIVGT 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013