EKS-TEN-00619

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00619

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	321.5	4.7E-96	28	298	271

Status

Unreviewed

Ensembl Protein

ENSTNIP00000010646

UniProt Accession

H3CQW2;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK2

Gene Synonyms/Alias

RIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000007826	ENSTNIP00000010646	ENSTNIT00000010827

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

572

Protein Sequence
(FASTA)

MEPSAAMGCV NICSLTSSLP VIPYQKLTDL YYLSRGGFGT VFKAQHSAWR TTVAIKCLKL 60

DSPVGERERN CLLKEAEVLH KARFNHIIQI LGICNEPEFF CIVTEYMSNG SLDLLLHEKD 120

IYPRLGWPLR LRILYEISLG VNFLHNMNPP LLHHDLKTQN ILLDGEFHVK IADFGLSKWR 180

QLSVSRGSGS KPTEMGGTVI YMPPERYDAS KSHRADVKHD MYSYSIIMWE VLSRQIPFEA 240

SEVTNPMQIM FSVLNGARPE ISLDSLPADI PSRDTLICLM TTGWTSNPDE RPSFLKCLVE 300

LEPMVRAYDE IDFLEAVLEI KRSQLMRRSG CCAAQSDCQR SEGGLHTLKD RPSPWQVSGS 360

SSGSGSGSSQ DTNISLPGPL TITSPITGGY FCPLEDSPGR LNKDSCSDNQ PNSPWLINDL 420

NIPTKTKLPD AEDESRLGNG SLKLQPPPQV PVAAYSPPTQ GPIAEWIASQ REEIVAQMTE 480

ACLNQSLDAL LARSMLMRED YELVKNQQTR TAKVRQLLDN CHRHNEDFCR IVVRKLHDNK 540

QMNLAPYPSE ITSPALASAP PVSMSYNITR NM 572

Nucleotide Sequence
(FASTA)

