EKS-TEN-00398

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00398

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	518.7	3.4E-156	677	946	270

Status

Unreviewed

Ensembl Protein

ENSTNIP00000011762

UniProt Accession

H3CU28;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000008909	ENSTNIP00000011762	ENSTNIT00000011951
ENSTNIG00000008909	ENSTNIP00000011763	ENSTNIT00000011952

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1154

Protein Sequence
(FASTA)

SSAGPNITLE GRYHCYQGPA ISLDRLCDFT RDCPLGDDEG DHCRDFLNGS YCSFEDGDCS 60

WKPIAGRTLS WKRLQSSAKP PRQSCPSSGA TFSVEGGHAK GQRGSALLRS PLFPPPLRNS 120

PCTVRFWLCS RGLHKGSLSL WLLENSTGPE EQRPLWSSAS EAKSEKSWKL ITLPLYGLAD 180

WFWLQFSTEN GPGPGSSVSL DNISFSMDCF LACEYTYNNL QTEAARATNI ARGNEVKWLS 240

PVIPRPPPSG NAAKKWIFQT CGARGPEGPT HTQCLNSYRK NNVSVTVAAQ GPLKGIQKWK 300

VLETGTYRIT AYGAAGGRSV LVMSRSHGVY LAGDFWLKKG EELYILVGQQ GEDACPSSNN 360

ILNKICQEQS GPMVNKTQVK WGGGGGGGAT YVFKVDNGVY VPLIIAAGGG GRGYSSQAET 420

QLEQMDYESS QHGRNGKSYA AGGGGGWNDS APISQGGRPL VLGGQGGQAC QHFSQTRGGF 480

GGGGGGCLSG GGGGGYRGGN TSIENNPRHD GDDGTSFLSQ LGVPFLSIPL KAIDGDGEVI 540

IGPVQNCSHC ESGECYDAKD GIVCFCEEDL ILAPDRVSCI KVTVLPPQAS LSHLALGLSV 600

GTSALIAALL LAVSGVMIMY RRKHTELQSI QLELQSPDCK LSKLRASTIM TDYNPNYCFA 660

GKTASVNDLK EVSRRNISLT RGLGHGAFGE VYEGLAVGIP GEPSPLQVAV KTLPEVCSEQ 720

DELDFLMEAL IISKFSHQNI VRCVGVSLQA MPRFILLELM TGGDLKTFMR ETRPRPEHPS 780

SLTMVDLLNI ARDIAKGCQY LEENQFIHRD IAARNCLLTC KGPGRVAKIG DFGMARDIYR 840

ASYYRKGGRA MLPVKWMPPE AFMEGIFTSK TDTWSFGVLL WEIFSLGYMP YPSRSNQEVL 900

EFVTNGGRMD PPKNCPGPVY RIMTQCWQHQ PEDRPNFSTI LERIDYCLQD PDVVTMPLPV 960

QYGPVPEEEE GAALRSDEPS APAVLVNAQV PDGEARQPAP SRSPEETCNG GEHPVVAGAA 1020

SEAKAQVASQ PGTEGGHINL AFTQGHQPEK DGHNGKSTSL WNPTYGSWFL QQKKQKQQRQ 1080

AGVGAAGGNG GRVPGEATPP PGLCRPLLPP PPPPTVQSPL LLDTATLPPV PLYRLRIPCG 1140

NIGYGYQEAG VTLD 1154

Nucleotide Sequence
(FASTA)

