EKS-TEN-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	382.9	6.6E-115	59	311	253

Status

Unreviewed

Ensembl Protein

ENSTNIP00000011504

UniProt Accession

H3CTC0;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000008656	ENSTNIP00000011504	ENSTNIT00000011686

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

781

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHSS VDGFAEPPAP PTKSASRHSL PRCRNSFTST EEHPHIGNYR 60

LLKTIGKGNF AKVKLARHVL TGREVAVKII DKTQLNPTSL QKLFREVRIM KLLNHPNIVK 120

LFEVIETEKT LYLVMEYASG GEVFDYLVAH GRMKEKEARA KFRQQIVSAV QYCHQRRIVH 180

RDLKAENLLL DADMNIKIAD FGFSNEFTMG SKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240

WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPVKRG 300

SLEQIMKDHW MNVGHEEEEL KPYIEPEADF SDSSRIELMV TMGYPKDEIT ESLHSQKYDD 360

VMATYLLLGR KAPEFEGSEP LANSVLAQRQ RPTSDINNSS SISPAHPKVT RSISANQKQR 420

RYSDHVGPSV PPAVSYTKRG QALSVESDHR EEWDGARRLE LSTSKGDVPA SPLGVQERKK 480

TSSTVGVFFS QTDGSMTRST YVCERSSTER YSAIPNGKDS SLTEVSGSTP STAISSTRPR 540

HTKSMSSSGH PSKSTLPPID DNTELKASSS SPRGPSNSPS AHSISTPEKN RFPRGTTSRS 600

TFHGAQLRDR RSATYNGPPA SPTLSHDTGA LAQQRRGTSA GIISKITSKF VRRVPSEGEA 660

SARTETPRSA SGDSKEEGRD AKPRSLRFTW SMKTTSSMEP TEMMKEIRKV LDANSCDYEQ 720

RERFLLFCVH GDARQDNLVQ WEMEVCKLPR LSLNGVRFKR ISGTSIAFKN IACKIANELK 780

L 781

Nucleotide Sequence
(FASTA)