ATGGAGCCGT CGGCGGCTAT GGGCTGTGTG AACATTTGCA GCCTGACCAG CAGCCTGCCG 60

GTGATCCCCT ACCAGAAGCT GACCGACCTC TACTACCTGA GCAGAGGCGG CTTCGGCACC 120

GTGTTCAAGG CGCAGCACTC CGCCTGGAGG ACCACCGTGG CCATCAAGTG TCTGAAACTC 180

GACAGCCCCG TCGGAGAGAG AGAGAGGAAC TGTCTGCTGA AGGAGGCAGA GGTGCTCCAC 240

AAAGCCAGAT TCAACCACAT CATCCAGATC TTGGGCATCT GCAACGAACC GGAGTTCTTC 300

TGCATAGTCA CGGAATACAT GAGCAACGGC TCTCTGGACC TGTTGCTCCA CGAGAAAGAC 360

ATCTACCCCA GGCTCGGCTG GCCTCTTCGA CTCAGGATTC TGTACGAGAT TTCCCTGGGG 420

GTTAACTTCC TTCACAACAT GAACCCGCCC CTCCTACATC ACGATCTGAA GACACAGAAC 480

ATTCTGCTGG ACGGGGAATT TCACGTCAAG ATTGCAGATT TCGGCCTGTC CAAGTGGCGG 540

CAGCTGTCTG TCAGTAGGGG CTCGGGCTCC AAACCCACAG AAATGGGCGG CACGGTCATT 600

TACATGCCCC CGGAGCGATA CGACGCCTCC AAGAGCCATC GGGCGGACGT GAAGCACGAC 660

ATGTACAGCT ATTCGATTAT CATGTGGGAA GTGCTGTCCA GGCAGATTCC ATTCGAAGCG 720

TCAGAGGTGA CCAACCCCAT GCAGATCATG TTCAGCGTGC TGAACGGGGC GCGGCCCGAG 780

ATCAGCCTGG ACAGCCTGCC GGCCGACATC CCCAGCAGGG ACACCCTCAT CTGTCTGATG 840

ACCACCGGGT GGACGTCCAA CCCGGACGAG CGTCCGTCCT TCCTCAAGTG TTTGGTTGAG 900

CTGGAGCCCA TGGTGAGGGC GTACGATGAA ATCGACTTTC TGGAGGCCGT GCTGGAGATC 960

AAGAGGTCAC AGCTGATGAG GAGGTCAGGC TGTTGTGCAG CCCAGTCAGA CTGTCAGAGG 1020

AGCGAAGGAG GACTCCACAC GCTGAAGGAC AGGCCCAGTC CCTGGCAGGT CAGTGGGAGC 1080

TCCTCAGGCT CCGGCTCTGG CTCCTCTCAG GACACCAACA TATCCCTGCC GGGCCCCCTC 1140

ACCATCACTT CACCAATAAC AGGTGGTTAT TTCTGCCCAT TAGAAGACAG CCCAGGAAGG 1200

CTGAATAAGG ACAGCTGCAG CGACAACCAG CCCAACAGTC CCTGGCTCAT CAACGACCTG 1260

AACATCCCCA CCAAAACCAA ACTGCCTGAT GCCGAAGATG AGAGCAGACT GGGGAACGGT 1320

TCCCTGAAGC TACAGCCTCC GCCACAAGTC CCGGTAGCCG CCTACTCGCC ACCCACTCAG 1380

GGCCCCATCG CCGAGTGGAT TGCATCGCAG CGCGAGGAGA TCGTGGCCCA GATGACAGAA 1440

GCCTGCCTGA ACCAGAGTTT GGATGCCCTG CTGGCCCGCT CCATGCTGAT GAGGGAGGAT 1500

TACGAACTGG TGAAAAACCA GCAAACGCGC ACGGCCAAGG TGCGGCAGCT GCTGGACAAC 1560

TGCCACAGGC ACAACGAGGA CTTCTGCCGC ATCGTCGTCC GCAAGCTGCA CGACAACAAG 1620

CAGATGAACC TGGCACCTTA TCCCTCGGAG ATCACCTCCC CCGCCCTGGC CAGCGCCCCG 1680

CCCGTGTCCA TGTCCTACAA CATCACCAGG AACATGTAA 1719

Domain Profile

S: 2     eelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyv  61

         ++l ++++Ggfg+vfka+h  wr++va+k l l+++  ++er++ll+ea++++k+rf+++

Q: 28    TDLYYLSRGGFGTVFKAQHSAWRTTVAIKCLKLDSPVGERERNCLLKEAEVLHKARFNHI  87

         67889*******************************************************

S: 62    lkllGvikeeeklglvmeymenGsLeklLkseielp...wplkfRilkevvlgmnyLhsl  118

         +++lG+++e+e+  +v+eym nGsL+ lL+++  +p   wpl++Ril e++lg+n+Lh++

Q: 88    IQILGICNEPEFFCIVTEYMSNGSLDLLLHEKDIYPrlgWPLRLRILYEISLGVNFLHNM  147

         ********************************8888999*********************

S: 119   kPpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssa..egGtlaYlaPel  176

         +Ppllh+DLk++niLlD e+hvkiaDfGlsk+ ++ s s+ + s++   gGt++Y++Pe+

Q: 148   NPPLLHHDLKTQNILLDGEFHVKIADFGLSKW-RQLSVSRGSGSKPteMGGTVIYMPPER  206

         ********************************.66666665555544699**********

S: 177   leevnk.kaseksDvYsfaiviWavlakkepye..eeknslqiiivvkkgnRPeleevse  233

         +  ++  +a+ k+D+Ys++i++W+vl+++ p+e  e++n +qi+++v +g RPe++   +

Q: 207   YDASKShRADVKHDMYSYSIIMWEVLSRQIPFEasEVTNPMQIMFSVLNGARPEISL--D  264

         *876655************************98335789**************9986..7

S: 234   elPrevpq...lieLmkrcWeadpeeRPsFleie  264

         +lP ++p+   li Lm  +W+++p+eRPsFl++

Q: 265   SLPADIPSrdtLICLMTTGWTSNPDERPSFLKCL  298

         78888877777********************986

Domain Sequence
(FASTA)

TDLYYLSRGG FGTVFKAQHS AWRTTVAIKC LKLDSPVGER ERNCLLKEAE VLHKARFNHI 60

IQILGICNEP EFFCIVTEYM SNGSLDLLLH EKDIYPRLGW PLRLRILYEI SLGVNFLHNM 120

NPPLLHHDLK TQNILLDGEF HVKIADFGLS KWRQLSVSRG SGSKPTEMGG TVIYMPPERY 180

DASKSHRADV KHDMYSYSII MWEVLSRQIP FEASEVTNPM QIMFSVLNGA RPEISLDSLP 240

ADIPSRDTLI CLMTTGWTSN PDERPSFLKC L 271

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042981	; P:regulation of apoptotic process

KEGG

InterPros

IPR001315	; CARD.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00619	; CARD; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50209	; CARD; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013