TCCTCAGCTG GTCCCAACAT TACACTGGAG GGCCGGTACC ACTGTTACCA GGGCCCTGCG 60

ATCTCACTCG ACAGACTTTG CGACTTTACA AGAGACTGTC CGCTGGGCGA TGACGAAGGC 120

GACCATTGTC GTGACTTTCT CAACGGCAGC TACTGCTCTT TCGAAGATGG TGATTGCAGC 180

TGGAAGCCGA TCGCAGGTCG CACTCTCTCC TGGAAAAGAC TCCAGTCGTC AGCCAAGCCT 240

CCCAGGCAGA GCTGCCCGTC GTCAGGCGCG ACGTTCTCTG TGGAAGGAGG CCACGCCAAA 300

GGGCAACGCG GTTCGGCATT ACTGAGGAGT CCCCTCTTCC CTCCCCCTCT GAGAAACTCC 360

CCGTGCACGG TGCGGTTCTG GCTGTGCTCC AGAGGCTTGC ACAAGGGCTC GCTGTCGCTG 420

TGGTTACTGG AGAACAGCAC AGGTCCAGAG GAGCAGCGCC CACTGTGGAG CTCAGCCAGT 480

GAAGCCAAAT CGGAAAAGTC CTGGAAACTC ATCACGCTTC CTCTTTATGG CCTGGCAGAC 540

TGGTTCTGGC TCCAGTTCAG CACCGAAAAT GGACCTGGAC CTGGTTCATC TGTCTCCCTC 600

GACAACATCT CTTTTAGTAT GGATTGCTTC CTGGCATGTG AGTACACATA TAACAATTTA 660

CAGACCGAAG CAGCCAGAGC AACCAACATA GCCAGAGGAA ATGAGGTCAA ATGGTTGTCA 720

CCTGTGATAC CCCGTCCTCC TCCTTCAGGA AATGCAGCCA AAAAATGGAT CTTTCAAACT 780

TGTGGGGCCA GGGGACCCGA AGGACCAACT CACACTCAGT GCCTCAATTC CTATCGGAAA 840

AACAATGTCA GCGTGACAGT TGCCGCGCAG GGGCCGCTGA AGGGCATTCA GAAGTGGAAG 900

GTCCTGGAAA CCGGCACCTA CAGAATCACG GCGTACGGTG CGGCCGGAGG TCGAAGCGTG 960

TTGGTCATGA GCCGGTCGCA CGGTGTCTAC CTCGCAGGGG ACTTCTGGCT GAAGAAGGGC 1020

GAGGAGCTCT ACATCCTTGT CGGACAGCAG GGAGAGGATG CGTGTCCCAG CTCTAACAAC 1080

ATCCTGAATA AGATCTGCCA GGAACAGAGC GGCCCGATGG TGAACAAAAC ACAAGTCAAA 1140

TGGGGCGGAG GAGGAGGAGG CGGGGCCACA TATGTATTCA AAGTGGACAA CGGCGTGTAC 1200

GTCCCTCTCA TCATCGCTGC TGGAGGAGGA GGCCGAGGCT ACAGCAGCCA GGCTGAAACC 1260

CAGCTGGAGC AGATGGACTA TGAATCAAGC CAACACGGAC GCAATGGGAA ATCTTATGCT 1320

GCAGGCGGCG GCGGAGGCTG GAATGACAGC GCTCCCATCA GTCAGGGCGG CCGACCGCTG 1380

GTGTTGGGGG GCCAGGGCGG CCAAGCCTGT CAACATTTTT CACAGACCCG TGGCGGATTC 1440

GGAGGTGGCG GAGGTGGATG TCTGTCTGGG GGTGGCGGCG GCGGCTACAG AGGTGGAAAC 1500

ACCTCGATAG AAAACAACCC CAGGCACGAT GGCGATGACG GCACATCCTT CCTCAGCCAG 1560

CTCGGGGTGC CCTTTCTGTC CATACCTCTG AAAGCCATTG ACGGGGATGG CGAGGTGATC 1620

ATAGGTCCTG TGCAGAACTG CAGCCACTGT GAGAGCGGTG AATGCTACGA TGCCAAGGAC 1680

GGCATCGTCT GCTTCTGTGA AGAAGACCTC ATCCTGGCAC CAGACCGAGT TTCCTGCATC 1740

AAGGTGACCG TGCTGCCCCC CCAGGCGTCC CTCTCCCACC TGGCTCTGGG TCTGTCCGTC 1800

GGTACTTCGG CCCTCATCGC CGCGCTGTTG CTGGCTGTGT CCGGAGTCAT GATCATGTAC 1860

CGGCGCAAAC ACACGGAGCT GCAGTCCATT CAGCTGGAGC TGCAGAGCCC AGACTGCAAG 1920

CTCAGCAAGC TGCGGGCCTC CACCATCATG ACCGACTACA ACCCCAACTA CTGCTTCGCT 1980

GGCAAGACGG CGTCAGTGAA CGACCTGAAG GAAGTCTCGC GTCGGAACAT CTCCCTCACC 2040

AGGGGTCTGG GTCACGGCGC TTTCGGCGAA GTCTACGAAG GACTGGCAGT GGGAATACCA 2100

GGAGAACCCA GTCCGCTGCA GGTGGCCGTC AAGACTCTTC CGGAGGTTTG CTCTGAGCAA 2160

GATGAGCTGG ACTTCCTCAT GGAGGCCCTG ATCATCAGTA AATTTAGCCA CCAGAACATC 2220

GTGAGGTGTG TTGGAGTCAG TCTGCAGGCT ATGCCCAGGT TCATCTTGCT GGAACTGATG 2280

