EKS-TEN-00618

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00618

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	365.4	1.9E-109	24	282	259

Status

Unreviewed

Ensembl Protein

ENSTNIP00000011422

UniProt Accession

H3CT38;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK4

Gene Synonyms/Alias

RIPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000008582	ENSTNIP00000011422	ENSTNIT00000011604

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

713

Protein Sequence
(FASTA)

MEVSDSPPGT MGLLRTFDCS EFGSWEKIGS GGFGQVYKVR HVRWKTWLAI KCPPCLHVDD 60

KERSELLEEA KKMEAAKFRY ILPVYGICGD PQGLVMEYME MGSLENLLAT ELLPWELRFR 120

IIHETAVGMN FLHCMKPPLL HLDLKPANIL LDAHYHVKIS DFGLARWNGL SRADDISRDG 180

FCGTIAYLPP ESIIEKDRVS DPKHDVYSFS IVIWGILTQK KPYQGENNIL QIMVKVVKGV 240

RPDLGSIPRC RPPVCSGFLS LMQRCWATDP NARPSFQEIT SEAEELYFKP QEEPKNTTES 300

APGPTPHKAT TSDQKGMRPK SAMLPEKDCS LSELLTQVDS WISRSFDRLK ENSCHSKEST 360

SKRLSGISFA DSAFSSQDSI TLSFEKENTF DSSEVQKRKL CDAIRTKDTA KLMKILQPQD 420

VDLLLDGGDS LLHHAVTLAN EEAVKFLLLN NANPNLANAR GSTVLHVATE RHLKPTVELL 480

LGRRSTNVNA KDEDQYTALH WAAQNGDEAI ARLLLDRGAA INETDGRGRT PAHIACQHGQ 540

ENVIRVLLSR GADVQIRGKD DWTALHLAAW QGHLGIVKLL VKQAGADVDG QTADGRTPLH 600

LASQRGQYRV ARILIELGAN VHMTSVGCTT LHVAAETGHT STSRLLVKHR ADVHAQSALG 660

LTPLHLASQR GHLATVKMLI EEGADPCRSG PGPCTPFQLA AENGHGEVLN ELL 713

Nucleotide Sequence
(FASTA)