ATGTCGACCA GAACGCCATT GCCGACCGTG AACGAGCGTG ACACCGAGAA CCACTCGTCG 60

GTTGACGGCT TTGCCGAACC CCCAGCCCCC CCGACAAAGT CTGCAAGTCG CCACAGCCTG 120

CCGCGATGCC GCAACTCGTT CACCTCCACC GAGGAACACC CCCACATCGG CAACTACCGT 180

CTCCTCAAGA CCATCGGGAA GGGGAACTTT GCCAAGGTGA AGCTGGCGCG ACATGTTCTG 240

ACTGGACGAG AGGTGGCGGT GAAGATTATA GACAAAACGC AGCTGAATCC CACCAGTCTA 300

CAGAAGCTCT TCAGGGAAGT CCGAATAATG AAGCTACTGA ATCATCCAAA CATAGTGAAA 360

CTATTCGAGG TGATTGAGAC AGAGAAGACA CTTTATTTGG TGATGGAGTA CGCCAGCGGC 420

GGAGAAGTAT TTGATTATCT TGTTGCTCAT GGCAGAATGA AGGAAAAGGA GGCCAGAGCC 480

AAGTTCAGGC AGCAGATCGT GTCTGCGGTG CAGTATTGTC ACCAGAGAAG AATAGTACAT 540

CGAGATCTAA AGGCTGAGAA CCTGCTGTTG GACGCGGATA TGAATATCAA GATAGCGGAT 600

TTTGGCTTCA GTAACGAGTT CACCATGGGC AGCAAGCTGG ACACGTTCTG CGGCTCCCCG 660

CCGTATGCCG CTCCGGAGCT TTTCCAGGGG AAGAAGTACG ATGGCCCAGA GGTGGATGTG 720

TGGAGCCTCG GTGTCATACT CTACACGCTG GTCAGCGGAT CGCTGCCCTT TGATGGCCAG 780

AACCTAAAGG AGCTGAGGGA GCGAGTCCTG CGGGGAAAAT ACCGTATTCC TTTCTACATG 840

TCCACGGACT GTGAAAATCT GCTGAAGAAA CTTCTTGTGC TCAACCCAGT AAAACGAGGC 900

AGTTTGGAGC AAATAATGAA AGACCATTGG ATGAATGTGG GTCACGAGGA GGAGGAGCTA 960

AAACCTTACA TCGAGCCAGA GGCGGACTTC AGTGATTCAT CCAGAATAGA ACTCATGGTG 1020

ACGATGGGCT ACCCTAAAGA TGAGATCACG GAGTCTTTGC ACAGCCAGAA ATACGATGAC 1080

GTTATGGCCA CATACTTGCT CTTGGGAAGG AAAGCTCCAG AATTTGAGGG GAGCGAGCCC 1140

CTGGCCAACA GTGTTCTGGC CCAGCGACAG AGACCGACAA GCGATATCAA CAACAGCTCC 1200

AGCATTTCTC CCGCCCATCC GAAGGTCACG CGTAGCATCT CGGCCAATCA GAAGCAGCGC 1260

CGCTACAGCG ATCATGTGGG CCCTTCCGTG CCCCCGGCAG TGTCGTATAC AAAGCGTGGC 1320

CAGGCCCTGA GCGTGGAGAG CGACCACCGG GAGGAGTGGG ATGGAGCACG CCGGCTGGAG 1380

CTCAGCACTT CCAAAGGAGA TGTTCCTGCT TCGCCACTGG GTGTGCAAGA GAGGAAGAAG 1440

ACTTCAAGCA CTGTGGGGGT GTTCTTCTCA CAGACCGATG GATCAATGAC TCGAAGCACA 1500

TATGTGTGTG AACGATCTTC TACTGAACGG TATTCAGCTA TTCCGAACGG CAAAGACAGC 1560

AGTTTGACCG AGGTGTCAGG TAGCACCCCG TCGACTGCTA TCAGTTCCAC GCGACCTCGT 1620

CACACCAAGT CCATGTCATC GTCAGGGCAT CCGTCAAAAA GCACACTGCC TCCCATCGAT 1680

GACAACACGG AGCTTAAAGC AAGCAGTTCC TCCCCCCGCG GCCCTTCCAA CTCTCCCTCT 1740

GCGCACAGTA TTAGCACCCC GGAGAAGAAC CGTTTCCCTC GTGGGACCAC CAGTCGCAGC 1800

ACTTTCCACG GGGCCCAGCT TAGAGACCGA CGCAGCGCCA CCTACAATGG CCCCCCAGCT 1860

TCACCCACAC TGTCCCATGA CACAGGGGCT CTTGCTCAGC AACGCAGGGG CACGTCTGCA 1920

GGGATAATCA GCAAGATCAC CTCAAAGTTT GTCCGCAGGG TGCCTAGTGA GGGAGAAGCC 1980

AGTGCCAGGA CAGAAACACC AAGAAGTGCA TCAGGTGATT CCAAGGAGGA AGGACGGGAT 2040

GCCAAGCCTC GCTCGCTACG CTTCACTTGG AGCATGAAGA CCACCTCATC CATGGAGCCC 2100

ACCGAGATGA TGAAGGAGAT CCGAAAGGTC CTAGACGCCA ACAGCTGCGA TTACGAGCAG 2160

CGCGAACGCT TCCTGCTGTT CTGCGTCCAC GGCGACGCGC GGCAAGACAA CCTGGTCCAG 2220

TGGGAGATGG AGGTGTGCAA GTTGCCCCGT TTGTCGCTCA ACGGCGTTCG CTTCAAAAGA 2280

ATATCGGGCA CATCCATCGC CTTTAAGAAC ATCGCCTGTA AAATCGCCAA TGAGCTCAAA 2340

CTGTGA 2346

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k l+hpni

Q: 59    YRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKLLNHPNI  118

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfk.qlvsavkYlhskgi  119

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+ q+vsav+Y+h+++i

Q: 119   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRqQIVSAVQYCHQRRI  178

         ******************************************99737*************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+v

Q: 179   VHRDLKAENLLLDADMNIKIADFGFSNEFTMGSKLDTFCGSPPYAAPELFQGKKYDGPEV  238

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         DvWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p k

Q: 239   DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPVK  298

         ************************************************************

S: 240   Ratieeilkhewl  252

         R ++e+i+k++w+

Q: 299   RGSLEQIMKDHWM  311

         ************8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKLLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQQIVS AVQYCHQRRI 120

VHRDLKAENL LLDADMNIKI ADFGFSNEFT MGSKLDTFCG SPPYAAPELF QGKKYDGPEV 180

DVWSLGVILY TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KKLLVLNPVK 240

RGSLEQIMKD HWM 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013