EKS-TEN-00536

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00536

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	330.6	7.2E-99	204	476	273

Status

Unreviewed

Ensembl Protein

ENSTNIP00000011643

UniProt Accession

H3CTQ9;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE2

Gene Synonyms/Alias

WEE2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000008794	ENSTNIP00000011643	ENSTNIT00000011831

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

MARPFDGISQ QLDFASGGED GSSSSSSDNS LDGFGFRIRS PRLASPGVLS PGSACRTPRV 60

RRHRGRSGAA SSPSQCTSPI PYATWRKLRL CDSPSTPKSL LSKSSQPCSS TKVCRSQRTL 120

RFVSTAASFV RLPPSVNVNP FTPQTVRRSS ELQRRNDFRG EDDEDYGRRL KHSLTSSEED 180

EENVLPPKRR AVQAFLLSRY ESEFLELERI GVGEFGAVYK CVKRLDGCLY AIKRSRRPLA 240

GSADEQLALK EVYAHAVLGH HPHVVRYYSA WAEDDHMIIQ NEYCDGGSLA DAISQKEVQG 300

ELFSEPEVKD LLLQVSMGLK YIHSSGLVHL DIKPSNIFIC HPDTSGTCGG ESEEEENDGR 360

TSSGVVYKIG DLGHVTSTSS PQVEEGDSRF LASEVLHEDY SNLPKADIFA LGLTVLLAAG 420

ASPLPQNGDE WHRLREGKLP TLPQELSSPF RALLQSLLHP DVTKRPSTKE LCKHVVLREE 480

KNGRLAAQLR RELNVEKFKT AMLEKELQEA RQAVLSPKRK VDLGLKSPAK LGCQPKAGRR 540

LVGGKTARSL SIGCPGYGI 559

Nucleotide Sequence
(FASTA)