ACGGGAGGAG ACCTCAAAAC CTTCATGAGA GAGACCAGAC CCCGACCGGA GCATCCTTCC 2340

AGCCTGACCA TGGTGGACCT TCTCAACATA GCTCGAGACA TCGCAAAGGG TTGCCAGTAC 2400

CTGGAGGAGA ACCAGTTTAT ACACAGGGAC ATCGCCGCCC GGAATTGCTT GCTGACTTGC 2460

AAAGGGCCGG GACGCGTGGC CAAAATCGGA GACTTCGGCA TGGCTCGGGA CATCTACAGG 2520

GCTAGCTATT ACAGGAAGGG TGGACGGGCC ATGCTGCCGG TCAAGTGGAT GCCGCCTGAA 2580

GCCTTCATGG AGGGCATCTT TACGTCAAAA ACAGACACGT GGTCATTCGG CGTTTTGCTG 2640

TGGGAGATCT TCTCTCTGGG ATACATGCCG TATCCGAGTC GCAGTAACCA GGAAGTGTTG 2700

GAGTTTGTAA CCAATGGGGG CAGAATGGAC CCCCCTAAAA ACTGCCCGGG GCCAGTGTAT 2760

CGGATAATGA CCCAGTGTTG GCAGCATCAG CCTGAAGACA GGCCCAACTT TTCAACTATC 2820

CTGGAGAGAA TCGACTACTG CTTACAGGAC CCAGATGTGG TGACCATGCC CCTGCCCGTG 2880

CAGTATGGAC CCGTCCCTGA AGAGGAGGAG GGTGCAGCCC TGCGCTCCGA TGAGCCCTCC 2940

GCTCCAGCCG TGCTGGTAAA CGCCCAGGTG CCTGATGGGG AGGCGCGGCA ACCCGCCCCA 3000

TCGCGTTCTC CGGAAGAGAC CTGCAACGGT GGAGAGCACC CCGTCGTGGC GGGCGCGGCG 3060

TCAGAGGCCA AAGCACAAGT GGCCAGCCAG CCCGGCACCG AGGGGGGCCA CATCAACCTA 3120

GCTTTCACCC AGGGCCACCA GCCCGAGAAG GACGGCCACA ACGGGAAGAG CACCAGCCTG 3180

TGGAACCCGA CGTACGGCTC GTGGTTCCTG CAGCAGAAGA AGCAGAAGCA GCAGAGGCAG 3240

GCGGGCGTGG GAGCAGCCGG GGGGAACGGC GGCAGGGTGC CCGGCGAAGC AACACCACCT 3300

CCAGGACTCT GTCGACCCCT GTTGCCCCCA CCACCGCCCC CTACGGTCCA GTCACCTCTG 3360

CTTTTGGATA CAGCCACGTT GCCCCCGGTC CCCCTCTACA GACTCAGAAT TCCCTGCGGG 3420

AACATCGGCT ACGGCTACCA GGAAGCGGGC GTAACGCTGG AC 3462

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i l+r+lG+GafGevyegl  g+pg++s+l+vavktlpe++seqdeldfl+ealiiskf+

Q: 677   ISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFS  736

         6789********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr++Gvsl+++pr+illel++GGdlk+f+re+rp+pe++ssl+m dll++a+d+ak

Q: 737   HQNIVRCVGVSLQAMPRFILLELMTGGDLKTFMRETRPRPEHPSSLTMVDLLNIARDIAK  796

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll++kGp+rvaki+dfGmardiyra+yyrkggra+lpvkw

Q: 797   GCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  856

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp++snqevle+v++Ggr+d+pk++p

Q: 857   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCP  916

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f +iler+++

Q: 917   GPVYRIMTQCWQHQPEDRPNFSTILERIDY  946

         ***************************986

Domain Sequence
(FASTA)

ISLTRGLGHG AFGEVYEGLA VGIPGEPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFS 60

HQNIVRCVGV SLQAMPRFIL LELMTGGDLK TFMRETRPRP EHPSSLTMVD LLNIARDIAK 120

GCQYLEENQF IHRDIAARNC LLTCKGPGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSRSN QEVLEFVTNG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FSTILERIDY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013