EKS-TEN-00384
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00384
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.91.2E-149571827257
StatusUnreviewed
Ensembl ProteinENSTNIP00000011153
UniProt AccessionH3CSB9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (1 of 2)
Gene Synonyms/Alias ERBB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000008323ENSTNIP00000011153ENSTNIT00000011335
OrganismTetraodon nigroviridis
Functional Description
Protein Length1142
Protein Sequence
(FASTA)
KFLCHADTIH WRDIIKNSLA ELLVVSSNSS NPGCRRCHRS CNGRCWGHQE DQCQTLTKTV 60
CAEQCDGRCF GPYVSDCCHR ECAGGCSGPK DTDCFACTNF NDSGACVTQC PQPFVYNPTS 120
FQLEHNPRAK YTYGAFCVKK CPHNFVVDHS SCVRACPSNK MEVEKNRIKM CIPCTDICPK 180
VCDGIGTGSL LKNQTVDASN IDKFVNCTKI NGNLIFLITG IKGDMYHGIG PLDPERLNVF 240
RTVREITGYL NIQAWPENMT DLGVFSNLAT IGGRSLYSIS GISLLILKQR WISSFKFQSL 300
DEISAGNVYI SNNSGLCFYN TVNWTSLFRT SNQKVLIRNN RDPKECSQLQ MVCDGMCSEE 360
GCWGSGPDQC LSCRYFKRGR SCVESCNLFE GDVPEFANGS VCLECDSQCE RMDGNALTCL 420
GQGPDQCVKC RHFKDGPNCV EKCPDGLQGA NSFIFKYAKA NNECHPCHAN CTQGCVGPRL 480
QDCVGFLCFS WKTESVLLRL CRTPLIAAGI IGGLFIIVIL ALSVAVYARR KSIKKKRALR 540
RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKILGSG AFGTVYKGIW VPEGETVKIP 600
VAIKILNEAT GPKANVEFMD EALIMASMEH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY 660
VHEHKDNIGS QLLLNWCVQI AKGMMYLEER RLVHRDLAAR NVLVKSPNHI KITDFGLARL 720
LDANEKEYNA DGGKMPIKWM ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGIPTR 780
EIPDILEKGE RLPQPPICTI DVYMVMVKCW MIDADSRPKF KELAAEFCRM ARDPQRYLVI 840
QGDDRMKLPS PNDSKFFQSL LDEEDLDNLM DADEYLVPQG YTLAPPSYTV RPRVDSNRNQ 900
FGYRDGGPVP TEGPVAGAQA GSSQETPGGL VSSLEDTRSN GNLHKKSMSQ SGAEDSGGQR 960
YSADPTVFLG ERTSRGDTDE DGYITPMKDK NSSEYLNPIE ENPFVSRRKN GEIHALDNPG 1020
YHSTPNSQPK TEDEYINEPL YLNTFHNPAE LSLEALSKVS GKKLKVTFDN PEYWQHSLPP 1080
RSSNQAAPDS TLGGSTNAKL FYKQNGHIRP VVAENPEYMS EFSLKPGTVL PPPPYRQRNT 1140
VV 1142
Nucleotide Sequence
(FASTA)
AAATTCCTGT GCCACGCTGA CACCATCCAC TGGCGTGACA TCATCAAAAA CTCTCTTGCG 60
GAACTCCTGG TGGTATCGTC CAACAGCAGT AACCCCGGAT GCAGACGCTG TCATCGCTCA 120
TGTAACGGAC GTTGCTGGGG GCACCAGGAA GACCAGTGCC AAACCTTGAC AAAGACGGTG 180
TGCGCAGAGC AGTGTGACGG TCGATGTTTT GGGCCTTACG TCAGCGACTG CTGCCATCGC 240
GAGTGTGCTG GCGGCTGCTC CGGCCCCAAG GACACAGATT GCTTCGCGTG CACCAATTTC 300
AACGACAGCG GGGCGTGCGT GACCCAGTGC CCTCAGCCGT TTGTGTACAA CCCCACATCT 360
TTTCAGCTGG AGCACAACCC CAGAGCCAAG TACACCTACG GCGCATTTTG CGTCAAGAAA 420