ATGGCAAGGC CGTTTGATGG GATCAGTCAG CAGCTGGATT TCGCCAGCGG TGGGGAGGAT 60

GGGAGCAGCA GCAGCAGCAG CGACAACAGT TTAGATGGCT TCGGCTTCAG GATCCGCAGC 120

CCCAGACTTG CGAGTCCCGG GGTTTTGAGC CCCGGGTCGG CATGCCGGAC ACCCAGGGTG 180

CGACGCCACC GCGGTAGAAG CGGCGCCGCG TCCTCCCCTT CCCAGTGCAC CAGCCCCATA 240

CCTTATGCTA CGTGGAGGAA ACTGAGGCTC TGCGACTCTC CCAGCACGCC AAAGAGCCTG 300

TTGTCCAAGT CCTCCCAGCC CTGCTCCAGC ACCAAGGTCT GCCGCAGCCA GAGGACCCTA 360

CGCTTCGTCT CCACCGCTGC CAGCTTCGTC CGCCTTCCTC CGTCCGTCAA CGTGAATCCG 420

TTCACCCCCC AAACGGTCCG CAGGAGCAGT GAGCTGCAGC GGAGGAACGA TTTCAGGGGA 480

GAGGACGATG AAGACTACGG ACGAAGGTTA AAACACAGTC TGACCTCATC TGAGGAGGAT 540

GAAGAAAACG TTCTCCCACC CAAGAGACGA GCCGTACAGG CTTTCTTGCT GTCTCGCTAC 600

GAGAGCGAGT TCCTGGAGCT GGAGCGCATC GGCGTAGGCG AGTTCGGGGC GGTTTACAAA 660

TGCGTGAAGA GGCTGGACGG CTGCTTGTAT GCCATAAAAC GATCTCGCCG ACCCCTGGCG 720

GGCTCCGCCG ACGAGCAGCT GGCCCTGAAG GAGGTCTACG CGCACGCGGT GCTCGGCCAC 780

CACCCACACG TTGTCCGGTA TTATTCGGCA TGGGCGGAGG ACGATCACAT GATCATTCAG 840

AACGAATACT GTGACGGTGG AAGTCTCGCC GATGCCATCT CACAGAAGGA GGTGCAGGGT 900

GAGCTCTTTT CCGAGCCGGA GGTGAAGGAT CTGCTTTTGC AGGTGTCGAT GGGCCTGAAA 960

TATATCCACA GCTCAGGCCT CGTGCACCTG GACATCAAAC CAAGTAACAT ATTTATCTGC 1020

CATCCGGACA CCAGTGGCAC GTGCGGAGGC GAGAGCGAGG AGGAGGAGAA CGATGGGAGA 1080

ACGTCATCGG GAGTCGTTTA TAAAATTGGG GATCTGGGTC ATGTGACGTC CACCAGCAGC 1140

CCTCAAGTGG AGGAAGGCGA CAGCCGCTTC TTAGCCAGCG AGGTTCTGCA CGAGGACTAC 1200

AGCAACCTCC CCAAGGCGGA CATCTTTGCT CTGGGCCTGA CGGTGCTGCT GGCGGCCGGG 1260

GCTTCTCCTC TGCCTCAGAA TGGTGATGAG TGGCACCGCC TGCGAGAGGG GAAGCTGCCC 1320

ACGCTGCCAC AGGAGCTCTC CTCTCCGTTT AGAGCCCTGC TGCAGTCGCT GCTGCATCCC 1380

GACGTGACCA AACGCCCATC AACCAAAGAG CTTTGCAAGC ATGTGGTGTT AAGAGAGGAG 1440

AAGAACGGGA GGCTGGCCGC TCAGCTCCGC AGAGAGCTCA ACGTGGAGAA GTTCAAGACT 1500

GCCATGCTTG AAAAAGAGCT TCAGGAGGCT CGCCAGGCAG TTTTGTCCCC CAAGCGCAAG 1560

GTTGATCTTG GGCTGAAGTC TCCTGCTAAG CTGGGCTGCC AGCCCAAAGC GGGGAGAAGG 1620

CTTGTTGGTG GGAAGACGGC AAGATCCTTG AGCATCGGCT GCCCAGGATA TGGAATATGA 1680

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+e+iG+Gefg v+k+vkr+dg+lyAik+s++pl+g+ +e+ al+Ev+ahavlg+h++

Q: 204   FLELERIGVGEFGAVYKCVKRLDGCLYAIKRSRRPLAGSADEQLALKEVYAHAVLGHHPH  263

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a+++ e + + ++e e+k++ll+++ gl+y+H

Q: 264   VVRYYSAWAEDDHMIIQNEYCDGGSLADAISQKEVQGELFSEPEVKDLLLQVSMGLKYIH  323

         ********************************9999************************

S: 121   ssslvHlDikpenifi......................tkevtlklgDlGlvtelnsedk  158

         ss lvHlDikp+nifi                      ++ v++k+gDlG+vt+    ++

Q: 324   SSGLVHLDIKPSNIFIchpdtsgtcggeseeeendgrtSSGVVYKIGDLGHVTST---SS  380

         *************************************98999***********99...9*

S: 159   skveEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklp  217

         ++veEGDsr+la E+l+e+ys+l kaDiF+lglt+l +a++ +lP+nG++Wh+lR+gklp

Q: 381   PQVEEGDSRFLASEVLHEDYSNLpKADIFALGLTVLLAAGASPLPQNGDEWHRLREGKLP  440

         ************************************************************

S: 218   deilkelsedlrellklmlepdperRptaeellkhev  254

           + +els+ +r ll+++l+pd ++Rp+++el kh v

Q: 441   -TLPQELSSPFRALLQSLLHPDVTKRPSTKELCKHVV  476

         .********************************9977

Domain Sequence
(FASTA)

FLELERIGVG EFGAVYKCVK RLDGCLYAIK RSRRPLAGSA DEQLALKEVY AHAVLGHHPH 60

VVRYYSAWAE DDHMIIQNEY CDGGSLADAI SQKEVQGELF SEPEVKDLLL QVSMGLKYIH 120

SSGLVHLDIK PSNIFICHPD TSGTCGGESE EEENDGRTSS GVVYKIGDLG HVTSTSSPQV 180

EEGDSRFLAS EVLHEDYSNL PKADIFALGL TVLLAAGASP LPQNGDEWHR LREGKLPTLP 240

QELSSPFRAL LQSLLHPDVT KRPSTKELCK HVV 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013