ATGGAGGTCT CGGATTCTCC ACCTGGGACG ATGGGACTGC TGAGGACTTT TGATTGCTCT 60

GAGTTTGGCA GCTGGGAGAA GATCGGCTCA GGTGGATTTG GACAAGTATA CAAAGTCCGG 120

CACGTACGCT GGAAAACATG GCTGGCAATC AAATGCCCTC CCTGCCTTCA CGTGGATGAC 180

AAGGAACGTT CGGAGCTGCT GGAGGAGGCC AAGAAGATGG AAGCGGCCAA GTTCCGCTAC 240

ATCCTGCCCG TGTACGGCAT CTGCGGGGAC CCTCAGGGCC TGGTCATGGA GTACATGGAG 300

ATGGGCTCCT TGGAGAACCT CCTGGCCACC GAGCTGCTGC CCTGGGAGCT GCGCTTCCGC 360

ATCATCCACG AGACGGCGGT GGGAATGAAC TTCCTGCACT GTATGAAACC CCCTCTGCTC 420

CACCTGGACC TGAAGCCCGC CAACATCCTC CTGGACGCTC ACTATCACGT CAAGATATCT 480

GATTTCGGGC TGGCGCGCTG GAACGGCCTG TCCAGGGCCG ACGACATCAG CAGAGACGGC 540

TTCTGCGGGA CCATCGCCTA CCTGCCCCCC GAGAGCATCA TCGAGAAGGA CAGAGTGTCG 600

GACCCCAAGC ACGACGTCTA CAGTTTCTCC ATTGTCATCT GGGGTATTCT CACTCAGAAA 660

AAACCCTACC AAGGAGAGAA TAATATCCTC CAGATCATGG TGAAGGTGGT GAAGGGGGTG 720

CGTCCAGATC TAGGCTCCAT CCCCCGCTGT CGGCCACCGG TCTGCTCGGG GTTCCTGAGC 780

CTGATGCAGC GCTGCTGGGC CACCGATCCC AACGCACGAC CCAGCTTTCA GGAAATCACA 840

TCTGAAGCCG AAGAGCTTTA CTTTAAACCT CAGGAGGAGC CGAAGAACAC AACCGAGTCA 900

GCACCAGGAC CCACACCCCA CAAAGCAACC ACTAGTGACC AGAAAGGGAT GCGTCCCAAG 960

TCGGCCATGC TGCCGGAGAA GGACTGCAGC CTGTCGGAGC TGCTGACCCA GGTGGACTCC 1020

TGGATCTCCA GGAGTTTCGA CCGTCTGAAG GAGAACAGCT GCCACAGCAA AGAAAGCACC 1080

AGTAAAAGAC TGTCCGGGAT CTCCTTCGCT GATTCTGCCT TCTCTTCCCA AGACTCCATC 1140

ACGCTCTCGT TCGAGAAAGA AAACACTTTC GACTCTTCAG AGGTGCAGAA GCGTAAACTC 1200

TGCGACGCCA TCAGGACCAA AGACACGGCC AAGTTGATGA AGATCCTCCA GCCTCAGGAC 1260

GTAGATCTTC TCCTAGACGG AGGGGACAGT CTGTTACACC ATGCCGTCAC GCTGGCGAAT 1320

GAAGAAGCTG TCAAGTTCCT CCTCCTGAAC AACGCGAACC CCAACCTGGC GAACGCTCGT 1380

GGCTCGACGG TGCTGCATGT CGCCACGGAG CGGCACCTAA AGCCCACGGT AGAACTTCTG 1440

CTCGGTCGCC GCAGCACCAA CGTCAACGCC AAGGACGAGG ACCAGTACAC GGCTTTACAC 1500

TGGGCCGCCC AGAACGGTGA CGAGGCCATC GCGCGCCTGC TGCTGGATCG GGGGGCGGCC 1560

ATCAACGAGA CCGACGGTCG CGGGCGCACG CCGGCTCACA TCGCGTGCCA GCACGGCCAG 1620

GAGAACGTGA TCCGCGTGCT GCTGAGTCGC GGGGCGGACG TCCAAATCAG GGGCAAGGAC 1680

GACTGGACGG CGCTCCACTT GGCCGCCTGG CAGGGTCACC TGGGCATCGT CAAGCTGCTC 1740

GTCAAACAGG CCGGCGCCGA CGTGGACGGC CAGACCGCGG ACGGTCGCAC TCCGCTGCAT 1800

CTGGCCTCCC AGAGGGGGCA GTACAGGGTG GCGCGCATCC TGATTGAACT GGGGGCAAAC 1860

GTTCACATGA CCTCGGTGGG TTGCACAACA CTCCACGTGG CGGCAGAGAC GGGCCACACC 1920

AGCACCTCTC GTCTCCTGGT CAAACACCGG GCGGACGTGC ACGCCCAGAG CGCCCTGGGA 1980

CTCACTCCTC TCCACCTAGC TTCTCAGCGA GGCCATTTGG CCACAGTCAA GATGCTGATA 2040

GAAGAGGGGG CGGACCCCTG CCGATCCGGC CCGGGCCCGT GCACCCCCTT TCAGCTGGCG 2100

GCGGAGAACG GTCACGGCGA AGTCTTGAAC GAGCTGCTC 2139

Domain Profile

S: 3     elelvgsGgfgkvfkarhrkwrvevavk.slvlktdaldserkelleeakkmeklrfsyv  61

          +e++gsGgfg+v+k+rh++w++++a+k  ++l++d  d+er+elleeakkme ++f+y+

Q: 24    SWEKIGSGGFGQVYKVRHVRWKTWLAIKcPPCLHVD--DKERSELLEEAKKMEAAKFRYI  81

         799*************************999*****..9*********************

S: 62    lkllGvikeeeklglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhslkPp  121

         l+++G++ ++  +glvmeyme GsLe+lL++e  lpw+l+fRi++e+++gmn+Lh++kPp

Q: 82    LPVYGICGDP--QGLVMEYMEMGSLENLLATE-LLPWELRFRIIHETAVGMNFLHCMKPP  138

         **********..9*******************.8**************************

S: 122   llhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPelleevn  181

         llh+DLkp+niLlD+++hvki+DfGl+++ ++ s+  ++s+++  Gt+aYl+Pe + e++

Q: 139   LLHLDLKPANILLDAHYHVKISDFGLARW-NGLSRADDISRDGFCGTIAYLPPESIIEKD  197

         *****************************.******************************

S: 182   kkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelPrevpq  241

         +  + k+DvYsf+iviW++l++k+py+ e+n+lqi+++v kg RP+l  +++ +P  +++

Q: 198   RVSDPKHDVYSFSIVIWGILTQKKPYQGENNILQIMVKVVKGVRPDLGSIPRCRPPVCSG  257

         ************************************************************

S: 242   lieLmkrcWeadpeeRPsFleieek  266

         + +Lm+rcW++dp++RPsF+ei+++

Q: 258   FLSLMQRCWATDPNARPSFQEITSE  282

         **********************987

Domain Sequence
(FASTA)

SWEKIGSGGF GQVYKVRHVR WKTWLAIKCP PCLHVDDKER SELLEEAKKM EAAKFRYILP 60

VYGICGDPQG LVMEYMEMGS LENLLATELL PWELRFRIIH ETAVGMNFLH CMKPPLLHLD 120

LKPANILLDA HYHVKISDFG LARWNGLSRA DDISRDGFCG TIAYLPPESI IEKDRVSDPK 180

HDVYSFSIVI WGILTQKKPY QGENNILQIM VKVVKGVRPD LGSIPRCRPP VCSGFLSLMQ 240

RCWATDPNAR PSFQEITSE 259

Keyword

ANK repeat; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12796	; Ank_2; 3.
PF00069	; Pkinase; 1.

SMARTs

SM00248

; ANK; 8.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013