TGTCCACATA ATTTTGTGGT GGACCACAGC TCTTGCGTCA GAGCTTGTCC CAGCAACAAG 480
ATGGAAGTGG AGAAAAACCG CATCAAAATG TGCATCCCGT GCACGGACAT CTGCCCCAAA 540
GTGTGCGACG GCATCGGGAC GGGAAGTTTG CTGAAGAATC AAACGGTGGA CGCAAGCAAC 600
ATTGACAAAT TCGTCAACTG CACCAAAATC AATGGCAACC TGATCTTCCT TATCACGGGG 660
ATTAAAGGGG ACATGTATCA CGGTATCGGA CCCCTGGACC CCGAGCGGCT GAACGTGTTC 720
CGCACTGTGA GAGAGATTAC AGGTTACCTC AACATCCAGG CCTGGCCGGA GAACATGACA 780
GATCTGGGTG TTTTTTCCAA CCTGGCAACA ATTGGAGGCA GATCTCTTTA TAGCATCAGC 840
GGTATCTCAC TGCTGATTCT GAAACAACGT TGGATCTCTT CTTTTAAGTT CCAGTCTCTG 900
GACGAGATCA GTGCCGGGAA TGTGTACATT TCAAACAACA GCGGCTTGTG CTTCTACAAC 960
ACCGTAAACT GGACGTCGCT CTTCAGGACA TCAAACCAGA AAGTCCTCAT CCGTAACAAT 1020
CGCGATCCAA AGGAATGCAG TCAGCTTCAG ATGGTGTGTG ATGGAATGTG TTCTGAAGAG 1080
GGATGCTGGG GTTCTGGGCC CGACCAGTGT CTTTCATGTC GATATTTCAA GCGGGGCCGC 1140
TCCTGCGTTG AATCCTGCAA CCTTTTTGAA GGGGACGTGC CGGAATTTGC CAACGGTTCC 1200
GTGTGTTTGG AGTGTGACAG CCAGTGTGAG CGCATGGATG GAAACGCCCT GACGTGTCTC 1260
GGCCAGGGCC CGGACCAATG TGTGAAATGT CGTCACTTCA AAGATGGACC GAACTGTGTG 1320
GAGAAATGCC CTGATGGGCT GCAGGGCGCC AACAGTTTTA TCTTCAAGTA TGCCAAGGCC 1380
AACAACGAGT GTCATCCATG CCACGCCAAC TGCACTCAGG GGTGTGTCGG GCCGAGACTA 1440
CAAGATTGTG TTGGATTTCT CTGCTTTTCT TGGAAAACAG AATCAGTCCT TCTCCGGCTC 1500
TGCAGGACAC CGCTGATAGC AGCTGGCATC ATTGGGGGCC TGTTCATCAT CGTCATCCTG 1560
GCGCTCAGCG TGGCCGTTTA CGCGCGCCGC AAAAGCATCA AGAAGAAGAG GGCCCTGCGG 1620
CGGTTCTTGG AGACAGAGCT GGTGGAGCCC CTGACCCCCA GCGGGACGGC CCCTAACCAG 1680
GCTCAGCTGC GGATCCTGAA GGAGACGGAG CTAAAAAGAG TGAAGATTCT GGGTTCGGGT 1740
GCTTTTGGAA CAGTCTACAA GGGCATCTGG GTTCCCGAAG GTGAGACGGT GAAGATTCCA 1800
GTCGCTATTA AAATCCTCAA CGAGGCTACA GGCCCTAAAG CCAACGTGGA GTTCATGGAC 1860
GAGGCCCTGA TCATGGCCAG CATGGAACAC CCCCACCTGG TGCGACTGCT GGGCGTCTGC 1920
CTGAGCCCCA CCATCCAACT GGTGACTCAG CTAATGCCCC ATGGCTGCCT GCTGGACTAT 1980
GTCCACGAGC ACAAGGACAA CATCGGCTCG CAGCTGCTGC TCAACTGGTG TGTCCAGATT 2040
GCCAAGGGAA TGATGTACCT GGAGGAGAGG AGGCTGGTCC ACAGGGATCT TGCGGCCCGT 2100
AACGTGCTGG TAAAGTCGCC CAATCACATC AAAATCACAG ACTTCGGCCT GGCGCGGCTT 2160
CTGGACGCCA ACGAGAAGGA ATACAACGCA GACGGGGGCA AGATGCCCAT TAAATGGATG 2220
GCCCTGGAAT GCATCCACTA CAGGAAGTTC ACCCATCAAA GTGATGTTTG GAGTTACGGA 2280
GTGACCATCT GGGAGCTGAT GACCTTCGGA GGCAAACCGT ATGATGGCAT CCCGACAAGA 2340
GAAATCCCAG ACATCCTGGA GAAAGGGGAG CGCTTACCGC AGCCTCCGAT CTGCACCATC 2400
