EKS-TEN-00575
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00575
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK423.63.9E-12733317285
StatusUnreviewed
Ensembl ProteinENSTNIP00000011198
UniProt AccessionH3D8P4;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK12 (2 of 3)
Gene Synonyms/Alias MAPK12 (2 of 3); MAPK12 (1 of 3);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000008367ENSTNIP00000011198ENSTNIT00000011380
OrganismTetraodon nigroviridis
Functional Description
Protein Length369
Protein Sequence
(FASTA)
ARFLIFFAMS KRVRPGFHRQ DINKTKWEVP ERYRDLRQVG TGAYGTVCSA VDIRTGSKVA 60
IKKLYRPFQS ELFAKRAYRE LRLLKHMKHE NVIGLLDVFT SDFSLDAFDD FYLVMPFMGT 120
DLGKVMKMQR LSEEKIQYLV YQMLRGLKYI HSAGIIHRDL KPGNLAINQD CELKILDFGL 180
ARQTDSTMTG YVVTRWYRAP EVILSWMHYT QTVDIWSVGC IMAEMLQGKP LFKGSDHLDQ 240
LNEIMKITGT PTQEFVAKLD SEDARRYIKG LQKIEKKDLQ TVFSTTNPQA VSVLERMLLL 300
DPESRASAAE ALALPYFSEF RDPEEETEAQ PYDHSLDNAD LPLSQWKRHT FTEILSFKPV 360
VSEFKETPL 369
Nucleotide Sequence
(FASTA)
GCAAGATTTC TGATCTTTTT TGCCATGTCC AAGCGAGTCA GACCCGGTTT TCACCGCCAG 60
GATATCAACA AAACCAAATG GGAGGTGCCG GAGCGGTACC GAGACCTTCG GCAGGTGGGG 120
ACCGGCGCGT ACGGGACGGT CTGCTCAGCA GTGGACATCA GGACCGGATC CAAGGTGGCC 180
ATCAAGAAGC TCTACAGGCC CTTCCAGTCG GAGCTGTTCG CCAAGCGGGC CTACAGGGAG 240
CTGAGGCTCC TCAAGCACAT GAAGCATGAA AACGTGATCG GCCTGCTGGA CGTGTTCACC 300
TCGGACTTCT CCCTGGACGC CTTCGATGAC TTTTATCTGG TGATGCCGTT CATGGGCACA 360
GACCTGGGGA AGGTGATGAA GATGCAGAGG CTGTCAGAGG AAAAGATTCA GTATTTAGTT 420
TATCAGATGC TTAGAGGCCT TAAGTATATT CATTCTGCTG GTATAATTCA CAGGGACCTC 480
AAACCTGGAA ACCTCGCCAT CAACCAAGAC TGTGAGCTTA AGATCTTGGA CTTTGGTTTG 540
GCGCGGCAGA CAGACAGCAC CATGACCGGT TATGTGGTCA CGCGTTGGTA CAGAGCCCCA 600
GAGGTCATCC TGAGCTGGAT GCATTACACA CAAACGGTGG ATATCTGGTC TGTGGGCTGC 660
ATCATGGCGG AGATGCTGCA GGGAAAACCT CTTTTCAAAG GCAGCGACCA CTTGGATCAA 720
CTAAATGAGA TTATGAAGAT TACAGGAACA CCGACTCAAG AATTTGTTGC CAAACTGGAT 780
TCTGAGGATG CGAGACGCTA CATCAAAGGT CTTCAAAAGA TTGAGAAGAA GGACCTCCAA 840
ACAGTATTTT CCACCACAAA CCCCCAAGCC GTGTCCGTGC TGGAGCGCAT GCTGCTGCTG 900
GACCCCGAGA GCAGGGCCTC GGCTGCAGAG GCCCTCGCGC TGCCTTACTT CTCCGAGTTC 960
AGAGACCCAG AGGAGGAGAC AGAAGCCCAG CCGTACGACC ACTCGCTGGA CAACGCGGAC 1020
CTGCCTCTGA GCCAGTGGAA GCGTCACACG TTCACAGAGA TCTTGAGCTT CAAACCTGTT 1080
GTGTCAGAAT TCAAGGAAAC GCCACTCTAA 1110
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l+++g+Gayg+v+savd rt+++vaikkl rpfq+e  akr++REl+llk++kheN+
Q: 33    YRDLRQVGTGAYGTVCSAVDIRTGSKVAIKKLYRPFQSELFAKRAYRELRLLKHMKHENV  92
         7889********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i lldvft++ +l++++d+Ylv+ +m+tdL kv+k+q+ls+e+i++l+yq+lrglky+Hs
Q: 93    IGLLDVFTSDFSLDAFDDFYLVMPFMGTDLGKVMKMQRLSEEKIQYLVYQMLRGLKYIHS  152
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKP+Nl++n+dcelkildFGlar++d++    +t+yv+trwYraPe++ls+++
Q: 153   AGIIHRDLKPGNLAINQDCELKILDFGLARQTDST----MTGYVVTRWYRAPEVILSWMH  208
         *********************************99....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         yt++vDiWsvGCI+aE+l+gkplf+g+d++dql++i++++gtp++ef++k+ se ar+yi
Q: 209   YTQTVDIWSVGCIMAEMLQGKPLFKGSDHLDQLNEIMKITGTPTQEFVAKLDSEDARRYI  268
         ************************************************************
S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         k l+k++kkd++++f++++++a+ +le++L ldp++R s++eaL+ pY+
Q: 269   KGLQKIEKKDLQTVFSTTNPQAVSVLERMLLLDPESRASAAEALALPYF  317
         ***********************************************95
Domain Sequence
(FASTA)
YRDLRQVGTG AYGTVCSAVD IRTGSKVAIK KLYRPFQSEL FAKRAYRELR LLKHMKHENV 60
IGLLDVFTSD FSLDAFDDFY LVMPFMGTDL GKVMKMQRLS EEKIQYLVYQ MLRGLKYIHS 120
AGIIHRDLKP GNLAINQDCE LKILDFGLAR QTDSTMTGYV VTRWYRAPEV ILSWMHYTQT 180
VDIWSVGCIM AEMLQGKPLF KGSDHLDQLN EIMKITGTPT QEFVAKLDSE DARRYIKGLQ 240
KIEKKDLQTV FSTTNPQAVS VLERMLLLDP ESRASAAEAL ALPYF 285
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00430
EKS-ANC-00447
EKS-BOT-00461
EKS-CAJ-00471
EKS-CAF-00462
EKS-CAP-00495
EKS-DAR-00870
EKS-EQC-00455
EKS-GAM-00269
EKS-GAG-00385
EKS-GAA-00560
EKS-HOS-00471
EKS-MAM-00460
EKS-MUM-00492
EKS-MYL-00458
EKS-NOL-00419
EKS-ORN-00583
EKS-ORC-00436
EKS-ORL-00530
EKS-OTG-00468
EKS-PES-00404
EKS-PEM-00254
EKS-RAN-00474
EKS-TAG-00528
EKS-TAR-00575
EKS-TUT-00169
EKS-XET-00611
EKS-XIM-00578
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013