EKS-TEN-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	477.2	1.2E-143	44	298	255

Status

Unreviewed

Ensembl Protein

ENSTNIP00000011358

UniProt Accession

H3CSX4;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB (1 of 2)

Gene Synonyms/Alias

PRKACB (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000008518	ENSTNIP00000011358	ENSTNIT00000011540

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

351

Protein Sequence
(FASTA)

MGNAATAKKG NELESVKEFL AKAKEDFLRK WECPPQSTTC LDDFDRLKTL GTGSFGRVML 60

VKHKGTEQYF AMKILDKQKV VKLKQIEHTL NEKRILQAVS FPFLVKLEYA FKDNSNLYMV 120

MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHHGY 180

IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240

ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RYGNLKNGVN DIKGHKWFAT 300

TDWIAIYERK VEAPFIPKCR GPGDTSNFDD YEEEEIRVSL TEKCAKEFAE F 351

Nucleotide Sequence
(FASTA)

ATGGGGAACG CTGCCACCGC AAAGAAGGGC AACGAGCTGG AGAGCGTCAA AGAGTTTCTG 60

GCCAAAGCCA AAGAAGATTT CCTACGGAAA TGGGAATGCC CACCACAGAG CACAACATGC 120

CTAGATGACT TTGACAGATT AAAAACCCTG GGAACCGGCT CGTTTGGAAG AGTTATGTTG 180

GTGAAACACA AAGGAACAGA GCAATACTTT GCCATGAAAA TATTGGACAA GCAAAAGGTG 240

GTGAAACTGA AGCAAATAGA ACACACTTTA AACGAGAAGA GGATACTACA GGCAGTGAGC 300

TTCCCCTTTC TCGTCAAACT TGAGTATGCA TTTAAGGACA ATTCTAATCT TTACATGGTG 360

ATGGAGTATG TTCCTGGGGG GGAGATGTTC TCACATCTAA GACGAATTGG AAGGTTTAGC 420

GAACCGCACG CACGCTTTTA CGCCGCCCAG ATAGTGCTGA CGTTTGAGTA CCTCCACTCA 480

TTAGATCTCA TATACCGAGA TCTGAAACCT GAGAACCTTC TAATCGACCA CCACGGGTAC 540

ATCCAGGTGA CAGACTTTGG TTTCGCCAAG CGAGTCAAAG GCAGGACCTG GACGTTGTGT 600

GGGACGCCAG AATACCTGGC ACCGGAAATC ATCCTCAGCA AAGGATATAA CAAAGCTGTG 660

GACTGGTGGG CGCTGGGAGT CCTCATCTAT GAAATGGCAG CTGGCTACCC CCCGTTCTTT 720

GCAGATCAAC CCATCCAGAT CTACGAGAAG ATTGTATCTG GGAAGGTGCG ATTCCCCTCC 780

CACTTCAGCT CCGACCTGAA GGATCTGCTG AGAAACCTGC TGCAGGTTGA TCTGACAAAA 840

CGCTACGGCA ACCTGAAGAA CGGAGTCAAC GACATCAAGG GCCACAAGTG GTTCGCCACG 900

ACAGACTGGA TCGCCATCTA CGAGAGAAAG GTGGAAGCCC CTTTCATACC AAAGTGCAGA 960

GGCCCGGGAG ACACCAGCAA CTTCGACGAC TACGAAGAAG AGGAAATCCG CGTTTCTTTG 1020

ACGGAAAAGT GCGCAAAGGA GTTTGCAGAG TTTTAG 1056

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         f+rlktlGtGsfGrv+lv++k +++y+a+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 44    FDRLKTLGTGSFGRVMLVKHKGTEQYFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPF  103

         7899********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lvkl+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 104   LVKLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  163

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 164   IYRDLKPENLLIDHHGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  223

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 224   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYG  283

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik hkwf

Q: 284   NLKNGVNDIKGHKWF  298

         **************9

Domain Sequence
(FASTA)

FDRLKTLGTG SFGRVMLVKH KGTEQYFAMK ILDKQKVVKL KQIEHTLNEK RILQAVSFPF 60

LVKLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDHHGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG 240

NLKNGVNDIK GHKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013