GACGTTTACA TGGTCATGGT CAAATGCTGG ATGATCGATG CAGACAGCCG GCCCAAGTTT 2460
AAAGAACTAG CTGCTGAGTT CTGCAGAATG GCCCGTGACC CCCAGCGGTA CCTCGTGATC 2520
CAGGGGGATG ACCGGATGAA GCTCCCGAGC CCCAATGATA GTAAGTTCTT CCAGAGCCTC 2580
CTGGATGAAG AGGACCTGGA CAACCTGATG GATGCTGATG AGTACCTGGT GCCGCAGGGC 2640
TACACCTTGG CTCCGCCGTC GTACACGGTC AGGCCTCGTG TTGACTCCAA CAGAAACCAG 2700
TTTGGCTATC GAGACGGTGG TCCAGTCCCC ACAGAGGGCC CTGTGGCAGG CGCTCAAGCT 2760
GGTAGCAGCC AGGAAACTCC AGGTGGATTA GTCTCATCCC TGGAGGACAC GCGCAGCAAT 2820
GGTAACCTGC ATAAAAAGAG CATGAGCCAG TCCGGGGCAG AGGACAGCGG AGGTCAGAGG 2880
TACAGCGCCG ACCCTACTGT CTTCCTGGGG GAGAGGACGT CCAGAGGAGA CACTGACGAA 2940
GACGGATACA TCACCCCCAT GAAGGACAAG AACTCCTCAG AATACCTGAA TCCAATTGAA 3000
GAAAACCCTT TTGTCTCAAG ACGCAAAAAT GGTGAGATCC ACGCCTTGGA TAACCCAGGG 3060
TACCACAGCA CACCCAACAG TCAGCCCAAA ACAGAGGATG AGTACATCAA CGAGCCCCTC 3120
TACCTCAACA CCTTCCACAA TCCTGCCGAG CTGAGTTTGG AAGCCCTGAG TAAAGTCAGT 3180
GGGAAGAAGC TGAAGGTCAC CTTTGACAAT CCAGAATACT GGCAGCACAG CTTGCCCCCC 3240
AGGTCTTCTA ACCAAGCGGC CCCTGACAGC ACACTGGGTG GCTCCACAAA TGCTAAGCTC 3300
TTCTACAAGC AGAACGGACA CATCCGGCCA GTGGTAGCCG AAAACCCCGA ATACATGTCG 3360
GAGTTTTCCC TGAAGCCTGG TACCGTCCTG CCGCCTCCGC CCTACCGACA GCGAAACACC 3420
GTGGTTTAG 3429
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as++h
Q: 571   LKRVKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNEATGPKANVEFMDEALIMASMEH  630
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 631   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  690
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnh+kitdfGla+ll+a+eke++a+ggk+pikw+ale+i++rk+
Q: 691   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKMPIKWMALECIHYRKF  750
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipd+lekGerl+qppictidvymv+vkcw
Q: 751   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCW  810
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srpkfkela+ef
Q: 811   MIDADSRPKFKELAAEF  827
         ***************99
Domain Sequence
(FASTA)
LKRVKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNEAT GPKANVEFMD EALIMASMEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDANEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDILEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00650
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-MAM-00300
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00385
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013